Comparative electrocatalytic studies of nanocomposites of mixed and covalently linked multiwalled carbon nanotubes and 4-(4, 6-diaminopyrimidin-2-ylthio) phthalocyaninato cobalt (II)
- Nyoni, Stephen, Nyokong, Tebello
- Authors: Nyoni, Stephen , Nyokong, Tebello
- Date: 2015
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/189285 , vital:44834 , xlink:href="https://doi.org/10.1016/j.poly.2015.05.038"
- Description: Electrocatalytic behavior of 4-(4,6-diaminopyrimidin-2-ylthio) phthalocyaninato cobalt(II) (CoPyPc) when mixed or covalently mixed to multiwalled carbon nanotubes (MWCNTs) is reported. Infra-red spectroscopy was used to confirm amide linkage of the covalently linked nanocomposite. Rotating disk electrode (RDE) and cyclic (CV) voltammetry studies were used for the electrochemical characterization of the prepared phthalocyanine and MWCNT nanocomposite. The electrocatalytic effects of the nanocomposites of the cobalt phthalocyanine derivative were then investigated towards L-cysteine oxidation using both RDE and CV experiments, and the electrocatalytic performance of the covalently linked cobalt phthalocyanine-MWCNT was found to be superior over the mixed nanocomposite.
- Full Text:
- Date Issued: 2015
- Authors: Nyoni, Stephen , Nyokong, Tebello
- Date: 2015
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/189285 , vital:44834 , xlink:href="https://doi.org/10.1016/j.poly.2015.05.038"
- Description: Electrocatalytic behavior of 4-(4,6-diaminopyrimidin-2-ylthio) phthalocyaninato cobalt(II) (CoPyPc) when mixed or covalently mixed to multiwalled carbon nanotubes (MWCNTs) is reported. Infra-red spectroscopy was used to confirm amide linkage of the covalently linked nanocomposite. Rotating disk electrode (RDE) and cyclic (CV) voltammetry studies were used for the electrochemical characterization of the prepared phthalocyanine and MWCNT nanocomposite. The electrocatalytic effects of the nanocomposites of the cobalt phthalocyanine derivative were then investigated towards L-cysteine oxidation using both RDE and CV experiments, and the electrocatalytic performance of the covalently linked cobalt phthalocyanine-MWCNT was found to be superior over the mixed nanocomposite.
- Full Text:
- Date Issued: 2015
Comparison between Endothelin, Nitric Oxide and their Association to Blood Pressure and Body Composition in HIV Patients, in Mthatha
- Authors: Zono, Sinethemba
- Date: 2015
- Language: English
- Type: Masters theses , text
- Identifier: http://hdl.handle.net/11260/2909 , vital:43105
- Description: Background: Dysfunction of the vascular endothelium is an early finding in the progression of cardiovascular disease and is closely related to clinical events in patients with obesity and hypertension. Vascular function is mediated by nitric oxide (NO) and endothelin (ET-1) which serve as natural counterparts. The aim of the study was to determine the physiological effects of HIV infection, blood pressure and body composition on the changes of ET-1 and NO and association between ET-1 and NO. Methods and results: This was a descriptive and comparative study. A Quota sample method was used. The study population consisted of 154 participants categorized into the following groups: 57 HIV negative participants (A), 40 HIV positive not on treatment participants and 57 HIV positive on treatment participants. Enzyme immunoassay kit was used for the quantitative determination of ET-1 and Nitrate/nitrite colorimetric assay kit was used for the determination of NO. Anthropometric measurements, body composition were determined. Hemodynamic measurements were also taken into account. Results: Resting metabolism, waist circumference (WC) and hip circumference had low mean levels in both HIV positives groups compared to HIV negative group. On lipid profiles visceral fat (VF), whole fat (WF) had low mean levels but skeletal muscle fat (SMF) showed the highest mean levels in both HIV positive groups. All the blood pressures between HIV groups were on a normal range scale. Mean values of endothelin and nitric oxide are increased in HIV positive not on ART and HIV (+) on ART compared with the HIV negative group. Conclusion: NO, ET-1, ART and HIV itself were associated with the pathogenesis of endothelial dysfunction in persons with HIV infection. Elevated endothelial markers namely ET-1 and NO can lead to improvement of endothelium dependent relaxation to some extent but not completely. Although these markers have deleterious effect on the endothelium but can also serve as up-regulator of hypertension. Key words: HIV-infection, antiretroviral therapy, endothelial dysfunction, Endothelin1 (ET-1), nitric oxide (NO), blood pressures (BPs). , Thesis (MSc) -- Faculty of Health Sciences, 2015
- Full Text:
- Date Issued: 2015
- Authors: Zono, Sinethemba
- Date: 2015
- Language: English
- Type: Masters theses , text
- Identifier: http://hdl.handle.net/11260/2909 , vital:43105
- Description: Background: Dysfunction of the vascular endothelium is an early finding in the progression of cardiovascular disease and is closely related to clinical events in patients with obesity and hypertension. Vascular function is mediated by nitric oxide (NO) and endothelin (ET-1) which serve as natural counterparts. The aim of the study was to determine the physiological effects of HIV infection, blood pressure and body composition on the changes of ET-1 and NO and association between ET-1 and NO. Methods and results: This was a descriptive and comparative study. A Quota sample method was used. The study population consisted of 154 participants categorized into the following groups: 57 HIV negative participants (A), 40 HIV positive not on treatment participants and 57 HIV positive on treatment participants. Enzyme immunoassay kit was used for the quantitative determination of ET-1 and Nitrate/nitrite colorimetric assay kit was used for the determination of NO. Anthropometric measurements, body composition were determined. Hemodynamic measurements were also taken into account. Results: Resting metabolism, waist circumference (WC) and hip circumference had low mean levels in both HIV positives groups compared to HIV negative group. On lipid profiles visceral fat (VF), whole fat (WF) had low mean levels but skeletal muscle fat (SMF) showed the highest mean levels in both HIV positive groups. All the blood pressures between HIV groups were on a normal range scale. Mean values of endothelin and nitric oxide are increased in HIV positive not on ART and HIV (+) on ART compared with the HIV negative group. Conclusion: NO, ET-1, ART and HIV itself were associated with the pathogenesis of endothelial dysfunction in persons with HIV infection. Elevated endothelial markers namely ET-1 and NO can lead to improvement of endothelium dependent relaxation to some extent but not completely. Although these markers have deleterious effect on the endothelium but can also serve as up-regulator of hypertension. Key words: HIV-infection, antiretroviral therapy, endothelial dysfunction, Endothelin1 (ET-1), nitric oxide (NO), blood pressures (BPs). , Thesis (MSc) -- Faculty of Health Sciences, 2015
- Full Text:
- Date Issued: 2015
Comparisons of isotopic niche widths of some invasive and indigenous fauna in a South African river
- Hill, Jaclyn M, Jones, Roy W, Hill, Martin P, Weyl, Olaf L F
- Authors: Hill, Jaclyn M , Jones, Roy W , Hill, Martin P , Weyl, Olaf L F
- Date: 2015
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/423711 , vital:72088 , xlink:href="https://doi.org/10.1111/fwb.12542"
- Description: Biological invasions threaten ecosystem integrity and bio-diversity, with numerous adverse implications for native flora and fauna. Established populations of two notorious freshwater invaders, the snail Tarebia granifera and the fish Pterygoplichthys disjunctivus, have been reported on three continents and are frequently predicted to be in di-rect competition with native species for dietary resources.
- Full Text:
- Date Issued: 2015
- Authors: Hill, Jaclyn M , Jones, Roy W , Hill, Martin P , Weyl, Olaf L F
- Date: 2015
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/423711 , vital:72088 , xlink:href="https://doi.org/10.1111/fwb.12542"
- Description: Biological invasions threaten ecosystem integrity and bio-diversity, with numerous adverse implications for native flora and fauna. Established populations of two notorious freshwater invaders, the snail Tarebia granifera and the fish Pterygoplichthys disjunctivus, have been reported on three continents and are frequently predicted to be in di-rect competition with native species for dietary resources.
- Full Text:
- Date Issued: 2015
Density and regrowth of a forest restio (Ischyrolepis eleocharis) under harvest and non-harvest treatments in dune forests of Eastern Cape Province, South Africa
- Ruwanza, Sheunesu, Shackleton, Charlie M
- Authors: Ruwanza, Sheunesu , Shackleton, Charlie M
- Date: 2015
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/180828 , vital:43649 , xlink:href="https://doi.org/10.1007/s12231-015-9306-y"
- Description: Ischyrolepis eleocharis (Mast.) H.P.Linder is a perennial rush or sedge-like herb in the Restionaceae family and has been harvested for various uses from coastal forest dunes of South Africa. Around 2005, a ban on I. eleocharis harvesting in Bathurst coastal forest was instituted by provincial conservation authorities based on their unsubstantiated impression that the species population was decreasing. Here we report on the population density pre and post the harvest ban, as well as further explore the autecology of the species by assessing plant density relative to environmental factors (slope and aspect) and a controlled experiment on regrowth after harvesting at different intensities. The results show that the shoot density of both living and dead I. eleocharis increased significantly over the past eight years. This concurs with results from the harvesting experiment which showed that I. eleocharis recovered rapidly within a year of harvesting. Both aspect and slope play a key role in the distribution of I. eleocharis, with most plants found in open patches in the forest located on the summit and upper slopes of dunes facing the landward side. These results indicate that I. eleocharis is highly abundant and resilient to harvesting.
- Full Text:
- Date Issued: 2015
- Authors: Ruwanza, Sheunesu , Shackleton, Charlie M
- Date: 2015
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/180828 , vital:43649 , xlink:href="https://doi.org/10.1007/s12231-015-9306-y"
- Description: Ischyrolepis eleocharis (Mast.) H.P.Linder is a perennial rush or sedge-like herb in the Restionaceae family and has been harvested for various uses from coastal forest dunes of South Africa. Around 2005, a ban on I. eleocharis harvesting in Bathurst coastal forest was instituted by provincial conservation authorities based on their unsubstantiated impression that the species population was decreasing. Here we report on the population density pre and post the harvest ban, as well as further explore the autecology of the species by assessing plant density relative to environmental factors (slope and aspect) and a controlled experiment on regrowth after harvesting at different intensities. The results show that the shoot density of both living and dead I. eleocharis increased significantly over the past eight years. This concurs with results from the harvesting experiment which showed that I. eleocharis recovered rapidly within a year of harvesting. Both aspect and slope play a key role in the distribution of I. eleocharis, with most plants found in open patches in the forest located on the summit and upper slopes of dunes facing the landward side. These results indicate that I. eleocharis is highly abundant and resilient to harvesting.
- Full Text:
- Date Issued: 2015
Detriments associated with substance abuse among out - of - school youth in Ntselamanzi, village, Alice Town
- Authors: Chatikobo, Nyasha
- Date: 2015
- Subjects: Substance abuse--South Africa--Eastern Cape , Drug abuse--South Africa--Eastern Cape , Youth--Substance use--South Africa--Eastern Cape
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10353/19442 , vital:43087
- Description: The main aim of the study was to investigate the detriments associated with substance abuse among the out- of- school youth of Ntselamanzi Village in Alice. This study intended to achieve the following objectives. (i) to establish the causes of increased indulgence in substance abuse in Ntselamanzi village, Eastern Cape. (ii) to identify the various kinds of drugs abused by the society of Ntselamanzi (iii) to identify the consequences of substance abuse to the lives of the out-of-school youth. (iv) to suggest the strategies that can be used to reduce substance abuse in order to enhance the youth‟s socio-economic growth and societal bliss. Using the quantitative method ninety-eight questionnaires were administered to the out-of-school youth in Ntselamanzi village and eighty questionnaires were returned fully answered. The major findings of the study outlined that dominating factors of substance abuse in Ntselamanzi village were family drug use, increased drug accessibility, lack of recreation and peer influence. As a result drug abuse among the out of school youth has indicated that the youth end up dropping out of school, unemployed, facing health complications and committing anti-social activities in the village which causing family conflicts and rifts in the community. These all affected the out-of-school youths‟ well-being, academic future and their quality of life was lowered due to all related issues with drug abuse. It can be concluded that drug use among rural outof-school youth is detrimental to the out-of-school youths, their families destroyed and their community crippled from the anti-social activities that take place. The future of the youths‟ education is hampered; the quality of persons in the community and families is lowered. Having unproductive out-of-school youth as a result of drug abuse is not good for the development of the village and all the persons therein. , Thesis (M Soc Sc) (Social Work) -- University of Fort Hare, 2015
- Full Text:
- Date Issued: 2015
- Authors: Chatikobo, Nyasha
- Date: 2015
- Subjects: Substance abuse--South Africa--Eastern Cape , Drug abuse--South Africa--Eastern Cape , Youth--Substance use--South Africa--Eastern Cape
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10353/19442 , vital:43087
- Description: The main aim of the study was to investigate the detriments associated with substance abuse among the out- of- school youth of Ntselamanzi Village in Alice. This study intended to achieve the following objectives. (i) to establish the causes of increased indulgence in substance abuse in Ntselamanzi village, Eastern Cape. (ii) to identify the various kinds of drugs abused by the society of Ntselamanzi (iii) to identify the consequences of substance abuse to the lives of the out-of-school youth. (iv) to suggest the strategies that can be used to reduce substance abuse in order to enhance the youth‟s socio-economic growth and societal bliss. Using the quantitative method ninety-eight questionnaires were administered to the out-of-school youth in Ntselamanzi village and eighty questionnaires were returned fully answered. The major findings of the study outlined that dominating factors of substance abuse in Ntselamanzi village were family drug use, increased drug accessibility, lack of recreation and peer influence. As a result drug abuse among the out of school youth has indicated that the youth end up dropping out of school, unemployed, facing health complications and committing anti-social activities in the village which causing family conflicts and rifts in the community. These all affected the out-of-school youths‟ well-being, academic future and their quality of life was lowered due to all related issues with drug abuse. It can be concluded that drug use among rural outof-school youth is detrimental to the out-of-school youths, their families destroyed and their community crippled from the anti-social activities that take place. The future of the youths‟ education is hampered; the quality of persons in the community and families is lowered. Having unproductive out-of-school youth as a result of drug abuse is not good for the development of the village and all the persons therein. , Thesis (M Soc Sc) (Social Work) -- University of Fort Hare, 2015
- Full Text:
- Date Issued: 2015
DNA-based identification of Lepidoptera associated with citrus in South Africa
- Marsberg, Tamryn, Hill, Martin P, Moore, Sean D, Timm, Alicia E
- Authors: Marsberg, Tamryn , Hill, Martin P , Moore, Sean D , Timm, Alicia E
- Date: 2015
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/405782 , vital:70205 , xlink:href="https://hdl.handle.net/10520/EJC167513"
- Description: A number of insects, primarily Lepidoptera, cause damage to citrus in South Africa. A major limitation to the management and control of these pests is their correct identification. The aim of this study was to develop a database of gene sequences to aid in the identification of these Lepidoptera. Multiple specimens of 12 species were sequenced for the ~650 bp of the cytochrome oxidase I gene. These sequence data were supplemented and validated using sequences available in public databases. Results showed that each species could be unambiguously identified, and neighbour-joining analysis based on K2P distances formed highly supported, distinct clusters for each species, i.e. the maximum intraspecific genetic distance was less than that of the minimum interspecific genetic distances. Thus, this data set provides a molecular means to successfully identify the most important Lepidoptera associated with citrus in South Africa.
- Full Text:
- Date Issued: 2015
- Authors: Marsberg, Tamryn , Hill, Martin P , Moore, Sean D , Timm, Alicia E
- Date: 2015
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/405782 , vital:70205 , xlink:href="https://hdl.handle.net/10520/EJC167513"
- Description: A number of insects, primarily Lepidoptera, cause damage to citrus in South Africa. A major limitation to the management and control of these pests is their correct identification. The aim of this study was to develop a database of gene sequences to aid in the identification of these Lepidoptera. Multiple specimens of 12 species were sequenced for the ~650 bp of the cytochrome oxidase I gene. These sequence data were supplemented and validated using sequences available in public databases. Results showed that each species could be unambiguously identified, and neighbour-joining analysis based on K2P distances formed highly supported, distinct clusters for each species, i.e. the maximum intraspecific genetic distance was less than that of the minimum interspecific genetic distances. Thus, this data set provides a molecular means to successfully identify the most important Lepidoptera associated with citrus in South Africa.
- Full Text:
- Date Issued: 2015
Editorial. Perspectives on transformations in learning and education
- Authors: Lotz-Sisitka, Heila
- Date: 2015
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/387277 , vital:68221 , xlink:href="https://www.ajol.info/index.php/sajee/article/view/137656"
- Description: Perspectives on transformations in learning and education
- Full Text:
- Date Issued: 2015
- Authors: Lotz-Sisitka, Heila
- Date: 2015
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/387277 , vital:68221 , xlink:href="https://www.ajol.info/index.php/sajee/article/view/137656"
- Description: Perspectives on transformations in learning and education
- Full Text:
- Date Issued: 2015
Educators and learners perceptions on english first additional language speakers use of english as medium of instruction
- Authors: Nqoma, Lungiswa
- Date: 2015
- Subjects: English language -- Study and teaching , English language
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10353/24934 , vital:63678
- Description: This study investigates Educators‟ and learners‟ perceptions on English first additional language speakers‟ use of English as medium of instruction in two primary schools in the East London District. The study made use of a qualitative research method which includes interviews, observation and document analysis (learners‟ books). The uncovered data is analyzed against the background of the socio-economic and historical factors that led to this medium of instruction using content analysis (CA). After the apartheid regime in 1994 and the formation of a new government in 1996, the South African Constitution declared 11 languages in an attempt to encourage multilingualism in the country with each province having its provincial language policy. In the Eastern Cape where the study is conducted the language policy recognizes Xhosa, English, and Afrikaans as the official languages with English as the medium of instruction especially at the intermediate phase. The theoretical and conceptual framework for the study is provided by studies on language policy and planning, English as an international language, and Language as a mediating tool. The findings of the study indicate the crucial role that language of instruction plays in teaching and learning. However, challenges arise when the language of instruction is not the mother tongue. The study indicates dissatisfaction in the use of EMOI as a result of inadequate proficiency in the language of instruction, school environment, lack of resources; and lack of parental support. As a result of the above, some educators resorted to code switching when teaching. Hence, the study sheds light on EFAL learner‟s perspective on both comprehension and the level of educator‟s English skills and whether there is a connection between these two aspects. This resulted to conceivable methods that could be used to improve learner performance, teaching and learning methods and the efficiency of East London District support system. , Thesis (MEd) -- Faculty of Education, 2015
- Full Text:
- Date Issued: 2015
- Authors: Nqoma, Lungiswa
- Date: 2015
- Subjects: English language -- Study and teaching , English language
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10353/24934 , vital:63678
- Description: This study investigates Educators‟ and learners‟ perceptions on English first additional language speakers‟ use of English as medium of instruction in two primary schools in the East London District. The study made use of a qualitative research method which includes interviews, observation and document analysis (learners‟ books). The uncovered data is analyzed against the background of the socio-economic and historical factors that led to this medium of instruction using content analysis (CA). After the apartheid regime in 1994 and the formation of a new government in 1996, the South African Constitution declared 11 languages in an attempt to encourage multilingualism in the country with each province having its provincial language policy. In the Eastern Cape where the study is conducted the language policy recognizes Xhosa, English, and Afrikaans as the official languages with English as the medium of instruction especially at the intermediate phase. The theoretical and conceptual framework for the study is provided by studies on language policy and planning, English as an international language, and Language as a mediating tool. The findings of the study indicate the crucial role that language of instruction plays in teaching and learning. However, challenges arise when the language of instruction is not the mother tongue. The study indicates dissatisfaction in the use of EMOI as a result of inadequate proficiency in the language of instruction, school environment, lack of resources; and lack of parental support. As a result of the above, some educators resorted to code switching when teaching. Hence, the study sheds light on EFAL learner‟s perspective on both comprehension and the level of educator‟s English skills and whether there is a connection between these two aspects. This resulted to conceivable methods that could be used to improve learner performance, teaching and learning methods and the efficiency of East London District support system. , Thesis (MEd) -- Faculty of Education, 2015
- Full Text:
- Date Issued: 2015
Effects of differently shaped silver nanoparticles on the photophysics of pyridylsulfanyl-substituted phthalocyanines
- D'Souza, Sarah, Mashazi, Philani N, Britton, Jonathan, Nyokong, Tebello
- Authors: D'Souza, Sarah , Mashazi, Philani N , Britton, Jonathan , Nyokong, Tebello
- Date: 2015
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/193564 , vital:45348 , xlink:href="https://doi.org/10.1016/j.poly.2015.06.038"
- Description: This paper reports on the photophysical behavior of (2-pyridylsulfanyl)phthalocyaninato zinc(II) and 2,9(10),16(17),23(24)-tetra-(2-pyridylsulfanyl)phthalocyaninato zinc(II) in the presence of differently shaped silver nanoparticles (nanospheres, nanotriangles and nanoflowers). The presence of shaped nanoparticles increased both triplet quantum yields and lifetimes of the tetra-substituted mercaptopyridine zinc phthalocyanine in DMSO. It is apparent from this work that the shape of the silver nanoparticle used is of little consequence in influencing photophysical behavior of the phthalocyanines.
- Full Text:
- Date Issued: 2015
- Authors: D'Souza, Sarah , Mashazi, Philani N , Britton, Jonathan , Nyokong, Tebello
- Date: 2015
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/193564 , vital:45348 , xlink:href="https://doi.org/10.1016/j.poly.2015.06.038"
- Description: This paper reports on the photophysical behavior of (2-pyridylsulfanyl)phthalocyaninato zinc(II) and 2,9(10),16(17),23(24)-tetra-(2-pyridylsulfanyl)phthalocyaninato zinc(II) in the presence of differently shaped silver nanoparticles (nanospheres, nanotriangles and nanoflowers). The presence of shaped nanoparticles increased both triplet quantum yields and lifetimes of the tetra-substituted mercaptopyridine zinc phthalocyanine in DMSO. It is apparent from this work that the shape of the silver nanoparticle used is of little consequence in influencing photophysical behavior of the phthalocyanines.
- Full Text:
- Date Issued: 2015
Effects of ZnO nanohexagons and nanorods on the fluorescence behavior of metallophthalocyanines
- D'Souza, Sarah, Moeno, Sharon, Nyokong, Tebello
- Authors: D'Souza, Sarah , Moeno, Sharon , Nyokong, Tebello
- Date: 2015
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/189741 , vital:44927 , xlink:href="https://doi.org/10.1016/j.poly.2014.09.012"
- Description: This paper looks at the fluorescence behavior of zinc phthalocyanines: 2,(3),9(10),16(17),23(24)-tetrakis- (mercaptoacetic acid phthalocyaninato) zinc(II) (ZnTMAAPc), 2,(3),9(10),16(17),23(24)-tetrakis-(mercaptopropanoic acid phthalocyaninato) zinc(II) (ZnTMPAPc) and (OH)AlPcSmix (the latter contains a mixture of the di-, tri- and tetra-sulfonated derivatives with an average of three sulfonated groups per molecule) in the presence of ZnO nanoparticles. Fluorescence lifetimes of Pc complexes generally decreased in the presence of ZnO nanoparticles, with generally longer lifetimes for ZnO nanohexagons compared to ZnO nanorods.
- Full Text:
- Date Issued: 2015
- Authors: D'Souza, Sarah , Moeno, Sharon , Nyokong, Tebello
- Date: 2015
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/189741 , vital:44927 , xlink:href="https://doi.org/10.1016/j.poly.2014.09.012"
- Description: This paper looks at the fluorescence behavior of zinc phthalocyanines: 2,(3),9(10),16(17),23(24)-tetrakis- (mercaptoacetic acid phthalocyaninato) zinc(II) (ZnTMAAPc), 2,(3),9(10),16(17),23(24)-tetrakis-(mercaptopropanoic acid phthalocyaninato) zinc(II) (ZnTMPAPc) and (OH)AlPcSmix (the latter contains a mixture of the di-, tri- and tetra-sulfonated derivatives with an average of three sulfonated groups per molecule) in the presence of ZnO nanoparticles. Fluorescence lifetimes of Pc complexes generally decreased in the presence of ZnO nanoparticles, with generally longer lifetimes for ZnO nanohexagons compared to ZnO nanorods.
- Full Text:
- Date Issued: 2015
Electrocatalytic activity of bimetallic Au–Pd nanoparticles in the presence of cobalt tetraaminophthalocyanine
- Maringa, Audacity, Mashazi, Philani N, Nyokong, Tebello
- Authors: Maringa, Audacity , Mashazi, Philani N , Nyokong, Tebello
- Date: 2015
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/189719 , vital:44925 , xlink:href="https://doi.org/10.1016/j.jcis.2014.10.056"
- Description: Au and Pd nanoparticles were individually or together electrodeposited on top of polymerized cobalt tetraaminophthalocyanine (poly-CoTAPc). When Pd and Au nanoparticles are co-deposited together, the electrode is denoted as Au–Pd (co-deposited)/poly-CoTAPc-GCE. X-ray photoelectron spectroscopy (XPS) was used to show the successful deposition of AuNPs, PdNPs and Au–Pd (co-deposited). The scanning electrochemical microscopy showed that Au–Pd (co-deposited)/poly-CoTAPc-GCE (with current range of 9.5–13.5 lA) was more conducting than Au–Pd (co-deposited)-GCE (with current range of 8–12 lA). Electrochemical impedance spectroscopy (EIS) showed that there was less resistance to charge transfer for Au–Pd (co-deposited)/poly-CoTAPc-GCE compared to the rest of the electrodes. Au–Pd (co-deposited)/poly-CoTAPc-GCE showed the best activity for the electrooxidation of hydrazine in terms of limit of detection (0.5 lM), hence shows promise as an electrocatalyst for electrooxidation of hydrazine.
- Full Text:
- Date Issued: 2015
- Authors: Maringa, Audacity , Mashazi, Philani N , Nyokong, Tebello
- Date: 2015
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/189719 , vital:44925 , xlink:href="https://doi.org/10.1016/j.jcis.2014.10.056"
- Description: Au and Pd nanoparticles were individually or together electrodeposited on top of polymerized cobalt tetraaminophthalocyanine (poly-CoTAPc). When Pd and Au nanoparticles are co-deposited together, the electrode is denoted as Au–Pd (co-deposited)/poly-CoTAPc-GCE. X-ray photoelectron spectroscopy (XPS) was used to show the successful deposition of AuNPs, PdNPs and Au–Pd (co-deposited). The scanning electrochemical microscopy showed that Au–Pd (co-deposited)/poly-CoTAPc-GCE (with current range of 9.5–13.5 lA) was more conducting than Au–Pd (co-deposited)-GCE (with current range of 8–12 lA). Electrochemical impedance spectroscopy (EIS) showed that there was less resistance to charge transfer for Au–Pd (co-deposited)/poly-CoTAPc-GCE compared to the rest of the electrodes. Au–Pd (co-deposited)/poly-CoTAPc-GCE showed the best activity for the electrooxidation of hydrazine in terms of limit of detection (0.5 lM), hence shows promise as an electrocatalyst for electrooxidation of hydrazine.
- Full Text:
- Date Issued: 2015
Electrocatalytic studies of covalently immobilized metal tetra-amino phthalocyanines onto derivatized screen-printed gold electrodes
- Mashazi, Philani N, Nyokong, Tebello
- Authors: Mashazi, Philani N , Nyokong, Tebello
- Date: 2015
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/249059 , vital:51774 , xlink:href="https://doi.org/10.1007/s00604-010-0438-6"
- Description: Metal tetra-amino phthalocyanine complexes (MTAPc; where M is Co or Mn) were immobilized on screen-printed gold electrodes pre-modified with monolayers of benzylamino groups. The functionalized electrodes were then activated using benzene-1,4-dicarbaldehyde as a linker before MTAPc complexes were immobilized. The surface coverages for the modified electrodes confirmed the perpendicular orientation of the MTAPcs. The apparent electron transfer constant (kapp) for the electrodes is 2.2 × 10−5 cm.s−1 for both CoTAPc and MnTAPc modified electrodes as calculated with data from impedance measurements. The kapp values for the bare and benzylamino modified electrodes were found to be 1.2 × 10−4 cm.s−1 and 4.9 × 10−6 cm.s−1, respectively. The electrocatalysis of the modified electrodes towards detection of H2O2 gave significant peak current densities and electrocatalytic potentials at −0.28 V and −0.31 V for the MnTAPc and CoTAPc modified electrodes, respectively.
- Full Text:
- Date Issued: 2015
- Authors: Mashazi, Philani N , Nyokong, Tebello
- Date: 2015
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/249059 , vital:51774 , xlink:href="https://doi.org/10.1007/s00604-010-0438-6"
- Description: Metal tetra-amino phthalocyanine complexes (MTAPc; where M is Co or Mn) were immobilized on screen-printed gold electrodes pre-modified with monolayers of benzylamino groups. The functionalized electrodes were then activated using benzene-1,4-dicarbaldehyde as a linker before MTAPc complexes were immobilized. The surface coverages for the modified electrodes confirmed the perpendicular orientation of the MTAPcs. The apparent electron transfer constant (kapp) for the electrodes is 2.2 × 10−5 cm.s−1 for both CoTAPc and MnTAPc modified electrodes as calculated with data from impedance measurements. The kapp values for the bare and benzylamino modified electrodes were found to be 1.2 × 10−4 cm.s−1 and 4.9 × 10−6 cm.s−1, respectively. The electrocatalysis of the modified electrodes towards detection of H2O2 gave significant peak current densities and electrocatalytic potentials at −0.28 V and −0.31 V for the MnTAPc and CoTAPc modified electrodes, respectively.
- Full Text:
- Date Issued: 2015
Electrode modification using alkynyl substituted Fe (II) phthalocyanine via electrografting and click chemistry for electrocatalysis
- Nxele, Siphesihle R, Mashazi, Philani N, Nyokong, Tebello
- Authors: Nxele, Siphesihle R , Mashazi, Philani N , Nyokong, Tebello
- Date: 2015
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/189296 , vital:44835 , xlink:href="https://doi.org/10.1002/elan.201500212"
- Description: In this work, tetrakis(5-hexyn-oxy)Fe(II) phthalocyanine was synthesised in order to perform a click reaction between the terminal alkyne groups and an azide group on a glassy carbon electrode (GCE) surface. An azide group was formed on the electrode surface following electrografting using 4-azidobenzene diazonium tetrafluoroborate by electrochemical reduction. The Cu(I) catalyzed alkyne-azide Huisgen cycloaddition reaction was then employed in order to react the terminal alkyne groups on the phthalocyanine with the azide groups on the GCE surface. The modified electrode was employed to catalyse the oxidation of hydrazine. The electrode showed good electrocatalytic ability towards the detection of hydrazine with a sensitivity of 15.38 µA mM−1 and a limit of detection of 1.09 µM.
- Full Text:
- Date Issued: 2015
- Authors: Nxele, Siphesihle R , Mashazi, Philani N , Nyokong, Tebello
- Date: 2015
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/189296 , vital:44835 , xlink:href="https://doi.org/10.1002/elan.201500212"
- Description: In this work, tetrakis(5-hexyn-oxy)Fe(II) phthalocyanine was synthesised in order to perform a click reaction between the terminal alkyne groups and an azide group on a glassy carbon electrode (GCE) surface. An azide group was formed on the electrode surface following electrografting using 4-azidobenzene diazonium tetrafluoroborate by electrochemical reduction. The Cu(I) catalyzed alkyne-azide Huisgen cycloaddition reaction was then employed in order to react the terminal alkyne groups on the phthalocyanine with the azide groups on the GCE surface. The modified electrode was employed to catalyse the oxidation of hydrazine. The electrode showed good electrocatalytic ability towards the detection of hydrazine with a sensitivity of 15.38 µA mM−1 and a limit of detection of 1.09 µM.
- Full Text:
- Date Issued: 2015
Enhanced optical limiting behaviour of indium phthalocyanine derivatives when in solution or embedded in poly (acrylic acid) or poly (methyl methacrylate) polymers
- Sanusi, Kayode, Nyokong, Tebello
- Authors: Sanusi, Kayode , Nyokong, Tebello
- Date: 2015
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/189445 , vital:44847 , xlink:href="https://doi.org/10.1016/j.jphotochem.2015.02.003"
- Description: The optical limiting performance of indium phthalocyanine-based polymer thin-films with large nonlinear absorption coefficients (βeff) and low limiting threshold intensity (Ilim) are described. The absorption cross-sections and the population dynamics of the excited states are also reported. The excited state absorption cross-sections (σexc) are shown to depend on the transition moment between the T1 and T2 states. βeff values have been shown to be related to the population density of the molecules in the T1 state. The improved optical limiting performance recorded for the investigated phthalocyanine complexes in the presence of polymer matrices has been attributed to the aggregation effects of the complexes in the polymer thin-films. The optical properties of the indium phthalocyanine moieties were found to possess robust sensitivity to a change of the polymer materials.
- Full Text:
- Date Issued: 2015
- Authors: Sanusi, Kayode , Nyokong, Tebello
- Date: 2015
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/189445 , vital:44847 , xlink:href="https://doi.org/10.1016/j.jphotochem.2015.02.003"
- Description: The optical limiting performance of indium phthalocyanine-based polymer thin-films with large nonlinear absorption coefficients (βeff) and low limiting threshold intensity (Ilim) are described. The absorption cross-sections and the population dynamics of the excited states are also reported. The excited state absorption cross-sections (σexc) are shown to depend on the transition moment between the T1 and T2 states. βeff values have been shown to be related to the population density of the molecules in the T1 state. The improved optical limiting performance recorded for the investigated phthalocyanine complexes in the presence of polymer matrices has been attributed to the aggregation effects of the complexes in the polymer thin-films. The optical properties of the indium phthalocyanine moieties were found to possess robust sensitivity to a change of the polymer materials.
- Full Text:
- Date Issued: 2015
Enhanced triplet state parameters for zinc carboxy phenoxy phthalocyanine following conjugation to ascorbic acid
- Ogbodu, Racheal O, Nyokong, Tebello
- Authors: Ogbodu, Racheal O , Nyokong, Tebello
- Date: 2015
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/189348 , vital:44839 , xlink:href="https://doi.org/10.1016/j.poly.2015.01.032"
- Description: Zinc phthalocyanine bearing four ascorbic acid units (formed via ester bond between zinc carboxy phenoxy phthalocyanines and ascorbic acid) was synthesized and characterized using different spectroscopic methods. The complex (with or without ascorbic acid) was further adsorbed onto single walled carbon nanotubes (SWCNTs) and further characterized using Raman spectroscopy, X-ray diffractometry, transmission electron microscopy and thermogravimetric analysis. The photophysical properties of the complexes were studied. The synthesized complex showed better photophysical properties when compared to the carboxy phenoxy phthalocyanines alone, this is evident in the increase of the triplet quantum yields (ΦT), triplet life-times (τT) and singlet oxygen quantum yields (ΦΔ). The zinc phthalocyanines bearing ascorbic acid showed improved triplet life-times even in the presence of SWCNTs.
- Full Text:
- Date Issued: 2015
- Authors: Ogbodu, Racheal O , Nyokong, Tebello
- Date: 2015
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/189348 , vital:44839 , xlink:href="https://doi.org/10.1016/j.poly.2015.01.032"
- Description: Zinc phthalocyanine bearing four ascorbic acid units (formed via ester bond between zinc carboxy phenoxy phthalocyanines and ascorbic acid) was synthesized and characterized using different spectroscopic methods. The complex (with or without ascorbic acid) was further adsorbed onto single walled carbon nanotubes (SWCNTs) and further characterized using Raman spectroscopy, X-ray diffractometry, transmission electron microscopy and thermogravimetric analysis. The photophysical properties of the complexes were studied. The synthesized complex showed better photophysical properties when compared to the carboxy phenoxy phthalocyanines alone, this is evident in the increase of the triplet quantum yields (ΦT), triplet life-times (τT) and singlet oxygen quantum yields (ΦΔ). The zinc phthalocyanines bearing ascorbic acid showed improved triplet life-times even in the presence of SWCNTs.
- Full Text:
- Date Issued: 2015
Enhanced triplet state yields in aqueous media of asymmetric zinc phthalocyanines when conjugated to silver nanoflowers
- D'Souza, Sarah, George, Reama, Göksel, Meltem, Atilla, Devrim, Durmus, Mahmut, Nyokong, Tebello
- Authors: D'Souza, Sarah , George, Reama , Göksel, Meltem , Atilla, Devrim , Durmus, Mahmut , Nyokong, Tebello
- Date: 2015
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/189099 , vital:44816 , xlink:href="https://doi.org/10.1016/j.poly.2015.08.017"
- Description: Novel low symmetry water-soluble zinc phthalocyanines (ZnPcs, complexes 1 and 2) were synthesized and then mixed with silver nanoflowers. Photophysical and photochemical studies were performed in order to determine the efficiency of complexes 1 and 2 as photosensitizers when alone and when combined with the silver nanoflowers. The Pcs show low fluorescence quantum yields and excellent triplet quantum yields of 0.78 (for 1) and 0.66 (for 2) in aqueous media. The triplet quantum yield values increased to 0.80 and 0.89, respectively, in the presence of silver nanoflowers. Long triplet lifetimes ranging from 180 to 200 μs in DMSO were obtained for complexes 1, 2 and their conjugates with silver nanoflowers.
- Full Text:
- Date Issued: 2015
- Authors: D'Souza, Sarah , George, Reama , Göksel, Meltem , Atilla, Devrim , Durmus, Mahmut , Nyokong, Tebello
- Date: 2015
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/189099 , vital:44816 , xlink:href="https://doi.org/10.1016/j.poly.2015.08.017"
- Description: Novel low symmetry water-soluble zinc phthalocyanines (ZnPcs, complexes 1 and 2) were synthesized and then mixed with silver nanoflowers. Photophysical and photochemical studies were performed in order to determine the efficiency of complexes 1 and 2 as photosensitizers when alone and when combined with the silver nanoflowers. The Pcs show low fluorescence quantum yields and excellent triplet quantum yields of 0.78 (for 1) and 0.66 (for 2) in aqueous media. The triplet quantum yield values increased to 0.80 and 0.89, respectively, in the presence of silver nanoflowers. Long triplet lifetimes ranging from 180 to 200 μs in DMSO were obtained for complexes 1, 2 and their conjugates with silver nanoflowers.
- Full Text:
- Date Issued: 2015
Establishment of human OCT4 as a putative HSP90 client protein: a case for HSP90 chaperoning pluripotency
- Authors: Sterrenberg, Jason Neville
- Date: 2015
- Subjects: Induced pluripotent stem cells , Heat shock proteins , Stem cells , Transcription factors , Molecular chaperones
- Language: English
- Type: Doctoral theses , text
- Identifier: http://hdl.handle.net/10962/194010 , vital:45415 , 10.21504/10962/194010
- Description: The therapeutic potential of stem cells is already being harnessed in clinical trails. Of even greater therapeutic potential has been the discovery of mechanisms to reprogram differentiated cells into a pluripotent stem cell-like state known as induced pluripotent stem cells (iPSCs). Stem cell nature is governed and maintained by a hierarchy of transcription factors, the apex of which is OCT4. Although much research has elucidated the transcriptional regulation of OCT4, OCT4 regulated gene expression profiles and OCT4 transcriptional activation mechanisms in both stem cell biology and cellular reprogramming to iPSCs, the fundamental biochemistry surrounding the OCT4 transcription factor remains largely unknown. In order to analyze the biochemical relationship between HSP90 and human OCT4 we developed an exogenous active human OCT4 expression model with human OCT4 under transcriptional control of a constitutive promoter. We identified the direct interaction between HSP90 and human OCT4 despite the fact that the proteins predominantly display differential subcellular localizations. We show that HSP90 inhibition resulted in degradation of human OCT4 via the ubiquitin proteasome degradation pathway. As human OCT4 and HSP90 did not interact in the nucleus, we suggest that HSP90 functions in the cytoplasmic stabilization of human OCT4. Our analysis suggests HSP90 inhibition inhibits the transcriptional activity of human OCT4 dimers without affecting monomeric OCT4 activity. Additionally our data suggests that the HSP90 and human OCT4 complex is modulated by phosphorylation events either promoting or abrogating the interaction between HSP90 and human OCT4. Our data suggest that human OCT4 displays the characteristics describing HSP90 client proteins, therefore we identify human OCT4 as a putative HSP90 client protein. The regulation of the transcription factor OCT4 by HSP90 provides fundamental insights into the complex biochemistry of stem cell biology. This may also be suggestive that HSP90 not only regulates stem cell biology by maintaining routine cellular homeostasis but additionally through the direct regulation of pluripotency factors. , Thesis (PhD) -- Faculty of Science, Biochemistry and Microbiology, 2015
- Full Text:
- Date Issued: 2015
- Authors: Sterrenberg, Jason Neville
- Date: 2015
- Subjects: Induced pluripotent stem cells , Heat shock proteins , Stem cells , Transcription factors , Molecular chaperones
- Language: English
- Type: Doctoral theses , text
- Identifier: http://hdl.handle.net/10962/194010 , vital:45415 , 10.21504/10962/194010
- Description: The therapeutic potential of stem cells is already being harnessed in clinical trails. Of even greater therapeutic potential has been the discovery of mechanisms to reprogram differentiated cells into a pluripotent stem cell-like state known as induced pluripotent stem cells (iPSCs). Stem cell nature is governed and maintained by a hierarchy of transcription factors, the apex of which is OCT4. Although much research has elucidated the transcriptional regulation of OCT4, OCT4 regulated gene expression profiles and OCT4 transcriptional activation mechanisms in both stem cell biology and cellular reprogramming to iPSCs, the fundamental biochemistry surrounding the OCT4 transcription factor remains largely unknown. In order to analyze the biochemical relationship between HSP90 and human OCT4 we developed an exogenous active human OCT4 expression model with human OCT4 under transcriptional control of a constitutive promoter. We identified the direct interaction between HSP90 and human OCT4 despite the fact that the proteins predominantly display differential subcellular localizations. We show that HSP90 inhibition resulted in degradation of human OCT4 via the ubiquitin proteasome degradation pathway. As human OCT4 and HSP90 did not interact in the nucleus, we suggest that HSP90 functions in the cytoplasmic stabilization of human OCT4. Our analysis suggests HSP90 inhibition inhibits the transcriptional activity of human OCT4 dimers without affecting monomeric OCT4 activity. Additionally our data suggests that the HSP90 and human OCT4 complex is modulated by phosphorylation events either promoting or abrogating the interaction between HSP90 and human OCT4. Our data suggest that human OCT4 displays the characteristics describing HSP90 client proteins, therefore we identify human OCT4 as a putative HSP90 client protein. The regulation of the transcription factor OCT4 by HSP90 provides fundamental insights into the complex biochemistry of stem cell biology. This may also be suggestive that HSP90 not only regulates stem cell biology by maintaining routine cellular homeostasis but additionally through the direct regulation of pluripotency factors. , Thesis (PhD) -- Faculty of Science, Biochemistry and Microbiology, 2015
- Full Text:
- Date Issued: 2015
Evaluation of knowledge and practices of nurses with regard to prevention of nosocomial infection in the intensive care units of Eastern Cape Province
- Mlenzana, Nosiphiwo Priscilla
- Authors: Mlenzana, Nosiphiwo Priscilla
- Date: 2015
- Subjects: Nosocomial infections http://id.loc.gov/authorities/subjects/sh85092770 , Cross infection--Prevention http://id.loc.gov/authorities/subjects/sh2009122612 , Infection http://id.loc.gov/authorities/subjects/sh85066076
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10353/19639 , vital:43154
- Description: Aim: To determine the level of knowledge and practice of the nurses in the prevention and control of nosocomial infection in the intensive care units and make recommendations aiming at bridging the gap identified. In this study, the level of knowledge and practice of nurses in the intensive care units was described and its relationship with the demographic characteristics was examined utilising a quantitative approach. A quantitative descriptive design was used to examine and describe knowledge and practices of intensive care nurses with regards to prevention and control of nosocomial infection. One hundred and thirty (130) nurses participated in the study taken from the intensive care units of the five (5) state hospitals of the Eastern Cape Province. A self-designed questionnaire with close-ended questions was utilised comprising of dichotomous questions, with ‘yes’ or ‘no’ measuring knowledge nurses have and a Likert scale that measured knowledge with regards to clinical practice utilised in the prevention and control of nosocomial infections. The following ethical considerations were addressed by the study: ethical clearance, permission to conduct the study, informed consent from participants, anonymity and confidentiality and respect of individual autonomy. Findings: The respondents showed encouraging agreement with the different practices that should be followed in order to prevent spreading of nosocomial infections in their units. This knowledge suggests that the problem of infection control in ICUs may be related to the individual characteristics of the profession as opposed to being institutional. Limitations: Not all the intensive care units of the Eastern Cape hospitals were included due to challenges of time, finance and geographic factors. Recommendations: The following recommendations were made: Orientation programme to all new staff coming into the ICUs including infection control policies and guidelines; Involvement of the ICU staff in the development of infection control policies so as to ensure ownership and ultimate compliance; The employer must ensure that all resources for infection control and prevention are available and accessible to the health care workers at all times to ensure compliance. , Thesis (MCur) -- University of Fort Hare, 2015
- Full Text:
- Date Issued: 2015
- Authors: Mlenzana, Nosiphiwo Priscilla
- Date: 2015
- Subjects: Nosocomial infections http://id.loc.gov/authorities/subjects/sh85092770 , Cross infection--Prevention http://id.loc.gov/authorities/subjects/sh2009122612 , Infection http://id.loc.gov/authorities/subjects/sh85066076
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10353/19639 , vital:43154
- Description: Aim: To determine the level of knowledge and practice of the nurses in the prevention and control of nosocomial infection in the intensive care units and make recommendations aiming at bridging the gap identified. In this study, the level of knowledge and practice of nurses in the intensive care units was described and its relationship with the demographic characteristics was examined utilising a quantitative approach. A quantitative descriptive design was used to examine and describe knowledge and practices of intensive care nurses with regards to prevention and control of nosocomial infection. One hundred and thirty (130) nurses participated in the study taken from the intensive care units of the five (5) state hospitals of the Eastern Cape Province. A self-designed questionnaire with close-ended questions was utilised comprising of dichotomous questions, with ‘yes’ or ‘no’ measuring knowledge nurses have and a Likert scale that measured knowledge with regards to clinical practice utilised in the prevention and control of nosocomial infections. The following ethical considerations were addressed by the study: ethical clearance, permission to conduct the study, informed consent from participants, anonymity and confidentiality and respect of individual autonomy. Findings: The respondents showed encouraging agreement with the different practices that should be followed in order to prevent spreading of nosocomial infections in their units. This knowledge suggests that the problem of infection control in ICUs may be related to the individual characteristics of the profession as opposed to being institutional. Limitations: Not all the intensive care units of the Eastern Cape hospitals were included due to challenges of time, finance and geographic factors. Recommendations: The following recommendations were made: Orientation programme to all new staff coming into the ICUs including infection control policies and guidelines; Involvement of the ICU staff in the development of infection control policies so as to ensure ownership and ultimate compliance; The employer must ensure that all resources for infection control and prevention are available and accessible to the health care workers at all times to ensure compliance. , Thesis (MCur) -- University of Fort Hare, 2015
- Full Text:
- Date Issued: 2015
Evaluation of selected non- governmental organizations (NGOs) in the provision of health , education & housing services in South Africa the study of Alice township Eastern cape province
- Kajiita, Robert Mutemi https://orcid.org/0000-0003-2829-4824
- Authors: Kajiita, Robert Mutemi https://orcid.org/0000-0003-2829-4824
- Date: 2015
- Subjects: Non-governmental organizations http://id.loc.gov/authorities/subjects/sh86007360 , Sustainable development--South Africa http://id.loc.gov/authorities/subjects/sh2010115191
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10353/19567 , vital:43144
- Description: The dynamism of human needs and the inability of the state and governments to guarantee a satisfactory access to, as well as consumption of private and public goods and services have prompted an up-sprung of alternative institutions such as the Non-Governmental Organizations. This study sought to evaluate selected NGOs in provision of health, education and housing services in Alice Township of the Eastern Cape Province. The study had the following specific objectives: to evaluate the role of selected NGOs in Alice in the provision of health, education and housing services; to examine the successes and possible gaps of selected NGOs in provision of aforementioned services; to examine the relationship between the NGOs and the government in provision of above mentioned services; and finally to establish the strategies that can be adopted to enhance NGOs’ capabilities in services delivery. To achieve these objectives, the study utilized mixed methods research approach, with an explorative and a mini-survey design. Non-probability sampling methodology was used and specifically purposive sampling was used to get a sample of 115 research participants and respondents. Data collection was cross- sectional and was facilitated by the use of in-depth interviews using semi-structured interviews and questionnaires. Data was analysed using both qualitative and quantitative approaches, and the results were triangulated to answer the research problem. The study was premised on the Public-Private Partnership (PPP) model of service delivery, and diverse literature was sought to strengthen the findings. The study revealed that: the females were more active in welfare sector than men; the concept NGO posed a conceptual challenge to the research participants; high level of unemployment and low level of tertiary literacy among study participants was reported. Furthermore, NGOs in Alice provided health based services which included creating awareness, control and treatment of communicable and non-communicable diseases such as HIV/AIDS, tuberculosis, diabetes, psychological and palliative care, counselling and old age care services. Educationally, early childhood development services took the lion’s share. This is evidenced by an array of day care centres in Alice. Regrettably, there were no housing services offered by NGOs in the area. The findings also revealed diametrically opposed debates on successes of NGOs in Alice, with some not seeing the success while others indicated some successful milestones. Notably, the NGOs in Alice suffered a paucity of resources which included: lack of funds, unskilled and inadequate staff, infrastructural and technological challenges, lack of transport facilities among others. The study also indicated a sour relationship between the government and the NGOs. Despite this, the NGOs were reported to adhere largely to the policy guidelines postulated by the government. Moreover, the government was the major funder of the most NGOs in the area of study. The findings revealed that fundraising skills were needed to bolster the NGOs financial muscle towards the achievement of project implementation. The state of infrastructure also needed to be addressed as well as scaling up the NGOs services to reach to a greater section of the society, Partnerships, collaborations and networking for NGOs would enable NGOs services delivery. The study also recommended: inclusivity in the welfare sector, establishment of vibrant housing NGOs in Alice, empowerment approaches to service provisioning, proper visibility of the NGOs in the community, systematic and regular promotion of training among the NGOs’ staff, sound and up to date harmonised policies, mutually designed partnerships, collaborations and networks, flexibility of donor funding approaches, intensive and extensive government support to NGOs, periodic scientific inquiry on NGOs operations and finally recommendation is made for further research in the area under the study. Conclusively, it is critical that NGOs in Alice are doing their best compared to their resource base and therefore, the government should study the environment of the NGOs in the area with the hope of coming up with plausible and pragmatic ways of bolstering their operations. , Thesis (M Soc Sc)(Social work) -- University of Fort Hare, 2015
- Full Text:
- Date Issued: 2015
- Authors: Kajiita, Robert Mutemi https://orcid.org/0000-0003-2829-4824
- Date: 2015
- Subjects: Non-governmental organizations http://id.loc.gov/authorities/subjects/sh86007360 , Sustainable development--South Africa http://id.loc.gov/authorities/subjects/sh2010115191
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10353/19567 , vital:43144
- Description: The dynamism of human needs and the inability of the state and governments to guarantee a satisfactory access to, as well as consumption of private and public goods and services have prompted an up-sprung of alternative institutions such as the Non-Governmental Organizations. This study sought to evaluate selected NGOs in provision of health, education and housing services in Alice Township of the Eastern Cape Province. The study had the following specific objectives: to evaluate the role of selected NGOs in Alice in the provision of health, education and housing services; to examine the successes and possible gaps of selected NGOs in provision of aforementioned services; to examine the relationship between the NGOs and the government in provision of above mentioned services; and finally to establish the strategies that can be adopted to enhance NGOs’ capabilities in services delivery. To achieve these objectives, the study utilized mixed methods research approach, with an explorative and a mini-survey design. Non-probability sampling methodology was used and specifically purposive sampling was used to get a sample of 115 research participants and respondents. Data collection was cross- sectional and was facilitated by the use of in-depth interviews using semi-structured interviews and questionnaires. Data was analysed using both qualitative and quantitative approaches, and the results were triangulated to answer the research problem. The study was premised on the Public-Private Partnership (PPP) model of service delivery, and diverse literature was sought to strengthen the findings. The study revealed that: the females were more active in welfare sector than men; the concept NGO posed a conceptual challenge to the research participants; high level of unemployment and low level of tertiary literacy among study participants was reported. Furthermore, NGOs in Alice provided health based services which included creating awareness, control and treatment of communicable and non-communicable diseases such as HIV/AIDS, tuberculosis, diabetes, psychological and palliative care, counselling and old age care services. Educationally, early childhood development services took the lion’s share. This is evidenced by an array of day care centres in Alice. Regrettably, there were no housing services offered by NGOs in the area. The findings also revealed diametrically opposed debates on successes of NGOs in Alice, with some not seeing the success while others indicated some successful milestones. Notably, the NGOs in Alice suffered a paucity of resources which included: lack of funds, unskilled and inadequate staff, infrastructural and technological challenges, lack of transport facilities among others. The study also indicated a sour relationship between the government and the NGOs. Despite this, the NGOs were reported to adhere largely to the policy guidelines postulated by the government. Moreover, the government was the major funder of the most NGOs in the area of study. The findings revealed that fundraising skills were needed to bolster the NGOs financial muscle towards the achievement of project implementation. The state of infrastructure also needed to be addressed as well as scaling up the NGOs services to reach to a greater section of the society, Partnerships, collaborations and networking for NGOs would enable NGOs services delivery. The study also recommended: inclusivity in the welfare sector, establishment of vibrant housing NGOs in Alice, empowerment approaches to service provisioning, proper visibility of the NGOs in the community, systematic and regular promotion of training among the NGOs’ staff, sound and up to date harmonised policies, mutually designed partnerships, collaborations and networks, flexibility of donor funding approaches, intensive and extensive government support to NGOs, periodic scientific inquiry on NGOs operations and finally recommendation is made for further research in the area under the study. Conclusively, it is critical that NGOs in Alice are doing their best compared to their resource base and therefore, the government should study the environment of the NGOs in the area with the hope of coming up with plausible and pragmatic ways of bolstering their operations. , Thesis (M Soc Sc)(Social work) -- University of Fort Hare, 2015
- Full Text:
- Date Issued: 2015
Facile synthesis, spectroscopic and electrochemical properties, and theoretical calculations of porphyrin dimers with a bridging amide-bonded xanthene moiety
- Liang, Xu, Xu, Li, Li, Minzhi, Mack, John, Stone, Justin, Nyokong, Tebello, Jiang, Yu, Kobayashi, Nagao, Zhu, Weihua
- Authors: Liang, Xu , Xu, Li , Li, Minzhi , Mack, John , Stone, Justin , Nyokong, Tebello , Jiang, Yu , Kobayashi, Nagao , Zhu, Weihua
- Date: 2015
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/241390 , vital:50935 , xlink:href="https://doi.org/10.1142/S1088424615500492"
- Description: A free base porphyrin dimer bridged by a flexible amide-bonded xanthene moiety and its binuclear zinc(II) complex zinc(II) complex were synthesized and characterized. Structural characterization by MS and 1H NMR spectroscopy confirmed the bridged porphyrin dimer structure. The properties of the dimers were characterized by IR, UV-visible absorption, fluorescence and magnetic circular dichroism (MCD) spectroscopy, and electrochemistry studies. Theoretical calculations were carried out to analyze the electronic structures of porphyrin dimers with a bridging amide-bonded xanthene moiety.
- Full Text:
- Date Issued: 2015
- Authors: Liang, Xu , Xu, Li , Li, Minzhi , Mack, John , Stone, Justin , Nyokong, Tebello , Jiang, Yu , Kobayashi, Nagao , Zhu, Weihua
- Date: 2015
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/241390 , vital:50935 , xlink:href="https://doi.org/10.1142/S1088424615500492"
- Description: A free base porphyrin dimer bridged by a flexible amide-bonded xanthene moiety and its binuclear zinc(II) complex zinc(II) complex were synthesized and characterized. Structural characterization by MS and 1H NMR spectroscopy confirmed the bridged porphyrin dimer structure. The properties of the dimers were characterized by IR, UV-visible absorption, fluorescence and magnetic circular dichroism (MCD) spectroscopy, and electrochemistry studies. Theoretical calculations were carried out to analyze the electronic structures of porphyrin dimers with a bridging amide-bonded xanthene moiety.
- Full Text:
- Date Issued: 2015