The design of an archive and memorial park in South End, Port Elizabeth: an interactive community educational project
- Authors: Struwig, Arno
- Date: 2018
- Subjects: Community centers -- South Africa -- Port Elizabeth -- Designs and plans , Community development -- South Africa -- Port Elizabeth -- Designs and plans Parks -- South Africa -- Port Elizabeth -- Planning Municipal archives -- Designs and plans
- Language: English
- Type: Thesis , Masters , MArch
- Identifier: http://hdl.handle.net/10948/23716 , vital:30604
- Description: This treatise addresses the current lack in concern for acknowledging and preserving the memories and historical elements of a once thriving place: South End, Port Elizabeth (fig. 11, p. 20). The Group Areas Act of 19501 (Y. Agherdien, A. C George, S. Hendricks, 1997) resulted in expropriation of land and the demolision of buildings and roads which started to take place in South End during the 1970’s, forcefully removing the residents from their home neighbourhood and home. The treatise focuses on the traces of what is left of South End (fig. 02, in red) and how these elements can be acknowledged and preserved for the future generations. Theories on the discourse of memory, specifically collective memory, are investigated to establish an understanding on different methods to capture, record and preserve these traces and memories of South End. This investigation will be followed by principle explorations to establish how these theories can be implemented and manifested in the historical landscape. It is proposed to design an archive next to St. Peter’s Church, above St. Mary’s Cemetery in South End and a memorial park on the “triangular site” across from the cemetery, addressing the existing conditions of the landscape and the memories of the ex-residents of South End (figs. 16-18, p. 24). The archive will consist of a conventional archive (static element) housing the maps and documentation related to the city of Port Elizabeth, and an oral archive (dynamic element) consisting of a recording studio that collects and records the stories of the ex-residents of South End, constantly changing and adding to the archive. The memorial park will resemble a “living archive” which constantly changes and re-evokes the memories of the original inhabitants of South End. The proposed project is intended to act as an educative catalyst to the visitors, citizens of Nelson Mandela Bay and the future generations.
- Full Text:
- Date Issued: 2018
- Authors: Struwig, Arno
- Date: 2018
- Subjects: Community centers -- South Africa -- Port Elizabeth -- Designs and plans , Community development -- South Africa -- Port Elizabeth -- Designs and plans Parks -- South Africa -- Port Elizabeth -- Planning Municipal archives -- Designs and plans
- Language: English
- Type: Thesis , Masters , MArch
- Identifier: http://hdl.handle.net/10948/23716 , vital:30604
- Description: This treatise addresses the current lack in concern for acknowledging and preserving the memories and historical elements of a once thriving place: South End, Port Elizabeth (fig. 11, p. 20). The Group Areas Act of 19501 (Y. Agherdien, A. C George, S. Hendricks, 1997) resulted in expropriation of land and the demolision of buildings and roads which started to take place in South End during the 1970’s, forcefully removing the residents from their home neighbourhood and home. The treatise focuses on the traces of what is left of South End (fig. 02, in red) and how these elements can be acknowledged and preserved for the future generations. Theories on the discourse of memory, specifically collective memory, are investigated to establish an understanding on different methods to capture, record and preserve these traces and memories of South End. This investigation will be followed by principle explorations to establish how these theories can be implemented and manifested in the historical landscape. It is proposed to design an archive next to St. Peter’s Church, above St. Mary’s Cemetery in South End and a memorial park on the “triangular site” across from the cemetery, addressing the existing conditions of the landscape and the memories of the ex-residents of South End (figs. 16-18, p. 24). The archive will consist of a conventional archive (static element) housing the maps and documentation related to the city of Port Elizabeth, and an oral archive (dynamic element) consisting of a recording studio that collects and records the stories of the ex-residents of South End, constantly changing and adding to the archive. The memorial park will resemble a “living archive” which constantly changes and re-evokes the memories of the original inhabitants of South End. The proposed project is intended to act as an educative catalyst to the visitors, citizens of Nelson Mandela Bay and the future generations.
- Full Text:
- Date Issued: 2018
Leonotis leonurus: the anticoagulant and antidiabetic activity of Leonotis leonurus
- Authors: Mnonopi, Nandipha
- Date: 2010
- Subjects: Medicinal plants -- South Africa , Materia medica, Vegetable -- South Africa , Diabetes -- Alternative treatment -- South Africa , Plant bioactive compounds , Leonotis leonurus -- Physiological aspects
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:10323 , http://hdl.handle.net/10948/1194 , Medicinal plants -- South Africa , Materia medica, Vegetable -- South Africa , Diabetes -- Alternative treatment -- South Africa , Plant bioactive compounds , Leonotis leonurus -- Physiological aspects
- Description: Commercial marrubiin, aqueous and organic extracts of Leonotis leonurus were tested in vitro for their anticoagulant and antiplatelet activities. The aqueous extract inhibited platelet aggregation by 69.5 percent (100 μg/mL), while the organic extract (100 μg/mL) and marrubiin (5 μg/mL) showed 92.5 percent and 91.6 percent inhibition, respectively, by inhibiting the binding of fibrinogen to glycoprotein IIb/IIIa receptor in a concentration dependent manner. The extracts significantly prolonged activated partial thromboplastin time compared to untreated plasma controls. Fibrin and D-Dimer formation were drastically decreased. The extracts and marrubiin concentration-dependently inhibited calcium mobilization induced by collagen and thrombin. The formation of thromboxane A2 was also significantly reduced by both the extracts and marrubiin. Protein secretion and platelet adhesion were significantly reduced by both the extracts and marrubiin. The organic extract and marrubiin showed a more pronounced effect than the aqueous extracts in all the in vitro assays. The ex-vivo animal model confirmed the results obtained in vitro. Similar to the in vitro studies, activated partial thromboplastin time clotting time was prolonged by marrubiin and the number of aggregated platelets were significantly reduced relative to aspirin. The findings reflect that marrubiin largely contributes to the organic extract's anticoagulant and antiplatelet effect in vitro. INS-1 cells were cultured under normo- and hyperglycaemic conditions. Marrubiin and the two Leonotis leonurus extracts were screened for anti-diabetic activity in vitro. The stimulatory index of INS-1 cells cultured under hyperglycaemic conditions was significantly increased by 60 percent and 61 percent (p<0.01; n=5) in cells exposed to the organic extract (10 μg/mL) and marrubiin (500 ng/mL), respectively, relative to the normoglycaemic conditions. The gene expression of insulin was significantly increased by 76.5 and 71 percent, and of glucose transporter-2 by 93 and 92.5 percent for marrubiin and the organic extract, respectively, under the same conditions stipulated above (p<0.01; n=4). The extract and marrubiin similarly showed an increase in respiratory rate under hyperglycaemic conditions. Marrubiin increased insulin secretion, HDL-cholesterol, while it decreased total cholesterol, LDL-cholesterol and the atherogenic index in the in vivo rat model.
- Full Text:
- Date Issued: 2010
- Authors: Mnonopi, Nandipha
- Date: 2010
- Subjects: Medicinal plants -- South Africa , Materia medica, Vegetable -- South Africa , Diabetes -- Alternative treatment -- South Africa , Plant bioactive compounds , Leonotis leonurus -- Physiological aspects
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:10323 , http://hdl.handle.net/10948/1194 , Medicinal plants -- South Africa , Materia medica, Vegetable -- South Africa , Diabetes -- Alternative treatment -- South Africa , Plant bioactive compounds , Leonotis leonurus -- Physiological aspects
- Description: Commercial marrubiin, aqueous and organic extracts of Leonotis leonurus were tested in vitro for their anticoagulant and antiplatelet activities. The aqueous extract inhibited platelet aggregation by 69.5 percent (100 μg/mL), while the organic extract (100 μg/mL) and marrubiin (5 μg/mL) showed 92.5 percent and 91.6 percent inhibition, respectively, by inhibiting the binding of fibrinogen to glycoprotein IIb/IIIa receptor in a concentration dependent manner. The extracts significantly prolonged activated partial thromboplastin time compared to untreated plasma controls. Fibrin and D-Dimer formation were drastically decreased. The extracts and marrubiin concentration-dependently inhibited calcium mobilization induced by collagen and thrombin. The formation of thromboxane A2 was also significantly reduced by both the extracts and marrubiin. Protein secretion and platelet adhesion were significantly reduced by both the extracts and marrubiin. The organic extract and marrubiin showed a more pronounced effect than the aqueous extracts in all the in vitro assays. The ex-vivo animal model confirmed the results obtained in vitro. Similar to the in vitro studies, activated partial thromboplastin time clotting time was prolonged by marrubiin and the number of aggregated platelets were significantly reduced relative to aspirin. The findings reflect that marrubiin largely contributes to the organic extract's anticoagulant and antiplatelet effect in vitro. INS-1 cells were cultured under normo- and hyperglycaemic conditions. Marrubiin and the two Leonotis leonurus extracts were screened for anti-diabetic activity in vitro. The stimulatory index of INS-1 cells cultured under hyperglycaemic conditions was significantly increased by 60 percent and 61 percent (p<0.01; n=5) in cells exposed to the organic extract (10 μg/mL) and marrubiin (500 ng/mL), respectively, relative to the normoglycaemic conditions. The gene expression of insulin was significantly increased by 76.5 and 71 percent, and of glucose transporter-2 by 93 and 92.5 percent for marrubiin and the organic extract, respectively, under the same conditions stipulated above (p<0.01; n=4). The extract and marrubiin similarly showed an increase in respiratory rate under hyperglycaemic conditions. Marrubiin increased insulin secretion, HDL-cholesterol, while it decreased total cholesterol, LDL-cholesterol and the atherogenic index in the in vivo rat model.
- Full Text:
- Date Issued: 2010
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