The relationship between employee wellness and gratitude
- Authors: Jordaan, Chrizelle
- Date: 2019
- Subjects: Employee health promotion -- South Africa , Work environment -- Psychological aspects Gratitude Psychology, Industrial
- Language: English
- Type: Thesis , Masters , MCom
- Identifier: http://hdl.handle.net/10948/39984 , vital:35636
- Description: A lack of research studies and available literature on the relationship between employee wellness and gratitude revealed enormous potential for further exploration and investigation, especially within a South African context. This is a relatively new field with limited literature and research evidence available. From the commencement of the research it was evident that there is possibility to successfully research if a relationship between employee wellness and gratitude exists, which formed the primary objective of the current study. The current study therefore aims to contribute to the existing body of knowledge regarding the possible relationship that exists between employee wellness and gratitude within South African organisations. The researcher utilised a quantitative research technique by making use of a composite questionnaire measuring employee wellness and gratitude respectively. The results were then analysed in an attempt to establish if a relationship exists between employee wellness and gratitude, based on the responses gathered from the research population. The research sample consisted of 121 employees working in the waste collection industry. A combination of the Mental Health Continuum – Short Form, Gratitude Questionnaire (6-item form) as well as a demographic variable information page was utilised to gather data for the current study. The results indicated that significant findings between the demographic variables and the individual constructs respectively, however, the relationship between the dimensions of employee wellness and gratitude was lower than expected. Based on the results obtained within this study, it was concluded that a small relationship exists between employee wellness and gratitude. Chapter 5 includes a discussion on the recommendations for both the organisation as well as future researchers.
- Full Text:
- Date Issued: 2019
- Authors: Jordaan, Chrizelle
- Date: 2019
- Subjects: Employee health promotion -- South Africa , Work environment -- Psychological aspects Gratitude Psychology, Industrial
- Language: English
- Type: Thesis , Masters , MCom
- Identifier: http://hdl.handle.net/10948/39984 , vital:35636
- Description: A lack of research studies and available literature on the relationship between employee wellness and gratitude revealed enormous potential for further exploration and investigation, especially within a South African context. This is a relatively new field with limited literature and research evidence available. From the commencement of the research it was evident that there is possibility to successfully research if a relationship between employee wellness and gratitude exists, which formed the primary objective of the current study. The current study therefore aims to contribute to the existing body of knowledge regarding the possible relationship that exists between employee wellness and gratitude within South African organisations. The researcher utilised a quantitative research technique by making use of a composite questionnaire measuring employee wellness and gratitude respectively. The results were then analysed in an attempt to establish if a relationship exists between employee wellness and gratitude, based on the responses gathered from the research population. The research sample consisted of 121 employees working in the waste collection industry. A combination of the Mental Health Continuum – Short Form, Gratitude Questionnaire (6-item form) as well as a demographic variable information page was utilised to gather data for the current study. The results indicated that significant findings between the demographic variables and the individual constructs respectively, however, the relationship between the dimensions of employee wellness and gratitude was lower than expected. Based on the results obtained within this study, it was concluded that a small relationship exists between employee wellness and gratitude. Chapter 5 includes a discussion on the recommendations for both the organisation as well as future researchers.
- Full Text:
- Date Issued: 2019
Subjective measurements of persistence of time series
- Authors: Poswayo, Sihle
- Date: 2018
- Subjects: Time-series analysis , Space and time Time -- Philosophy
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: http://hdl.handle.net/10948/34372 , vital:33361
- Description: In this paper we suggest the use of subjective judgements to measure persistence in time series by comparing pairs of graphs with different Hurst exponents. The group of respondents consisted of 40 volunteers who were asked to identify the more jagged out of two graphs presented to them (that is, less persistent). The respondents were approached as a group and requested to work independently in the completion of ques- tionnaires administered to them. The respondents were supervised by the researchers. The graphs were simulated using time series package of Mathematica R [26]. The re- sponses were processed using an algorithm based on the Thurstone-Mosteller model for paired comparisons [29]. The results of the analysis show that the human eye is capable of distinguishing graphs of time series with Hurst exponent difference as small as only 0.02.
- Full Text:
- Date Issued: 2018
- Authors: Poswayo, Sihle
- Date: 2018
- Subjects: Time-series analysis , Space and time Time -- Philosophy
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: http://hdl.handle.net/10948/34372 , vital:33361
- Description: In this paper we suggest the use of subjective judgements to measure persistence in time series by comparing pairs of graphs with different Hurst exponents. The group of respondents consisted of 40 volunteers who were asked to identify the more jagged out of two graphs presented to them (that is, less persistent). The respondents were approached as a group and requested to work independently in the completion of ques- tionnaires administered to them. The respondents were supervised by the researchers. The graphs were simulated using time series package of Mathematica R [26]. The re- sponses were processed using an algorithm based on the Thurstone-Mosteller model for paired comparisons [29]. The results of the analysis show that the human eye is capable of distinguishing graphs of time series with Hurst exponent difference as small as only 0.02.
- Full Text:
- Date Issued: 2018
In vitro drug-herb interaction potential of African medicinal plant products used by Type II diabetics
- Authors: Fang, Yuan Yuan
- Date: 2011
- Subjects: Materia medica, Vegetable -- South Africa , Drugs -- Therapeutic use , Drug-herb interactions -- South Africa , Non-insulin-dependent diabetes -- South Africa , Non-insulin-dependent diabetes -- Treatment -- South Africa
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:10317 , http://hdl.handle.net/10948/1341 , Materia medica, Vegetable -- South Africa , Drugs -- Therapeutic use , Drug-herb interactions -- South Africa , Non-insulin-dependent diabetes -- South Africa , Non-insulin-dependent diabetes -- Treatment -- South Africa
- Description: In Africa, use of medicinal plants for the treatment of diabetes is very common. However, efficacy on co-administering of medicinal plants with therapeutic drugs hasn't been fully determined, especially for African medicinal plants. The current study focused on assessing the in vitro modulation effects of three popular African medicinal plants, namely: Aloe ferox, Sutherlandia frutescens and Prunus africana (including five commercial preparations containing these medicinal plants) on two of the most important anti-diabetic drug metabolising enzymes, Cytochrome P450 (CYP450) 2C9 and CYP3A4 and a key drug efflux transporter, P-glycoprotein (P-gp). Vivid® microsome-based screening kits were used to assess inhibitory potency of plants preparations on CYP2C9 and CYP3A4 enzymes activities. The study showed that P. africana was a more potent inhibitor of CYP2C9 and CYP3A4 activity than the corresponding positive controls Ginkgo biloba and St. John's wort, which are known to cause clinically significant drug-herb interactions. S. frutescens leaf extract demonstrated potent to moderate inhibition on both the tested CYP activities, while its commercial products (Promune® and Probetix®) possessed moderate to mild inhibitory effects on the activities of both CYPs. Potent inhibitory effect on CYP2C9 and CYP3A4 was seen with Aloe Ferox®. Prosit® and Aloes powder® showed potent to moderate inhibition on CYP2C9 activity and moderate to mild inhibition on CYP3A4 activity. In addition to CYP450 activity, the present study also investigated the effects of the selected medicinal plant products on the activity of the main drug efflux protein, P-gp. A screening assay was specifically developed to assess the potential for herbal remedies to interact with P-gp mediated drug absorption. The assay is based on the principle of the reversal of drug resistance in modified Caco-2 cells specifically altered to express high iv efflux protein activity. These cells display a multidrug resistance phenotype and the addition of a plant extract containing a P-gp inhibitor or substrate will inhibit or compete with any cytotoxic drug and consequently reverse the drug resistance. The suitability of the assay was confirmed using a known P-gp inhibitor. The study observed that the anti-proliferation effect of vinblastine was significantly enhanced in vinblastine-resistant Caco-2 cells, which have high P-gp expression, when they were exposed to the selected African herbal preparations. This observation indicates that the studied plant preparations may alter P-gp functionality and therefore lead to interference with the absorption of co-administered drugs. The outcomes of this study provide useful information on whether there are any potential drug-herb interactions between the commonly used African medicinal plants and oral anti-diabetic drugs, at the level of CYP and P-gp drug metabolism and could contribute to better therapeutic management of Type II diabetics. However these predicted interactions will need to be verified in a clinical setting.
- Full Text:
- Date Issued: 2011
- Authors: Fang, Yuan Yuan
- Date: 2011
- Subjects: Materia medica, Vegetable -- South Africa , Drugs -- Therapeutic use , Drug-herb interactions -- South Africa , Non-insulin-dependent diabetes -- South Africa , Non-insulin-dependent diabetes -- Treatment -- South Africa
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:10317 , http://hdl.handle.net/10948/1341 , Materia medica, Vegetable -- South Africa , Drugs -- Therapeutic use , Drug-herb interactions -- South Africa , Non-insulin-dependent diabetes -- South Africa , Non-insulin-dependent diabetes -- Treatment -- South Africa
- Description: In Africa, use of medicinal plants for the treatment of diabetes is very common. However, efficacy on co-administering of medicinal plants with therapeutic drugs hasn't been fully determined, especially for African medicinal plants. The current study focused on assessing the in vitro modulation effects of three popular African medicinal plants, namely: Aloe ferox, Sutherlandia frutescens and Prunus africana (including five commercial preparations containing these medicinal plants) on two of the most important anti-diabetic drug metabolising enzymes, Cytochrome P450 (CYP450) 2C9 and CYP3A4 and a key drug efflux transporter, P-glycoprotein (P-gp). Vivid® microsome-based screening kits were used to assess inhibitory potency of plants preparations on CYP2C9 and CYP3A4 enzymes activities. The study showed that P. africana was a more potent inhibitor of CYP2C9 and CYP3A4 activity than the corresponding positive controls Ginkgo biloba and St. John's wort, which are known to cause clinically significant drug-herb interactions. S. frutescens leaf extract demonstrated potent to moderate inhibition on both the tested CYP activities, while its commercial products (Promune® and Probetix®) possessed moderate to mild inhibitory effects on the activities of both CYPs. Potent inhibitory effect on CYP2C9 and CYP3A4 was seen with Aloe Ferox®. Prosit® and Aloes powder® showed potent to moderate inhibition on CYP2C9 activity and moderate to mild inhibition on CYP3A4 activity. In addition to CYP450 activity, the present study also investigated the effects of the selected medicinal plant products on the activity of the main drug efflux protein, P-gp. A screening assay was specifically developed to assess the potential for herbal remedies to interact with P-gp mediated drug absorption. The assay is based on the principle of the reversal of drug resistance in modified Caco-2 cells specifically altered to express high iv efflux protein activity. These cells display a multidrug resistance phenotype and the addition of a plant extract containing a P-gp inhibitor or substrate will inhibit or compete with any cytotoxic drug and consequently reverse the drug resistance. The suitability of the assay was confirmed using a known P-gp inhibitor. The study observed that the anti-proliferation effect of vinblastine was significantly enhanced in vinblastine-resistant Caco-2 cells, which have high P-gp expression, when they were exposed to the selected African herbal preparations. This observation indicates that the studied plant preparations may alter P-gp functionality and therefore lead to interference with the absorption of co-administered drugs. The outcomes of this study provide useful information on whether there are any potential drug-herb interactions between the commonly used African medicinal plants and oral anti-diabetic drugs, at the level of CYP and P-gp drug metabolism and could contribute to better therapeutic management of Type II diabetics. However these predicted interactions will need to be verified in a clinical setting.
- Full Text:
- Date Issued: 2011
- «
- ‹
- 1
- ›
- »