List of Titles

An in vitro investigation of novel quinolone derivatives on selected pharmacological targets for diabetes mellitus and associated complications

- Ayodele, Omobolanle Opeyemi

Authors: Ayodele, Omobolanle Opeyemi
Date: 2023-03-29
Subjects: Diabetes , Hyperglycemia , Quinolone antibacterial agents , Cardiovascular system Diseases , Diabetes Alternative treatment , In vitro experiment
Language: English
Type: Academic theses , Master's theses , text
Identifier: http://hdl.handle.net/10962/409813 , vital:70632
Description: Diabetes mellitus (DM) is a group of endocrine and metabolic disorders characterised and identified by the presence of hyperglycaemia over a long period and, to an extent, accompanied by hyperlipidaemia. CVD has been reported to be the leading cause of mortality in patients with DM. Several antidiabetic agents are available for managing DM, but these agents are not for curative therapy and present with undesirable side effects. In addition, these agents become less effective as the patient's condition progresses to complete beta-cell failure. Therefore, developing newer antidiabetic agents with minimal undesirable side effects, prolonged efficacy and protection against the development of DM complications are necessary. This study was conducted to identify potential novel antidiabetic agents with cardiovascular-protective activity. The compounds of interest for the study were quinolone derivatives since quinolones have been reported to have an antihyperglycaemic effect. , Thesis (MSc) -- Faculty of Pharmacy, 2023
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Date Issued: 2023-03-29

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Elele nje usathetha: Ukukhapha as an expression of amaXhosa language world-sense

- Dana, Zikho

Authors: Dana, Zikho
Date: 2022-10-14
Subjects: Xhosa language Discourse analysis , Guides (Spiritualism) , Grief Religious aspects , Historical linguistics , Xhosa language Religious aspects , Xhosa (African people) Death , Death Religious aspects
Language: English
Type: Academic theses , Master's theses , text
Identifier: http://hdl.handle.net/10962/406309 , vital:70257
Description: This study examines ukukhapha as an expression of amaXhosa language world-sense. Firstly, it examines how ukukhapha as a rite of passage to accompany the spirit of the deceased from the physical realm into the spiritual realm maintains the nexus between the living and the dead. Secondly, it explores ukukhapha as a ritual of collective mourning. Both dimensions of the study are pursued using language as a point of departure. This study draws on four key texts written across different times in history, namely: Intlalo kaXhosa (The Social Life of amaXhosa) by Tiyo Burnside (TB) Soga (1974); the three volume Greater Dictionary of isiXhosa (1989, 2003 and 2006); Nokuzola Mndende’s (2002) PhD thesis entitled: Signifying practices: AmaXhosa ritual speech; and Khaya Dlanga’s (2015) memoire: To Quote Myself. This thesis examines ukukhapha in the context of death to establish how amaXhosa speak about death and how this shapes their understanding and its practice. Discourse analysis is employed to clarify some practices and examples of ukukhapha. It’s also used to trace the evolution of ukukhapha over time in isiXhosa. It is utilized as a reservoir of knowledge epitomizing the world-sense of amaXhosa rather than solely as a means of communication. This study reveals that while ukukhapha as a ritual slaughtering of an ox to accompany the deceased is found in literature, its examination as a practice of communal and collective grief is scanty. The four key texts studied in this thesis reveal that ukukhapha goes beyond a mere ritual slaughtering of a sacrificial beast to accompany the spirit of the deceased to the ancestral realm. It is a practice that has allowed amaXhosa to collectively grief. Furthermore, it has provided the bereaved various forms of support which are pivotal in maintaining and strengthening kinship and communal ties among the living. This study further reveals that for the Africans in general, and for amaXhosa in particular, death is not the end of life. It is a continuation of life where the deceased morphs and graduates to an ancestor who joins a larger community of ancestors who act as intermediaries between the living and uMdali, the Creator. The findings demonstrate that through ukukhapha, there is no bifurcation between gender and age, rather they complement each other as the successful execution of the mourning period and farewell of a loved one is dependent on the roles played by both women and men respectively. , Olu phando luceba ukuphonononga ukukhapha njengendlela yokuphila equlathwe kulwimi lwamaXhosa. Okokuqala, luzakuphanda indlela ukukhapha njengesiko lokukhapha umphefumlo womfi ukusukela kwelenyama ukuya kwelemimoya kugcina ngayo ubudlelwane phakathi kwabaphilayo nabaleli ukuthula. Okwesibini, luzakuphanda ukukhapha njengesiko lokuzila ndawoni nye. Zombini ezi nkalo zizakuvelelwa ngokugxila kulwimi. Olu phando lucaphula kwimibhalo emine engundoqo kumaxesha ohlukileyo kwimbali, iquka: Intlalo kaXhosa owabhalwa nguTiyo Burnside Soga (ngowe1974); isichazi-magama esinemiqulu emithathu iThe Greater Dictionary of isiXhosa (ngowama-1989, owama-2003 nowama-2006); ithisisi yePhD kaNokuzola Mndende (ngowama-2002) ebizwa Signifying practices: amaXhosa ritual speech; nencwadi engunomalisa wobom, ebhalwe nguKhaya Dlanga (ngowama-2015) ebizwa To Quote Myself. Le thisisi isebenzisa ukukhapha kwilixa lokufa ukuphanda indlela amaXhosa athetha ngkufa, nokuba le ndlela yokuthetha iyichaphazela njani indlela abakuqonda ngayo ukufa nendlela abakhaphana ngayo. IDiscourse Analysis isetyenziswa njengesixhobo sokucacisa ukukhapha. Iphinde isetyenziswe ukunika imizekelo yeli siko nendlela yokuphila kwakunye nendlela ukukhapha kutshintshe ngayo ekuhambeni kwexesha kulwimi lwesiXhosa njengokuba sizakusetyenziswa njengovimba wolwazi, endaweni yokusetyenziswa njengesixhobo sonxibelelwano kuphela. Olu phando lubonisa ukuba njengokuba ukukhapha njengesiko lokuphalaza igazi lenkomo ukukhapha umfi kubhaliwe ngako kuncwadi, indlela abaphilayo enyameni abakhaphana ngayo iyasilela kuncwadi. Le mibhalo mine echongiweyo nephononongiweyo kolu phando ivelisa ukuba ukukhapha akuphelelanga ekuphalazeni igazi lenkomo kuphela njengesiko lokukhapha umfi ukuze awelele kweleminyanya, yindlela eyavumela amaXhosa ukuba azile ngemanyano apho uluntu luxhasa abafelweyo ngeendlela ezahlukeneyo ezithi zomeleze imanyano phakathi kwabazalanayo noluntu lwabaphilayo. Olu phando lutyhila into yokuba kumaAfrika jikelele, ingakumbi amaXhosa, ukufa ayikuko ukuphela kobom, nto nje luhambo olugqithisa umfi kubom obulandelayo apho ongeza kwinani kwelezinyanya apho izinyanya zilikhonco phakathi koMdali nabaphilayo. Iziphumo ngokukhapha zibonisa ukuba akukho ukuchasana phakathi kwesini neminyaka, nto nje, le miba mibini iyathungelana ekuncediseni nasekuqinisekiseni ukuba abafazi namadoda benza iindima zabo ngokufanelekileyo ekuqinisekiseni ukuba ixesha lezila nokubeka umfi kwikhaya lakhe lokugqibela ziyimpumelelo. , Thesis (MA) -- Faculty of Humanities, School of Languages and Literatures, 2022
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Date Issued: 2022-10-14

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Curriculum adjustment and adaptive leadership in two service-learning courses at Rhodes University as a consequence of the COVID-19 pandemic

- Khuhlane, Heide Nozuko

Authors: Khuhlane, Heide Nozuko
Date: 2021-10-29
Subjects: COVID-19 (Disease) , Curriculum planning South Africa Makhanda , Rhodes University , Service learning South Africa Makhanda , Educational leadership South Africa Makhanda , Educational change South Africa Makhanda , Adaptive leadership
Language: English
Type: Master's theses , text
Identifier: http://hdl.handle.net/10962/191192 , vital:45069
Description: The COVID-19 global pandemic altered many aspects of learning. Learning through service, a component of community engagement in higher education linking academic learning and the community was no exception. Informed by Experiential Learning Theory, this study investigated the curriculum adjustment of two service-learning courses at Rhodes University and the leadership development of those who lead the courses as a consequence of COVID-19. The study’s initial goal was to highlight the position of service-learning as a component of academic learning. With the onset of the COVID-19 pandemic the goal was extended to understanding the impact of the pandemic not only on service-learning, but on leadership as well. Furthermore, the study sought to determine the responsiveness of service-learning policies at Rhodes University at a time of crisis. The study was designed as an interpretivist case study with four participants and one secondary participant. The study employed document analysis, individual interviews and a focus group interview to collect data. Data analysis took the form of content analysis and coding, through the lens of Experiential Learning Theory and an alternative service-based model. The study findings revealed that as a result of the COVID-19 global pandemic both service-learning courses had to be adapted to ensure successful completion. The adaptations included attention to scaffolded learning, assessment and course outcomes; in one course the service engagement aspect with the community was lost entirely to ensure the saftey of students through adherence to COVID-19 safety regulations. The study also found that the participants developed adaptive leadership competencies and skills, technological and collaboration skills as well as a heightened regard for pastoral care and social justice. However, it was evident that the pandemic revealed gaps in the conceptual understanding of service-learning in the context of the two courses, a need for responsive policy, and practical strategies to implement those policies in smaller units in the institution. The study thus recommends an alternative service-based model approach to service-learning, increased policy responsiveness to issues posed by the ‘new normal’ to support adaptive leadership development, re-defining of the university-community partnership and the identification of opportunities for innovation and collaboration intra-departmentally through service-learning. , Thesis (MEd) -- Faculty of Education, Education, 2021
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Date Issued: 2021-10-29

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& salt the earth behind you

- Naidoo, Prenesa

Authors: Naidoo, Prenesa
Date: 2021-04
Subjects: Creative writing (Higher education) -- South Africa , South African fiction (English) -- 21st century , South African poetry (English) -- 21st century , Short stories, South African (English) -- 21st century , Diaries -- Authorship , Korean fiction -- 21st century -- History and criticism , Short stories, Argentine -- 21st century -- History and criticism , Arabic fiction -- Palestine 21st century -- History and criticism , Argentine fiction -- 21st century -- History and criticism
Language: English
Type: thesis , text , Masters , MA
Identifier: http://hdl.handle.net/10962/178212 , vital:42921
Description: My thesis is a collection of prose pieces in the form of short stories, flash fiction and prose poetry drawing on memory and lived experiences to explore the trauma of death, grief and displacement, solace and the paroxysms of home. As a young woman from an Indian South Africa community, Hindu superstitions and folktales are my second skin, and shape both my worldview and my writing. I am inspired by Lidia Yuknavitch’s observation that, “all artists see things that are not there”, and by Dambudzo Marechera’s belief that, “Beneath reality, there is always fantasy: the writer’s task is to reveal it, to open it out, to feel it, to experience it.” In my stories about trauma and grief, I often distort the line between seen and unseen worlds, where, for example, hauntings are taken seriously as lived experiences. I have also been influenced by Han Kang’s The White Book, Kali Fajardo-Anstine’s Sabrina & Corina, and Sandra Cisneros’ The House on Mango Street. Read together, Kang’s stand-alone short stories form part of a greater collective ‘memory’ or ‘life’; Fajardo-Anstine’s collection illustrates how to write about a specific female Latina community while still telling individual stories; and Cisneros’ fragments of memories tell the story of a person’s life in narratives which are as long or short as they need to be. , Thesis (MA) -- Faculty of Humanities, School of Languages and Literatures, 2021
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Date Issued: 2021-04

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Ranked factors influencing the sustainability and growth of SMMEs in the city of Port Elizabeth

- Bussy, Matthew

Authors: Bussy, Matthew
Date: 2021-04
Subjects: Business enterprises -- South Africa -- Port Elizabeth , Small business -- South Africa -- Port Elizabeth , Sustainable development -- South Africa -- Port Elizabeth
Language: English
Type: Master's theses , text
Identifier: http://hdl.handle.net/10948/51050 , vital:43204
Description: SMMEs are the backbone of both established and developing economies with their ability to contribute to a country’s GDP, create employment, stimulate innovation and create new revenue streams. In South Africa the majority of SMMEs do not reach the critical threshold period for sustainability, defined by the Small Enterprise Development Agency (SEDA) as three years. This study explores twenty-five barriers and influences (nine external and sixteen internal) as experienced by small businesses operating in the city of Port Elizabeth, and their effect on the sustainability and success of the small business. The internal barriers and influences are ranked according to their relative importance to business sustainability and success as viewed by small businesses in the city of Port Elizabeth. The research is exploratory in nature and was conducted using a structured questionnaire. The findings show that the nineteen barriers and influencers that are controllable within the business are all important to the success and sustainability of small businesses. Of these internal factors, the most important one relatively speaking is found to be the general management abilities of management, and the least important, relatively speaking, is the education levels of the non-management employees. , Thesis (MBA) -- Faculty of Business and Economic Sciences, Business Administration, 2021
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Date Issued: 2021-04

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