Spatial Distribution of Drug-Resistant Mycobacterium tuberculosis Infections in Rural Eastern Cape Province of South Africa
- Faye, M Lindiwe, Hosu, C Mojisola, Vasaikar, Sandeep, Dippenaar, Anzaan, Oostvogels, Selien, Warren, M Rob, Apalata, Teke
- Authors: Faye, M Lindiwe , Hosu, C Mojisola , Vasaikar, Sandeep , Dippenaar, Anzaan , Oostvogels, Selien , Warren, M Rob , Apalata, Teke
- Date: 2023
- Subjects: Tuberculosis , Spatial analysis , Mutations , Spoligotypes , Heteroresistance
- Language: English
- Type: Article
- Identifier: http://hdl.handle.net/11260/13642 , vital:78969 , DOI: https://doi.org/10.3390/pathogens12030475
- Description: Tuberculosis (TB), an infectious airborne disease caused by Mycobacterium tuberculosis (Mtb), is a serious public health threat reported as the leading cause of morbidity and mortality worldwide. South Africa is a high-TB-burden country with TB being the highest infectious disease killer. This study investigated the distribution of Mtb mutations and spoligotypes in rural Eastern Cape Province. The Mtb isolates included were 1157 from DR-TB patients and analysed by LPA followed by spoligotyping of 441 isolates. The distribution of mutations and spoligotypes was done by spatial analysis. The rpoB gene had the highest number of mutations. The distribution of rpoB and katG mutations was more prevalent in four healthcare facilities, inhA mutations were more prevalent in three healthcare facilities, and heteroresistant isolates were more prevalent in five healthcare facilities. The Mtb was genetically diverse with Beijing more prevalent and largely distributed. Spatial analysis and mapping of gene mutations and spoligotypes revealed a better picture of distribution.
- Full Text:
- Date Issued: 2023
- Authors: Faye, M Lindiwe , Hosu, C Mojisola , Vasaikar, Sandeep , Dippenaar, Anzaan , Oostvogels, Selien , Warren, M Rob , Apalata, Teke
- Date: 2023
- Subjects: Tuberculosis , Spatial analysis , Mutations , Spoligotypes , Heteroresistance
- Language: English
- Type: Article
- Identifier: http://hdl.handle.net/11260/13642 , vital:78969 , DOI: https://doi.org/10.3390/pathogens12030475
- Description: Tuberculosis (TB), an infectious airborne disease caused by Mycobacterium tuberculosis (Mtb), is a serious public health threat reported as the leading cause of morbidity and mortality worldwide. South Africa is a high-TB-burden country with TB being the highest infectious disease killer. This study investigated the distribution of Mtb mutations and spoligotypes in rural Eastern Cape Province. The Mtb isolates included were 1157 from DR-TB patients and analysed by LPA followed by spoligotyping of 441 isolates. The distribution of mutations and spoligotypes was done by spatial analysis. The rpoB gene had the highest number of mutations. The distribution of rpoB and katG mutations was more prevalent in four healthcare facilities, inhA mutations were more prevalent in three healthcare facilities, and heteroresistant isolates were more prevalent in five healthcare facilities. The Mtb was genetically diverse with Beijing more prevalent and largely distributed. Spatial analysis and mapping of gene mutations and spoligotypes revealed a better picture of distribution.
- Full Text:
- Date Issued: 2023
Tuberculosis management and referral practices among traditional medicine practitioners in Lagos, Nigeria
- Adepoju, Abiola Victor, Oladimeji, Olanrewwaju, Sibiya, Nokuthula Maureen, Inegbeboh, Jude, Egesemba, Ginika
- Authors: Adepoju, Abiola Victor , Oladimeji, Olanrewwaju , Sibiya, Nokuthula Maureen , Inegbeboh, Jude , Egesemba, Ginika
- Date: 2023
- Subjects: Traditional birth attendant , Traditional healers , Tuberculosis , Traditional medicine board
- Language: English
- Type: Article
- Identifier: http://hdl.handle.net/11260/13368 , vital:78661 , DOI: 10.4081/jphia.2023.1480
- Description: Introduction: Despite the potential role of Traditional Birth Attendants (TBAs) and Traditional Healers (THs), little is known about their knowledge of tuberculosis (TB) management and refer ral practices in Nigeria. Objective: To determine knowledge and self-reported prac tices of traditional birth attendants and traditional healers in man aging TB in Lagos, Nigeria. Methods: A cross-sectional study of 120 THs and TBAs in three high TB burden Local Government Areas (LGAs) in Lagos, Nigeria. Data were collected between April 2018 to September 2018 through interviewer-administered questionnaires. We used Statistical Package for Social Sciences software for data analyses…
- Full Text:
- Date Issued: 2023
- Authors: Adepoju, Abiola Victor , Oladimeji, Olanrewwaju , Sibiya, Nokuthula Maureen , Inegbeboh, Jude , Egesemba, Ginika
- Date: 2023
- Subjects: Traditional birth attendant , Traditional healers , Tuberculosis , Traditional medicine board
- Language: English
- Type: Article
- Identifier: http://hdl.handle.net/11260/13368 , vital:78661 , DOI: 10.4081/jphia.2023.1480
- Description: Introduction: Despite the potential role of Traditional Birth Attendants (TBAs) and Traditional Healers (THs), little is known about their knowledge of tuberculosis (TB) management and refer ral practices in Nigeria. Objective: To determine knowledge and self-reported prac tices of traditional birth attendants and traditional healers in man aging TB in Lagos, Nigeria. Methods: A cross-sectional study of 120 THs and TBAs in three high TB burden Local Government Areas (LGAs) in Lagos, Nigeria. Data were collected between April 2018 to September 2018 through interviewer-administered questionnaires. We used Statistical Package for Social Sciences software for data analyses…
- Full Text:
- Date Issued: 2023
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