Principles of Computer Architecture
- Authors: Machanick, Philip
- Date: 2022
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/439184 , vital:73553 , https://homes.cs.ru.ac.za/philip/Courses/CSHonsArch/HonsArchNotes2022.pdf
- Description: Last week, Control Data ... announced the 6600 system. I understand that in the laboratory developing the system there are only 34 people including the janitor. Of these, 14 are engineers and 4 are programmers... Contrasting this modest effort with our vast development activities, I fail to understand why we have lost our industry leadership position by letting someone else offer the world’s most powerful computer – Thomas Watson Jr., IBM CEO, August 1963 It seems like Mr. Watson has answered his own question – Seymour Cray
- Full Text:
- Date Issued: 2022
- Authors: Machanick, Philip
- Date: 2022
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/439184 , vital:73553 , https://homes.cs.ru.ac.za/philip/Courses/CSHonsArch/HonsArchNotes2022.pdf
- Description: Last week, Control Data ... announced the 6600 system. I understand that in the laboratory developing the system there are only 34 people including the janitor. Of these, 14 are engineers and 4 are programmers... Contrasting this modest effort with our vast development activities, I fail to understand why we have lost our industry leadership position by letting someone else offer the world’s most powerful computer – Thomas Watson Jr., IBM CEO, August 1963 It seems like Mr. Watson has answered his own question – Seymour Cray
- Full Text:
- Date Issued: 2022
The extent and impact of variation in ADME genes in sub-Saharan African populations
- da Rocha, Jorge E B, Othman, Houcemeddine, Botha, Gerrit, Cottino, Laura, Twesigomwe, David, Ahmed, Samah, Drögemöller, Britt I, Fadlelmola, Faisal M, Machanick, Philip, Mbiyavanga, Mamana, Panji, Sumir, Wright, Galen E B, Adebamowo, Clement, Matshaba, Mogomotsi, Ramsay, Michéle, Simo, Gustave, Simuunza, Martin C, Tiemessen, Caroline T, Baldwin, Sandra, Chiano, Mathias, Cox, Charles, Gross, Annette S, Thomas, Pamela, Gamo, Francisco-Javier, Scott Hazelhurst
- Authors: da Rocha, Jorge E B , Othman, Houcemeddine , Botha, Gerrit , Cottino, Laura , Twesigomwe, David , Ahmed, Samah , Drögemöller, Britt I , Fadlelmola, Faisal M , Machanick, Philip , Mbiyavanga, Mamana , Panji, Sumir , Wright, Galen E B , Adebamowo, Clement , Matshaba, Mogomotsi , Ramsay, Michéle , Simo, Gustave , Simuunza, Martin C , Tiemessen, Caroline T , Baldwin, Sandra , Chiano, Mathias , Cox, Charles , Gross, Annette S , Thomas, Pamela , Gamo, Francisco-Javier , Scott Hazelhurst
- Date: 2022
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/439202 , vital:73555 , https://homes.cs.ru.ac.za/philip/Courses/CSHonsArch/HonsArchNotes2022.pdf
- Description: Investigating variation in genes involved in the absorption, distribution, metabolism, and excretion (ADME) of drugs are key to characterizing pharmacogenomic (PGx) relationships. ADME gene variation is relatively well characterized in European and Asian populations, but data from African populations are under-studied—which has implications for drug safety and effective use in Africa.
- Full Text:
- Date Issued: 2022
- Authors: da Rocha, Jorge E B , Othman, Houcemeddine , Botha, Gerrit , Cottino, Laura , Twesigomwe, David , Ahmed, Samah , Drögemöller, Britt I , Fadlelmola, Faisal M , Machanick, Philip , Mbiyavanga, Mamana , Panji, Sumir , Wright, Galen E B , Adebamowo, Clement , Matshaba, Mogomotsi , Ramsay, Michéle , Simo, Gustave , Simuunza, Martin C , Tiemessen, Caroline T , Baldwin, Sandra , Chiano, Mathias , Cox, Charles , Gross, Annette S , Thomas, Pamela , Gamo, Francisco-Javier , Scott Hazelhurst
- Date: 2022
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/439202 , vital:73555 , https://homes.cs.ru.ac.za/philip/Courses/CSHonsArch/HonsArchNotes2022.pdf
- Description: Investigating variation in genes involved in the absorption, distribution, metabolism, and excretion (ADME) of drugs are key to characterizing pharmacogenomic (PGx) relationships. ADME gene variation is relatively well characterized in European and Asian populations, but data from African populations are under-studied—which has implications for drug safety and effective use in Africa.
- Full Text:
- Date Issued: 2022
Practising Adaptive IWRM (Integrated Water Resources Management) in South Africa
- Palmer, Carolyn G, Munnik, Victor, du Toit, Derick, Rogers, Kevin H, Pollard, Sharon, Hamer, Nick, Weaver, Matthew J T, Retief, Hugo, Sahula, Asiphe, O’Keeffe, Jay H
- Authors: Palmer, Carolyn G , Munnik, Victor , du Toit, Derick , Rogers, Kevin H , Pollard, Sharon , Hamer, Nick , Weaver, Matthew J T , Retief, Hugo , Sahula, Asiphe , O’Keeffe, Jay H
- Date: 2018
- Subjects: To be catalogued
- Language: English
- Type: text , report
- Identifier: http://hdl.handle.net/10962/438005 , vital:73428 , ISBN 978-1-4312-0983-5 , https://wrcwebsite.azurewebsites.net/wp-content/uploads/mdocs/2248-1-18.pdf
- Description: This chapter serves as a general introduction to the TPNP case stud-ies, with feedback from the progress of the RESILIM-O project. We draw attention here, and note clearly, that each case is set in a different context and scale, and proceeded in different ways, as well as combin-ing in use different discourses/practices and methodologies. To ensure a basis for comparability, each case study was required to use the Adaptive IWRM approach and methodologies, while not being required to record results in the same format. Case studies were designed to enable an exploration of scale effects–a core theoretical concept in complex social-ecological systems. We will be in a position to write a scholarly paper on a scale-comparison of practice-based Adaptive IWRM learning at different spatial and governance (institutional and social) scales, as a result of these findings.
- Full Text:
- Date Issued: 2018
- Authors: Palmer, Carolyn G , Munnik, Victor , du Toit, Derick , Rogers, Kevin H , Pollard, Sharon , Hamer, Nick , Weaver, Matthew J T , Retief, Hugo , Sahula, Asiphe , O’Keeffe, Jay H
- Date: 2018
- Subjects: To be catalogued
- Language: English
- Type: text , report
- Identifier: http://hdl.handle.net/10962/438005 , vital:73428 , ISBN 978-1-4312-0983-5 , https://wrcwebsite.azurewebsites.net/wp-content/uploads/mdocs/2248-1-18.pdf
- Description: This chapter serves as a general introduction to the TPNP case stud-ies, with feedback from the progress of the RESILIM-O project. We draw attention here, and note clearly, that each case is set in a different context and scale, and proceeded in different ways, as well as combin-ing in use different discourses/practices and methodologies. To ensure a basis for comparability, each case study was required to use the Adaptive IWRM approach and methodologies, while not being required to record results in the same format. Case studies were designed to enable an exploration of scale effects–a core theoretical concept in complex social-ecological systems. We will be in a position to write a scholarly paper on a scale-comparison of practice-based Adaptive IWRM learning at different spatial and governance (institutional and social) scales, as a result of these findings.
- Full Text:
- Date Issued: 2018
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