A comparative study of multiculturalism in South Africa and Canada: evaluating successes and failures.
- Authors: Anele Mngadi
- Date: 2022-12
- Subjects: Race discrimination -- Economic aspects – South Africa , Social justice -- South Africa , Xenophobia
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/59435 , vital:62114
- Description: The purpose of this study was to evaluate the successes and failures of multiculturalism in South Africa and Canada through the lens of critical multiculturalism as its theoretical frame. As Canada is widely-acknowledged as having one of the best multiculturalism policy and implementation programmes in the world, this study aimed to draw lessons from the Canadian model of multiculturalism in order to make recommendations to improve multicultural practices in South Africa. It is worth noting that multiculturalism in Canada is not perfect as government still struggles to implement inclusive and reconciliatory programmes for the previously colonised Indigenous communities. This study used a qualitative thematic analysis to enable a comparison of multiculturalism in these two countries. The findings of this study suggest that having a comprehensive multiculturalism policy is fundamental to ensure that aspirations of a socially cohesive multiculturalism are not merely philosophical, but are formulated into government policies, with guidelines for implementation through the guidance of critical multiculturalism theory. The findings of this study also suggest that the persistent racialised socio-economic inequalities in South Africa continue to undermine multiculturalism and nation-building efforts. , Thesis (MA) -- Faculty of Humanities, School of Governmental and Social Sciences, 2022
- Full Text:
- Date Issued: 2022-12
- Authors: Anele Mngadi
- Date: 2022-12
- Subjects: Race discrimination -- Economic aspects – South Africa , Social justice -- South Africa , Xenophobia
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/59435 , vital:62114
- Description: The purpose of this study was to evaluate the successes and failures of multiculturalism in South Africa and Canada through the lens of critical multiculturalism as its theoretical frame. As Canada is widely-acknowledged as having one of the best multiculturalism policy and implementation programmes in the world, this study aimed to draw lessons from the Canadian model of multiculturalism in order to make recommendations to improve multicultural practices in South Africa. It is worth noting that multiculturalism in Canada is not perfect as government still struggles to implement inclusive and reconciliatory programmes for the previously colonised Indigenous communities. This study used a qualitative thematic analysis to enable a comparison of multiculturalism in these two countries. The findings of this study suggest that having a comprehensive multiculturalism policy is fundamental to ensure that aspirations of a socially cohesive multiculturalism are not merely philosophical, but are formulated into government policies, with guidelines for implementation through the guidance of critical multiculturalism theory. The findings of this study also suggest that the persistent racialised socio-economic inequalities in South Africa continue to undermine multiculturalism and nation-building efforts. , Thesis (MA) -- Faculty of Humanities, School of Governmental and Social Sciences, 2022
- Full Text:
- Date Issued: 2022-12
A model to predict the development of preeclampsia in South African women
- Authors: Smith, Nathan
- Date: 2022-12
- Subjects: Medical instruments and apparatus -- Design and construction , Hypertension in pregnancy -- measurements-- South Africa , Fetus -- Physiology
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/59980 , vital:62724
- Description: Preeclampsia is the new onset of hypertension and is one of the leading causes of maternal mortality in South Africa and the world. Preeclampsia is usually diagnosed after 20 weeks’ gestation. Due to South Africa’s poor level of antenatal care, the prediction of pregnant women at risk of developing preeclampsia can be an essential component of improving the level of antenatal. This study used an antenatal care dataset from a South African obstetrician. A review of the literature and existing systems was conducted to identify the eight risk factors. These risk factors are systolic blood pressure, diastolic blood pressure, maternal age, body mass index, diabetes status, hypertension history, nulliparity, and maternal disease. This study used antenatal care datasets from a South African obstetrician. Two models were developed that could accurately predict the development of preeclampsia, one before 16 weeks’ gestation and the other within three check-ups. The model was evaluated using five evaluation metrics: classification accuracy, area under the curve, precision, recall and F-Score. The results of this study show a promising future for the use of machine learning models in health care. To the researcher’s knowledge, this model is the first machine learning model for predicting preeclampsia using a South African dataset. Future work will revolve around validating the model on data collected from field studies in hospitals and clinics around South Africa , Thesis (MSc) -- Faculty of Science, School of Computer Science, Mathematics, Physics and Statistics, 2022
- Full Text:
- Date Issued: 2022-12
- Authors: Smith, Nathan
- Date: 2022-12
- Subjects: Medical instruments and apparatus -- Design and construction , Hypertension in pregnancy -- measurements-- South Africa , Fetus -- Physiology
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/59980 , vital:62724
- Description: Preeclampsia is the new onset of hypertension and is one of the leading causes of maternal mortality in South Africa and the world. Preeclampsia is usually diagnosed after 20 weeks’ gestation. Due to South Africa’s poor level of antenatal care, the prediction of pregnant women at risk of developing preeclampsia can be an essential component of improving the level of antenatal. This study used an antenatal care dataset from a South African obstetrician. A review of the literature and existing systems was conducted to identify the eight risk factors. These risk factors are systolic blood pressure, diastolic blood pressure, maternal age, body mass index, diabetes status, hypertension history, nulliparity, and maternal disease. This study used antenatal care datasets from a South African obstetrician. Two models were developed that could accurately predict the development of preeclampsia, one before 16 weeks’ gestation and the other within three check-ups. The model was evaluated using five evaluation metrics: classification accuracy, area under the curve, precision, recall and F-Score. The results of this study show a promising future for the use of machine learning models in health care. To the researcher’s knowledge, this model is the first machine learning model for predicting preeclampsia using a South African dataset. Future work will revolve around validating the model on data collected from field studies in hospitals and clinics around South Africa , Thesis (MSc) -- Faculty of Science, School of Computer Science, Mathematics, Physics and Statistics, 2022
- Full Text:
- Date Issued: 2022-12
A systematic review of published literature examining the impact of father absence on adolescent identity formation
- Authors: Fata, Hope Aneliswa
- Date: 2022-12
- Subjects: Absentee fathers , Adolescent analysis , Adolescent psychology
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10353/27039 , vital:66239
- Description: One of the major developmental crises an adolescent must overcome before becoming an adult is identity formation. Many studies focused on how the family influences the identity formation of adolescents, but little emphasis has been made specifically on how the absence of a father impacts the adolescent’s development of identity. This study aims to conduct a systematic review to examine the impact of absent fatherhood on the identity formation of adolescents. Several studies, from the year 2010 to date, have explored the impact of father absence on the identity formation of adolescents. The majority of studies conducted have been mostly quantitative and failed to explore the experiences of adolescents raised in absent-father households during this crucial stage of development. This study sought to add to the body of knowledge and bridge that gap by exploring the possible (negative or positive) impact of absent fatherhood in the identity-formation period of adolescents. This was a systematic review study that included a qualitative research design, whereby published literature and studies were identified through searching electronic databases. To synthesize and analyse the data, thematic analysis was used. This study’s exploration discovered that absent fatherhood can be experienced both positively and negatively by adolescents. Positively, it was found that a sense of independency developed in the adolescent and strengthens family relations and unity, with extended family members or external role models becoming more involved in the upbringing of the adolescent. Significantly, on the negative side, adolescents developed anger and resentment towards their absent fathers, questioning their absence and the individual’s sense of who they are and where they belong. , Thesis (MSoc) -- Faculty of Social Sciences and Humanities, 2022
- Full Text:
- Date Issued: 2022-12
- Authors: Fata, Hope Aneliswa
- Date: 2022-12
- Subjects: Absentee fathers , Adolescent analysis , Adolescent psychology
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10353/27039 , vital:66239
- Description: One of the major developmental crises an adolescent must overcome before becoming an adult is identity formation. Many studies focused on how the family influences the identity formation of adolescents, but little emphasis has been made specifically on how the absence of a father impacts the adolescent’s development of identity. This study aims to conduct a systematic review to examine the impact of absent fatherhood on the identity formation of adolescents. Several studies, from the year 2010 to date, have explored the impact of father absence on the identity formation of adolescents. The majority of studies conducted have been mostly quantitative and failed to explore the experiences of adolescents raised in absent-father households during this crucial stage of development. This study sought to add to the body of knowledge and bridge that gap by exploring the possible (negative or positive) impact of absent fatherhood in the identity-formation period of adolescents. This was a systematic review study that included a qualitative research design, whereby published literature and studies were identified through searching electronic databases. To synthesize and analyse the data, thematic analysis was used. This study’s exploration discovered that absent fatherhood can be experienced both positively and negatively by adolescents. Positively, it was found that a sense of independency developed in the adolescent and strengthens family relations and unity, with extended family members or external role models becoming more involved in the upbringing of the adolescent. Significantly, on the negative side, adolescents developed anger and resentment towards their absent fathers, questioning their absence and the individual’s sense of who they are and where they belong. , Thesis (MSoc) -- Faculty of Social Sciences and Humanities, 2022
- Full Text:
- Date Issued: 2022-12
Amendments to the labour relations act to curb violent and intractable strikes
- Authors: Mafa, Bonolo
- Date: 2022-12
- Subjects: labour union , Violence , Labour law
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/59841 , vital:62447
- Description: Since the dawn of South Africa’s constitutional democracy, the right to strike has been protected. It is perceived to be fundamental to orderly collective bargaining and the courts have stressed the need to ensure that it is not unjustifiably limited or undermined. In the collective bargaining process, employers and employees have mechanisms at their disposal and a power-play ensues. One such mechanism, for striking employees, is to withhold their labour in an effort to compel employers to succumb to their demands. Newspaper articles and the jurisprudence that has emerged from the courts illustrate that strike-related violence has become a destructive feature of industrial action.[1] Not only are strikes destructive to the economy but they are often associated with violence. The courts have been inundated with claims seeking to interdict violent and protracted strikes. While many commentators are of the view that strike violence is a result of underlying socio-economic issues, which should be addressed by the government, employers and the general public often bear the brunt of the destruction and mayhem left in the wake of violent strikes. In the wake of one of the worst tragedies, the Marikana massacre, which saw 32 striking miners shot and killed when police opened fire at Lonmin's operations in the Northwest province, the South African government, organised labour, and employers were compelled to take swift action to address the deficiencies that existed when it came to the constitutionally entrenched right to strike. The Labour Relations Amendment Act 8 of 2018 seeks to address this. Whilst some of the provisions introduced by the amendments have been the subject matter of litigation resulting in progressive judgments, other provisions are yet to be judicially tested. , Thesis (LLM) -- Faculty of Law, Department of Mercantile law, 2022
- Full Text:
- Date Issued: 2022-12
- Authors: Mafa, Bonolo
- Date: 2022-12
- Subjects: labour union , Violence , Labour law
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/59841 , vital:62447
- Description: Since the dawn of South Africa’s constitutional democracy, the right to strike has been protected. It is perceived to be fundamental to orderly collective bargaining and the courts have stressed the need to ensure that it is not unjustifiably limited or undermined. In the collective bargaining process, employers and employees have mechanisms at their disposal and a power-play ensues. One such mechanism, for striking employees, is to withhold their labour in an effort to compel employers to succumb to their demands. Newspaper articles and the jurisprudence that has emerged from the courts illustrate that strike-related violence has become a destructive feature of industrial action.[1] Not only are strikes destructive to the economy but they are often associated with violence. The courts have been inundated with claims seeking to interdict violent and protracted strikes. While many commentators are of the view that strike violence is a result of underlying socio-economic issues, which should be addressed by the government, employers and the general public often bear the brunt of the destruction and mayhem left in the wake of violent strikes. In the wake of one of the worst tragedies, the Marikana massacre, which saw 32 striking miners shot and killed when police opened fire at Lonmin's operations in the Northwest province, the South African government, organised labour, and employers were compelled to take swift action to address the deficiencies that existed when it came to the constitutionally entrenched right to strike. The Labour Relations Amendment Act 8 of 2018 seeks to address this. Whilst some of the provisions introduced by the amendments have been the subject matter of litigation resulting in progressive judgments, other provisions are yet to be judicially tested. , Thesis (LLM) -- Faculty of Law, Department of Mercantile law, 2022
- Full Text:
- Date Issued: 2022-12
An Afrocentric exploration of South African cultural-religious narratives of depression
- Authors: Conway-Cleaves, Matthew
- Date: 2022-12
- Subjects: Depression, Mental , Psychology and religion , Affect (Psychology) -- Religious aspects
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10353/26962 , vital:66206
- Description: The perceptions of causes of depression are diverse, formulated from many different factors such as personal experiences, education, generational and cultural influences, and religious beliefs. While there is a large body of literature on both depression and religion and culture, there is a limited amount available that synthesizes the findings of multiple different studies, finding key common themes. Therefore, this review aimed to develop a comprehensive understanding of how religious and cultural narratives describe and influence depression. As a result, a meta-ethnography was carried out to synthesise existing literature on cultural-religious narratives of depression within a South African context. Five published journal articles were sampled for translation and synthesis. From this process, three key themes were developed, namely Conflictual Coexistence, Observation-Based Discernment, and Status or Stigma. The result is a lens that is formed through a mixture of traditional cultural religious traditions and beliefs interconnected with contemporary ways of understanding and being. This framework for diagnosing and treating a mental illness is heavily reliant on observable symptoms. As a result, status or stigma can be attached to multiple aspects of the situation surrounding an individual with or suspected of having a mental illness. Stigmatisation can be noted to form a cycle that becomes inclusive of prognosis, finance/employment and not being able to fulfil culturally held expectations. As a result, future research, and therapeutic intervention of this mental disorder within this demographic will be better informed. , Thesis (MSoc) -- Faculty of Social Sciences and Humanities, 2022
- Full Text:
- Date Issued: 2022-12
- Authors: Conway-Cleaves, Matthew
- Date: 2022-12
- Subjects: Depression, Mental , Psychology and religion , Affect (Psychology) -- Religious aspects
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10353/26962 , vital:66206
- Description: The perceptions of causes of depression are diverse, formulated from many different factors such as personal experiences, education, generational and cultural influences, and religious beliefs. While there is a large body of literature on both depression and religion and culture, there is a limited amount available that synthesizes the findings of multiple different studies, finding key common themes. Therefore, this review aimed to develop a comprehensive understanding of how religious and cultural narratives describe and influence depression. As a result, a meta-ethnography was carried out to synthesise existing literature on cultural-religious narratives of depression within a South African context. Five published journal articles were sampled for translation and synthesis. From this process, three key themes were developed, namely Conflictual Coexistence, Observation-Based Discernment, and Status or Stigma. The result is a lens that is formed through a mixture of traditional cultural religious traditions and beliefs interconnected with contemporary ways of understanding and being. This framework for diagnosing and treating a mental illness is heavily reliant on observable symptoms. As a result, status or stigma can be attached to multiple aspects of the situation surrounding an individual with or suspected of having a mental illness. Stigmatisation can be noted to form a cycle that becomes inclusive of prognosis, finance/employment and not being able to fulfil culturally held expectations. As a result, future research, and therapeutic intervention of this mental disorder within this demographic will be better informed. , Thesis (MSoc) -- Faculty of Social Sciences and Humanities, 2022
- Full Text:
- Date Issued: 2022-12
An analysis of corporate power in South Africa’s public policy, 1996-2014
- Authors: Mvenene,Mbasa
- Date: 2022-12
- Subjects: Business enterprises --Law and legislation --South Africa , Political corruption – South Africa , South Africa -- Politics and government
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/59489 , vital:62122
- Description: The crux of this study is an analysis of the relations between corporate power and public policy in South Africa, in the period 1996 to 2014. The study’s focus is on corporate power’s influence on South Africa’s public policy and the various means through which power is exerted by the former to shape and control the latter, through the influence of the public policy process and outcome. The study achieves this by arguing that the GEAR and BEE policies failed to achieve their stated objectives, and instead serve as conduits for the exertion of inordinate public policy influence by corporate power. The study analyses how the placing of ANC leaders on major corporate boards has influenced South Africa’s public policy. The study will also examine the ways in which private corporate donations influence public officeholders in the governing ANC. The study also seeks to explore why the ANC with its seemingly progressive stance and history is susceptible to following neoliberal policies pushed for by political forces largely but not exclusively outside the party in the industries described to be targets of redistribution, mining, energy, and finance. The study asserts that private corporate donations made to the governing ANC have a corrupting effect on public policy and corrode democratic decision making and ultimately the public good. This study presents the argument that the ANC-aligned black political elite was co-opted into the structure of economic dominance with the GEAR and BEE policies and hence the prevalence of neoliberal economic policy in post-apartheid South Africa. The study also addresses the intricate relationship between the corporate and political elite, business, and money in South Africa’s elitist public policy landscape , Thesis (MA) -- Faculty of Humanities, School of Governmental and Social Sciences, 2022
- Full Text:
- Date Issued: 2022-12
- Authors: Mvenene,Mbasa
- Date: 2022-12
- Subjects: Business enterprises --Law and legislation --South Africa , Political corruption – South Africa , South Africa -- Politics and government
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/59489 , vital:62122
- Description: The crux of this study is an analysis of the relations between corporate power and public policy in South Africa, in the period 1996 to 2014. The study’s focus is on corporate power’s influence on South Africa’s public policy and the various means through which power is exerted by the former to shape and control the latter, through the influence of the public policy process and outcome. The study achieves this by arguing that the GEAR and BEE policies failed to achieve their stated objectives, and instead serve as conduits for the exertion of inordinate public policy influence by corporate power. The study analyses how the placing of ANC leaders on major corporate boards has influenced South Africa’s public policy. The study will also examine the ways in which private corporate donations influence public officeholders in the governing ANC. The study also seeks to explore why the ANC with its seemingly progressive stance and history is susceptible to following neoliberal policies pushed for by political forces largely but not exclusively outside the party in the industries described to be targets of redistribution, mining, energy, and finance. The study asserts that private corporate donations made to the governing ANC have a corrupting effect on public policy and corrode democratic decision making and ultimately the public good. This study presents the argument that the ANC-aligned black political elite was co-opted into the structure of economic dominance with the GEAR and BEE policies and hence the prevalence of neoliberal economic policy in post-apartheid South Africa. The study also addresses the intricate relationship between the corporate and political elite, business, and money in South Africa’s elitist public policy landscape , Thesis (MA) -- Faculty of Humanities, School of Governmental and Social Sciences, 2022
- Full Text:
- Date Issued: 2022-12
An analysis of factors affecting media freedom at the South African Broadcasting Corporation
- Authors: Mawandu, Charity Lufuno
- Date: 2022-12
- Subjects: Mass media – Censorship – South Africa , Freedom of the press --South Africa – History
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/59337 , vital:62065
- Description: This research sought to analyse factors that affect media freedom at the South African Broadcasting Corporation using a descriptive research design and qualitative research methodology. Studies and media reports show that the South African Broadcasting Corporation is facing a myriad of challenges including woes related to media freedom hampering its mandate to inform, educate and entertain the public of South Africa. There is a dearth of studies conducted to understand the media freedom challenges at the South African Broadcasting Corporation. A qualitative approach was used in data collection, and in-depth interviews were utilised as instruments to collect data from participants. Non-probability sampling in particular purposive sampling method was used to select 4 directors, 4 editors and 4 journalists at the South African Broadcasting Corporation. Data was analysed using thematic analysis. The findings show that challenges facing the South African Broadcasting Corporation include poor legal environment as the broadcaster lacks support from government to implement effective policies to protect employees and create a media freedom environment to allow workers to carry out their work independently. The study found that the political environment in the South African Broadcasting Corporation at affects media freedom. Some political 0rganisations, influential individuals and entities are meddling in the operation of the broadcaster by trying to influence the narrative of the content broadcasted. The finding revealed that economic environment at the broadcaster is affects media freedom. The broadcaster is struggling financially resulting in poor income for employees, retrenchments, and inability to run approved programmes. In the context of constitution and policies, there is need for the South African Broadcasting Corporation to develop strategies that will specifically address both internal and external political, economic, and legal challenges it is facing if it is to be a high performing, financially sustainable, digitised national public broadcaster that provides compelling, informative, educational, and entertaining content via all platforms. , Thesis (MA) -- Faculty of Humanities , School of language Media and Communications, 2022
- Full Text:
- Date Issued: 2022-12
- Authors: Mawandu, Charity Lufuno
- Date: 2022-12
- Subjects: Mass media – Censorship – South Africa , Freedom of the press --South Africa – History
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/59337 , vital:62065
- Description: This research sought to analyse factors that affect media freedom at the South African Broadcasting Corporation using a descriptive research design and qualitative research methodology. Studies and media reports show that the South African Broadcasting Corporation is facing a myriad of challenges including woes related to media freedom hampering its mandate to inform, educate and entertain the public of South Africa. There is a dearth of studies conducted to understand the media freedom challenges at the South African Broadcasting Corporation. A qualitative approach was used in data collection, and in-depth interviews were utilised as instruments to collect data from participants. Non-probability sampling in particular purposive sampling method was used to select 4 directors, 4 editors and 4 journalists at the South African Broadcasting Corporation. Data was analysed using thematic analysis. The findings show that challenges facing the South African Broadcasting Corporation include poor legal environment as the broadcaster lacks support from government to implement effective policies to protect employees and create a media freedom environment to allow workers to carry out their work independently. The study found that the political environment in the South African Broadcasting Corporation at affects media freedom. Some political 0rganisations, influential individuals and entities are meddling in the operation of the broadcaster by trying to influence the narrative of the content broadcasted. The finding revealed that economic environment at the broadcaster is affects media freedom. The broadcaster is struggling financially resulting in poor income for employees, retrenchments, and inability to run approved programmes. In the context of constitution and policies, there is need for the South African Broadcasting Corporation to develop strategies that will specifically address both internal and external political, economic, and legal challenges it is facing if it is to be a high performing, financially sustainable, digitised national public broadcaster that provides compelling, informative, educational, and entertaining content via all platforms. , Thesis (MA) -- Faculty of Humanities , School of language Media and Communications, 2022
- Full Text:
- Date Issued: 2022-12
An assessment of the role of the Speaker in the management of the National Assembly: the case of a democratic South Africa
- Authors: Lunyawo, Sipho
- Date: 2022-12
- Subjects: Legislative bodies -- South Africa -- Presiding officers , Mediation -- South Africa
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10353/26742 , vital:65976
- Description: This study interrogates the role of the Speaker in the management of the National Assembly in post-apartheid South Africa. The major focus is on the tenure of the fifth Speaker which was marked with widespread parliament disruptions largely orchestrated by opposition parties. The research employed a qualitative secondary data methodology in which data was collected from secondary sources such as government documents and newspapers. Content analysis and critical discourse analysis were used to analyze data. The Study found that the Speaker plays a fundamental role in the management of the National Assembly. Nevertheless, the study also established that there are numerous challenges faced by the Speaker in the management of the National Assembly. The challenges include mediating the chaos and conflicts among members. The study also established the nature and causes of chaos in the House as well as the efforts put in place by the Speaker to encourage fair debate among MPs. The study concludes that the role of the Speaker in monitoring and regulating the House is crucial in ensuring that there is order in the House at any given time. This is also because the Speaker plays a fundamental role as the Peacekeeper of the House and this emanates from the Speaker’s role in the management of the House. Based on the findings and conclusions of the Study, three recommendations were put forward and these are; embracing a system where the Speaker is independent, introducing hefty penalties against deliberate misconduct, and the use of previous unfavorable incidents to amend the rules of the House. , Thesis (MPA) -- Faculty of Management and Commerce, 2022
- Full Text:
- Date Issued: 2022-12
- Authors: Lunyawo, Sipho
- Date: 2022-12
- Subjects: Legislative bodies -- South Africa -- Presiding officers , Mediation -- South Africa
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10353/26742 , vital:65976
- Description: This study interrogates the role of the Speaker in the management of the National Assembly in post-apartheid South Africa. The major focus is on the tenure of the fifth Speaker which was marked with widespread parliament disruptions largely orchestrated by opposition parties. The research employed a qualitative secondary data methodology in which data was collected from secondary sources such as government documents and newspapers. Content analysis and critical discourse analysis were used to analyze data. The Study found that the Speaker plays a fundamental role in the management of the National Assembly. Nevertheless, the study also established that there are numerous challenges faced by the Speaker in the management of the National Assembly. The challenges include mediating the chaos and conflicts among members. The study also established the nature and causes of chaos in the House as well as the efforts put in place by the Speaker to encourage fair debate among MPs. The study concludes that the role of the Speaker in monitoring and regulating the House is crucial in ensuring that there is order in the House at any given time. This is also because the Speaker plays a fundamental role as the Peacekeeper of the House and this emanates from the Speaker’s role in the management of the House. Based on the findings and conclusions of the Study, three recommendations were put forward and these are; embracing a system where the Speaker is independent, introducing hefty penalties against deliberate misconduct, and the use of previous unfavorable incidents to amend the rules of the House. , Thesis (MPA) -- Faculty of Management and Commerce, 2022
- Full Text:
- Date Issued: 2022-12
An evaluation of hibiscus sabdariffa gold nanoparticles for the treatment of triple negative breast cancer
- Authors: Reddy, Nireshini
- Date: 2022-12
- Subjects: Breast--Cancer--Treatment--Technological innovations , Nanomedicine – South Africa , Roselle
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/59945 , vital:62697
- Description: Cancer is responsible for the millions of deaths worldwide every year, being ranked as the second leading cause of mortality in the world. Triple negative breast cancer (TNBC) is the most severe type of breast cancer, as it is the most aggressive and difficult to treat. Current treatment methods involve surgery, hormonal-, radiation- and chemotherapy. These are costly and often have severe adverse effects. There has been increasing research in the development of alternative treatment methods to reduce the side effects of cancer therapeutics, as well as the cost. The rapidly growing field of nanotechnology has allowed for the incorporation of several diagnostic, targeting, and therapeutic agents into nanomaterials for cancer treatment. The application of gold nanoparticles (AuNPs) in the diagnosis and treatment of various types of cancers has been widely investigated. AuNPs vary in size, shape, and structure, allowing for the development of diverse formulations for various treatments. The use of green materials, particularly plant material, to synthesise nanomaterials has allowed for the safe, cost-friendly and eco-friendly production of AuNPs that can be used to treat TNBC. The aim of this study was to evaluate the efficiency of green AuNPs synthesised with Hibiscus sabdariffa to treat TNBC in a pilot murine model. Spherical AuNPs were synthesised using an aqueous extract of the calyces of this plant. The AuNPs were characterised using UV-Vis spectrometry, dynamic light scattering, high resolution – transmission electron microscopy, and in vitro stability testing. A cell viability assay showed that these AuNPs exhibited cytotoxicity towards E0771 cells in a dose-dependent manner, where cells treated with the highest concentration of AuNPs (250 µg/mL) exhibited the lowest cell viability (7%). During the in vivo pilot study, C57BL/6 mice were inoculated with TNBC using the E0771 cells. It was found that TNBC had rapidly spread, resulting in metastasis in the liver, as well as omentum and mesentery. This resulted in a number of mice dying; therefore, shortening treatment time of the AuNPs. It is suggested that AuNP treatment may have exacerbated mouse death by promoting ROS production in metastasised tissue, suggesting that AuNP treatment may not be suitable for stage 4 TNBC. Tumor analysis of caspase-3 content showed that the AuNPs exhibited potential pro-apoptotic activity in the tumours, prompting further research into the tumour uptake and apoptotic mechanism of these AuNPs. , Thesis (MSc) -- Faculty of Science, School of Biomolecular and Chemical Sciences, 2022
- Full Text:
- Date Issued: 2022-12
- Authors: Reddy, Nireshini
- Date: 2022-12
- Subjects: Breast--Cancer--Treatment--Technological innovations , Nanomedicine – South Africa , Roselle
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/59945 , vital:62697
- Description: Cancer is responsible for the millions of deaths worldwide every year, being ranked as the second leading cause of mortality in the world. Triple negative breast cancer (TNBC) is the most severe type of breast cancer, as it is the most aggressive and difficult to treat. Current treatment methods involve surgery, hormonal-, radiation- and chemotherapy. These are costly and often have severe adverse effects. There has been increasing research in the development of alternative treatment methods to reduce the side effects of cancer therapeutics, as well as the cost. The rapidly growing field of nanotechnology has allowed for the incorporation of several diagnostic, targeting, and therapeutic agents into nanomaterials for cancer treatment. The application of gold nanoparticles (AuNPs) in the diagnosis and treatment of various types of cancers has been widely investigated. AuNPs vary in size, shape, and structure, allowing for the development of diverse formulations for various treatments. The use of green materials, particularly plant material, to synthesise nanomaterials has allowed for the safe, cost-friendly and eco-friendly production of AuNPs that can be used to treat TNBC. The aim of this study was to evaluate the efficiency of green AuNPs synthesised with Hibiscus sabdariffa to treat TNBC in a pilot murine model. Spherical AuNPs were synthesised using an aqueous extract of the calyces of this plant. The AuNPs were characterised using UV-Vis spectrometry, dynamic light scattering, high resolution – transmission electron microscopy, and in vitro stability testing. A cell viability assay showed that these AuNPs exhibited cytotoxicity towards E0771 cells in a dose-dependent manner, where cells treated with the highest concentration of AuNPs (250 µg/mL) exhibited the lowest cell viability (7%). During the in vivo pilot study, C57BL/6 mice were inoculated with TNBC using the E0771 cells. It was found that TNBC had rapidly spread, resulting in metastasis in the liver, as well as omentum and mesentery. This resulted in a number of mice dying; therefore, shortening treatment time of the AuNPs. It is suggested that AuNP treatment may have exacerbated mouse death by promoting ROS production in metastasised tissue, suggesting that AuNP treatment may not be suitable for stage 4 TNBC. Tumor analysis of caspase-3 content showed that the AuNPs exhibited potential pro-apoptotic activity in the tumours, prompting further research into the tumour uptake and apoptotic mechanism of these AuNPs. , Thesis (MSc) -- Faculty of Science, School of Biomolecular and Chemical Sciences, 2022
- Full Text:
- Date Issued: 2022-12
An exploration of teachers’ views and experiences on the effects of community Violence on learners at Lusikisiki
- Authors: Gwarubana, Nolufefe
- Date: 2022-12
- Subjects: Kerr-Soltis model -- Lusikisiki , Posttraumatic Stress Disorder -- Lusikisiki
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/60144 , vital:63206
- Description: A significant number of children in the South African context are exposed to community violence and become traumatised. In South Africa, many learners bring trauma histories into the classroom. To attend to this problem, it is important to understand how Exposure to Community Violence (ECV) affects learners, how this exposure is manifested in the classroom, and how teachers and schools can best support and mitigate adverse outcomes for trauma-impacted learners. The study aimed to understand teachers’ views and experiences on the effects of community violence on learners and the nature of the support that they offer to learners with trauma related to community violence. An exploratory design was used within which qualitative data was collected using semi-structured interviews. Data was gathered from Mkhankomo Full Service School, which is located in Lusikisiki. A maximum number of 10 teachers participated in the study and interviews were audio-recorded. Results of this study provide insight into the effects of community violence on the learners who were victims either directly or as witnesses. Based on thematic analysis, the results clearly showed that the effects of community violence were found to be mainly emotional, behavioural and psychological. All these effects were seen to affect the learners’ performance at school in the long run. In addition, the findings point to the teachers showing a willingness to support learners exposed to community violence, however, they felt ill-equipped to do so given that they had never worked with learners exposed to trauma. Also, in their attempts to support learners, teachers implemented support systems such as offering individual lessons to learners and additionally assuming supportive roles such as that of mentor and mother. Moreover, the findings indicated that teachers were not provided with any v training to help them work with learners exposed to trauma and their expectations for the Department of Basic Education to assist were not met. Consequently, the study provides an understanding of the effects of community violence on learners from the perspectives of teachers in the school. It also assists with information regarding teachers’ preparedness and ability to respond to learners’ chronic exposure to community violence. Furthermore, this study gives an understanding of teachers’ approach to supporting learners experiencing traumatic stress in the classroom. , Thesis (MA) -- Faculty of Health Sciences, 2022
- Full Text:
- Date Issued: 2022-12
- Authors: Gwarubana, Nolufefe
- Date: 2022-12
- Subjects: Kerr-Soltis model -- Lusikisiki , Posttraumatic Stress Disorder -- Lusikisiki
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/60144 , vital:63206
- Description: A significant number of children in the South African context are exposed to community violence and become traumatised. In South Africa, many learners bring trauma histories into the classroom. To attend to this problem, it is important to understand how Exposure to Community Violence (ECV) affects learners, how this exposure is manifested in the classroom, and how teachers and schools can best support and mitigate adverse outcomes for trauma-impacted learners. The study aimed to understand teachers’ views and experiences on the effects of community violence on learners and the nature of the support that they offer to learners with trauma related to community violence. An exploratory design was used within which qualitative data was collected using semi-structured interviews. Data was gathered from Mkhankomo Full Service School, which is located in Lusikisiki. A maximum number of 10 teachers participated in the study and interviews were audio-recorded. Results of this study provide insight into the effects of community violence on the learners who were victims either directly or as witnesses. Based on thematic analysis, the results clearly showed that the effects of community violence were found to be mainly emotional, behavioural and psychological. All these effects were seen to affect the learners’ performance at school in the long run. In addition, the findings point to the teachers showing a willingness to support learners exposed to community violence, however, they felt ill-equipped to do so given that they had never worked with learners exposed to trauma. Also, in their attempts to support learners, teachers implemented support systems such as offering individual lessons to learners and additionally assuming supportive roles such as that of mentor and mother. Moreover, the findings indicated that teachers were not provided with any v training to help them work with learners exposed to trauma and their expectations for the Department of Basic Education to assist were not met. Consequently, the study provides an understanding of the effects of community violence on learners from the perspectives of teachers in the school. It also assists with information regarding teachers’ preparedness and ability to respond to learners’ chronic exposure to community violence. Furthermore, this study gives an understanding of teachers’ approach to supporting learners experiencing traumatic stress in the classroom. , Thesis (MA) -- Faculty of Health Sciences, 2022
- Full Text:
- Date Issued: 2022-12
An investigation into the psychological impact of unemployment and coping mechanisms amongst graduates in Pietermaritzburg
- Authors: Nkasa, Nonjabulo Fortunate
- Date: 2022-12
- Subjects: Unemployment -- Social aspects , Mental health
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/60209 , vital:63539
- Description: Graduates expect to find employment after completing their tertiary qualifications, but they often face various challenges in finding employment. These challenges may be due to a variety of factors such as the type of qualification, structural changes in the economy, lack of experience, or the lack of relevant social networks. This has the potential to affect a graduate’s psychological well-being. The current study explored the psychological impact of unemployment in 100 unemployed graduates between 21 and 35 years of age in Pietermaritzburg. The study was quantitative and used two questionnaires, the GHQ-12 and a self-designed questionnaire, to collect data. Purposive sampling was used to obtain research participants. The Excel spreadsheet and a statistical software package called JASP (2020, version 0.12) was used to analyse data. The findings revealed that unemployment had a negative impact on the participants’ psychological well-being. Participants experienced feelings of high anxiety and depression, and felt stigmatised. Participants also felt shame and experienced lower self-esteem. Unemployment had a financial impact on participants, including financial dependency on family and friends. Some participants blamed themselves, the government system, and the education system for their unemployment. Participants reported to have a positive attitude towards employment, including remaining optimistic about their chances of finding employment. Participants used adaptive coping mechanisms, such as keeping a positive attitude, and maladaptive coping mechanisms, such as hiding their feelings. Further research needs to focus on psychological services that could assist unemployed graduates to find employment through building and maintaining their self-esteem and confidence which are key factors when initially seeking and obtaining work. Unemployment and its impact on psychological well-being has been shown to be to be a complex subject that requires intervention from different parties such as employers and health-care workers, as well as the education system. Keywords: Coping, graduates, psychological impact and unemployment , Thesis (MA) -- Faculty of Health Sciences, 2022
- Full Text:
- Date Issued: 2022-12
- Authors: Nkasa, Nonjabulo Fortunate
- Date: 2022-12
- Subjects: Unemployment -- Social aspects , Mental health
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/60209 , vital:63539
- Description: Graduates expect to find employment after completing their tertiary qualifications, but they often face various challenges in finding employment. These challenges may be due to a variety of factors such as the type of qualification, structural changes in the economy, lack of experience, or the lack of relevant social networks. This has the potential to affect a graduate’s psychological well-being. The current study explored the psychological impact of unemployment in 100 unemployed graduates between 21 and 35 years of age in Pietermaritzburg. The study was quantitative and used two questionnaires, the GHQ-12 and a self-designed questionnaire, to collect data. Purposive sampling was used to obtain research participants. The Excel spreadsheet and a statistical software package called JASP (2020, version 0.12) was used to analyse data. The findings revealed that unemployment had a negative impact on the participants’ psychological well-being. Participants experienced feelings of high anxiety and depression, and felt stigmatised. Participants also felt shame and experienced lower self-esteem. Unemployment had a financial impact on participants, including financial dependency on family and friends. Some participants blamed themselves, the government system, and the education system for their unemployment. Participants reported to have a positive attitude towards employment, including remaining optimistic about their chances of finding employment. Participants used adaptive coping mechanisms, such as keeping a positive attitude, and maladaptive coping mechanisms, such as hiding their feelings. Further research needs to focus on psychological services that could assist unemployed graduates to find employment through building and maintaining their self-esteem and confidence which are key factors when initially seeking and obtaining work. Unemployment and its impact on psychological well-being has been shown to be to be a complex subject that requires intervention from different parties such as employers and health-care workers, as well as the education system. Keywords: Coping, graduates, psychological impact and unemployment , Thesis (MA) -- Faculty of Health Sciences, 2022
- Full Text:
- Date Issued: 2022-12
An It risk management implementation strategy for a non-profit organisation in south africa
- Authors: Exner, Ulandi
- Date: 2022-12
- Subjects: ITIL (Information technology management standard) -- South Africa , Nonprofit organizations -- South africa
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/59370 , vital:62075
- Description: All organisations, for-profit or non-profit, have strategic objectives as their raison d’être. The achievement of these objectives is challenged by the occurrence and impact of unexpected events, commonly referred to as risks. The Digital Revolution in the late 70s introduced computers and the internet and opened up a whole new way of life. It also brought new challenges, namely IT risk. IT risk is business risk. Non-profit organisations, whose main priority is to maximise its available resources to serve the needs of their stakeholders and community, do not have adequate IT risk management practices in place because it is not top of mind for them. An effective IT risk management strategy provides several enhanced capabilities for organisations. Non-profit organisations have IT risk management standards, frameworks and methodologies to choose from, but these organisations do not have the required financial means and expertise or possibly the necessary appetite to implement these frameworks successfully. The primary objective of the study is to develop a proposed IT risk management implementation strategy for non-profit organisations to aid in the management of IT risk. The design science research paradigm was used for the study. Qualitative and quantitative research methods were used to understand the current landscape of a non-profit organisation in so far as their approach to managing IT risk. The findings of the literature review and mixed method research were used to develop a proposed IT risk implementation strategy. The evaluation of the implementation strategy in terms of its effectiveness and utility will form part of a future study. The proposed implementation strategy can be considered as an instrument for the NPO to aid in the management of IT risk. The conclusion of this study contributes to the field of IT risk research of non-profit organisations in South Africa. , Thesis (MA) -- Faculty of Engineering, the Built Environment, and Technology, 2022
- Full Text:
- Date Issued: 2022-12
- Authors: Exner, Ulandi
- Date: 2022-12
- Subjects: ITIL (Information technology management standard) -- South Africa , Nonprofit organizations -- South africa
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/59370 , vital:62075
- Description: All organisations, for-profit or non-profit, have strategic objectives as their raison d’être. The achievement of these objectives is challenged by the occurrence and impact of unexpected events, commonly referred to as risks. The Digital Revolution in the late 70s introduced computers and the internet and opened up a whole new way of life. It also brought new challenges, namely IT risk. IT risk is business risk. Non-profit organisations, whose main priority is to maximise its available resources to serve the needs of their stakeholders and community, do not have adequate IT risk management practices in place because it is not top of mind for them. An effective IT risk management strategy provides several enhanced capabilities for organisations. Non-profit organisations have IT risk management standards, frameworks and methodologies to choose from, but these organisations do not have the required financial means and expertise or possibly the necessary appetite to implement these frameworks successfully. The primary objective of the study is to develop a proposed IT risk management implementation strategy for non-profit organisations to aid in the management of IT risk. The design science research paradigm was used for the study. Qualitative and quantitative research methods were used to understand the current landscape of a non-profit organisation in so far as their approach to managing IT risk. The findings of the literature review and mixed method research were used to develop a proposed IT risk implementation strategy. The evaluation of the implementation strategy in terms of its effectiveness and utility will form part of a future study. The proposed implementation strategy can be considered as an instrument for the NPO to aid in the management of IT risk. The conclusion of this study contributes to the field of IT risk research of non-profit organisations in South Africa. , Thesis (MA) -- Faculty of Engineering, the Built Environment, and Technology, 2022
- Full Text:
- Date Issued: 2022-12
Beauty from Ashes:short term postfire regeneration of dune fynbos -thicket vegetation in the South Eastern Cape floristic region
- Authors: Gcina, Sinenjongo
- Date: 2022-12
- Subjects: Fynbos ecology – Nelson Mandela University Campus Nature Reserve , Forest fires -- Prevention and control
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/59666 , vital:62319
- Description: Aim This study aims to provide an understanding and a description of the short-term postfire regeneration and ecology of the fynbos-thicket vegetation on a coastal dune system in the southeastern Cape Floristic Region. Another aim is to assess the recovery of the vegetation community by assessing the growth forms and the disturbance response across a range of species from thicket and fynbos communities and to provide a belowground bud bank classification for each of these species in the coastal dune systems. Location The study site was the Mandela University Reserve and the Noordhoek dune fields, situated in Gqeberha, Eastern Cape, which is part of the south-eastern Cape Floristic Region. The study site hosts thicket-fynbos mosaic vegetation type that occurs in a Mediterranean-Climate Ecosystem (MCE). Methods Firstly, field observations and photographs of plant species were taken weekly to assess and identify the species that were emerging and persisting in the dune system in the first 12 months postfire. Phenological events of the species that emerged (e.g., flowering, fruiting, leaf growth, leaf yellowing, and leaf abscission) were also observed and reported on. Secondly, an excavation of 21 species (e.g., Jamesbrittenia microphylla, Euclea racemosa, Olea exasperata, Searsia laevigata) was conducted to classify the species into their belowground bud bank types. Results There was a rapid emergence of resprouters (facultative resprouters and obligate resprouters) in the first 12 months postfire. This was followed by their growth; primarily occurring after the rainfall events. The dominant resprouting species (facultative resprouters and obligate resprouters) entered the system two weeks after the fire. There was a significant difference in the time to the first emergence of the different regeneration groups postfire (P < 0.001): on average, obligate sprouters (OS) appeared 1 month after fire – two months earlier than facultative sprouters (FS) and four months earlier than non-sprouters (NS). There was no statistical evidence to suggest that the FS and non-sprouters NS emerged at different times postfire; however, most NS species were observed in the system 5 months after fire. 4 Exceptions were the NS species Pelargonium grossularoides and Mesembryanthemum aitonis, both annuals that emerged 1 month after fire. A wide range of OS species that appeared earlier in the system (e.g., Euclea racemosa, Olea exasperata, Searsia laevigata, and Lauridia tetragona) exhibit underground lateral growth with belowground bud banks (BBBs) from which they recover after disturbance. In total, six BBB types were recorded in this study, namely: bud-bearing root, rhizome, rhizophore, woody rhizome, stem tuber, and corms. The bud-bearing root from woody species was the dominant BBB in this system. Main conclusion The return of species that occurs in the first year after fire occurs rapidly in the first 2 months as resprouting species (primarily OS) appear in the system. Following this, the rate of return of species decreases as reseeding species (primarily NS) gradually reestablish and occupy the gaps in the dune fynbos-thicket vegetation. This study has shown that plant species in this ecosystem are adapted to fire disturbance as their populations are able to reestablish through various regeneration strategies, including resprouting from different types of BBB. , Thesis (MSc) -- Faculty of Science, School of Environmental Sciences, 2022
- Full Text:
- Date Issued: 2022-12
- Authors: Gcina, Sinenjongo
- Date: 2022-12
- Subjects: Fynbos ecology – Nelson Mandela University Campus Nature Reserve , Forest fires -- Prevention and control
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/59666 , vital:62319
- Description: Aim This study aims to provide an understanding and a description of the short-term postfire regeneration and ecology of the fynbos-thicket vegetation on a coastal dune system in the southeastern Cape Floristic Region. Another aim is to assess the recovery of the vegetation community by assessing the growth forms and the disturbance response across a range of species from thicket and fynbos communities and to provide a belowground bud bank classification for each of these species in the coastal dune systems. Location The study site was the Mandela University Reserve and the Noordhoek dune fields, situated in Gqeberha, Eastern Cape, which is part of the south-eastern Cape Floristic Region. The study site hosts thicket-fynbos mosaic vegetation type that occurs in a Mediterranean-Climate Ecosystem (MCE). Methods Firstly, field observations and photographs of plant species were taken weekly to assess and identify the species that were emerging and persisting in the dune system in the first 12 months postfire. Phenological events of the species that emerged (e.g., flowering, fruiting, leaf growth, leaf yellowing, and leaf abscission) were also observed and reported on. Secondly, an excavation of 21 species (e.g., Jamesbrittenia microphylla, Euclea racemosa, Olea exasperata, Searsia laevigata) was conducted to classify the species into their belowground bud bank types. Results There was a rapid emergence of resprouters (facultative resprouters and obligate resprouters) in the first 12 months postfire. This was followed by their growth; primarily occurring after the rainfall events. The dominant resprouting species (facultative resprouters and obligate resprouters) entered the system two weeks after the fire. There was a significant difference in the time to the first emergence of the different regeneration groups postfire (P < 0.001): on average, obligate sprouters (OS) appeared 1 month after fire – two months earlier than facultative sprouters (FS) and four months earlier than non-sprouters (NS). There was no statistical evidence to suggest that the FS and non-sprouters NS emerged at different times postfire; however, most NS species were observed in the system 5 months after fire. 4 Exceptions were the NS species Pelargonium grossularoides and Mesembryanthemum aitonis, both annuals that emerged 1 month after fire. A wide range of OS species that appeared earlier in the system (e.g., Euclea racemosa, Olea exasperata, Searsia laevigata, and Lauridia tetragona) exhibit underground lateral growth with belowground bud banks (BBBs) from which they recover after disturbance. In total, six BBB types were recorded in this study, namely: bud-bearing root, rhizome, rhizophore, woody rhizome, stem tuber, and corms. The bud-bearing root from woody species was the dominant BBB in this system. Main conclusion The return of species that occurs in the first year after fire occurs rapidly in the first 2 months as resprouting species (primarily OS) appear in the system. Following this, the rate of return of species decreases as reseeding species (primarily NS) gradually reestablish and occupy the gaps in the dune fynbos-thicket vegetation. This study has shown that plant species in this ecosystem are adapted to fire disturbance as their populations are able to reestablish through various regeneration strategies, including resprouting from different types of BBB. , Thesis (MSc) -- Faculty of Science, School of Environmental Sciences, 2022
- Full Text:
- Date Issued: 2022-12
Challenges faced by healthcare professionals in reporting near miss incidents in a hospital, at the Amathole District, Eastern Cape Province, South Africa
- Authors: Ntlanganiso, Lindiwe
- Date: 2022-12
- Subjects: Industrial accidents , Accident investigation
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10353/27094 , vital:66276
- Description: Background Recording and investigation of NMIs can provide valuable information on monitoring and enhancing patient safety in the healthcare facilities. This in turn, can reduce the likelihood of medico-legal claims. Regardless of attempts to establish efficient incident reporting systems across the entire healthcare industry, underreporting of errors persists worldwide. Therefore, not only do near miss incidents serve as early warning signs of impending potential failure in the healthcare system, but they also provide a chance for patient safety improvement. With that in mind, this study was undertaken to investigate challenges faced by health care professionals in reporting near miss incidents at a hospital in the Amathole District, in the Eastern Cape province of South Africa. Aim The aim of the study was to develop recommendations for healthcare management and healthcare professionals on how to better manage NMIs, and by identifying the challenges faced by health care professionals and the impact they have on the quality of care at one state-funded district hospital. Setting The study was conducted with healthcare professionals at a district hospital in the Amathole District, Eastern Cape Province, South Africa. Methods This study used a mixed method study design. Purposive and convenience sampling were used for participants’ selection for the study. Quantitative data was collected using the WHO Near-Miss Approach while individual and focus group interviews with healthcare professionals were carried out for collecting qualitative data. The maternity and neonatal intensive care units were identified as the two high-risk areas from which most medical negligence claims are lodged. The number of complications that occurred in each month of the year 2019 was determined by using components of the WHO near miss approach. The researcher adopted this approach to serve as a baseline assessment. Data was analysed using both Nvivo Version 10 and SPSS Version 20. Findings The challenges that healthcare professionals face in reporting near miss incidents at the study site included lack of knowledge about the reporting tool and system, inability to identify a near miss incident and healthcare professional attitudes and practices. The document review revealed that the NMIs are existent but not reported on the prescribed reporting system, a total of 210 actual incidents had occurred in the maternity and neonatal units of the hospital, which accounts for 62% of the 357 deliveries in the year 2019. Conclusion Based on the study result and findings, the healthcare system should shift towards a proactive rather than a reactive approach to medical and clinical errors. Continuously reducing the incidence of all patient safety incidents requires improved prevention strategies and effective strategies for recovery from possible medico-legal claims. The study further suggests that additional focus should be placed on NMI reporting and investigation so that operative improvement plans can be developed, implemented, monitored and evaluated. In essence, these improvement plans should be designed to progress patient care, reduce avoidable PSIs and reduce medico-legal claims. , Thesis (MCur) -- Faculty of Health Sciences, 2022
- Full Text:
- Date Issued: 2022-12
- Authors: Ntlanganiso, Lindiwe
- Date: 2022-12
- Subjects: Industrial accidents , Accident investigation
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10353/27094 , vital:66276
- Description: Background Recording and investigation of NMIs can provide valuable information on monitoring and enhancing patient safety in the healthcare facilities. This in turn, can reduce the likelihood of medico-legal claims. Regardless of attempts to establish efficient incident reporting systems across the entire healthcare industry, underreporting of errors persists worldwide. Therefore, not only do near miss incidents serve as early warning signs of impending potential failure in the healthcare system, but they also provide a chance for patient safety improvement. With that in mind, this study was undertaken to investigate challenges faced by health care professionals in reporting near miss incidents at a hospital in the Amathole District, in the Eastern Cape province of South Africa. Aim The aim of the study was to develop recommendations for healthcare management and healthcare professionals on how to better manage NMIs, and by identifying the challenges faced by health care professionals and the impact they have on the quality of care at one state-funded district hospital. Setting The study was conducted with healthcare professionals at a district hospital in the Amathole District, Eastern Cape Province, South Africa. Methods This study used a mixed method study design. Purposive and convenience sampling were used for participants’ selection for the study. Quantitative data was collected using the WHO Near-Miss Approach while individual and focus group interviews with healthcare professionals were carried out for collecting qualitative data. The maternity and neonatal intensive care units were identified as the two high-risk areas from which most medical negligence claims are lodged. The number of complications that occurred in each month of the year 2019 was determined by using components of the WHO near miss approach. The researcher adopted this approach to serve as a baseline assessment. Data was analysed using both Nvivo Version 10 and SPSS Version 20. Findings The challenges that healthcare professionals face in reporting near miss incidents at the study site included lack of knowledge about the reporting tool and system, inability to identify a near miss incident and healthcare professional attitudes and practices. The document review revealed that the NMIs are existent but not reported on the prescribed reporting system, a total of 210 actual incidents had occurred in the maternity and neonatal units of the hospital, which accounts for 62% of the 357 deliveries in the year 2019. Conclusion Based on the study result and findings, the healthcare system should shift towards a proactive rather than a reactive approach to medical and clinical errors. Continuously reducing the incidence of all patient safety incidents requires improved prevention strategies and effective strategies for recovery from possible medico-legal claims. The study further suggests that additional focus should be placed on NMI reporting and investigation so that operative improvement plans can be developed, implemented, monitored and evaluated. In essence, these improvement plans should be designed to progress patient care, reduce avoidable PSIs and reduce medico-legal claims. , Thesis (MCur) -- Faculty of Health Sciences, 2022
- Full Text:
- Date Issued: 2022-12
Characterising termite mound spatial patterns in the Eastern Cape Karoo : applying drone remote sensing,GIS and spatial statistics
- Mngcele, Lizalise Sive Nqaba
- Authors: Mngcele, Lizalise Sive Nqaba
- Date: 2022-12
- Subjects: Drone aircraft in remote sensing – Eastern Cape Karoo , Termites , Geographic information Systems – South Africa
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/59555 , vital:62169
- Description: The Eastern Cape Karoo in South Africa has been earmarked for potential Shale Gas development, which has necessitated the understanding of existing ecosystems to be quantiĄed pre-development, in order to have a baseline against which the exploration can be monitored. Termite mounds as baseline mechanisms, are known to be sensitive to ecosystem disturbance and because of their abundance in the exploration zone, have been studied as indicator species. They are both a surface and subsurface phenomena which makes them an ideal baseline monitoring mechanism. Termite mound height, basal circumference and geospatial data was collected against natural and anthropogenic factors: elevation, vegetation, water, soil, geology, human settlements and roads. Mound distributions were observed across four study sites, and seven plots, using a DJI Phantom 4 Pro drone, an aerial and ground survey. Observed mound data on the drone and aerial survey was compared to that of the ground survey. Overall, the drone survey outperformed the aerial survey in recording accurate termite mound data. This was largely attributed to the scale of the study which gave the drone a competitive advantage. It allowed for drone data to be collected at 40 m altitude with an image resolution of 2-6 cm/pixel on each plot. In addition, drone detection accuracy was improved through the ability to generate digital surface models (DSMs) through point clouds and overlaying them with orthomosaics. Considering observed mound spatial point patterns, both the drone and aerial survey were more than 50% percent consistent with the ground survey, although the drone survey detected 28.57% more accurate mound spatial point patterns than the aerial survey. , Thesis (MSc) -- Faculty of Science, School of Environmental Sciences, 2022
- Full Text:
- Date Issued: 2022-12
- Authors: Mngcele, Lizalise Sive Nqaba
- Date: 2022-12
- Subjects: Drone aircraft in remote sensing – Eastern Cape Karoo , Termites , Geographic information Systems – South Africa
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/59555 , vital:62169
- Description: The Eastern Cape Karoo in South Africa has been earmarked for potential Shale Gas development, which has necessitated the understanding of existing ecosystems to be quantiĄed pre-development, in order to have a baseline against which the exploration can be monitored. Termite mounds as baseline mechanisms, are known to be sensitive to ecosystem disturbance and because of their abundance in the exploration zone, have been studied as indicator species. They are both a surface and subsurface phenomena which makes them an ideal baseline monitoring mechanism. Termite mound height, basal circumference and geospatial data was collected against natural and anthropogenic factors: elevation, vegetation, water, soil, geology, human settlements and roads. Mound distributions were observed across four study sites, and seven plots, using a DJI Phantom 4 Pro drone, an aerial and ground survey. Observed mound data on the drone and aerial survey was compared to that of the ground survey. Overall, the drone survey outperformed the aerial survey in recording accurate termite mound data. This was largely attributed to the scale of the study which gave the drone a competitive advantage. It allowed for drone data to be collected at 40 m altitude with an image resolution of 2-6 cm/pixel on each plot. In addition, drone detection accuracy was improved through the ability to generate digital surface models (DSMs) through point clouds and overlaying them with orthomosaics. Considering observed mound spatial point patterns, both the drone and aerial survey were more than 50% percent consistent with the ground survey, although the drone survey detected 28.57% more accurate mound spatial point patterns than the aerial survey. , Thesis (MSc) -- Faculty of Science, School of Environmental Sciences, 2022
- Full Text:
- Date Issued: 2022-12
Co-development of online violence against women and girls prevention interventions with school-going adolescents
- Authors: Ndungu, Jane
- Date: 2022-12
- Subjects: Prevention , Transformative communication
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/60188 , vital:63214
- Description: Background: Violence against women and girls (VAWG)amongst adolescents remains a global public health problem. Globally, an estimated 24 per cent of girls aged 15-19 are reported to have experienced VAWG before the age of 20. Experience of VAWG has far reaching health and educational consequences. Thus, the prevention of VAWG needs to be a priority. In recent years, there has been an increase in web-based or online violence prevention interventions. However, these interventions are either secondary prevention interventions, or primary prevention interventions, focused on emergency or protective solutions. Current evidence indicates that group-based participatory violence prevention interventions are an important approach to the primary prevention of VAWG but there remains a gap in understanding if these interventions can be delivered online. Further, it remains unclear if co-development of group-based participatory violence prevention interventions with young people – which has been proposed to enhance contextualisation of interventions – can occur online. Goal and specific objectives: This study aimed to explore and understand the feasibility of co-developing an online group-based participatory VAWG prevention intervention for adolescents. The specific objectives of this study were (i) from the perspective of experts understand the feasibility, acceptability and challenges of a group-based participatory VAWG prevention intervention developed and delivered online, (ii) from the perspective of adolescents, understand the feasibility, acceptability and challenges of a group-based participatory VAWG prevention intervention developed and delivered online and (iii) Undertake an online co-development process of an online group-based participatory VAWG prevention intervention with adolescents. ix Methods: This qualitative study was conducted in Gqeberha (formerly known as Port Elizabeth), in the Nelson Mandela Bay municipality, Eastern Cape Province of South Africa. The study was guided by the intervention development framework: 6 Essential Steps for Quality Intervention Development (6SQuID). Data were collected online using in-depth semi-structured interviews, with 20 experts sampled through convenience and snowball strategies and 18 purposively sampled adolescents, to achieve objectives one and two. This was then followed by a co-development process with high school-going adolescents (ages 18- 19 years) to achieve objective three. In the co-development process, the candidate worked with a small group of adolescents (four adolescents) for five sessions online, over a period of two weeks. In these sessions, the co-development team engaged in discussions on sexual violence, which resulted in creation of a problem tree and populated a theory of change table. Data were transcribed in English, verbatim and analysed using thematic network analyses. Findings: Findings for the first objective about understanding from the perspective of experts the feasibility, acceptability and challenges of a group-based participatory VAWG prevention intervention developed and delivered online, showed experts identified several opportunities for these. Specifically, experts identified the potential of bringing these interventions to scale, which has been a challenge for in-person interventions, as well as accessing hard to reach groups, such as people in conflict settings, those on the move and people with limited mobility. However, experts felt there were many complex questions in the development of an online VAWG prevention intervention that needed resolving. Some of the challenges raised by experts included concerns of achieving privacy, trust, and safety online, which are central to achieving transformative communication. Experts also struggled to grapple with how a sense of community could be achieved online. There were also concerns amongst experts about material challenges such as access to devices, access to data and poor connectivity. x Interestingly, younger experts were more open to online participatory interventions than the more experienced experts. Findings for objective two “from the perspective of adolescents, understand the feasibility, acceptability and challenges of a group-based participatory VAWG prevention intervention developed and delivered online”, young people reported they were keen and open to the idea of online group-based participatory VAWG prevention interventions. They discussed how they enjoyed engaging in online groups and often experienced a sense of belonging in these groups. Yet, like the experts, school-going adolescents were concerned about safety, privacy, and trust in online groups. These concerns shaped adolescents’ willingness to disclose sensitive information online and ability to engage in open dialogue. Concern over privacy, trust and safety online also influenced adolescents’ choices over which apps to engage with, and with whom. Young people were active in thinking through and addressing how they dealt with safety, privacy and trust issues online. The third objective was “to undertake an online co-development process of an online group-based participatory VAWG prevention intervention with adolescents”, which was done over two weeks. A range of positive outcomes were identified. Firstly, young people enjoyed the level of autonomy and their depth of involvement in the process. They had come into the process anticipating being lectured to and were pleasantly surprised to find that their role was central, and they would drive the process. Secondly, adolescents were eager to be involved and appreciated being ‘heard’. This allowed for a more extensive exploration of their understanding on the topic, and development of the intervention activities that emerged. Thirdly, young people found it easy to build rapport online, both amongst each other, and with the facilitator, which made communication in the group easier. Importantly, this group of adolescents had their own laptops, or cell phones to use, and the project provided data for the young people to participate. However, there were also challenges to the process of coxi development. The central challenge was that young people and facilitator often slipped into a form of teacher-learner communication, driven by their prior histories of didactic education, which led the adolescents to ‘fearing’ to give ‘wrong’ responses. The facilitator also struggled on how to maintain adolescents’ autonomy of thought, while also incorporating ‘scientific evidence’ in the emerging intervention activities. Furthermore, the more talkative school-going adolescents took the centre stage in the discussions, with the quieter ones remaining quiet. Conclusions: The findings of this study showed that the feasibility of taking group-based participatory interventions online are possible, but this is shaped by a complex set of factors, that impact on the possibilities for transformative communication, and on the creation of safe social spaces – such as trust, privacy, safety. The central question is whether the theoretical constructs of transformative communication and safe social spaces are achievable online. A significant step in moving towards enabling transformative communication online will be addressing the issues of privacy, safety and trust. Careful training of facilitators around skills to facilitate group-based participatory VAWG prevention interventions online is also recommended. The complexities of delivering online participatory interventions require careful consideration, and this needs to be developed and thought about in conjunction with school-going adolescents (the target group), to ensure that interventions resonate with their needs and requirements. Future directions in this research field are provided. , Thesis (PhD) -- Faculty of Health Sciences, 2022
- Full Text:
- Date Issued: 2022-12
- Authors: Ndungu, Jane
- Date: 2022-12
- Subjects: Prevention , Transformative communication
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/60188 , vital:63214
- Description: Background: Violence against women and girls (VAWG)amongst adolescents remains a global public health problem. Globally, an estimated 24 per cent of girls aged 15-19 are reported to have experienced VAWG before the age of 20. Experience of VAWG has far reaching health and educational consequences. Thus, the prevention of VAWG needs to be a priority. In recent years, there has been an increase in web-based or online violence prevention interventions. However, these interventions are either secondary prevention interventions, or primary prevention interventions, focused on emergency or protective solutions. Current evidence indicates that group-based participatory violence prevention interventions are an important approach to the primary prevention of VAWG but there remains a gap in understanding if these interventions can be delivered online. Further, it remains unclear if co-development of group-based participatory violence prevention interventions with young people – which has been proposed to enhance contextualisation of interventions – can occur online. Goal and specific objectives: This study aimed to explore and understand the feasibility of co-developing an online group-based participatory VAWG prevention intervention for adolescents. The specific objectives of this study were (i) from the perspective of experts understand the feasibility, acceptability and challenges of a group-based participatory VAWG prevention intervention developed and delivered online, (ii) from the perspective of adolescents, understand the feasibility, acceptability and challenges of a group-based participatory VAWG prevention intervention developed and delivered online and (iii) Undertake an online co-development process of an online group-based participatory VAWG prevention intervention with adolescents. ix Methods: This qualitative study was conducted in Gqeberha (formerly known as Port Elizabeth), in the Nelson Mandela Bay municipality, Eastern Cape Province of South Africa. The study was guided by the intervention development framework: 6 Essential Steps for Quality Intervention Development (6SQuID). Data were collected online using in-depth semi-structured interviews, with 20 experts sampled through convenience and snowball strategies and 18 purposively sampled adolescents, to achieve objectives one and two. This was then followed by a co-development process with high school-going adolescents (ages 18- 19 years) to achieve objective three. In the co-development process, the candidate worked with a small group of adolescents (four adolescents) for five sessions online, over a period of two weeks. In these sessions, the co-development team engaged in discussions on sexual violence, which resulted in creation of a problem tree and populated a theory of change table. Data were transcribed in English, verbatim and analysed using thematic network analyses. Findings: Findings for the first objective about understanding from the perspective of experts the feasibility, acceptability and challenges of a group-based participatory VAWG prevention intervention developed and delivered online, showed experts identified several opportunities for these. Specifically, experts identified the potential of bringing these interventions to scale, which has been a challenge for in-person interventions, as well as accessing hard to reach groups, such as people in conflict settings, those on the move and people with limited mobility. However, experts felt there were many complex questions in the development of an online VAWG prevention intervention that needed resolving. Some of the challenges raised by experts included concerns of achieving privacy, trust, and safety online, which are central to achieving transformative communication. Experts also struggled to grapple with how a sense of community could be achieved online. There were also concerns amongst experts about material challenges such as access to devices, access to data and poor connectivity. x Interestingly, younger experts were more open to online participatory interventions than the more experienced experts. Findings for objective two “from the perspective of adolescents, understand the feasibility, acceptability and challenges of a group-based participatory VAWG prevention intervention developed and delivered online”, young people reported they were keen and open to the idea of online group-based participatory VAWG prevention interventions. They discussed how they enjoyed engaging in online groups and often experienced a sense of belonging in these groups. Yet, like the experts, school-going adolescents were concerned about safety, privacy, and trust in online groups. These concerns shaped adolescents’ willingness to disclose sensitive information online and ability to engage in open dialogue. Concern over privacy, trust and safety online also influenced adolescents’ choices over which apps to engage with, and with whom. Young people were active in thinking through and addressing how they dealt with safety, privacy and trust issues online. The third objective was “to undertake an online co-development process of an online group-based participatory VAWG prevention intervention with adolescents”, which was done over two weeks. A range of positive outcomes were identified. Firstly, young people enjoyed the level of autonomy and their depth of involvement in the process. They had come into the process anticipating being lectured to and were pleasantly surprised to find that their role was central, and they would drive the process. Secondly, adolescents were eager to be involved and appreciated being ‘heard’. This allowed for a more extensive exploration of their understanding on the topic, and development of the intervention activities that emerged. Thirdly, young people found it easy to build rapport online, both amongst each other, and with the facilitator, which made communication in the group easier. Importantly, this group of adolescents had their own laptops, or cell phones to use, and the project provided data for the young people to participate. However, there were also challenges to the process of coxi development. The central challenge was that young people and facilitator often slipped into a form of teacher-learner communication, driven by their prior histories of didactic education, which led the adolescents to ‘fearing’ to give ‘wrong’ responses. The facilitator also struggled on how to maintain adolescents’ autonomy of thought, while also incorporating ‘scientific evidence’ in the emerging intervention activities. Furthermore, the more talkative school-going adolescents took the centre stage in the discussions, with the quieter ones remaining quiet. Conclusions: The findings of this study showed that the feasibility of taking group-based participatory interventions online are possible, but this is shaped by a complex set of factors, that impact on the possibilities for transformative communication, and on the creation of safe social spaces – such as trust, privacy, safety. The central question is whether the theoretical constructs of transformative communication and safe social spaces are achievable online. A significant step in moving towards enabling transformative communication online will be addressing the issues of privacy, safety and trust. Careful training of facilitators around skills to facilitate group-based participatory VAWG prevention interventions online is also recommended. The complexities of delivering online participatory interventions require careful consideration, and this needs to be developed and thought about in conjunction with school-going adolescents (the target group), to ensure that interventions resonate with their needs and requirements. Future directions in this research field are provided. , Thesis (PhD) -- Faculty of Health Sciences, 2022
- Full Text:
- Date Issued: 2022-12
Comparison of in vitro activities of selected Ganoderma species in relation to skin diseases
- Authors: Van Aardt, Robin Kaylah
- Date: 2022-12
- Subjects: Ganoderma diseases of plants -- South Africa , Macrophages
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/61143 , vital:69766
- Description: Ganoderma species of macrofungi have been reported to have a multitude of medicinal properties, however, there is limited information on this genus in South Africa. The goal of this study was to compare biological activities of selected Ganoderma spp. in relation to skin diseases with emphasis on the antibacterial, antioxidant, anti-inflammatory and cytotoxic in vitro activities. Ethanolic and aqueous extracts prepared from six samples of G. lucidum [two commercial products (MG-LZ8 and Medi Mushroom Reishi extract), polar, antler, fruiting body and mycelium] and ten cultivated Ganoderma spp. were screened for bioactivities. Antibacterial activity was assessed using the 2-(4-iodophenyl)-3-(4-nitrophenyl)-5-phenyl-2H-tetrazolium (INT) assay against skin pathogens (Staphylococcus aureus, Streptococcus pyogenes, Pseudomonas aeruginosa, Escherichia coli and Klebsiella pneumoniae). Cytotoxicity was determined using bisBenzamide H 33342 trihydrochloride/propidium iodide (Hoechst/ PI) staining on the B16F10 melanoma cell line. The 2,2-Diphenyl-1- picrylhydrazyl (DPPH) and Ferric reducing ability of plasma (FRAP) assays were used to investigate antioxidant activity. Immune modulatory effects included detection of phagocytic activity and phenotypic changes of RAW 264.7 murine macrophage cells. The phenotypic macrophage polarisation of the extracts on RAW 264.7 murine macrophage cells was tested by treating the cells with the extracts and measuring the fluorescence of cell surface markers. CD86 was used as indicator for the M1 phenotype and CD206 as a general marker for M2 phenotypes. The commercially available and cultivated G. lucidum extracts did not show antibacterial activity within the 0-2mg/mL concentration range tested. The commercially available MG-LZ8 G. lucidum extract expressed cytotoxic activity with an IC50 value of 21.26 µg/mL while the ethanolic conk fruiting body and mycelial G. lucidum extract showed a significant reduction in live cells, indicating anti-proliferative activity. G. destructans mycelial ethanol extract displayed anti-proliferative activity at a concentration of 200 μg/mL which shows great potential as a mycelial extract. All the G. lucidum extracts exhibited free radical scavenging abilities with the Ganoderma spp. showing little to no measurable activity. G. lucidum and Ganoderma spp extracts had similar responses without inflammatory activity for the concentration ranges tested. The extracts did not increase macrophage phagocytic activity using the pHrodo™ Green E. coli iii BioParticles™ Conjugate. G. lucidum and Ganoderma spp. extracts induced macrophage polarisation toward the M2 phenotype, with the G. lucidum antler and conk fruiting body extracts displaying significant activity. This study illustrates one of the first investigations of the bioactivity of indigenous Ganoderma spp.; G. destructans type and G. eickeri, spp. nov. identified by Coeztee et al (2015). , Thesis (MSc) -- Faculty of Science, School of Biochemistry and Microbiology, 2023
- Full Text:
- Date Issued: 2022-12
- Authors: Van Aardt, Robin Kaylah
- Date: 2022-12
- Subjects: Ganoderma diseases of plants -- South Africa , Macrophages
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/61143 , vital:69766
- Description: Ganoderma species of macrofungi have been reported to have a multitude of medicinal properties, however, there is limited information on this genus in South Africa. The goal of this study was to compare biological activities of selected Ganoderma spp. in relation to skin diseases with emphasis on the antibacterial, antioxidant, anti-inflammatory and cytotoxic in vitro activities. Ethanolic and aqueous extracts prepared from six samples of G. lucidum [two commercial products (MG-LZ8 and Medi Mushroom Reishi extract), polar, antler, fruiting body and mycelium] and ten cultivated Ganoderma spp. were screened for bioactivities. Antibacterial activity was assessed using the 2-(4-iodophenyl)-3-(4-nitrophenyl)-5-phenyl-2H-tetrazolium (INT) assay against skin pathogens (Staphylococcus aureus, Streptococcus pyogenes, Pseudomonas aeruginosa, Escherichia coli and Klebsiella pneumoniae). Cytotoxicity was determined using bisBenzamide H 33342 trihydrochloride/propidium iodide (Hoechst/ PI) staining on the B16F10 melanoma cell line. The 2,2-Diphenyl-1- picrylhydrazyl (DPPH) and Ferric reducing ability of plasma (FRAP) assays were used to investigate antioxidant activity. Immune modulatory effects included detection of phagocytic activity and phenotypic changes of RAW 264.7 murine macrophage cells. The phenotypic macrophage polarisation of the extracts on RAW 264.7 murine macrophage cells was tested by treating the cells with the extracts and measuring the fluorescence of cell surface markers. CD86 was used as indicator for the M1 phenotype and CD206 as a general marker for M2 phenotypes. The commercially available and cultivated G. lucidum extracts did not show antibacterial activity within the 0-2mg/mL concentration range tested. The commercially available MG-LZ8 G. lucidum extract expressed cytotoxic activity with an IC50 value of 21.26 µg/mL while the ethanolic conk fruiting body and mycelial G. lucidum extract showed a significant reduction in live cells, indicating anti-proliferative activity. G. destructans mycelial ethanol extract displayed anti-proliferative activity at a concentration of 200 μg/mL which shows great potential as a mycelial extract. All the G. lucidum extracts exhibited free radical scavenging abilities with the Ganoderma spp. showing little to no measurable activity. G. lucidum and Ganoderma spp extracts had similar responses without inflammatory activity for the concentration ranges tested. The extracts did not increase macrophage phagocytic activity using the pHrodo™ Green E. coli iii BioParticles™ Conjugate. G. lucidum and Ganoderma spp. extracts induced macrophage polarisation toward the M2 phenotype, with the G. lucidum antler and conk fruiting body extracts displaying significant activity. This study illustrates one of the first investigations of the bioactivity of indigenous Ganoderma spp.; G. destructans type and G. eickeri, spp. nov. identified by Coeztee et al (2015). , Thesis (MSc) -- Faculty of Science, School of Biochemistry and Microbiology, 2023
- Full Text:
- Date Issued: 2022-12
Converged data and sensing over optical fiber networks
- Authors: Shumane, Vela
- Date: 2022-12
- Subjects: Optical fiber subscriber loops -- South Africa , Chemical detectors , Internet -- Technological innovations
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/59968 , vital:62722
- Description: Internet connectivity, data and sensors have become increasingly important across all spheres of business and industry, especially in the mining sector. Recent years have seen deeper mining explorations as a result of the depletion of natural resources in shallow strata. Due to complex and unexpected geological conditions as well as significant ground stresses, deep stratum mining operations encounter a number of difficulties. It is essential that the mining industry be more innovative with their equipment and monitoring systems given the rise in expenses caused by energy consumption, concessions to surface integrity, worldwide freshwater shortage, as well as health and safety of miners. Any attempt to eliminate these mining consequences must start with early discovery. An effective plan to anticipate, prevent, or manage geohazards events must be in place because to these complex and unpredictably occurring geological circumstances. Due to their capacity to combine gigabits of data from remote locations within the mine to a centralized control centre, optical fiber offers a variety of distinctive advantages within the mining industry. In order to attain maximum productivity, modern and effective mining operations use enhanced control techniques and increasing mechanization. Additionally, optical fibers can be utilized in a mine to safely monitor seismic activity, methane, roof collapses, rock bursts, explosions, and dangerous underground mine settings. Multimode or multi-core fibers represent a particularly intriguing alternative for transmissions over small distances, especially for broad band local area networks like LANs, as they enable the use of affordable components. Due to the current state of these issues, there is a drive to create fiber optic communication links that can also function as distributed optical fiber sensors, where each point along the fiber can function as a continuous array of sensors. In this thesis, we suggested and experimentally demonstrated a converged solution for precise vibration sensing and high-speed data in mining applications. With wireless access for people and equipment inside cavities, the solution uses multimode fiber to link nearby mining cavities. To track vibrations and earth tremors causing rock falls, polarization-based vibration sensors over multimode fiber is used. With a modal dispersion penalty of just 1.6 dB, photonic data transmission across 100 m of multimode fiber is successfully accomplished. Successful 1.7 GHz wireless transmission across a distance of 1 m is demonstrated, and vibrations between 50 Hz and 1 kHz may be reliably detected to within 0.02 percent of the true value. , Thesis (MSc) -- Faculty of Science, School of Computer Science, Mathematics, Physics and Statistics, 2022
- Full Text:
- Date Issued: 2022-12
- Authors: Shumane, Vela
- Date: 2022-12
- Subjects: Optical fiber subscriber loops -- South Africa , Chemical detectors , Internet -- Technological innovations
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/59968 , vital:62722
- Description: Internet connectivity, data and sensors have become increasingly important across all spheres of business and industry, especially in the mining sector. Recent years have seen deeper mining explorations as a result of the depletion of natural resources in shallow strata. Due to complex and unexpected geological conditions as well as significant ground stresses, deep stratum mining operations encounter a number of difficulties. It is essential that the mining industry be more innovative with their equipment and monitoring systems given the rise in expenses caused by energy consumption, concessions to surface integrity, worldwide freshwater shortage, as well as health and safety of miners. Any attempt to eliminate these mining consequences must start with early discovery. An effective plan to anticipate, prevent, or manage geohazards events must be in place because to these complex and unpredictably occurring geological circumstances. Due to their capacity to combine gigabits of data from remote locations within the mine to a centralized control centre, optical fiber offers a variety of distinctive advantages within the mining industry. In order to attain maximum productivity, modern and effective mining operations use enhanced control techniques and increasing mechanization. Additionally, optical fibers can be utilized in a mine to safely monitor seismic activity, methane, roof collapses, rock bursts, explosions, and dangerous underground mine settings. Multimode or multi-core fibers represent a particularly intriguing alternative for transmissions over small distances, especially for broad band local area networks like LANs, as they enable the use of affordable components. Due to the current state of these issues, there is a drive to create fiber optic communication links that can also function as distributed optical fiber sensors, where each point along the fiber can function as a continuous array of sensors. In this thesis, we suggested and experimentally demonstrated a converged solution for precise vibration sensing and high-speed data in mining applications. With wireless access for people and equipment inside cavities, the solution uses multimode fiber to link nearby mining cavities. To track vibrations and earth tremors causing rock falls, polarization-based vibration sensors over multimode fiber is used. With a modal dispersion penalty of just 1.6 dB, photonic data transmission across 100 m of multimode fiber is successfully accomplished. Successful 1.7 GHz wireless transmission across a distance of 1 m is demonstrated, and vibrations between 50 Hz and 1 kHz may be reliably detected to within 0.02 percent of the true value. , Thesis (MSc) -- Faculty of Science, School of Computer Science, Mathematics, Physics and Statistics, 2022
- Full Text:
- Date Issued: 2022-12
Development of a continuous flow process towards the synthesis of fluvastatin: a lipid lowering drug
- Authors: Singata, Mzuvukile
- Date: 2022-12
- Subjects: Drug development – South Africa , Drugs --Law and legislation , Pharmaceutical technology -- South Africa
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/59587 , vital:62175
- Description: Access to pharmaceuticals in low to middle income countries affects not only the health of a nation, but also the economy. Global pandemics such as the SARS COVID-19 pandemic have demonstrated this disparity. A potential solution to this crisis is an efficient and reliable means of local production of active pharmaceutical ingredients. Current manufacturing plants heavily rely on batch processes as their primary form of production. Batch production has been shown to have numerous disadvantages that impede the reliable production of drugs. Flow chemistry presents a possible solution to this impediment. Numerous advantages of flow chemistry make this technology a better and safer option for production; these include improved safety, faster reaction times and improved reaction control. In this research we present the use of flow chemistry towards the synthesis of fluvastatin, a lipid lowering drug for individuals that suffer from hypercholesterolemia, which is characterised by elevated levels of low-density lipoprotein that is sometimes referred to as bad cholesterol. Chapter 1 provides a detailed description of the background to the problem of hypercholesterolemia; in this chapter the role of cholesterol in the body and how it can end up becoming a problem is outlined. An in-depth analysis of flow chemistry is provided and finally the problem statement, aims and objectives are presented. Chapter 2 give a detailed description of the instrumentation and chemicals used in the research. A description of experimental methodology towards the synthesis of all intermediates in batch and flow systems is provided. Chapter 3 provides all the data collected from the research and describes a multivariate optimization of the intermediates towards the synthesis of fluvastatin. The first intermediate was successfully synthesized in batch (60%) and flow systems at an improved conversion of 98% in a residence time of 15 minutes. The second intermediate was also obtained in batch (32%) and using continuous flow systems at a conversion of 75% and a residence time of 25 minutes. The third intermediate was successfully cyclized in batch using ZnCl2 (50%) and via continuous flow using Amberlite IR120 in a packed column reactor at a residence time of 15 minutes at 95°C, to obtain a conversion of 98%. The final intermediate was successfully synthesized in batch (62%) and in flow; it was obtained at 98% at a residence time of 15 minutes using continuous flow. Chapter 4 provides a conclusion of the study; it also provides a description of the future work and recommendations for this research. , Thesis (MSc) -- Faculty of Science, School of Biomolecular and Chemical Sciences, 2022
- Full Text:
- Date Issued: 2022-12
Development of a continuous flow process towards the synthesis of fluvastatin: a lipid lowering drug
- Authors: Singata, Mzuvukile
- Date: 2022-12
- Subjects: Drug development – South Africa , Drugs --Law and legislation , Pharmaceutical technology -- South Africa
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/59587 , vital:62175
- Description: Access to pharmaceuticals in low to middle income countries affects not only the health of a nation, but also the economy. Global pandemics such as the SARS COVID-19 pandemic have demonstrated this disparity. A potential solution to this crisis is an efficient and reliable means of local production of active pharmaceutical ingredients. Current manufacturing plants heavily rely on batch processes as their primary form of production. Batch production has been shown to have numerous disadvantages that impede the reliable production of drugs. Flow chemistry presents a possible solution to this impediment. Numerous advantages of flow chemistry make this technology a better and safer option for production; these include improved safety, faster reaction times and improved reaction control. In this research we present the use of flow chemistry towards the synthesis of fluvastatin, a lipid lowering drug for individuals that suffer from hypercholesterolemia, which is characterised by elevated levels of low-density lipoprotein that is sometimes referred to as bad cholesterol. Chapter 1 provides a detailed description of the background to the problem of hypercholesterolemia; in this chapter the role of cholesterol in the body and how it can end up becoming a problem is outlined. An in-depth analysis of flow chemistry is provided and finally the problem statement, aims and objectives are presented. Chapter 2 give a detailed description of the instrumentation and chemicals used in the research. A description of experimental methodology towards the synthesis of all intermediates in batch and flow systems is provided. Chapter 3 provides all the data collected from the research and describes a multivariate optimization of the intermediates towards the synthesis of fluvastatin. The first intermediate was successfully synthesized in batch (60%) and flow systems at an improved conversion of 98% in a residence time of 15 minutes. The second intermediate was also obtained in batch (32%) and using continuous flow systems at a conversion of 75% and a residence time of 25 minutes. The third intermediate was successfully cyclized in batch using ZnCl2 (50%) and via continuous flow using Amberlite IR120 in a packed column reactor at a residence time of 15 minutes at 95°C, to obtain a conversion of 98%. The final intermediate was successfully synthesized in batch (62%) and in flow; it was obtained at 98% at a residence time of 15 minutes using continuous flow. Chapter 4 provides a conclusion of the study; it also provides a description of the future work and recommendations for this research. , Thesis (MSc) -- Faculty of Science, School of Biomolecular and Chemical Sciences, 2022
- Full Text:
- Date Issued: 2022-12
Development of a crumb rubber adsorbent for the sorption of lead and copper from waste water: Optimization of sorption in a binary component system
- Authors: Hlabana,Relebohile Gladys
- Date: 2022-12
- Subjects: Port Elizabeth (South Africa) , Eastern Cape (South Africa) , South Africa
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/59688 , vital:62356
- Description: Waste tyre is becoming a global environmental problem due to challenges in its disposal management and the fact that it poses fire hazards and metal leaching risk. Waste tyre can also breed mosquitos if it traps water thereby becoming an environmental health problem. There is also a portion of unused tyre in a waste tyre that is valuable and should be recycled. In South Africa waste tyre recycling is in three industries, one of which is crumb rubber where waste tyre is applied into various sized particles called crumb rubber. Crumb rubber can be applied in environmental remediation as an organic and inorganic pollutants’ adsorbent. Considering the fact that South Africa’s environment is loaded with heavy metal pollutants due to contributions by mining and agriculture as examples, it is postulated that crumb rubber produced in South Africa could be used to remediate the environment of these toxic metals. In this study adsorption of Pb (II) and Cu (II) from the synthetic waste water using waste tyre crumb rubber produced in South Africa was studied. Crumb rubber was activated using aqueous NaOH (0.02%) to make crumb rubber wettable followed by it being treated with 0.02 % acidified KMnO4 for modification of its ability to sorp positively charged metal species. Trial sorption experiments on 50 mg / L Cu (II) were successful with sorption of over 70% in 250 minutes. Final optimization of the sorption of combined Pb (II) and Cu (II) was studied using a full factorial design and optimum conditions of sorption were found to be pH 5.4; [metal] 0.617 mmol / L for Pb (II); and pH 5.4; the optimization of Cu (II) was found to be pH 5.4; [metal] 0.777 mmol / L. In Pb (II) sorptions the mechanism of adsorption on the activated crumb rubber was found to be following the Freundlich model indicating that the adsorption seemed to occur on a multilayer adsorbent, while the mechanism of copper(II) adsorption on to the activated crumb rubber was found to be following Langmuir model, indicating that the adsorption seemed to occur on a monolayer. With adsorption percentages ranging from 98.2 % to 100.0 %, for Pb (II), the crumb rubber produced under the conditions of this study, can be used in South Africa for selective removal of Pb (II). , Thesis (MSc) -- Faculty of Science, School of Biomolecular and Chemical Sciences, 2022
- Full Text:
- Date Issued: 2022-12
- Authors: Hlabana,Relebohile Gladys
- Date: 2022-12
- Subjects: Port Elizabeth (South Africa) , Eastern Cape (South Africa) , South Africa
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/59688 , vital:62356
- Description: Waste tyre is becoming a global environmental problem due to challenges in its disposal management and the fact that it poses fire hazards and metal leaching risk. Waste tyre can also breed mosquitos if it traps water thereby becoming an environmental health problem. There is also a portion of unused tyre in a waste tyre that is valuable and should be recycled. In South Africa waste tyre recycling is in three industries, one of which is crumb rubber where waste tyre is applied into various sized particles called crumb rubber. Crumb rubber can be applied in environmental remediation as an organic and inorganic pollutants’ adsorbent. Considering the fact that South Africa’s environment is loaded with heavy metal pollutants due to contributions by mining and agriculture as examples, it is postulated that crumb rubber produced in South Africa could be used to remediate the environment of these toxic metals. In this study adsorption of Pb (II) and Cu (II) from the synthetic waste water using waste tyre crumb rubber produced in South Africa was studied. Crumb rubber was activated using aqueous NaOH (0.02%) to make crumb rubber wettable followed by it being treated with 0.02 % acidified KMnO4 for modification of its ability to sorp positively charged metal species. Trial sorption experiments on 50 mg / L Cu (II) were successful with sorption of over 70% in 250 minutes. Final optimization of the sorption of combined Pb (II) and Cu (II) was studied using a full factorial design and optimum conditions of sorption were found to be pH 5.4; [metal] 0.617 mmol / L for Pb (II); and pH 5.4; the optimization of Cu (II) was found to be pH 5.4; [metal] 0.777 mmol / L. In Pb (II) sorptions the mechanism of adsorption on the activated crumb rubber was found to be following the Freundlich model indicating that the adsorption seemed to occur on a multilayer adsorbent, while the mechanism of copper(II) adsorption on to the activated crumb rubber was found to be following Langmuir model, indicating that the adsorption seemed to occur on a monolayer. With adsorption percentages ranging from 98.2 % to 100.0 %, for Pb (II), the crumb rubber produced under the conditions of this study, can be used in South Africa for selective removal of Pb (II). , Thesis (MSc) -- Faculty of Science, School of Biomolecular and Chemical Sciences, 2022
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- Date Issued: 2022-12