Understanding the sexual practices of medically circumcised males in the context of HIV and AIDS : a study in Harare Zimbabwe
- Authors: Chamuka, Paidashe
- Date: 2014
- Subjects: Circumcision -- Zimbabwe , Men -- Sexual behavior -- Zimbabwe -- Case studies , AIDS (Disease) -- Zimbabwe -- Prevention , HIV infections -- South Africa -- Prevention
- Language: English
- Type: Thesis , Masters , MSocSc
- Identifier: vital:3363 , http://hdl.handle.net/10962/d1011745 , Circumcision -- Zimbabwe , Men -- Sexual behavior -- Zimbabwe -- Case studies , AIDS (Disease) -- Zimbabwe -- Prevention , HIV infections -- South Africa -- Prevention
- Description: Zimbabwe is one of the priority countries nominated by the World Health Organisation and the Joint United Nations Programme on HIV and AIDS to adopt and implement voluntary medical male circumcision (VMMC) because of its high rate of HIV prevalence and its low level of male circumcision. VMMC, which was introduced in Zimbabwe in 2009, is a new HIV prevention method which reportedly offers partial protection of about 60 percent for circumcised males with respect to contracting HIV through sexual relations. The other key prevention method, namely the use of condoms consistently and correctly, has a protection rate of up to 95 percent. As a result, because of only partial protection, medically-circumcised men are encouraged to use condoms to decrease the chances of HIV infection. Concerns though have been raised about the possibility of risk compensation by circumcised males by way of increases in unsafe or risky sexual practices subsequent to circumcision and arising from perceptions of reduced risk through VMMC. This compensation may take the form of condom use aversion including when involved with concurrent sexual partners. If risk compensation does take place, this would lead to increases in HIV transmissions affecting not only the circumcised men but their sexual partners as well. The supposed effectiveness of VMMC as a HIV prevention method has been subjected to significant criticism and, as yet, no significant study has been undertaken in Zimbabwe on the relationship between VMMC, condom use, concurrent sexual partners and risk compensation. Based on a study of twenty-five medically-circumcised males in Harare, the capital of Zimbabwe, this thesis seeks to understand and explain the relationship between voluntary medical male circumcision and risky sexual practices with particular reference to condom use amongst men engaged in concurrent sexual partnerships. While the thesis finds evidence of risky sexual practices subsequent to circumcision, risk compensation does not seem to be particularly prevalent.
- Full Text:
- Date Issued: 2014
Synthesis and photophysical properties of antimony and lead phthalocyanines
- Authors: Modibane, Kwena Desmond , Guest
- Date: 2009 , 2009-02-27
- Subjects: Phthalocyanines , Photochemistry , Antimony compounds , Lead compounds
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:4370 , http://hdl.handle.net/10962/d1005035 , Phthalocyanines , Photochemistry , Antimony compounds , Lead compounds
- Description: This work hereby presents the synthesis, spectroscopic and photophysical properties of newly synthesized lead (PbPc) and antimony (SbPc) phthalocyanines. The complexes are either unsubstituted or substituted at the peripheral and non-peripheral positions with phenoxy, 4-t-butylphenoxy and 4-benzyloxyphenoxy groups. The photophysical properties of these complexes were studied in dimethylsulfoxide, dimethylformamide, toluene, tetrahydrofuran and chloroform as solvents. The fluorescence spectra for PbPc complexes were different to that of the excitation spectra due to demetallation upon excitation. On the other hand, the excitation spectra of oxidized antimony (Sb(V)Pc) derivatives were found to be similar to absorption spectra. High triplet quantum yields for PbPc and SbPc complexes ranging from 0.70 to 0.86, low triplet lifetimes (20–60 μs in DMSO, while they were <10 μs in the rest of the solvents) and low fluorescence quantum yields were observed and is attributed to the presence of heavy atoms (Pb and Sb ions). The nonlinear optical properties of PbPc complexes were studied in dimethylsulfoxide. The optical limiting threshold intensity (Ilim) for the PbPc derivatives were calculated and ranged from 2.1 to 6.8 W/cm2. The photodegradation studies of the PbPc and SbPc complexes synthesized showed that then are stable.
- Full Text:
- Date Issued: 2009
Studies towards the development of novel multidentate ligands
- Authors: Magqi, Nceba
- Date: 2007
- Subjects: Density functionals , Ligands , Ligands -- Design , Ligands -- Analysis , Camphor
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:4358 , http://hdl.handle.net/10962/d1005023 , Density functionals , Ligands , Ligands -- Design , Ligands -- Analysis , Camphor
- Description: In this study, attention has been given to the design and synthesis of novel multidentate ligands for use in the construction of ruthenium-based metathesis catalysts, and their chelating potential has been explored by computer modelling at the Density Functional Theory (DFT) level. Both Kemp’s triacid (1,3,5-trimethyl-1,3,5-cyclohexanetricarboxylic acid) and D-(+)-camphor have been investigated as molecular scaffolds for the development of such ligands. However selective elaboration of the functional groups in Kemp’s triacid proved difficult to achieve, and the research has focused on the development of camphor derivatives. The synthesis of the camphor-based ligands has involved C-8 functionalisation and ring-opening of the bicyclic system to afford tridentate products. The formation of 9-iodocamphorquinone bis(ethylene ketal) together with the desired product, the 8-iodo isomer, has been confirmed by single crystal X-ray analysis of both compounds. Formation of the 9-iodo analogue has provided new insights into the intramolecular rearrangement of camphor skeleton, and the mechanistic implications have been assessed by coset analysis. Attempts to effect nucleophilic displacement of the 8-halogeno groups by nucleophilic donor moieties proved unexpectedly difficult and, coupled with the susceptibility of the carbonyl groups to nucleophilic attack, has led to the formation of novel tricyclic products, viz., 1,6-dimethyl-3-(2-pyridylamino)-4-oxatricyclo[4.3.0.0[superscript 3,7]]-2-nonanone and 6,7-dimethyl-3-(2-pyridylamino)-4-oxatricyclo -[4.3.0.0[superscript 3,7]]-2-nonanone. However the diphenylphosphine group was successfully introduced at C-8 and oxidative ring-opening of the camphor skeleton has afforded the tridentate ligands, 2-(diphenylphosphinoylmethyl)-1,2-dimethyl-1,3-cyclopentanedicarboxylic acid and 2-(diphenylphosphinoylmethyl)-1,3-bis(hydroxymethyl)1,2-dimethylcyclopentane. One- and two-dimensional NMR and, where appropriate, high-resolution MS methods have been used to characterise the products. Three [superscript 13]C NMR chemical shift prediction programmes, viz., ChemWindow and the MODGRAPH neural network and HOSE (Hierachially Ordered Spherical description of Environment), have been applied to representative compounds to assess their efficacy. While the predicted shifts correlated reasonably well with the experimental data, they proved to be insufficiently accurate to differentiate the isomeric systems examined.
- Full Text:
- Date Issued: 2007
An investigation of the neuroprotective effects of estrogen in a model of quinolinic acid-induced neurodegeneration
- Authors: Heron, Paula Michelle
- Date: 2002
- Subjects: Estrogen , Quinolinic acid , Nervous system -- Degeneration
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:3759 , http://hdl.handle.net/10962/d1003237 , Estrogen , Quinolinic acid , Nervous system -- Degeneration
- Description: The hippocampus, located in the medial temporal lobe, is an important region of the brain responsible for the formation of memory. Thus, any agent that induces stress in this area has detrimental effects and could lead to various types of dementia. Such agents include the neurotoxin, Quinolinic acid. Quinolinic acid (QUIN) is a neurotoxic metabolite of the tryptophan-kynurenine pathway and is an endogenous glutamate agonist that selectively injures and kills vulnerable neurons via the activation of the NMDA class of excitatory amino acid receptors. Estrogen is a female hormone that is responsible for reproduction. However, in the last decade estrogen has been shown to exhibit a wide range of actions on the brain, including neuroprotection. Estrogen has been shown to exhibit intrinsic antioxidant activity and protects cultured neurons against oxidative cell death. This is achieved by estrogen’s ability to scavenge free radicals, which is dependent on the presence of the hydroxyl group at the C3 position on the A ring of the steroid molecule. Numerous studies have shown that estrogen protects neurons against various toxic substances and may play a role in delaying the onset of neurodegenerative diseases, such as Alzheimer’s disease. Neuronal damage due to oxidative stress has been implicated in several neurodegenerative disorders. The detection and measurement of lipid peroxidation is the evidence most frequently cited to support the involvement of free radical reactions in toxicology and in human disease. The study aims to elucidate and further characterise the mechanism behind estrogen’s neuroprotection, using QUIN as a model of neurotoxicity. Initial studies confirm estrogen’s ability to scavenge potent free radicals. In addition, the results show that estrogen forms an interaction with iron (II) and also acts at the NMDA receptor as an agonist. Both mechanisms reduce the ability of QUIN to cause damage to neurons, since QUIN-induced toxicity is dependent on the activation of the NMDA receptor and the formation of a complex with iron (II) to induce lipid peroxidation. Heat shock proteins, especially Hsp 70 play a role in cytoprotection by capturing denatured proteins and facilitating the refolding of these proteins once the stress has been relieved. Estrogen has been shown to increase the level of expression of Hsp70, both inducible and cognate forms of the protein. This suggests that estrogen helps to protect against cellular protein damage induced by any form of stress the cell may encounter. The discovery of neuroprotective agents, such as estrogen, is becoming important as accumulating evidence indicates a protective role in vivo. Thus further research may favour the use of these agents in the treatment of several neurodegenerative disorders. Considering how devastating diseases, such as Alzheimer’s disease, are to a patient and the patient’s families, the discovery of new protective agents are a matter of urgency.
- Full Text:
- Date Issued: 2002
Interactions between fig wasps and their host figs
- Authors: Nefdt, Rory John Charlton
- Date: 1990
- Subjects: Wasps , Mutualism (Biology)
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:5718 , http://hdl.handle.net/10962/d1005404 , Wasps , Mutualism (Biology)
- Description: Fig trees (Ficus spp.) and fig wasps (Hymenoptera: Agaonidae) are partners in an intimate mutualism. The trees provide ovules in which wasp larvae develop while the wasps pollinate the flowers and are therefore indispensible for fig seed production. Agaonid fig wasps oviposit down the styles of fig flowers and it has generally been accepted that they were unable to reach the ovules of "long" styled flowers , which would produce seeds, thus maintaining an evolutionary stable mutualism. African fig species were found to have unimodal style length frequencies, with no separation into long and short styled flowers. In several species the ovipositors of their associated agaonids were long enough to reach the majority of ovules. The number of foundress agaonids entering a fig influenced fig seed set and therefore was an important factor regulating the proportion of flowers producing seeds or pollinators. In the two Ficus species that were studied, entry of more than three agaonid foundresses into one fig resulted in competition for limited oviposition sites and less female - biased offspring sex ratios. It is hypothesised that sequential laying of male eggs followed by female eggs, under variable oviposition site limitation, results in sex ratio adjustment, as predicted by local mate competition theory. Evidence in support of this hypothesis is presented. A number of non - pollinating torymid and pteromalid fig wasps also oviposit into each fig species. The sycophagines and sycoecines oviposit down the styles from inside the fig inflorescences like their agaonid counterparts, while other species insert their ovipositors through the wall of the fig from the outside. Like the agaonids, sycophagines were characterised by being pro - ovigenic, with numerous fully developed eggs at emergence. Sycoecines were able to re - emerge from figs they had oviposited in and lay their eggs in more than one fig. They had short ovipositors, allowing access to a smaller proportion of flowers than agaonids or sycophagines. Externally ovipositing fig wasps were syn-ovigenic, able to develop eggs as adults and invested more energy and time during each oviposition event. Differences in the ovipositor lengths of these species did not segregate their oviposition sites spatially, and therefore does not reduce competition between species. Attack by parasitoids and inquiline fig wasps from the exterior did not constitute a selection pressure against agaonids ovipositing in ovules closer to the periphery of the fig's surface, as predicted by Michaloud's enemy-free-space hypothes is. It cannot therefore explain the preference shown by ovipositing agaonids for shorter styled flowers.
- Full Text:
- Date Issued: 1990
Geodynamics, rifting, stratiform and stratabound mineral deposits
- Authors: Dingemans, D.R.W.
- Date: 1981 , 2013-03-19
- Subjects: Ore deposits , Geodynamics , Mines and mineral resources , Rifts (Geology)
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:5012 , http://hdl.handle.net/10962/d1006107 , Ore deposits , Geodynamics , Mines and mineral resources , Rifts (Geology)
- Description: Stratiform and stratabound ore deposits commonly show a direct relationship with rifts. This association is studied by developing a geodynamic model of mantle processes and crustal responses. The geodynamics of the earth can be modelled by the process of mantle advection, which involves the episodic generation and segregation of low density mantle diapirs and their rise and subsequent interaction with the crust. The theory of mantle advection explains the genetic association between rifting, magmatism, basin development and subsequent orogeny and metamorphism. Global evolution has passed through a number of major stages of non-uniformitarian development in which each cycle was characterized by fairly uniform behaviour terminated by intense geodynamic upheaval. The relationship between geological evolution and mantle advection is examined by reviewing the major characteristics of each of the cycles, which correspond to the Archean, Early Proterozoic, Mid Proterozoic, Late Proterozoic-Palaeo2oic, and Mesozoic - Cainozoic eras. Although mentle advection has controlled crustal processes throughout time, the decrease in the thermal energy of the earth has caused >the major evolutionary changes in response to thickening and a greater rigidity of the sialic crust. Rifts are penetrative taphrogenic faults in the earths crust which act as major conduits for the transfer of magmas, from the mantle and lower crustal levels, to the upper crust and the surface. Rifts are also permeable zones for the migration of metalliferous brines, generated by magmatic differentiation. These metalliferous brines would either be exhaled at surface to form stratiform volcanogenic and volcanosedimentary ore deposits , or would interact with preferential host horizons to form stratabound ore deposits . The associat ion between rifting and stratiform and stratabound ore deposits is illustrated by examining :he tectonic setting, and st ratigraphic relationships of typical ore deposit types .
- Full Text:
- Date Issued: 1981
Ray tracing at very low frequencies when the effects of heavy ions are considered
- Authors: Terry, Patrick D.
- Date: 1969
- Subjects: Ionospheric radio wave propagation , Ionosphere -- Graphic methods , Ray tracing algorithms
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:5542 , http://hdl.handle.net/10962/d1013350
- Description: The behaviour of very low frequency (V.L.F.) radio waves propagating in an ionlzed medium, such as the ionosphere and exosphere, may exhibit markedly different characteristics from those of frequencies such as are used for communication in the short-wave bands. The anisotropy introduced into the medium by the presence of the earth's magnetic field has a significant effect, while at frequencies below about 5KHz the presence of heavy positive ions may further affect propagation. In particular it is found that, under suitable conditions, V.L.F. signals may propagate along paths closely following the lines of force of the earth's magnetic field. The study of such signals has a practical interest in that, from consideration of their propagation times and dispersion properties, they can provide an inexpensive method of determining electron densities at well beyond the range of satellite investigation. For this reason, if for no other, theoretical investigation of the paths traced in a model exosphere may indicate how closely the model exosphere approximates the true one. A powerful method of tracing out these paths is by the use of "ray-tracing", provided the properties of the medium vary slowly in space, a condition not always fulfilled in practice. It has been the subject of this thesis to carry out ray-tracing studies, in particular noting the effects of the positive ions in the exosphere; effects which have not received much notice before as they were thought to be unimportant. Intro., p. 1-2.
- Full Text:
- Date Issued: 1969