Novobiocin–ferrocene conjugates possessing anticancer and antiplasmodial activity independent of HSP90 inhibition.
- Mbaba, Mziyanda, de la Mare, Jo-Anne, Sterrenberg, Jason N, Kajewole, Deborah, Maharaj, Shantal, Edkins, Adrienne L, Isaacs, Michelle, Hoppe, Heinrich C, Khanye, Setshaba D
- Authors: Mbaba, Mziyanda , de la Mare, Jo-Anne , Sterrenberg, Jason N , Kajewole, Deborah , Maharaj, Shantal , Edkins, Adrienne L , Isaacs, Michelle , Hoppe, Heinrich C , Khanye, Setshaba D
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/122858 , vital:35359 , https://doi.org/10.1007/s00775-018-1634-9
- Description: A series of tailored novobiocin–ferrocene conjugates was prepared in moderate yields and investigated for in vitro anticancer and antiplasmodial activity against the MDA-MB-231 breast cancer line and Plasmodium falciparum 3D7 strain, respectively. While the target compounds displayed moderate anticancer activity against the breast cancer cell line with IC50 values in the mid-micromolar range, compounds 10a–c displayed promising antiplasmodial activity as low as 0.889 µM. Furthermore, the most promising compounds were tested for inhibitory effects against a postulated target, heat shock protein 90 (Hsp90).
- Full Text:
- Authors: Mbaba, Mziyanda , de la Mare, Jo-Anne , Sterrenberg, Jason N , Kajewole, Deborah , Maharaj, Shantal , Edkins, Adrienne L , Isaacs, Michelle , Hoppe, Heinrich C , Khanye, Setshaba D
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/122858 , vital:35359 , https://doi.org/10.1007/s00775-018-1634-9
- Description: A series of tailored novobiocin–ferrocene conjugates was prepared in moderate yields and investigated for in vitro anticancer and antiplasmodial activity against the MDA-MB-231 breast cancer line and Plasmodium falciparum 3D7 strain, respectively. While the target compounds displayed moderate anticancer activity against the breast cancer cell line with IC50 values in the mid-micromolar range, compounds 10a–c displayed promising antiplasmodial activity as low as 0.889 µM. Furthermore, the most promising compounds were tested for inhibitory effects against a postulated target, heat shock protein 90 (Hsp90).
- Full Text:
Structure and agency in the age of climate change
- Authors: Cherry, Janet
- Subjects: South Africa -- Economic conditions , South Africa -- Social conditions , f-sa
- Language: English
- Type: text , Lectures
- Identifier: http://hdl.handle.net/10948/21033 , vital:29429
- Description: What I will present here is based on my grappling over the past three decades with one of the central problems of social science – the relationship between social structure and human agency. This is not a new problem for social scientists; from Karl Marx, who understood that human beings make history, but not in circumstances of their choosing; to the French structuralists who conceived the term ‘relative autonomy’ and ‘overdetermination’; to Anthony Giddens’ ‘structuration theory’ and other contemporary sociologists. What is new are the changing physical circumstances of the world in which we live, which mean that human society can no longer afford to analyse ourselves and our social, political and economic systems independently of the natural world.
- Full Text:
- Authors: Cherry, Janet
- Subjects: South Africa -- Economic conditions , South Africa -- Social conditions , f-sa
- Language: English
- Type: text , Lectures
- Identifier: http://hdl.handle.net/10948/21033 , vital:29429
- Description: What I will present here is based on my grappling over the past three decades with one of the central problems of social science – the relationship between social structure and human agency. This is not a new problem for social scientists; from Karl Marx, who understood that human beings make history, but not in circumstances of their choosing; to the French structuralists who conceived the term ‘relative autonomy’ and ‘overdetermination’; to Anthony Giddens’ ‘structuration theory’ and other contemporary sociologists. What is new are the changing physical circumstances of the world in which we live, which mean that human society can no longer afford to analyse ourselves and our social, political and economic systems independently of the natural world.
- Full Text:
Tax deduction for married women
- Cape Town Trade Union Library
- Authors: Cape Town Trade Union Library
- Subjects: Cape Town Trade Union Library
- Language: English
- Type: text
- Identifier: http://hdl.handle.net/10962/152439 , vital:39277
- Description: All married women earning over R150 per month or over R34 per week have PAYE deducted from their wages. PAYE is income tax which is paid by workers on the "pay as you earn" system. Married men, however, pay tax only when their wages are over R500 per month. Single women pay tax only when their wages are over R350 per month. As you can see from the tables which follow, the tax on married women can be quite high. For example, if a married woman earns R220 per month, she will have R9,45 per month deducted from her wages for PAYE. (See Table No. 4). Married women who have children pay the same tax as if they haul no children, too. And there is no reduction in tax if you are over 60 years old, as there is for men. There is nothing can be done about this discrimination against married women until the government changes the tax rules.
- Full Text:
- Authors: Cape Town Trade Union Library
- Subjects: Cape Town Trade Union Library
- Language: English
- Type: text
- Identifier: http://hdl.handle.net/10962/152439 , vital:39277
- Description: All married women earning over R150 per month or over R34 per week have PAYE deducted from their wages. PAYE is income tax which is paid by workers on the "pay as you earn" system. Married men, however, pay tax only when their wages are over R500 per month. Single women pay tax only when their wages are over R350 per month. As you can see from the tables which follow, the tax on married women can be quite high. For example, if a married woman earns R220 per month, she will have R9,45 per month deducted from her wages for PAYE. (See Table No. 4). Married women who have children pay the same tax as if they haul no children, too. And there is no reduction in tax if you are over 60 years old, as there is for men. There is nothing can be done about this discrimination against married women until the government changes the tax rules.
- Full Text:
What do you read, my lord? Words, words, words.
- Authors: Crous, Marius
- Subjects: Shakespear, William, 1564-1616 , Shakespear, William, Hamlet
- Language: English
- Type: text , PDF , Lectures
- Identifier: http://hdl.handle.net/10948/66415 , vital:75241
- Description: The title of this lecture is from Shakespeare’s Hamlet and the two keywords, namely read and words will form the basis of my reflection on my life as an academic. Both are essential components of any academic project and both still play a significant role in my everyday life as a reader, a critic, a teacher, a reviewer, a poet or a translator. In my lecture I will focus briefly on the art of reading, reading and meaning, types of reading and end on a more personalized note with an analysis of the role of the poet as reader and make reference to both my poems and other poems within the discipline of Afrikaans literature.
- Full Text:
- Authors: Crous, Marius
- Subjects: Shakespear, William, 1564-1616 , Shakespear, William, Hamlet
- Language: English
- Type: text , PDF , Lectures
- Identifier: http://hdl.handle.net/10948/66415 , vital:75241
- Description: The title of this lecture is from Shakespeare’s Hamlet and the two keywords, namely read and words will form the basis of my reflection on my life as an academic. Both are essential components of any academic project and both still play a significant role in my everyday life as a reader, a critic, a teacher, a reviewer, a poet or a translator. In my lecture I will focus briefly on the art of reading, reading and meaning, types of reading and end on a more personalized note with an analysis of the role of the poet as reader and make reference to both my poems and other poems within the discipline of Afrikaans literature.
- Full Text: