Analysis of non-peptidic compounds as potential malarial inhibitors against plasmodial cysteine proteases via integrated virtual screening workflow

Musyoka, Thommas M; Kanzi, Aquillah M; Lobb, Kevin A; Tastan Bishop, Özlem

Title: Analysis of non-peptidic compounds as potential malarial inhibitors against plasmodial cysteine proteases via integrated virtual screening workflow
Creator: Musyoka, Thommas M
Creator: Kanzi, Aquillah M
Creator: Lobb, Kevin A
Creator: Tastan Bishop, Özlem
Date Issued: 2016
Date: 2016
Type: text
Type: article
Identifier: http://hdl.handle.net/10962/123074
Identifier: vital:35403
Identifier: https://doi.10.1080/07391102.2015.1108231
Description: Malaria is an infectious disease caused by a diverse group of erythrocytic protozoan parasites of the genus Plasmodium. It remains an exigent public health problem in the tropical areas of Africa, South America and parts of Asia and continues to take its toll in morbidity and mortality with half of the world’s population under a permanent risk of infection leading to more than half a million deaths annually (WHO, 2013). Five Plasmodium species, namely P. falciparum (Pf ), P. vivax (Pv), P. ovale (Po), P. malariae (Pm) and P. knowlesi (Pk), are known to infect humans with Pf responsible for more than 90% of the malarial fatalities reported in sub-Saharan Africa. The predominance of Pf is attributed to its adaptability (Ashley, McGready, Proux, & Nosten, 2006; Prugnolle et al., 2011). Although the high occurrence of the Duffy negative trait among African populations lowers the threat posed by Pv, it is the most frequent and widely causative agent of benign tertian malaria in other parts of the world (Mendis, Sina, Marchesini, & Carter, 2001). In addition to the listed human malarial parasite forms, several other Plasmodium species, which infect non-human laboratory models, have been identified and are of significant importance in understanding the parasite biology, the host–parasite interactions and in the drug development process (Langhorne et al., 2011).
Format: 18pages
Format: pdf
Language: English
Relation: Journal of Biomolecular Structure and Dynamics
Relation: Musyoka, T.M., Kanzi, A.M., Lobb, K.A. and Tastan Bishop, Ö., 2016. Analysis of non-peptidic compounds as potential malarial inhibitors against Plasmodial cysteine proteases via integrated virtual screening workflow. Journal of Biomolecular Structure and Dynamics, 34(10), pp.2084-2101.
Relation: Journal of Biomolecular Structure and Dynamics volume 34 number 10 2084 2101 28 January 2016 0739-1102
Rights: Journal of Biomolecular Structure and Dynamics
Rights: Use of this resource is governed by the terms and conditions of the Taylor & Francis Online Terms and Conditions Statement (https://www.tandfonline.com/terms-and-conditions)

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Tastan Bishop, Ozlem (Prof)

RU Research Unit in Bioinformatics (RUBi)

Lobb, Kevin Allan (Assoc Prof)

RU Department of Chemistry

SDG 03. Good Health and Well-Being

RU Department of Biochemistry, Microbiology and Bioinformatics

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