Synthesis of chromium carbene scaffolds for use in medicinal chemistry
- Rafael, Christopher Carlos Ferreira
- Authors: Rafael, Christopher Carlos Ferreira
- Date: 2014
- Subjects: Carbenes (Methylene compounds) , Pharmaceutical chemistry
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:4456 , http://hdl.handle.net/10962/d1010863 , Carbenes (Methylene compounds) , Pharmaceutical chemistry
- Description: This study involves using methyllithium to synthesize Fischer carbene complexes as precursors for metal templated α,β-unsaturated complexes with potential as acceptors in the Baylis Hillman reaction as well as in Dötz benzannulation. Fischer carbene complexes contain low oxidation state metal centers, are electrophilic in nature and are stabilized by π-donating substituents such as alkoxy and amino groups. The increased electron withdrawing nature of the metal carbonyl moiety was expected to improve the rates of reaction compared to organic carbonyls. Four Fischer carbenes were synthesized via nucleophilic addition of MeLi to chromium and tungsten hexacarbonyl at low temperatures followed by alkylation using either a Meerwein salt (Me₃OBF₄) to give the desired Fischer metal methyl methoxy carbenes or Et₄NBr/alkylhalide to make the corresponding ethoxy and allyloxy carbenes. Characterization was by means of ¹³C NMR, ¹H NMR, and IR. In silico studies were carried out looking at the effect of substituents on the carbene bond. Synthesis of α,β-unsaturated complexes was effected via the aldol condensation route and found to be unfavorable using enolizable aldehydes, although the use of two aryl aldehydes resulted in successful preparation of two α,β-unsaturated complexes. Difficulty in the purification of these complexes hindered their full characterization. Computational studies looked at the effect of substituents on the system as well as variation of the metal from Cr to Mo and W. Synthesis of Baylis Hillman adducts using α,β-unsaturated complexes as acceptors was unsuccessful due to the ease of product oxidization. One potential product was obtained in its crude form although purification was not possible due to oxidation. Computational studies suggested that the oxygen on the ligand negatively impacts the stability of these Fischer carbene derived Baylis Hillman adducts promoting intramolecular oxidation of the metal. The α,β-unsaturated complexes and Baylis Hillman adducts were considered to be candidates to undergo Dötz benzannulation methodology. The use of the α,β-unsaturated complexes in this reaction was generally unsuccessful, both in the microwave and in conventional reflux conditions. Computational studies of these compounds were carried out to facilitate understanding of their stability and configuration.
- Full Text:
- Date Issued: 2014
- Authors: Rafael, Christopher Carlos Ferreira
- Date: 2014
- Subjects: Carbenes (Methylene compounds) , Pharmaceutical chemistry
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:4456 , http://hdl.handle.net/10962/d1010863 , Carbenes (Methylene compounds) , Pharmaceutical chemistry
- Description: This study involves using methyllithium to synthesize Fischer carbene complexes as precursors for metal templated α,β-unsaturated complexes with potential as acceptors in the Baylis Hillman reaction as well as in Dötz benzannulation. Fischer carbene complexes contain low oxidation state metal centers, are electrophilic in nature and are stabilized by π-donating substituents such as alkoxy and amino groups. The increased electron withdrawing nature of the metal carbonyl moiety was expected to improve the rates of reaction compared to organic carbonyls. Four Fischer carbenes were synthesized via nucleophilic addition of MeLi to chromium and tungsten hexacarbonyl at low temperatures followed by alkylation using either a Meerwein salt (Me₃OBF₄) to give the desired Fischer metal methyl methoxy carbenes or Et₄NBr/alkylhalide to make the corresponding ethoxy and allyloxy carbenes. Characterization was by means of ¹³C NMR, ¹H NMR, and IR. In silico studies were carried out looking at the effect of substituents on the carbene bond. Synthesis of α,β-unsaturated complexes was effected via the aldol condensation route and found to be unfavorable using enolizable aldehydes, although the use of two aryl aldehydes resulted in successful preparation of two α,β-unsaturated complexes. Difficulty in the purification of these complexes hindered their full characterization. Computational studies looked at the effect of substituents on the system as well as variation of the metal from Cr to Mo and W. Synthesis of Baylis Hillman adducts using α,β-unsaturated complexes as acceptors was unsuccessful due to the ease of product oxidization. One potential product was obtained in its crude form although purification was not possible due to oxidation. Computational studies suggested that the oxygen on the ligand negatively impacts the stability of these Fischer carbene derived Baylis Hillman adducts promoting intramolecular oxidation of the metal. The α,β-unsaturated complexes and Baylis Hillman adducts were considered to be candidates to undergo Dötz benzannulation methodology. The use of the α,β-unsaturated complexes in this reaction was generally unsuccessful, both in the microwave and in conventional reflux conditions. Computational studies of these compounds were carried out to facilitate understanding of their stability and configuration.
- Full Text:
- Date Issued: 2014
Synthesis of fluorescent polymers with pendant triazole-quinoline groups via raft polymerization
- Ngororabanga, Jean Marie Vianney
- Authors: Ngororabanga, Jean Marie Vianney
- Date: 2014
- Subjects: Fluorescent polymers , Polymerization
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:10440 , http://hdl.handle.net/10948/d1020798
- Description: In this study, fluorescent polymers with pendant quinoline groups were synthesized by reversible addition-fragmentation chain transfer polymerization (RAFT) from a fluorescent quinoline-based vinyl monomer, synthesized in multiple steps from p-nitroaniline and crotonaldehyde. The structures of the synthesized vinyl monomer and polymers were confirmed by NMR and FT-IR spectroscopy, X-ray studies and modeling stdies. The photophysical properties of the synthesized quinoline compounds and resulting polymers were investigated. In order to evaluate the binding potential of our quinoline-based polymer in the presence of transition metal ions, preliminary studies on a complexation of quinoline-based polymers with Zn, Cd, Hg, Fe, and Ni were carried out. The investigation of fluorescence properties of the complexes showed fluorescence quenching for Fe(II), and fluorescence enhancement for the remaining ions [Zn(II), Cd(II), Hg(II), and Ni(II)].
- Full Text:
- Date Issued: 2014
- Authors: Ngororabanga, Jean Marie Vianney
- Date: 2014
- Subjects: Fluorescent polymers , Polymerization
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:10440 , http://hdl.handle.net/10948/d1020798
- Description: In this study, fluorescent polymers with pendant quinoline groups were synthesized by reversible addition-fragmentation chain transfer polymerization (RAFT) from a fluorescent quinoline-based vinyl monomer, synthesized in multiple steps from p-nitroaniline and crotonaldehyde. The structures of the synthesized vinyl monomer and polymers were confirmed by NMR and FT-IR spectroscopy, X-ray studies and modeling stdies. The photophysical properties of the synthesized quinoline compounds and resulting polymers were investigated. In order to evaluate the binding potential of our quinoline-based polymer in the presence of transition metal ions, preliminary studies on a complexation of quinoline-based polymers with Zn, Cd, Hg, Fe, and Ni were carried out. The investigation of fluorescence properties of the complexes showed fluorescence quenching for Fe(II), and fluorescence enhancement for the remaining ions [Zn(II), Cd(II), Hg(II), and Ni(II)].
- Full Text:
- Date Issued: 2014
Synthesis of silver nanoparticles and their role against a thiazolekinase enzyme from Plasmodium falciparum
- Yao, Jia
- Authors: Yao, Jia
- Date: 2014
- Subjects: Silver , Nanoparticles , Thiazoles , Plasmodium falciparum , Antimalarials , Malaria -- Chemotherapy
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:4168 , http://hdl.handle.net/10962/d1020894
- Description: Malaria, a mosquito-borne infectious disease, caused by the protozoan Plasmodium genus, is the greatest health challenges worldwide. The plasmodial vitamin B1 biosynthetic enzyme PfThzK diverges significantly, both structurally and functionally from its counterpart in higher eukaryotes, thereby making it particularly attractive as a biomedical target. In the present study, PfThzK was recombinantly produced as 6×His fusion protein in E. coli BL21, purified using nickel affinity chromatography and size exclusion chromatography resulting in 1.03% yield and specific activity 0.28 U/mg. The enzyme was found to be a monomer with a molecular mass of 34 kDa. Characterization of the PfThzK showed an optimum temperature and pH of 37°C and 7.5 respectively, and it is relatively stable (t₁/₂=2.66 h). Ag nanoparticles were synthesized by NaBH₄/tannic acid, and characterized by UV-vis spectroscopy and transmission electron microscopy. The morphologies of these Ag nanoparticles (in terms of size) synthesized by tannic acid appeared to be more controlled with the size of 7.06±2.41 nm, compared with those synthesized by NaBH₄, with the sized of 12.9±4.21 nm. The purified PfThzK was challenged with Ag NPs synthesized by tannic acid, and the results suggested that they competitively inhibited PfThzK (89 %) at low concentrations (5-10 μM) with a Ki = 6.45 μM.
- Full Text:
- Date Issued: 2014
- Authors: Yao, Jia
- Date: 2014
- Subjects: Silver , Nanoparticles , Thiazoles , Plasmodium falciparum , Antimalarials , Malaria -- Chemotherapy
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:4168 , http://hdl.handle.net/10962/d1020894
- Description: Malaria, a mosquito-borne infectious disease, caused by the protozoan Plasmodium genus, is the greatest health challenges worldwide. The plasmodial vitamin B1 biosynthetic enzyme PfThzK diverges significantly, both structurally and functionally from its counterpart in higher eukaryotes, thereby making it particularly attractive as a biomedical target. In the present study, PfThzK was recombinantly produced as 6×His fusion protein in E. coli BL21, purified using nickel affinity chromatography and size exclusion chromatography resulting in 1.03% yield and specific activity 0.28 U/mg. The enzyme was found to be a monomer with a molecular mass of 34 kDa. Characterization of the PfThzK showed an optimum temperature and pH of 37°C and 7.5 respectively, and it is relatively stable (t₁/₂=2.66 h). Ag nanoparticles were synthesized by NaBH₄/tannic acid, and characterized by UV-vis spectroscopy and transmission electron microscopy. The morphologies of these Ag nanoparticles (in terms of size) synthesized by tannic acid appeared to be more controlled with the size of 7.06±2.41 nm, compared with those synthesized by NaBH₄, with the sized of 12.9±4.21 nm. The purified PfThzK was challenged with Ag NPs synthesized by tannic acid, and the results suggested that they competitively inhibited PfThzK (89 %) at low concentrations (5-10 μM) with a Ki = 6.45 μM.
- Full Text:
- Date Issued: 2014
Synthesis of ytterbium bisphthalocyanines
- Sekhosana, Kutloano E, Nyokong, Tebello
- Authors: Sekhosana, Kutloano E , Nyokong, Tebello
- Date: 2014
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/189887 , vital:44943 , xlink:href="https://doi.org/10.1016/j.optmat.2014.05.013"
- Description: Herein we report on the syntheses, photophysico-chemical properties and nonlinear absorption parameters of bis-{1(4), 8(11), 15(18), 22(25)-(tetrapyridin-2-yloxy phthalocyaninato)} ytterbium (III) (3) and bis-{1(4), 8(11), 15(18), 22(25)-(tetrapyridin-4-yloxy phthalocyaninato)} ytterbium (III) (4). The fluorescence and singlet oxygen quantum yields obtained for complexes 3 and 4 are low. The triplet quantum yield obtained for complex 3 is high at ΦT = 0.89 whereas for complex 4 ΦT = 0.48. The third order optical susceptibility values are of the order: 10−11 esu (for complex 3), and 10−13 esu (for complex 4) while the hyperpolarizability values are of the order: 10−28 esu (for complex 3) and 10−31 esu (for complex 4). Complexes 3 and 4 show two-photon absorption coefficients of the order of 10−46 cm4 s/photon and 10−48 cm4 s/photon, and threshold intensities as low as 0.3 J cm−2 and 0.0045 J cm−2, respectively.
- Full Text:
- Date Issued: 2014
- Authors: Sekhosana, Kutloano E , Nyokong, Tebello
- Date: 2014
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/189887 , vital:44943 , xlink:href="https://doi.org/10.1016/j.optmat.2014.05.013"
- Description: Herein we report on the syntheses, photophysico-chemical properties and nonlinear absorption parameters of bis-{1(4), 8(11), 15(18), 22(25)-(tetrapyridin-2-yloxy phthalocyaninato)} ytterbium (III) (3) and bis-{1(4), 8(11), 15(18), 22(25)-(tetrapyridin-4-yloxy phthalocyaninato)} ytterbium (III) (4). The fluorescence and singlet oxygen quantum yields obtained for complexes 3 and 4 are low. The triplet quantum yield obtained for complex 3 is high at ΦT = 0.89 whereas for complex 4 ΦT = 0.48. The third order optical susceptibility values are of the order: 10−11 esu (for complex 3), and 10−13 esu (for complex 4) while the hyperpolarizability values are of the order: 10−28 esu (for complex 3) and 10−31 esu (for complex 4). Complexes 3 and 4 show two-photon absorption coefficients of the order of 10−46 cm4 s/photon and 10−48 cm4 s/photon, and threshold intensities as low as 0.3 J cm−2 and 0.0045 J cm−2, respectively.
- Full Text:
- Date Issued: 2014
Synthesis, characterization & comparative evaluation of photo-catalytic & antimicrobial activity of Ag2O and TiO2 immobilized on nanofibres for treatment
- Authors: Gxumisa, Xoliswa
- Date: 2014
- Subjects: Pollution http://id.loc.gov/authorities/subjects/sh85104530 , Titanium dioxide http://id.loc.gov/authorities/subjects/sh85135627 , Photocatalysis http://id.loc.gov/authorities/subjects/sh93001301
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10353/19545 , vital:43138
- Description: Water is a very essential substance for the existence of organisms and the environment where it functions as a transport medium for valuable chemicals, minerals, nutrients and also as a reaction medium. However, the remarkable water properties are not just limited to the dissolution of biological valuable substances, but also to harmful entities during pollution. This has led to research in the improvement and development of new techniques for water treatment. In this study, titanium dioxide (TiO2) and silver oxide (Ag2O) were prepared using the sol gel process and precipitation method respectively. The TiO2 was doped using a sol gel process with carbon and nitrogen so as to reduce the band gap. TiO2/Ag2O, N-TiO2/Ag2O and C-TiO2/Ag2O composites were also prepared using a precipitation method. The average particle size of prepared TiO2, C-TiO2, N-TiO2, Ag2O, TiO2/Ag2O, N-TiO2/Ag2O and CTiO2/Ag2O was found to be 13nm, 7nm, 10nm, 23nm, 28nm, 24nm and 21nm respectively as measured by TEM analysis. The photo-catalysts, Ag2O and TiO2 and their composites were immobilized on stabilized nanofibres using the electrospinning process to allow subsequent separation and reconciliation of the photo-catalyst after use in water treatment. The photocatalytic and antimicrobial activities of photo-catalysts were also evaluated using water contaminated with phenol red dye and Escherichia coli. The prepared materials were characterized by XRD, TEM, HRSEM, DRS, EDX, FT-IR, and TGA. Carbon was found to be more effective as a dopant than nitrogen. It reduced the band gap by 0.4 while nitrogen doping showed a reduction in band gap of 0.2 compared to undoped titanium dioxide. The doped TiO2 exhibited higher photo-catalytic and antimicrobial activity than the undoped TiO2. Introduction of Ag2O allowed utilization of visible light by the TiO2- Ag2O nano-composite leading to an improved rate of photo-degradation of phenol red and inactivation of E coli. Photo-catalytic properties showed that carbon doped materials have a higher photo-catalytic activity than nitrogen doped materials, while for antimicrobial v properties it is vice-versa. The immobilization of photo-catalysts on support material made it less effective towards the degradation of phenol red. The rate of photo-oxidation of phenol red was three times faster using powder TiO2 compared to immobilized TiO2. Therefore, this study suggests that photo-catalysis can be used as an effective method for water disinfection and production of potable and pathogen free drinking water even though better methods of immobilization should be sought. , Thesis (MSc) (Chemistry) -- University of Fort Hare, 2014
- Full Text:
- Date Issued: 2014
- Authors: Gxumisa, Xoliswa
- Date: 2014
- Subjects: Pollution http://id.loc.gov/authorities/subjects/sh85104530 , Titanium dioxide http://id.loc.gov/authorities/subjects/sh85135627 , Photocatalysis http://id.loc.gov/authorities/subjects/sh93001301
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10353/19545 , vital:43138
- Description: Water is a very essential substance for the existence of organisms and the environment where it functions as a transport medium for valuable chemicals, minerals, nutrients and also as a reaction medium. However, the remarkable water properties are not just limited to the dissolution of biological valuable substances, but also to harmful entities during pollution. This has led to research in the improvement and development of new techniques for water treatment. In this study, titanium dioxide (TiO2) and silver oxide (Ag2O) were prepared using the sol gel process and precipitation method respectively. The TiO2 was doped using a sol gel process with carbon and nitrogen so as to reduce the band gap. TiO2/Ag2O, N-TiO2/Ag2O and C-TiO2/Ag2O composites were also prepared using a precipitation method. The average particle size of prepared TiO2, C-TiO2, N-TiO2, Ag2O, TiO2/Ag2O, N-TiO2/Ag2O and CTiO2/Ag2O was found to be 13nm, 7nm, 10nm, 23nm, 28nm, 24nm and 21nm respectively as measured by TEM analysis. The photo-catalysts, Ag2O and TiO2 and their composites were immobilized on stabilized nanofibres using the electrospinning process to allow subsequent separation and reconciliation of the photo-catalyst after use in water treatment. The photocatalytic and antimicrobial activities of photo-catalysts were also evaluated using water contaminated with phenol red dye and Escherichia coli. The prepared materials were characterized by XRD, TEM, HRSEM, DRS, EDX, FT-IR, and TGA. Carbon was found to be more effective as a dopant than nitrogen. It reduced the band gap by 0.4 while nitrogen doping showed a reduction in band gap of 0.2 compared to undoped titanium dioxide. The doped TiO2 exhibited higher photo-catalytic and antimicrobial activity than the undoped TiO2. Introduction of Ag2O allowed utilization of visible light by the TiO2- Ag2O nano-composite leading to an improved rate of photo-degradation of phenol red and inactivation of E coli. Photo-catalytic properties showed that carbon doped materials have a higher photo-catalytic activity than nitrogen doped materials, while for antimicrobial v properties it is vice-versa. The immobilization of photo-catalysts on support material made it less effective towards the degradation of phenol red. The rate of photo-oxidation of phenol red was three times faster using powder TiO2 compared to immobilized TiO2. Therefore, this study suggests that photo-catalysis can be used as an effective method for water disinfection and production of potable and pathogen free drinking water even though better methods of immobilization should be sought. , Thesis (MSc) (Chemistry) -- University of Fort Hare, 2014
- Full Text:
- Date Issued: 2014
Synthesis, characterization and photodynamic therapy properties of an octa-4-tert-butylphenoxy-substituted phosphorus (V) triazatetrabenzcorrole
- Shi, Maohu, Tian, Jiangwei, Mkhize, Colin, Kubheka, Gugu, Zhou, Jinfeng, Mack, John, Nyokong, Tebello, Shen, Zhen
- Authors: Shi, Maohu , Tian, Jiangwei , Mkhize, Colin , Kubheka, Gugu , Zhou, Jinfeng , Mack, John , Nyokong, Tebello , Shen, Zhen
- Date: 2014
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/241494 , vital:50944 , xlink:href="https://doi.org/10.1142/S1088424614500436"
- Description: A novel octa-4-tert-butylphenoxy-substituted phosphorus(V) triazatetrabenzcorrole (PVTBC), has been synthesized and characterized by MALDI-TOF MS and NMR, FT-IR and MCD spectroscopy. The fluorescence emission spectrum was used to determine the fluorescence quantum yield and the quantum yield for singlet oxygen generation was calculated by using 1,3-diphenylisobenzofuran as a scavenger. The photocytoxicity against U87MG cells was measured. The results indicated that PVTBC is potentially useful as an NIR region photosensitizer for photodynamic therapy (PDT).
- Full Text:
- Date Issued: 2014
- Authors: Shi, Maohu , Tian, Jiangwei , Mkhize, Colin , Kubheka, Gugu , Zhou, Jinfeng , Mack, John , Nyokong, Tebello , Shen, Zhen
- Date: 2014
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/241494 , vital:50944 , xlink:href="https://doi.org/10.1142/S1088424614500436"
- Description: A novel octa-4-tert-butylphenoxy-substituted phosphorus(V) triazatetrabenzcorrole (PVTBC), has been synthesized and characterized by MALDI-TOF MS and NMR, FT-IR and MCD spectroscopy. The fluorescence emission spectrum was used to determine the fluorescence quantum yield and the quantum yield for singlet oxygen generation was calculated by using 1,3-diphenylisobenzofuran as a scavenger. The photocytoxicity against U87MG cells was measured. The results indicated that PVTBC is potentially useful as an NIR region photosensitizer for photodynamic therapy (PDT).
- Full Text:
- Date Issued: 2014
Synthesis, characterization, and biological studies of pyrazolone Schiff bases and their transition metal complexes
- Authors: Idemudia, Omoruyi Gold
- Date: 2014
- Language: English
- Type: Thesis , Doctoral , PhD (Chemistry)
- Identifier: vital:11340 , http://hdl.handle.net/10353/d1016068
- Description: Some new acylpyrazolone Schiff bases have been synthesized from the condensation reaction of two acylpyrazolone diketone precursors with phenylhydrazine, 2,4-dinitrophenylhydrazine and sulfanilamide. They have been fully characterized by elemental analysis and spectroscopic techniques (IR,1H and 13C NMR, and mass-spectra). The single crystal structure of the benzoyl derivative acylpyrazolone Schiff bases have been obtained and analyzed by X-ray crystallography technique. Solid state X-ray diffraction revealed a keto tautomer Schiff base in solid state. Mn(II), Co(II), Ni(II) and Cu(II) complexes with the Schiff bases have been synthesized and characterized by elemental analysis, IR and UV-VIS spectroscopy, magnetic susceptibility measurements, and thermal studies (TGA and DTG). An octahedral geometry around the transition metal ion, consisting of two bidentate Schiff base ligands bonding through the azometine nitrogen and ketonic oxygen have been proposed based on careful interpretation of available analytical and spectroscopic characterization results. Two water molecules as ligands complete the octahedral geometry in all cases. Using the invitro disc diffusion method for screening synthesized compounds against selected gram positive and gram negative bacterial at 40 mg/mL, and the DPPH free radical scavenging methods at 0.50, 0.25 and 0.13 mg/mL, the synthesized Schiff base and metal complexes showed varying biological activities. 4-benzoyl-3-methyl-1-phenyl-2-pyrazolin-5-one sul29 fanilamide showed more activity generally, exhibiting a broad spectrum activity against all selected bacterial in some cases. Mn(II), Co(II) and Ni(II) complexes of sulfanilamide Schiff base with the acetylpyrazolone derivative 4-acetyl-3-methyl-1-phenyl-2-pyrazolin-5-one sulfanilamide, exhibited a stronger and very good DPPH radical scavenging activity as good as ascorbic acid on comparing, but not with Cu(II). As such they could be important antitumour candidates.
- Full Text:
- Date Issued: 2014
- Authors: Idemudia, Omoruyi Gold
- Date: 2014
- Language: English
- Type: Thesis , Doctoral , PhD (Chemistry)
- Identifier: vital:11340 , http://hdl.handle.net/10353/d1016068
- Description: Some new acylpyrazolone Schiff bases have been synthesized from the condensation reaction of two acylpyrazolone diketone precursors with phenylhydrazine, 2,4-dinitrophenylhydrazine and sulfanilamide. They have been fully characterized by elemental analysis and spectroscopic techniques (IR,1H and 13C NMR, and mass-spectra). The single crystal structure of the benzoyl derivative acylpyrazolone Schiff bases have been obtained and analyzed by X-ray crystallography technique. Solid state X-ray diffraction revealed a keto tautomer Schiff base in solid state. Mn(II), Co(II), Ni(II) and Cu(II) complexes with the Schiff bases have been synthesized and characterized by elemental analysis, IR and UV-VIS spectroscopy, magnetic susceptibility measurements, and thermal studies (TGA and DTG). An octahedral geometry around the transition metal ion, consisting of two bidentate Schiff base ligands bonding through the azometine nitrogen and ketonic oxygen have been proposed based on careful interpretation of available analytical and spectroscopic characterization results. Two water molecules as ligands complete the octahedral geometry in all cases. Using the invitro disc diffusion method for screening synthesized compounds against selected gram positive and gram negative bacterial at 40 mg/mL, and the DPPH free radical scavenging methods at 0.50, 0.25 and 0.13 mg/mL, the synthesized Schiff base and metal complexes showed varying biological activities. 4-benzoyl-3-methyl-1-phenyl-2-pyrazolin-5-one sul29 fanilamide showed more activity generally, exhibiting a broad spectrum activity against all selected bacterial in some cases. Mn(II), Co(II) and Ni(II) complexes of sulfanilamide Schiff base with the acetylpyrazolone derivative 4-acetyl-3-methyl-1-phenyl-2-pyrazolin-5-one sulfanilamide, exhibited a stronger and very good DPPH radical scavenging activity as good as ascorbic acid on comparing, but not with Cu(II). As such they could be important antitumour candidates.
- Full Text:
- Date Issued: 2014
Synthesis, photophysicochemical properties and TD-DFT calculations of tetrakis (2-benzoyl-4-chlorophenoxy) phthalocyanines
- Yilmaz, Yusuf, Mack, John, Sener, M Kasim, Sönmez, Mehmet, Nyokong, Tebello
- Authors: Yilmaz, Yusuf , Mack, John , Sener, M Kasim , Sönmez, Mehmet , Nyokong, Tebello
- Date: 2014
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/241538 , vital:50948 , xlink:href="https://doi.org/10.1142/S1088424614500047"
- Description: The synthesis of metal free, magnesium and zinc tetrakis(2-benzoyl-4-chlorophenoxy) phthalocyanine derivatives (2–4) is described along with their characterization by elemental analysis, IR, UV-visible absorption, and 1H NMR spectroscopy and mass spectrometry. Trends observed in the fluorescence, triplet state, singlet oxygen and photodegradation quantum yields and the triplet state lifetimes are also analyzed. The compounds exhibit high solubility in a wide range of organic solvents and no evidence of aggregation was observed over a wide concentration range. The Zn(II) complex (4) was found to have a very high singlet oxygen quantum yield (ΦΔ = 0.78) in dimethylsulfoxide (DMSO) and a reasonably large triplet state quantum yield (ΦT = 0.82). The photophysical and photochemical properties clearly demonstrate that these compounds could prove useful in singlet oxygen applications such as photodynamic therapy (PDT). DFT and TD-DFT calculations were used to assess the impact of the positional isomerism of the 2-benzoyl-4-chlorophenoxy substituents on the electronic structures and optical spectroscopy.
- Full Text:
- Date Issued: 2014
- Authors: Yilmaz, Yusuf , Mack, John , Sener, M Kasim , Sönmez, Mehmet , Nyokong, Tebello
- Date: 2014
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/241538 , vital:50948 , xlink:href="https://doi.org/10.1142/S1088424614500047"
- Description: The synthesis of metal free, magnesium and zinc tetrakis(2-benzoyl-4-chlorophenoxy) phthalocyanine derivatives (2–4) is described along with their characterization by elemental analysis, IR, UV-visible absorption, and 1H NMR spectroscopy and mass spectrometry. Trends observed in the fluorescence, triplet state, singlet oxygen and photodegradation quantum yields and the triplet state lifetimes are also analyzed. The compounds exhibit high solubility in a wide range of organic solvents and no evidence of aggregation was observed over a wide concentration range. The Zn(II) complex (4) was found to have a very high singlet oxygen quantum yield (ΦΔ = 0.78) in dimethylsulfoxide (DMSO) and a reasonably large triplet state quantum yield (ΦT = 0.82). The photophysical and photochemical properties clearly demonstrate that these compounds could prove useful in singlet oxygen applications such as photodynamic therapy (PDT). DFT and TD-DFT calculations were used to assess the impact of the positional isomerism of the 2-benzoyl-4-chlorophenoxy substituents on the electronic structures and optical spectroscopy.
- Full Text:
- Date Issued: 2014
Synthetic analogues of marine bisindole alkaloids as potent selective inhibitors of MRSA pyruvate kinase
- Veale, Clinton Gareth Lancaster
- Authors: Veale, Clinton Gareth Lancaster
- Date: 2014 , 2014-04-02
- Subjects: Alkaloids , Pyruvate kinase , Staphylococcus aureus , Antibiotics , Sponges -- South Africa , Imidazoles , Biological assay , Antibacterial agents
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:4563 , http://hdl.handle.net/10962/d1020893
- Description: Globally, methicillin resistant Staphylococcus aureus (MRSA) has become increasingly difficult to manage in the clinic and new antibiotics are required. The structure activity relationship (SAR) study presented in this thesis forms part of an international collaborative effort to identify potent and selective inhibitors of an MRSA pyruvate kinase (PK) enzyme target. In earlier work the known marine natural product bromodeoxytopsentin (1.6), isolated from a South African marine sponge Topsentia pachastrelloides, exhibited selective and significant inhibition of MRSA PK (IC₅₀ 60 nM). Accordingly bromodeoxytopsentin provided the initial chemical scaffold around which our SAR study was developed. Following a comprehensive introduction, providing the necessary background to the research described in subsequent Chapters, this thesis has been divided into three major parts. Part one (Chapter 2) documents the synthesis of two natural imidazole containing topsentin analogues 1.40, 1.46, five new synthetic analogues 1.58—1.61, 2.104. In the process we developed a new method for the synthesis of topsentin derivatives via selenium dioxide mediated oxidation of N-Boc protected 3-acetylindoles to yield glyoxal intermediates which were subsequently cyclized and deprotected to yield the desired products. Interestingly we were able to demonstrate a delicate relationship between the relative equivalents of selenium dioxide and water used during the oxidation step, careful manipulation of which was required to prevent the uncontrolled formation of side products. Synthetic compounds 1.40, 1.46, 1.58—1.61 were found to be potent inhibitors of MRSA PK (IC₅₀ 238, 2.1, 23, 1.4, 6.3 and 3.2 nM respectively) with 1000-10000 fold selectivity for MRSA PK over four human orthologs. In the second part of this thesis (Chapter 3) we report the successful synthesis of a cohort of previously unknown thiazole containing bisindole topsentin analogues 1.62—1.68 via a Hantzsch thiazole synthesis. Bioassay results revealed that these compounds were only moderate inhibitors of MRSA PK (IC₅₀ 5.1—20 μM) which suggested that inhibitory activity was significantly reduced upon substitution of the central imidazole ring of topsentin type analogues with a thiazole type ring. In addition in Chapter 3 we describe unsuccessful attempts to regiospecifically synthesize oxazole and imidazole topsentin analogues through a similar Hantzsch method. As a consequence of our efforts in this regard we investigated three key reactions in depth, namely the synthesis of 2.2, 3.38, 3.40, 3.41 via α-bromination of 3-acetylindole and the synthesis of indolyl-3-carbonylnitriles 2.13, 3.45—3.47 and α-oxo-1H-indole-3-thioacetamides 3.48—3.51. The investigation of the latter led to the isolation and elucidation of two anomalous N,N-dimethyl-1H-indole-3-carboxamides 3.52 and 3.53. Finally the third part of this thesis (Chapter 4) deals with in silico assessment of the binding of both the imidazole and thiazole containing bisindole alkaloids to the MRSA PK protein which initially guided our SAR studies. In this chapter we reveal that there appears to be no correlation between in silico binding predictions and in vitro MRSA PK inhibitory bioassay data. Superficially it seems that binding energy as determined by the docking program used for these studies correlated with the size of the indole substituents and did not reflect IC₅₀ MRSA PK inhibitory data. Although this led us to computationally explore possible alternative binding sites no clear alternative has been identified.
- Full Text:
- Date Issued: 2014
- Authors: Veale, Clinton Gareth Lancaster
- Date: 2014 , 2014-04-02
- Subjects: Alkaloids , Pyruvate kinase , Staphylococcus aureus , Antibiotics , Sponges -- South Africa , Imidazoles , Biological assay , Antibacterial agents
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:4563 , http://hdl.handle.net/10962/d1020893
- Description: Globally, methicillin resistant Staphylococcus aureus (MRSA) has become increasingly difficult to manage in the clinic and new antibiotics are required. The structure activity relationship (SAR) study presented in this thesis forms part of an international collaborative effort to identify potent and selective inhibitors of an MRSA pyruvate kinase (PK) enzyme target. In earlier work the known marine natural product bromodeoxytopsentin (1.6), isolated from a South African marine sponge Topsentia pachastrelloides, exhibited selective and significant inhibition of MRSA PK (IC₅₀ 60 nM). Accordingly bromodeoxytopsentin provided the initial chemical scaffold around which our SAR study was developed. Following a comprehensive introduction, providing the necessary background to the research described in subsequent Chapters, this thesis has been divided into three major parts. Part one (Chapter 2) documents the synthesis of two natural imidazole containing topsentin analogues 1.40, 1.46, five new synthetic analogues 1.58—1.61, 2.104. In the process we developed a new method for the synthesis of topsentin derivatives via selenium dioxide mediated oxidation of N-Boc protected 3-acetylindoles to yield glyoxal intermediates which were subsequently cyclized and deprotected to yield the desired products. Interestingly we were able to demonstrate a delicate relationship between the relative equivalents of selenium dioxide and water used during the oxidation step, careful manipulation of which was required to prevent the uncontrolled formation of side products. Synthetic compounds 1.40, 1.46, 1.58—1.61 were found to be potent inhibitors of MRSA PK (IC₅₀ 238, 2.1, 23, 1.4, 6.3 and 3.2 nM respectively) with 1000-10000 fold selectivity for MRSA PK over four human orthologs. In the second part of this thesis (Chapter 3) we report the successful synthesis of a cohort of previously unknown thiazole containing bisindole topsentin analogues 1.62—1.68 via a Hantzsch thiazole synthesis. Bioassay results revealed that these compounds were only moderate inhibitors of MRSA PK (IC₅₀ 5.1—20 μM) which suggested that inhibitory activity was significantly reduced upon substitution of the central imidazole ring of topsentin type analogues with a thiazole type ring. In addition in Chapter 3 we describe unsuccessful attempts to regiospecifically synthesize oxazole and imidazole topsentin analogues through a similar Hantzsch method. As a consequence of our efforts in this regard we investigated three key reactions in depth, namely the synthesis of 2.2, 3.38, 3.40, 3.41 via α-bromination of 3-acetylindole and the synthesis of indolyl-3-carbonylnitriles 2.13, 3.45—3.47 and α-oxo-1H-indole-3-thioacetamides 3.48—3.51. The investigation of the latter led to the isolation and elucidation of two anomalous N,N-dimethyl-1H-indole-3-carboxamides 3.52 and 3.53. Finally the third part of this thesis (Chapter 4) deals with in silico assessment of the binding of both the imidazole and thiazole containing bisindole alkaloids to the MRSA PK protein which initially guided our SAR studies. In this chapter we reveal that there appears to be no correlation between in silico binding predictions and in vitro MRSA PK inhibitory bioassay data. Superficially it seems that binding energy as determined by the docking program used for these studies correlated with the size of the indole substituents and did not reflect IC₅₀ MRSA PK inhibitory data. Although this led us to computationally explore possible alternative binding sites no clear alternative has been identified.
- Full Text:
- Date Issued: 2014
Talent management as a strategy to promote succession of junior managers at Edgars
- Authors: Walters, Charles
- Date: 2014
- Subjects: Organizational effectiveness , Occupation , Career development , Success in business
- Language: English
- Type: Thesis , Masters , MBA
- Identifier: http://hdl.handle.net/10948/47837 , vital:40385
- Description: Talent Management has become one of the biggest challenges facing businesses today. With the skill shortage and the influx of clothing retailers into South Africa in the past two years, the war on talent has intensified. With this in mind the objective of the study was to investigate if Edgars had a successful talent management strategy to promote junior managers through succession. Talent management has different parts including recruitment, learning and development, performance management, reward, leadership, employee value proposition, retention and succession. This study unpacks the literature on talent management and its components and takes a deeper look at the strategy adopted by Edgars. The study highlights the importance of talent management and that there should be clear strategies for every part that makes up the talent management framework. Empirical studies are done on the different sub sections of talent management, findings and recommendations are reported in the final chapters. The target population for this study consisted of junior managers at Edgars, where the majority of key value roles critical for development and store manager succession are. A sample of forty respondents was randomly selected from the total junior management population at Edgars. The findings suggested that when an organisation has effective talent management strategy, it is more likely to create a compelling employee value proposition that is conducive to sustain succession of great talent. Furthermore, the findings revealed that Edgars is effective in applying certain talent strategies while other areas required more attention and focus.
- Full Text:
- Date Issued: 2014
- Authors: Walters, Charles
- Date: 2014
- Subjects: Organizational effectiveness , Occupation , Career development , Success in business
- Language: English
- Type: Thesis , Masters , MBA
- Identifier: http://hdl.handle.net/10948/47837 , vital:40385
- Description: Talent Management has become one of the biggest challenges facing businesses today. With the skill shortage and the influx of clothing retailers into South Africa in the past two years, the war on talent has intensified. With this in mind the objective of the study was to investigate if Edgars had a successful talent management strategy to promote junior managers through succession. Talent management has different parts including recruitment, learning and development, performance management, reward, leadership, employee value proposition, retention and succession. This study unpacks the literature on talent management and its components and takes a deeper look at the strategy adopted by Edgars. The study highlights the importance of talent management and that there should be clear strategies for every part that makes up the talent management framework. Empirical studies are done on the different sub sections of talent management, findings and recommendations are reported in the final chapters. The target population for this study consisted of junior managers at Edgars, where the majority of key value roles critical for development and store manager succession are. A sample of forty respondents was randomly selected from the total junior management population at Edgars. The findings suggested that when an organisation has effective talent management strategy, it is more likely to create a compelling employee value proposition that is conducive to sustain succession of great talent. Furthermore, the findings revealed that Edgars is effective in applying certain talent strategies while other areas required more attention and focus.
- Full Text:
- Date Issued: 2014
Tapping into the World of Terpenoids
- Authors: Oyedeji, A O
- Date: 2014
- Subjects: Terpenoids , Terpenes , Medicinal plants -- Analysis
- Language: English
- Type: text , Lectures
- Identifier: http://hdl.handle.net/11260/1111 , vital:30607
- Description: Terpenes are a class of secondary metabolites found in plants and insects (such as termites or swallowtail butterflies). Terpenes are strong-smelling aromatic hydrocarbon which are used by plants/ insects to protect themselves by deterring parasites. They are secondary metabolites synthesized in plants. When a hydrogen or atoms of hydrogen, are replaced by other atoms such as oxygen, in a terpene compound, the terpene becomes a terpenoid (also known as isoprenoids). Terpenoids are a large and diverse class of naturally occurring organic chemicals, derived from five-carbon isoprene units assembled and modified in thousands of ways. They are multicyclic structures that differ from one another not only in functional group but also in their basic carbon skeletons. Terpenoids are found in all classes of living things, and are the largest group of natural products.
- Full Text:
- Date Issued: 2014
- Authors: Oyedeji, A O
- Date: 2014
- Subjects: Terpenoids , Terpenes , Medicinal plants -- Analysis
- Language: English
- Type: text , Lectures
- Identifier: http://hdl.handle.net/11260/1111 , vital:30607
- Description: Terpenes are a class of secondary metabolites found in plants and insects (such as termites or swallowtail butterflies). Terpenes are strong-smelling aromatic hydrocarbon which are used by plants/ insects to protect themselves by deterring parasites. They are secondary metabolites synthesized in plants. When a hydrogen or atoms of hydrogen, are replaced by other atoms such as oxygen, in a terpene compound, the terpene becomes a terpenoid (also known as isoprenoids). Terpenoids are a large and diverse class of naturally occurring organic chemicals, derived from five-carbon isoprene units assembled and modified in thousands of ways. They are multicyclic structures that differ from one another not only in functional group but also in their basic carbon skeletons. Terpenoids are found in all classes of living things, and are the largest group of natural products.
- Full Text:
- Date Issued: 2014
Targeting and characterizing potentially high yield aquifers in the neotectonic zones in the Eastern Cape Province in South Africa
- Authors: Madi, Kakaba
- Date: 2014
- Language: English
- Type: Thesis , Doctoral , PhD (Geology)
- Identifier: vital:11530 , http://hdl.handle.net/10353/d1021270
- Description: The Eastern Cape Province has, besides the three known neotectonic belts (southern, eastern and northern) a fourth zone, which is inactive. This inactive zone is located almost in its central part north of the southern neotectonic zone, and south of the northern neotectonic belt. The three above mentioned neotectonic belts (southern, eastern and northern) were chosen for this study, each one with its own characteristics. This study aims at characterizing and targeting potentially high yield aquifers in the neotectonic zones in the Eastern Cape Province. The methods used in this study include: 1) A comprehensive literature review on neotectonics in South Africa in general and in the Eastern Cape Province in particular; 2) Extraction of lineaments through remote sensing and examination of digital elevation models; 3) Examination of seismic data for the subsurface visualization onshore and offshore; 4) Study on the genesis of the Grahamstown kaolin deposits through the structural component; and 5) Acquisition and interpretation of magnetic, electromagnetic and radiometric data from three of the hot springs in the northern neotectonic belt. The results indicate the following: 1) Old map of seismic epicentres in South Africa need to be reviewed continually. The Eastern Cape was regarded as quiescent in terms of seismicity. However, the investigation from recent seismic epicenters downloadable from the IRIS website has shown that recent seismic events occurred in the Eastern Cape Province especially in the northern and southern neotectonic belts. The central part located north of the southern neotectonic belt and south of the northern neotectonic belt is inactive. This inactive zone can be considered for the storage of nuclear wastes. 2) The eastern neotectonic belt has, like the northern neotectonic belt, a higher density of lineaments oriented northwest-southeast, which makes it the second important neotectonic belt. These lineaments correlate with the normalized difference vegetation index indicative of a good circulation of groundwater. In the south, the Eastern Cape great lineament oriented east-west is now considered a neotectonic domain because many seismic epicentres occur therein. Its geomorphologic shape in graben type form is a favourable structure for groundwater catchment. The surface topography is not uniform and high elevations in the east are related to the uplift that took place in the Quaternary. Most vector gradients are oriented east-west, a fact to be reckon with in the study of surface water flow and aquifers characterization. 3) Offshore along the east coast, the subsurface is affected by neotectonic faults, which are probably splays of the Agulhas Falkland Fractured Zone (AFFZ). The folds that occur are related to the regional compressional stress known as the Wegener Stress Anomaly (WSM). On land, straight lines from seismic profiles indicate that weathering occurs in consolidated materials probably along faults or fractures, unconsolidated sediments always have wavy profiles. On the other hand, field observations in King Williams Town have clearly shown that a tectonic uplift took place on a dolerite sill overlain by mudstones and sandstones. The uplift is possibly related to the Amatole-Swaziland event that occurred in the last five millions years. The escarpment along this dolerite sill overlain by sedimentary rocks is a meso-scale fault with a dip-slip component. Healthy vegetation and a river flowing parallel to the cliff indicate groundwater flow in the zone of weakness. 4) In the southern neotectonic belt there is a clear northwest-southeast horizontal compression and a southwest-northeast vertical to sub-vertical extension. Enrichment of granitic breccias and feldspar in the Grahamstown Dwyka tillite is the source for the formation of kaolin deposits. The weathering starts in the granitic breccias through their extensional fractures and then extends in the matrix, which has micro-fractures that are only visible with the transmitted microscope. Combined extensional strike-slip and dip-slip faulting is responsible for the earthquakes in the region of Grahamstown where the kaolin is formed. There is also an unreported thermal (quartz veins) and neotectonic event identified in this region. 5) The hot springs in the northern neotectonic belt are connected by a regional neotectonic fault. The use of magnetic and electromagnetic methods helped to decipher the occurrence of faults, fractures, dolerite dykes, and variable degree of weathering. Uranium/potassium ratios derived from radiometric surveys show that areas around some hot springs are characterized by enrichment in uranium. High concentrations of thorium are related to its low capacity of being easily dissolved in water. It can be concluded that seismicity, hot springs and accordingly deep groundwater circulation, high density of lineaments, quaternary tectonic uplift, are the predominate characteristics of the three neotectonic zones. Furthermore, on the environmental point of view, thorium concentration is higher than that of either uranium or potassium. Although it is nonetheless below the world average threshold of 7.4 ppm according to United Nations Scientific Committee on the Effects of Atomic Radiation (UNSCEAR), it may be a source of radiation hazard to humans and animals if they are subjected to prolonged exposure. All the neotectonic zones in the Eastern Cape Province present potentials to host good and important aquifers. It is suggested that the Eastern Cape great lineament in the southern neotectonic belt and the Kokstad-Koffiefontein seismic belt in the northern neotectonic belt, be monitored for future research regarding, neotectonics, seismic risk assessment and hydrogeology.
- Full Text:
- Date Issued: 2014
- Authors: Madi, Kakaba
- Date: 2014
- Language: English
- Type: Thesis , Doctoral , PhD (Geology)
- Identifier: vital:11530 , http://hdl.handle.net/10353/d1021270
- Description: The Eastern Cape Province has, besides the three known neotectonic belts (southern, eastern and northern) a fourth zone, which is inactive. This inactive zone is located almost in its central part north of the southern neotectonic zone, and south of the northern neotectonic belt. The three above mentioned neotectonic belts (southern, eastern and northern) were chosen for this study, each one with its own characteristics. This study aims at characterizing and targeting potentially high yield aquifers in the neotectonic zones in the Eastern Cape Province. The methods used in this study include: 1) A comprehensive literature review on neotectonics in South Africa in general and in the Eastern Cape Province in particular; 2) Extraction of lineaments through remote sensing and examination of digital elevation models; 3) Examination of seismic data for the subsurface visualization onshore and offshore; 4) Study on the genesis of the Grahamstown kaolin deposits through the structural component; and 5) Acquisition and interpretation of magnetic, electromagnetic and radiometric data from three of the hot springs in the northern neotectonic belt. The results indicate the following: 1) Old map of seismic epicentres in South Africa need to be reviewed continually. The Eastern Cape was regarded as quiescent in terms of seismicity. However, the investigation from recent seismic epicenters downloadable from the IRIS website has shown that recent seismic events occurred in the Eastern Cape Province especially in the northern and southern neotectonic belts. The central part located north of the southern neotectonic belt and south of the northern neotectonic belt is inactive. This inactive zone can be considered for the storage of nuclear wastes. 2) The eastern neotectonic belt has, like the northern neotectonic belt, a higher density of lineaments oriented northwest-southeast, which makes it the second important neotectonic belt. These lineaments correlate with the normalized difference vegetation index indicative of a good circulation of groundwater. In the south, the Eastern Cape great lineament oriented east-west is now considered a neotectonic domain because many seismic epicentres occur therein. Its geomorphologic shape in graben type form is a favourable structure for groundwater catchment. The surface topography is not uniform and high elevations in the east are related to the uplift that took place in the Quaternary. Most vector gradients are oriented east-west, a fact to be reckon with in the study of surface water flow and aquifers characterization. 3) Offshore along the east coast, the subsurface is affected by neotectonic faults, which are probably splays of the Agulhas Falkland Fractured Zone (AFFZ). The folds that occur are related to the regional compressional stress known as the Wegener Stress Anomaly (WSM). On land, straight lines from seismic profiles indicate that weathering occurs in consolidated materials probably along faults or fractures, unconsolidated sediments always have wavy profiles. On the other hand, field observations in King Williams Town have clearly shown that a tectonic uplift took place on a dolerite sill overlain by mudstones and sandstones. The uplift is possibly related to the Amatole-Swaziland event that occurred in the last five millions years. The escarpment along this dolerite sill overlain by sedimentary rocks is a meso-scale fault with a dip-slip component. Healthy vegetation and a river flowing parallel to the cliff indicate groundwater flow in the zone of weakness. 4) In the southern neotectonic belt there is a clear northwest-southeast horizontal compression and a southwest-northeast vertical to sub-vertical extension. Enrichment of granitic breccias and feldspar in the Grahamstown Dwyka tillite is the source for the formation of kaolin deposits. The weathering starts in the granitic breccias through their extensional fractures and then extends in the matrix, which has micro-fractures that are only visible with the transmitted microscope. Combined extensional strike-slip and dip-slip faulting is responsible for the earthquakes in the region of Grahamstown where the kaolin is formed. There is also an unreported thermal (quartz veins) and neotectonic event identified in this region. 5) The hot springs in the northern neotectonic belt are connected by a regional neotectonic fault. The use of magnetic and electromagnetic methods helped to decipher the occurrence of faults, fractures, dolerite dykes, and variable degree of weathering. Uranium/potassium ratios derived from radiometric surveys show that areas around some hot springs are characterized by enrichment in uranium. High concentrations of thorium are related to its low capacity of being easily dissolved in water. It can be concluded that seismicity, hot springs and accordingly deep groundwater circulation, high density of lineaments, quaternary tectonic uplift, are the predominate characteristics of the three neotectonic zones. Furthermore, on the environmental point of view, thorium concentration is higher than that of either uranium or potassium. Although it is nonetheless below the world average threshold of 7.4 ppm according to United Nations Scientific Committee on the Effects of Atomic Radiation (UNSCEAR), it may be a source of radiation hazard to humans and animals if they are subjected to prolonged exposure. All the neotectonic zones in the Eastern Cape Province present potentials to host good and important aquifers. It is suggested that the Eastern Cape great lineament in the southern neotectonic belt and the Kokstad-Koffiefontein seismic belt in the northern neotectonic belt, be monitored for future research regarding, neotectonics, seismic risk assessment and hydrogeology.
- Full Text:
- Date Issued: 2014
Taxonomy and life history of the zebra seabream, Diplodus cervinus (Perciformes: Sparidae), in southern Angola
- Authors: Winkler, Alexander Claus
- Date: 2014
- Subjects: Diplodus -- Classification Fish populations -- Angola Diplodus -- Angola Diplodus -- South Africa Diplodus -- Morphology Fisheries -- Angola Sparidae
- Language: English
- Type: Thesis , Masters , MA
- Identifier: vital:5361 , http://hdl.handle.net/10962/d1012062
- Description: The zebra sea bream, Diplodus cervinus (Sparidae) is an inshore fish comprised of two boreal subspecies from the Gulf of Oman and the Mediterranean / north eastern Atlantic and one austral subspecies from South Africa and southern Angola. The assumption of a single austral subspecies has, however, been questioned due to mounting molecular and morphological evidence suggesting that the cool Benguela current is a vicariant barrier that has separated many synonymous inshore fish species between South Africa and southern Angola. The aims of this thesis are to conduct a comparative morphological analysis of Diplodus cervinus in southern Angola and South Africa in order to classify the southern Angolan population and then to conduct a life history assessment to assess the life history impact of allopatry on this species between the two regions. Results of the morphological findings of the present study (ANOSIM, p < 0.05, Rmeristic = 0.42) and (Rmorphometric = 0.30) along with a concurrent molecular study (FST = 0.4 – 0.6), identified significant divergence between specimens from South Africa (n = 25) and southern Angola (n = 37) and supported stock separation and possibly sub-speciation, depending on the classification criteria utilised. While samples from the two boreal subspecies were not available for the comparative morphological or molecular analysis, comparisons of the colouration patterns between the three subspecies, suggested similarity between the southern Angola and the northern Atlantic / Mediterranean populations. In contrast, the colouration patterns between the southern Angolan and South African specimens differed substantially, further supporting the morphological and molecular results. The distinct morphological divergence between the southern Angolan and South African populations was not reflected within the life history traits of both populations. A combination of methods, including length/age frequency analyses, adult sex ratios and histological analysis was used to determine that this species is a rudimentary hermaphrodite in southern Angola. Peak spawning season was observed between June and July. The overall sex ratio (M: F) was 1:1.52 with females dominating smaller younger size classes and 50% maturity was attained at 210 mm FL and 4.6 years. Females [L(t) = 287.5(1-e⁻°·¹⁸⁽t⁻²·⁸⁴⁾)] grew significantly faster (LRT, p < 0.05) than males [L(t) = 380.19(1-e⁻°·°⁶⁽t⁻⁷·¹²⁾)]. The higher maximum age of the southern Angolan population of D. cervinus (43 years) was older than that of South African individuals sampled in the tsitsikamma national park. The similarities in the life history of the two austral populations are probably a consequence of similar selective pressures in the similar warmtemperate habitats. Evidence to support the above comments was found in the feeding study which showed that the South African and Angolan populations were almost identical, with both populations feeding primarily on amphipods and polychaete worms throughout ontogeny. In contrast, the diet of their boreal conspecifics from the Mediterranean was different, where larger individuals tended to select larger, and more robust, prey items. The life history differences observed between the boreal and austral populations can be attributed to either sampling bias or environmental factors. Sampling biases included the use of different age and growth estimation techniques, while the environmental factors would include differential selective pressures most likely driven by different resource availability and exploitation. The present study provides crucial baseline life history information of a potentially exploitable species off southern Angola as well as information on the life history plasticity of the species. Unfortunately, the current lack of uniformity in the methods used to estimate life history parameters between studies conducted on the boreal and austral populations have complicated our understanding of the evolution of various life history trends in sparid fish. From a management perspective however, the results from the present study can be used to propose management strategies for an emerging trap fishery in southern Angola. Using a balanced exploitation fishery approach (harvesting up to the size-at-100% maturity), the size of the fish traps entrance was calculated based the morphological information from this and other small sparid species that are targeted and was estimated to be 62 mm.
- Full Text:
- Date Issued: 2014
- Authors: Winkler, Alexander Claus
- Date: 2014
- Subjects: Diplodus -- Classification Fish populations -- Angola Diplodus -- Angola Diplodus -- South Africa Diplodus -- Morphology Fisheries -- Angola Sparidae
- Language: English
- Type: Thesis , Masters , MA
- Identifier: vital:5361 , http://hdl.handle.net/10962/d1012062
- Description: The zebra sea bream, Diplodus cervinus (Sparidae) is an inshore fish comprised of two boreal subspecies from the Gulf of Oman and the Mediterranean / north eastern Atlantic and one austral subspecies from South Africa and southern Angola. The assumption of a single austral subspecies has, however, been questioned due to mounting molecular and morphological evidence suggesting that the cool Benguela current is a vicariant barrier that has separated many synonymous inshore fish species between South Africa and southern Angola. The aims of this thesis are to conduct a comparative morphological analysis of Diplodus cervinus in southern Angola and South Africa in order to classify the southern Angolan population and then to conduct a life history assessment to assess the life history impact of allopatry on this species between the two regions. Results of the morphological findings of the present study (ANOSIM, p < 0.05, Rmeristic = 0.42) and (Rmorphometric = 0.30) along with a concurrent molecular study (FST = 0.4 – 0.6), identified significant divergence between specimens from South Africa (n = 25) and southern Angola (n = 37) and supported stock separation and possibly sub-speciation, depending on the classification criteria utilised. While samples from the two boreal subspecies were not available for the comparative morphological or molecular analysis, comparisons of the colouration patterns between the three subspecies, suggested similarity between the southern Angola and the northern Atlantic / Mediterranean populations. In contrast, the colouration patterns between the southern Angolan and South African specimens differed substantially, further supporting the morphological and molecular results. The distinct morphological divergence between the southern Angolan and South African populations was not reflected within the life history traits of both populations. A combination of methods, including length/age frequency analyses, adult sex ratios and histological analysis was used to determine that this species is a rudimentary hermaphrodite in southern Angola. Peak spawning season was observed between June and July. The overall sex ratio (M: F) was 1:1.52 with females dominating smaller younger size classes and 50% maturity was attained at 210 mm FL and 4.6 years. Females [L(t) = 287.5(1-e⁻°·¹⁸⁽t⁻²·⁸⁴⁾)] grew significantly faster (LRT, p < 0.05) than males [L(t) = 380.19(1-e⁻°·°⁶⁽t⁻⁷·¹²⁾)]. The higher maximum age of the southern Angolan population of D. cervinus (43 years) was older than that of South African individuals sampled in the tsitsikamma national park. The similarities in the life history of the two austral populations are probably a consequence of similar selective pressures in the similar warmtemperate habitats. Evidence to support the above comments was found in the feeding study which showed that the South African and Angolan populations were almost identical, with both populations feeding primarily on amphipods and polychaete worms throughout ontogeny. In contrast, the diet of their boreal conspecifics from the Mediterranean was different, where larger individuals tended to select larger, and more robust, prey items. The life history differences observed between the boreal and austral populations can be attributed to either sampling bias or environmental factors. Sampling biases included the use of different age and growth estimation techniques, while the environmental factors would include differential selective pressures most likely driven by different resource availability and exploitation. The present study provides crucial baseline life history information of a potentially exploitable species off southern Angola as well as information on the life history plasticity of the species. Unfortunately, the current lack of uniformity in the methods used to estimate life history parameters between studies conducted on the boreal and austral populations have complicated our understanding of the evolution of various life history trends in sparid fish. From a management perspective however, the results from the present study can be used to propose management strategies for an emerging trap fishery in southern Angola. Using a balanced exploitation fishery approach (harvesting up to the size-at-100% maturity), the size of the fish traps entrance was calculated based the morphological information from this and other small sparid species that are targeted and was estimated to be 62 mm.
- Full Text:
- Date Issued: 2014
Teacher conversations : what happens when teachers talk
- Authors: Klitsie, Clara
- Date: 2014
- Subjects: Communication in education , Interaction analysis in education
- Language: English
- Type: Thesis , Masters , MEd
- Identifier: vital:9457 , http://hdl.handle.net/10948/d1020081
- Description: Teaching has a primary focus on engagement with students, but paradoxically, it can be experienced as lonely, private work, in classrooms behind closed doors, with an accompanying sense of deep disconnection from peers. When six experienced teachers sought to counteract this isolation, they formed a group which embarked on a shared journey of reflection and conversation, with the purpose of increasing selfknowledge, clarifying a sense of self as teacher, extending understanding of the selfhood of other teachers, and exposing the deeper sources of meaning underlying the vocation of teacher. This study sought to describe the information, opinions and beliefs which were exchanged among participants within the group and to describe the dynamics within the group. Furthermore, it sought to identify and describe the self-perceived impact of the experience of such a group, on the vocational vitality of each of the participants. Within an interpretivist epistemology a qualitative phenomenological research approach was adopted for the study. Data were obtained from two sources, consisting of transcripts of conversations from the meetings of a collaborative reflective group and from semi-structured individual interviews with group participants. These were analysed using an inductive approach with the aid of qualitative data analysis software: Atlas ti®. Findings from the study show that a high level of trust and a sense of safety were created through the use of guiding principles for meetings. Content chosen for reflective conversations and the general experience of meetings was perceived as providing a rare opportunity for participants to discover their selfhood as teachers. They reported that this understanding was further broadened by exposure to the selfhood of other teachers. Furthermore, members of the talk group reported that participation had resulted in a lowering of their sense of professional isolation and a renewal of vitality in their teaching. It is hoped that the findings from the study will inform an understanding of the experience of dialogue in a reflective, peer group where teachers focus on exploring together “who they are” as teachers. It provides valuable insights of the personal and professional transformations which can take place for teachers participating in conversations which focus on their inner landscape. Furthermore, the study has the potential to inform South African teacher professional development programmes with approaches which focus on teacher vocational renewal and vitality.
- Full Text:
- Date Issued: 2014
- Authors: Klitsie, Clara
- Date: 2014
- Subjects: Communication in education , Interaction analysis in education
- Language: English
- Type: Thesis , Masters , MEd
- Identifier: vital:9457 , http://hdl.handle.net/10948/d1020081
- Description: Teaching has a primary focus on engagement with students, but paradoxically, it can be experienced as lonely, private work, in classrooms behind closed doors, with an accompanying sense of deep disconnection from peers. When six experienced teachers sought to counteract this isolation, they formed a group which embarked on a shared journey of reflection and conversation, with the purpose of increasing selfknowledge, clarifying a sense of self as teacher, extending understanding of the selfhood of other teachers, and exposing the deeper sources of meaning underlying the vocation of teacher. This study sought to describe the information, opinions and beliefs which were exchanged among participants within the group and to describe the dynamics within the group. Furthermore, it sought to identify and describe the self-perceived impact of the experience of such a group, on the vocational vitality of each of the participants. Within an interpretivist epistemology a qualitative phenomenological research approach was adopted for the study. Data were obtained from two sources, consisting of transcripts of conversations from the meetings of a collaborative reflective group and from semi-structured individual interviews with group participants. These were analysed using an inductive approach with the aid of qualitative data analysis software: Atlas ti®. Findings from the study show that a high level of trust and a sense of safety were created through the use of guiding principles for meetings. Content chosen for reflective conversations and the general experience of meetings was perceived as providing a rare opportunity for participants to discover their selfhood as teachers. They reported that this understanding was further broadened by exposure to the selfhood of other teachers. Furthermore, members of the talk group reported that participation had resulted in a lowering of their sense of professional isolation and a renewal of vitality in their teaching. It is hoped that the findings from the study will inform an understanding of the experience of dialogue in a reflective, peer group where teachers focus on exploring together “who they are” as teachers. It provides valuable insights of the personal and professional transformations which can take place for teachers participating in conversations which focus on their inner landscape. Furthermore, the study has the potential to inform South African teacher professional development programmes with approaches which focus on teacher vocational renewal and vitality.
- Full Text:
- Date Issued: 2014
Teacher conversations: what happens when teachers talk
- Authors: Klitsie, Clara
- Date: 2014
- Subjects: Communication in education , Interaction analysis in education , Teachers -- Training of
- Language: English
- Type: Thesis , Masters , MEd
- Identifier: vital:9589 , http://hdl.handle.net/10948/d1021080
- Description: Teaching has a primary focus on engagement with students, but paradoxically, it can be experienced as lonely, private work, in classrooms behind closed doors, with an accompanying sense of deep disconnection from peers. When six experienced teachers sought to counteract this isolation, they formed a group which embarked on a shared journey of reflection and conversation, with the purpose of increasing selfknowledge, clarifying a sense of self as teacher, extending understanding of the selfhood of other teachers, and exposing the deeper sources of meaning underlying the vocation of teacher. This study sought to describe the information, opinions and beliefs which were exchanged among participants within the group and to describe the dynamics within the group. Furthermore, it sought to identify and describe the self-perceived impact of the experience of such a group, on the vocational vitality of each of the participants. Within an interpretivist epistemology a qualitative phenomenological research approach was adopted for the study. Data were obtained from two sources, consisting of transcripts of conversations from the meetings of a collaborative reflective group and from semi-structured individual interviews with group participants. These were analysed using an inductive approach with the aid of qualitative data analysis software: Atlas ti®. Findings from the study show that a high level of trust and a sense of safety were created through the use of guiding principles for meetings. Content chosen for reflective conversations and the general experience of meetings was perceived as providing a rare opportunity for participants to discover their selfhood as teachers. They reported that this understanding was further broadened by exposure to the selfhood of other teachers. Furthermore, members of the talk group reported that participation had resulted in a lowering of their sense of professional isolation and a renewal of vitality in their teaching.
- Full Text:
- Date Issued: 2014
- Authors: Klitsie, Clara
- Date: 2014
- Subjects: Communication in education , Interaction analysis in education , Teachers -- Training of
- Language: English
- Type: Thesis , Masters , MEd
- Identifier: vital:9589 , http://hdl.handle.net/10948/d1021080
- Description: Teaching has a primary focus on engagement with students, but paradoxically, it can be experienced as lonely, private work, in classrooms behind closed doors, with an accompanying sense of deep disconnection from peers. When six experienced teachers sought to counteract this isolation, they formed a group which embarked on a shared journey of reflection and conversation, with the purpose of increasing selfknowledge, clarifying a sense of self as teacher, extending understanding of the selfhood of other teachers, and exposing the deeper sources of meaning underlying the vocation of teacher. This study sought to describe the information, opinions and beliefs which were exchanged among participants within the group and to describe the dynamics within the group. Furthermore, it sought to identify and describe the self-perceived impact of the experience of such a group, on the vocational vitality of each of the participants. Within an interpretivist epistemology a qualitative phenomenological research approach was adopted for the study. Data were obtained from two sources, consisting of transcripts of conversations from the meetings of a collaborative reflective group and from semi-structured individual interviews with group participants. These were analysed using an inductive approach with the aid of qualitative data analysis software: Atlas ti®. Findings from the study show that a high level of trust and a sense of safety were created through the use of guiding principles for meetings. Content chosen for reflective conversations and the general experience of meetings was perceived as providing a rare opportunity for participants to discover their selfhood as teachers. They reported that this understanding was further broadened by exposure to the selfhood of other teachers. Furthermore, members of the talk group reported that participation had resulted in a lowering of their sense of professional isolation and a renewal of vitality in their teaching.
- Full Text:
- Date Issued: 2014
Teachers' perceptions of behavioural problems manifested by Grade 11 and 12 learners in three Namibian schools
- Authors: Akawa, Ester Anna Nelago
- Date: 2014
- Subjects: Education, Secondary -- Namibia School children -- Namibia -- Attitudes Learning disabilities -- Social aspects Behavior disorders in children -- Education (Secondary) -- Namibia Children with social disabilities -- Education (Secondary) -- Namibia Emotional problems of children -- Education (Secondary) -- Namibia Teachers -- Job stress -- Namibia
- Language: English
- Type: Thesis , Masters , MEd
- Identifier: vital:1962 , http://hdl.handle.net/10962/d1010868
- Description: In Namibia today few learners with behavioural and learning problems are within special schools as most are placed within the mainstream school system. Placing these learners within the mainstream system is part of the policy of Inclusive Education (IE) because it argues that this would benefit these learners and also save resources. IE is concerned with addressing barriers to learning and behavioural problems are regarded as one of these barriers. IE argues for a series of new approaches to the diagnosis and response to learners with behavioural problems. This poses challenges for teachers in mainstream schools. Teachers are at the forefront of this situation as they are usually the first to observe and experience the behavioural problems in the schools and are expected to respond appropriately. They find this situation both challenging and problematic. This research explores a sample of teachers’ perceptions of learners’ behavioural problems. To collect in-depth information, this study followed a qualitative approach with a case study design. The data were collected through semi-structured interviews, supplemented with observation and document analysis. The study consisted of fifteen respondents: three principals, three teacher counsellors and nine teachers from the three selected schools. This study illuminates the types of behaviour that teachers encounter, the impact of these behaviours, the factors seen as contributing to these behaviours, and how teachers and the school system deal with these behaviours. In addition the study applies Bronfenbrenner’s bioecological model (1992) to explain how the behaviours manifested by Grade 11 and 12 learners, and identified as problematic by teachers, are part of an interconnected nested social system. The results from the study indicate the manifestation of behavioural problems to be common occurrences in secondary schools are evident, amongst others, through fighting, bullying, substance abuse, truancy, and disrespect of teachers and authority. The teachers pointed to the prevalence of these problems as well as the serious impact such problems have on these learners, their fellow learners, and on the teachers. The teachers identified a complex array of what they saw as contributing factors located within the school, peer groups, family and home circumstances, the local community, as well within the national education policy, the economy and society. The study points to some specific, as well as broader, lessons and opportunities for action both for those managing the education system at the national level and for schools and teachers.
- Full Text:
- Date Issued: 2014
- Authors: Akawa, Ester Anna Nelago
- Date: 2014
- Subjects: Education, Secondary -- Namibia School children -- Namibia -- Attitudes Learning disabilities -- Social aspects Behavior disorders in children -- Education (Secondary) -- Namibia Children with social disabilities -- Education (Secondary) -- Namibia Emotional problems of children -- Education (Secondary) -- Namibia Teachers -- Job stress -- Namibia
- Language: English
- Type: Thesis , Masters , MEd
- Identifier: vital:1962 , http://hdl.handle.net/10962/d1010868
- Description: In Namibia today few learners with behavioural and learning problems are within special schools as most are placed within the mainstream school system. Placing these learners within the mainstream system is part of the policy of Inclusive Education (IE) because it argues that this would benefit these learners and also save resources. IE is concerned with addressing barriers to learning and behavioural problems are regarded as one of these barriers. IE argues for a series of new approaches to the diagnosis and response to learners with behavioural problems. This poses challenges for teachers in mainstream schools. Teachers are at the forefront of this situation as they are usually the first to observe and experience the behavioural problems in the schools and are expected to respond appropriately. They find this situation both challenging and problematic. This research explores a sample of teachers’ perceptions of learners’ behavioural problems. To collect in-depth information, this study followed a qualitative approach with a case study design. The data were collected through semi-structured interviews, supplemented with observation and document analysis. The study consisted of fifteen respondents: three principals, three teacher counsellors and nine teachers from the three selected schools. This study illuminates the types of behaviour that teachers encounter, the impact of these behaviours, the factors seen as contributing to these behaviours, and how teachers and the school system deal with these behaviours. In addition the study applies Bronfenbrenner’s bioecological model (1992) to explain how the behaviours manifested by Grade 11 and 12 learners, and identified as problematic by teachers, are part of an interconnected nested social system. The results from the study indicate the manifestation of behavioural problems to be common occurrences in secondary schools are evident, amongst others, through fighting, bullying, substance abuse, truancy, and disrespect of teachers and authority. The teachers pointed to the prevalence of these problems as well as the serious impact such problems have on these learners, their fellow learners, and on the teachers. The teachers identified a complex array of what they saw as contributing factors located within the school, peer groups, family and home circumstances, the local community, as well within the national education policy, the economy and society. The study points to some specific, as well as broader, lessons and opportunities for action both for those managing the education system at the national level and for schools and teachers.
- Full Text:
- Date Issued: 2014
Teachers’ experiences of change : a case study analysis of a school-based intervention in rural Kwazulu-Natal
- Authors: James, Sally Jane
- Date: 2014
- Subjects: David Rattray Foundation , Educational change -- South Africa -- KwaZulu-Natal -- Case studies , Rural schools -- South Africa -- KwaZulu-Natal , Teachers -- Training of -- South Africa -- KwaZulu-Natal , Community and school -- South Africa -- KwaZulu-Natal , KwaZulu-Natal (South Africa) -- Social conditions , KwaZulu-Natal (South Africa) -- Economic conditions
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:1980 , http://hdl.handle.net/10962/d1013118
- Description: The research presented in this thesis is a case study analysis of the school-based intervention initiated by the David Rattray Foundation [DRF]. David Rattray, a South African historian well known for his contribution to the 1879-1896 Anglo-Zulu War heritage, was murdered in January 2007. In response to his untimely death, the DRF was established by family and friends with the hope of improving education within the Umzinyathi rural municipal district of KwaZulu-Natal. This study consisted of three phases: Phase I (May-December 2011); Phase II (January-December 2012), and Phase III (December 2012-October 2013). During Phase I, the focus was on describing the broader context in which the case is located. It resulted in a narrative account of the emergence of the DRF as a non-governmental organisation [NGO] working towards change within the local rural school community. During Phase II the focus shifted from the broader socio-political and economic context to the human dimension which included teachers, principals, volunteer workers and a district official working in the schools. During Phase II the approach to change adopted by the DRF was critically analysed in relation to models of change described in the literature. Teachers’ experiences of change were also examined. Phase III was a synthesis of the findings from the first two research phases. By drawing on systems and complexity theory perspectives, insights were gained enabling a deep understanding of the DRF’s school-based intervention as a whole. This research is a qualitative study that seeks to understand individual teachers’ experiences and participation in a process of change that reaches beyond the individual and his/her immediate context. The adoption of a realist ontology (Maxwell, 2012) and application of an explanatory heuristic based on the critical realist philosophy of Bhaskar (1979, 1980, 2011) enabled the layered analysis and in-depth interpretation that characterises the study. The findings of the study reveal a complex and ongoing process of change within a rural school context. The results illuminate the efficacy of a collaborative partnership between civil society (the DRF), the local community, under the leadership of a tribal authority, and the local government (KwaZulu-Natal Provincial Department of Education). It also reveals how teachers within this particular context do not have a strong voice in the change process and hence participate only superficially in the school-based intervention. It is probable that the constraining mechanisms revealed through this research are not exclusive to this particular case study, but are common across the South African rural school context. The main contention of this thesis is that these mechanisms need further interrogation in order to enable further change and permit the active participation of teachers in the process.While the study illuminates many of the tensions and problems faced by the schools and the community in which they are located, it also highlights the achievements and selfless attitude of many people working towards change and improvement within the schools. This case study thus provides an example to all South Africans of what can be achieved with commitment and effort.
- Full Text:
- Date Issued: 2014
- Authors: James, Sally Jane
- Date: 2014
- Subjects: David Rattray Foundation , Educational change -- South Africa -- KwaZulu-Natal -- Case studies , Rural schools -- South Africa -- KwaZulu-Natal , Teachers -- Training of -- South Africa -- KwaZulu-Natal , Community and school -- South Africa -- KwaZulu-Natal , KwaZulu-Natal (South Africa) -- Social conditions , KwaZulu-Natal (South Africa) -- Economic conditions
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:1980 , http://hdl.handle.net/10962/d1013118
- Description: The research presented in this thesis is a case study analysis of the school-based intervention initiated by the David Rattray Foundation [DRF]. David Rattray, a South African historian well known for his contribution to the 1879-1896 Anglo-Zulu War heritage, was murdered in January 2007. In response to his untimely death, the DRF was established by family and friends with the hope of improving education within the Umzinyathi rural municipal district of KwaZulu-Natal. This study consisted of three phases: Phase I (May-December 2011); Phase II (January-December 2012), and Phase III (December 2012-October 2013). During Phase I, the focus was on describing the broader context in which the case is located. It resulted in a narrative account of the emergence of the DRF as a non-governmental organisation [NGO] working towards change within the local rural school community. During Phase II the focus shifted from the broader socio-political and economic context to the human dimension which included teachers, principals, volunteer workers and a district official working in the schools. During Phase II the approach to change adopted by the DRF was critically analysed in relation to models of change described in the literature. Teachers’ experiences of change were also examined. Phase III was a synthesis of the findings from the first two research phases. By drawing on systems and complexity theory perspectives, insights were gained enabling a deep understanding of the DRF’s school-based intervention as a whole. This research is a qualitative study that seeks to understand individual teachers’ experiences and participation in a process of change that reaches beyond the individual and his/her immediate context. The adoption of a realist ontology (Maxwell, 2012) and application of an explanatory heuristic based on the critical realist philosophy of Bhaskar (1979, 1980, 2011) enabled the layered analysis and in-depth interpretation that characterises the study. The findings of the study reveal a complex and ongoing process of change within a rural school context. The results illuminate the efficacy of a collaborative partnership between civil society (the DRF), the local community, under the leadership of a tribal authority, and the local government (KwaZulu-Natal Provincial Department of Education). It also reveals how teachers within this particular context do not have a strong voice in the change process and hence participate only superficially in the school-based intervention. It is probable that the constraining mechanisms revealed through this research are not exclusive to this particular case study, but are common across the South African rural school context. The main contention of this thesis is that these mechanisms need further interrogation in order to enable further change and permit the active participation of teachers in the process.While the study illuminates many of the tensions and problems faced by the schools and the community in which they are located, it also highlights the achievements and selfless attitude of many people working towards change and improvement within the schools. This case study thus provides an example to all South Africans of what can be achieved with commitment and effort.
- Full Text:
- Date Issued: 2014
Teachers’ understanding and implementation of inclusive education in an Eastern Cape primary school
- Authors: Mcconnachie, Karola
- Date: 2014
- Subjects: Inclusive education -- South Africa , Special education -- South Africa , Education (Primary) -- Government policy -- South Africa , Alcoholism -- Social aspects -- South Africa
- Language: English
- Type: Thesis , Masters , MEd
- Identifier: vital:1984 , http://hdl.handle.net/10962/d1013150
- Description: Since 2001 the South African Department of Basic Education has been working towards implementing Inclusive Education over a twenty year period. This is in accordance with international trends in education. This study set out to investigate the implementation of Inclusive Education in a South African context by conducting a case study at an Eastern Cape no‐fee‐paying primary school. It looked at how the government policy, as set out in Education White Paper 6 (EWP6) (DoE, 2001), is understood and being implemented by teachers at the Welcome Primary school. The study further investigated the introduction of the National Strategy on Screening, Identification, Assessment and Support (SIAS strategy) (DoE, 2008a) to gain insight into how teachers identify and assess barriers to learning in an ordinary primary school. In addition it looked at emerging factors that could impact on the implementation of this policy. With 16 years teaching experience in ordinary and private schools and 19 years experience in a special needs school as a teacher, head of department and then principal, I have personal experience of the crisis in the Eastern Cape Department of Basic Education. This awareness provided the impetus and interest in researching Inclusive Education policy implementation. It is my view that only when we begin to grapple with the problems right at the source of the education crisis within the majority of the no‐fee‐paying schools that informed decisions about policy and policy implementation can be made. As I am able to understand and converse in isiXhosa, I was able to observe and experience the implementation of EWP6 and the SIAS strategy in a school that is an isiXhosa‐medium ordinary primary school and similar to the majority of ordinary public schools in the district. A qualitative research approach based within an interpretive paradigm using the case study method was used for this study. Semi‐structured interviews, detailed field notes as well as documents generated by meetings and education conferences helped me to investigate and refine my research goals. The research found that the implementation of EWP6 and the SIAS strategy posed a major challenge for the Department of Basic Education, and highlighted the significant gap between ordinary primary schools and special needs schools. However, the fact that there is a partial engagement with the process of providing inclusive education, does present some measure of hope for a better future for those learners that have experienced the injustice of exclusion from education and society. The Eastern Cape Department of Basic Education will have to ‘catch up’ to other provinces in its delivery of every child’s constitutional right to education in an inclusive school environment. Factors emerged from the study that showed that the assessment of learners’ barriers to learning with the resultant support needs was a relatively new concept, as teachers tended to rely on traditional classroom tests and simple informal classroom assessments to assess the learners. Teachers expressed a good verbal knowledge of learners with support needs but found it very challenging to put this verbal knowledge into a written document. In addition there was inadequate support from the District Based Support Team to implement the SIAS strategy. This study showed that the medical model of assessment was still being adhered to in the research district with little evidence of a move to a social model of assessment in terms of the SIAS strategy. In addition, factors emerged indicating the serious impact that alcohol abuse has on children and the society in which they live. The evidence of increasing numbers of children with Fetal Alcohol Spectrum Disorder (FASD) in a single educational district is a matter of grave concern from an educational and financial perspective. It is my contention that this is a matter of national urgency and that the Department of Basic Education must confront the escalating problem of alcohol abuse and the resultant challenges of a large number of learners with serious barriers to learning that need to be included in the education system.
- Full Text:
- Date Issued: 2014
- Authors: Mcconnachie, Karola
- Date: 2014
- Subjects: Inclusive education -- South Africa , Special education -- South Africa , Education (Primary) -- Government policy -- South Africa , Alcoholism -- Social aspects -- South Africa
- Language: English
- Type: Thesis , Masters , MEd
- Identifier: vital:1984 , http://hdl.handle.net/10962/d1013150
- Description: Since 2001 the South African Department of Basic Education has been working towards implementing Inclusive Education over a twenty year period. This is in accordance with international trends in education. This study set out to investigate the implementation of Inclusive Education in a South African context by conducting a case study at an Eastern Cape no‐fee‐paying primary school. It looked at how the government policy, as set out in Education White Paper 6 (EWP6) (DoE, 2001), is understood and being implemented by teachers at the Welcome Primary school. The study further investigated the introduction of the National Strategy on Screening, Identification, Assessment and Support (SIAS strategy) (DoE, 2008a) to gain insight into how teachers identify and assess barriers to learning in an ordinary primary school. In addition it looked at emerging factors that could impact on the implementation of this policy. With 16 years teaching experience in ordinary and private schools and 19 years experience in a special needs school as a teacher, head of department and then principal, I have personal experience of the crisis in the Eastern Cape Department of Basic Education. This awareness provided the impetus and interest in researching Inclusive Education policy implementation. It is my view that only when we begin to grapple with the problems right at the source of the education crisis within the majority of the no‐fee‐paying schools that informed decisions about policy and policy implementation can be made. As I am able to understand and converse in isiXhosa, I was able to observe and experience the implementation of EWP6 and the SIAS strategy in a school that is an isiXhosa‐medium ordinary primary school and similar to the majority of ordinary public schools in the district. A qualitative research approach based within an interpretive paradigm using the case study method was used for this study. Semi‐structured interviews, detailed field notes as well as documents generated by meetings and education conferences helped me to investigate and refine my research goals. The research found that the implementation of EWP6 and the SIAS strategy posed a major challenge for the Department of Basic Education, and highlighted the significant gap between ordinary primary schools and special needs schools. However, the fact that there is a partial engagement with the process of providing inclusive education, does present some measure of hope for a better future for those learners that have experienced the injustice of exclusion from education and society. The Eastern Cape Department of Basic Education will have to ‘catch up’ to other provinces in its delivery of every child’s constitutional right to education in an inclusive school environment. Factors emerged from the study that showed that the assessment of learners’ barriers to learning with the resultant support needs was a relatively new concept, as teachers tended to rely on traditional classroom tests and simple informal classroom assessments to assess the learners. Teachers expressed a good verbal knowledge of learners with support needs but found it very challenging to put this verbal knowledge into a written document. In addition there was inadequate support from the District Based Support Team to implement the SIAS strategy. This study showed that the medical model of assessment was still being adhered to in the research district with little evidence of a move to a social model of assessment in terms of the SIAS strategy. In addition, factors emerged indicating the serious impact that alcohol abuse has on children and the society in which they live. The evidence of increasing numbers of children with Fetal Alcohol Spectrum Disorder (FASD) in a single educational district is a matter of grave concern from an educational and financial perspective. It is my contention that this is a matter of national urgency and that the Department of Basic Education must confront the escalating problem of alcohol abuse and the resultant challenges of a large number of learners with serious barriers to learning that need to be included in the education system.
- Full Text:
- Date Issued: 2014
Teaching in higher education
- Authors: Quinn, Lynn
- Date: 2014
- Language: English
- Type: text , review
- Identifier: http://hdl.handle.net/10962/66557 , vital:28963 , https://doi.org/10.1080/1360144X.2014.908094
- Description: publisher version , As Becker and Denicolo point out in their introduction, traditionally most lecturers in higher education begin teaching with little or no formal training: ‘It is assumed if you were expert in your field you would be able, by some ill-defined means, to teach others’ (p. 1). This book aims to remedy that situation and does exactly what it sets out to do: it provides a useful, step-by-step training guide for teachers in higher education. It provides much needed advice for new academics for ways in which they can successfully combine their teaching and their research roles. It is written in an accessible style, draws on the experiences of people who have taught in higher education for some time, and provides practical advice for teaching in a range of contexts and for dealing with different challenges that may arise.
- Full Text: false
- Date Issued: 2014
- Authors: Quinn, Lynn
- Date: 2014
- Language: English
- Type: text , review
- Identifier: http://hdl.handle.net/10962/66557 , vital:28963 , https://doi.org/10.1080/1360144X.2014.908094
- Description: publisher version , As Becker and Denicolo point out in their introduction, traditionally most lecturers in higher education begin teaching with little or no formal training: ‘It is assumed if you were expert in your field you would be able, by some ill-defined means, to teach others’ (p. 1). This book aims to remedy that situation and does exactly what it sets out to do: it provides a useful, step-by-step training guide for teachers in higher education. It provides much needed advice for new academics for ways in which they can successfully combine their teaching and their research roles. It is written in an accessible style, draws on the experiences of people who have taught in higher education for some time, and provides practical advice for teaching in a range of contexts and for dealing with different challenges that may arise.
- Full Text: false
- Date Issued: 2014
Teaching strategies to improve the writing skills for grade and 9 learners in English first additional language: a case study of Forth High School in the Cradock Education district
- Authors: Kalipha, Zimkhitha
- Date: 2014
- Subjects: Teaching strategies -- writing skills , Writing skills -- Study and teaching -- South Africa , English language -- Study and teaching -- South Africa
- Language: English
- Type: Thesis , Masters , M Ed
- Identifier: vital:16215 , http://hdl.handle.net/10353/d1017297 , Teaching strategies -- writing skills , Writing skills -- Study and teaching -- South Africa , English language -- Study and teaching -- South Africa
- Description: Writing skills is are an essential requirement to lifelong learner success yet the way teachers teach and provide feedback to their learners on writing is quite challenging. This study sought to explore the teaching strategies to improve writing skills as an essential requirement for effective learning in schools for grade 8 and 9 learners in English First Additional Language. For people living in the townships and rural areas in South Africa, exposure to English is limited, because the majority of people communicate with each other in local languages. With teachers and learners residing in the townships where communication occurs mostly in isiXhosa, problems in language proficiency, in particular writing in English First Additional Language, are often encountered not only by the learners, but by educators as well. This was a case study of four high schools in the Cradock Education District. In-depth interviews were conducted with eight participants in the four schools. There were eight main findings, which are as follows: Lack of support for teachers, lack of a culture of learning amongst learners, and lack of competence in English for both learners and parents, which need to be addressed; and strategies proposed to improve writing skills are: the importance of creative writing; regular feedback and the importance of drafts.
- Full Text:
- Date Issued: 2014
- Authors: Kalipha, Zimkhitha
- Date: 2014
- Subjects: Teaching strategies -- writing skills , Writing skills -- Study and teaching -- South Africa , English language -- Study and teaching -- South Africa
- Language: English
- Type: Thesis , Masters , M Ed
- Identifier: vital:16215 , http://hdl.handle.net/10353/d1017297 , Teaching strategies -- writing skills , Writing skills -- Study and teaching -- South Africa , English language -- Study and teaching -- South Africa
- Description: Writing skills is are an essential requirement to lifelong learner success yet the way teachers teach and provide feedback to their learners on writing is quite challenging. This study sought to explore the teaching strategies to improve writing skills as an essential requirement for effective learning in schools for grade 8 and 9 learners in English First Additional Language. For people living in the townships and rural areas in South Africa, exposure to English is limited, because the majority of people communicate with each other in local languages. With teachers and learners residing in the townships where communication occurs mostly in isiXhosa, problems in language proficiency, in particular writing in English First Additional Language, are often encountered not only by the learners, but by educators as well. This was a case study of four high schools in the Cradock Education District. In-depth interviews were conducted with eight participants in the four schools. There were eight main findings, which are as follows: Lack of support for teachers, lack of a culture of learning amongst learners, and lack of competence in English for both learners and parents, which need to be addressed; and strategies proposed to improve writing skills are: the importance of creative writing; regular feedback and the importance of drafts.
- Full Text:
- Date Issued: 2014