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Novobiocin–ferrocene conjugates possessing anticancer and antiplasmodial activity independent of HSP90 inhibition.

  • Authors: Mbaba, Mziyanda , de la Mare, Jo-Anne , Sterrenberg, Jason N , Kajewole, Deborah , Maharaj, Shantal , Edkins, Adrienne L , Isaacs, Michelle , Hoppe, Heinrich C , Khanye, Setshaba D
  • Language: English
  • Type: text , article
  • Identifier: http://hdl.handle.net/10962/122858 , vital:35359 , https://doi.org/10.1007/s00775-018-1634-9
  • Description: A series of tailored novobiocin–ferrocene conjugates was prepared in moderate yields and investigated for in vitro anticancer and antiplasmodial activity against the MDA-MB-231 breast cancer line and Plasmodium falciparum 3D7 strain, respectively. While the target compounds displayed moderate anticancer activity against the breast cancer cell line with IC50 values in the mid-micromolar range, compounds 10a–c displayed promising antiplasmodial activity as low as 0.889 µM. Furthermore, the most promising compounds were tested for inhibitory effects against a postulated target, heat shock protein 90 (Hsp90).
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Now a jazz from distinctively South African

NPC Cyperus distans.pdf

  • Authors: Oyedeji, Adebola Omowunmi
  • Language: English
  • Identifier: http://hdl.handle.net/11260/2476 , vital:41904
  • Description: Various articles from Prof Adebola Oyedeji
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NUMSA Report - Motor industry negotiations

  • Authors: NUMSA
  • Subjects: NUMSA
  • Language: English
  • Type: text
  • Identifier: http://hdl.handle.net/10962/113106 , vital:33707
  • Description: Today the bosses can see that workers are standing up for their rights. Their organisations are growing. 230 000 metal workers are united in NUMSA and more than 1 million workers are united in COSATU. The united power of workers have forced the bosses to accept changes to the vicious LRA. The united voice of the oppressed and exploited people have forced the bosses government to unban our organisations. And so the workers voice demanding control over their own lives is growing stronger day by day. The bosses can see that the workers have a plan. That workers are marching along a road which will lead them to victory and freedom. But the bosses too come with their own plan. And the bosses plan is aimed at protecting and increasing their profits and priviledges. The bosses plan is trying to force the workers to walk along the road of deregulation and increased profits for the bosses. This plan is seeking to divide workers and so to break their strength. The bosses plan aims to undermine centralised bargaining. They are scared to face the united power of motor workers. So they try to shift bargaining to plant and company level.
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NUMSA workers build co-operatives

  • Authors: NUMSA
  • Subjects: NUMSA
  • Language: English
  • Type: text
  • Identifier: http://hdl.handle.net/10962/114271 , vital:33961
  • Description: There are two main co-operative activities that are supported by NUMSA. The one is SAWCO in Natal and the other is the project that is starting here in the East Cape. Does NUMSA have a policy on co-operatives? NUMSA in its Central Committee has taken a decision to support co-ops. But NUMSA is still busy thinking of how we can formulate a policy on co-operatives. We are working towards such a policy. So what is NUMSA's aim in giving support to co-ops? In other words, how can organised workers benefit from the support that NUMSA is giving to these co-op activities? Interview with Cde John Gomomo NUMSA East Cape Regional Chairperson We, the organised workers on the shop floor are becoming more and more mobilised and politicised. We do not believe that the struggle should just end on the shop floor. The struggle of organised workers should also benefit the community. Co-operatives is such an activity that can be of interest to all groups of oppressed people. We, the organised workers with all the skills we have gathered in the organisation, we believe that if we take the lead, co-ops could be fully democratised organisations in the community.
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Nurse managers' perceptions of the Eastern Cape department of health employee assistance programme

  • Authors: Stenge, Nyameka
  • Subjects: Employee assistance programs -- South Africa -- Eastern Cape , Nurse administrators -- South Africa -- Eastern Cape
  • Language: English
  • Type: Thesis , Masters , MA
  • Identifier: vital:10088 , http://hdl.handle.net/10948/d1021203
  • Description: Organizations assist employees to deal effectively with demanding work and the work environment, including their personal problems, through an Employee Assistance Programme (EAP). The essence of the EAP is the application of knowledge about behaviour and behavioural health to make accurate assessments, followed by appropriate action to improve the productivity and healthy functioning of the employees. According to the report from the Employee Wellness Directorate of the Eastern Cape, the Employee Assistance Programme Practitioners saw 576 employees in 2010. These statistics only represent a few districts in the Eastern Cape as some districts do not have Employee Assistance Practitioners offering employee assistance, hence this number could be higher. In some instances employees do self-referral, which may increase the number without the managers knowing who is utilizing the EAP. This makes it difficult for the managers to monitor such employees and the effectiveness of the intervention rendered. Managers refer employees but do not have control over whether employees made use of the EAP and on the progress in sessions as they do not always receive the feedback. The Employee Assistance counsellor may receive a written referral from the nursing manager and then consults the referred employee in private. The employee gives consent and then the EAP counsellor addresses the problem at hand. If it is a complex case needing expert intervention arrangements are made. If the intervention requires follow up sessions, the EAP counsellor makes the necessary arrangements through the referring manager until the problem is resolved. The EAP counsellor monitors the employee and asks the manager to support the employee without divulging details of the problem that was being addressed. However, the Nursing Managers do not know how effective the programme is and whether the employees benefit from the use. The above-mentioned problem led the researcher to ask the following questions: • What are the perceptions that Nurse Managers in the Department of Health in the Eastern Cape Province have of the effectiveness of the Employee Assistance Programme? • How can Nurse Managers optimize employees’ use of the EAP? The goal of this study was to identify the perceptions of Nurse Managers of the Employee Assistance Programme in order to determine how the programme’s use can be optimized. The researcher used a qualitative, explorative, descriptive and contextual design. The research population was selected purposively and included the Nursing Managers in the Department of Health in the Chris Hani District, Eastern Cape, who have referred employees to the Employee Assistance Programme. Semi-structured interviews were used during the data gathering process. Interviews were conducted at a venue convenient to the participants. Open-ended questions were asked to enable participants to express their perceptions on the topic. The researcher also used observation and field-notes to ensure that the data gathering provided rich information. The data was analysed using Tesch’s method of data analysis. Trustworthiness was ensured by using Guba’s model of trustworthiness. The ethical strategies of informed consent, confidentiality and anonymity, avoidance of harm and voluntary participation were ensured. Two themes emerged from the data analysis. Theme one showed that the participants had contrasting perceptions regarding the effectiveness of the current Employee Assistance Programme. Some felt that they have benefitted from the programme while others felt differently. Theme two described the participants’ views elated to improving the utilization of the EAP. Positive and negative factors that impacted on the implementation of EAP have been identified. Results show that both the employer and the employees could benefit if EAP is well implemented. Decentralization of EAP could be very cost effective and could save the employer thousands of rands because resources would be utilized better.
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Nyokong is the top woman scientist in Africa

  • Authors: Lang, Steven
  • Language: English
  • Type: Article
  • Identifier: vital:7197 , http://hdl.handle.net/10962/d1006361
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Nyokong puts women in Science on the map

  • Authors: Matiwana, Zamuxolo
  • Language: English
  • Type: Article
  • Identifier: vital:7171 , http://hdl.handle.net/10962/d1006076
  • Description: Tebello Nyokong has again been honored for her outstanding work in the field of Science when she was awarded an Honorary Doctorate of Philosophy from The University of South Africa recently. Nyokong is a professor at Rhodes University and currently DST / NRF Research Professor of medicinal chemistry and nanotechnology and Director of the DST/ Mintek Nanotechnology Innovation Centre -Sensors. She is also an Adjunct Professor at the University of Tromso in Norway.
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Nyokong wins Prestigious L'Oreal - Unesco Award for Woman in Science

  • Authors: Peter, Kerry
  • Language: English
  • Type: Article
  • Identifier: vital:7192 , http://hdl.handle.net/10962/d1006356
  • Description: Rhodes University’s Professor Tebello Nyokong, has won the Africa-Arab State 2009 L’Oréal-Unesco Award for Women in Science for her pioneering research into photodynamic therapy which looks at harnessing light for cancer therapy and environmental clean-up. Nyokong is the third South African Scientist to receive this award, and reaffirms Rhodes’s place as one of the top research institutions in the country. University of Cape Town’s Professor Jennifer Thompson was previously recognised for her work on genetic engineering while Wits University’s Professor Valerie Mizrahi was recognised for her tuberculosis research.
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Obituaries: Chris McGregor

  • Authors: Voce, Steve
  • Language: English
  • Type: Article
  • Identifier: vital:13666 , http://hdl.handle.net/10962/d1012578
  • Description: Photocopied epitaph of Chris McGregor from the newspaper The Independent.
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Obituaries: Chris McGregor

  • Authors: McRae, Barry , Redfern, David
  • Subjects: McGregor, Chris--1936-1990 , Jazz , Jazz Musicians
  • Language: English
  • Type: Article
  • Identifier: vital:13610 , http://hdl.handle.net/10962/d1012476 , McGregor, Chris--1936-1990 , Jazz , Jazz Musicians
  • Description: Photocopied obituary of Chris McGregor from the Jazz Journal. A concert is also announced as a memorial tribute to Chris McGregor. A picture of Chris McGregor is also accompanying this article.
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Obituaries: Dudu Pukwana

  • Authors: Voce, Steve , Redfern, David
  • Language: English
  • Type: Article
  • Identifier: vital:13667 , http://hdl.handle.net/10962/d1012579
  • Description: Photocopied obituary of Dudu Pukwana from the newspaper The Independent. A picture of Dudu Pukwana occupies the center of the article.
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Of science and small things: recollections of the past twenty(-)odd years

  • Authors: Botha, J. R
  • Subjects: Nanoscience , Nanotechnology , f-sa
  • Language: English
  • Type: text , Lectures
  • Identifier: http://hdl.handle.net/10948/20867 , vital:29409
  • Description: I will start, therefore, with an overview of achievements in a “new” field of endeavour, a science of small things, popularly called nanoscience, and its spin-off called nanotechnology. I will present a brief history, look at the approaches that have been followed by scientists and engineers to develop and understand small things, and summarise some of the benefits to society in terms of new materials and processes, energy storage and generation, electronics, environmental applications, medicine and transportation. Since our own research focuses on the development on semiconductors, I will conclude the scientific part of the presentation by considering the contribution of semiconductors to the development of nanotechnology and highlight a few examples from our own research during the past two decades on the development of nano-scale semiconductor structures, like nanorods, quantum wells and superlattices.
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Opening address to Conference of Headmasters and Headmistresses of Private Schools - 1977

  • Authors: Henderson, Derek Scott
  • Language: English
  • Type: Text
  • Identifier: vital:7353 , http://hdl.handle.net/10962/d1017082
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Opening of Rhodes Summer School 1975 - East London Library, November 3rd 1975

Opening of Robert Niven Trust school at Amanzi farm 1978

  • Authors: Henderson, Derek Scott
  • Language: English
  • Type: Text
  • Identifier: vital:7368 , http://hdl.handle.net/10962/d1017248
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Opening Professor Scully's multi-image presentation

  • Authors: Henderson, Derek Scott
  • Language: English
  • Type: Text
  • Identifier: vital:7385 , http://hdl.handle.net/10962/d1017274
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Optical nonlinearities and photophysicochemical behaviour of green and blue forms of lutetium bisphthalocyanines

  • Authors: Sekhosana, Kutloano Edward , Amuhaya, Edith , Mack, John , Nyokong, Tebello
  • Language: English
  • Type: Article
  • Identifier: vital:7316 , http://hdl.handle.net/10962/d1020543
  • Description: A rare earth sandwich-type phthalocyanine: bis-{2,3,9,10,16,17,23,24-octa(4-tert-butylphenoxy) phthalocyaninato} lutetium(III) has been synthesized. The photophysical and nonlinear optical behavior of both the “green” and “blue” forms ([LuIIIPc2] and [LuIIIPc2]−, respectively) of the complex have been investigated. High triplet state and singlet oxygen quantum yield values were obtained for the neutral blue form which contains no unpaired electrons. Relatively high third order susceptibility and hyperpolarizability values of the order of 10−10 and 10−28 esu were obtained for both the green and blue forms, respectively. A very low threshold intensity of 0.00051 J cm−2 was obtained for the blue form. Hence the complex shows promise for non-linear optical applications. , Original publication is available at http://dx.doi.org/10.1039/C4TC00505H
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Optical nonlinearities in non-peripherally substituted pyridyloxy phthalocyanines: a combined effect of symmetry, ring-strain and demetallation

  • Authors: Sanusi, Kayode , Antunes, Edith M , Nyokong, Tebello
  • Language: English
  • Type: Article
  • Identifier: vital:7301 , http://hdl.handle.net/10962/d1020375
  • Description: The optical nonlinearities of six non-peripherally-substituted pyridyloxy phthalocyanines have been studied at 532 nm using a nanosecond Z-scan technique in a dimethyl sulphoxide solution. Ring-strain effects and the absence of a metal center were found to greatly reduce the inherent high nonlinearities expected of some of these phthalocyanine complexes. Of the six molecules investigated, 1(4),8(11),15(18),22(25)-tetrakis-(2-pyridyloxy)phthalocyaninato lead(II) 3, 1(4),8(11),15(18),22(25)-tetrakis-(2-pyridyloxy)phthalocyanine 5, and 1(4),8(11),15(18),22(25)-tetrakis-(4-pyridyloxy)phthalocyanine 6 were found to exhibit negligible nonlinear optical behavior, due to either the absence of asymmetry or central metal and/or the presence of a ring-strain effect. A two-photon absorption process was found to be the major contributor to the observed reverse saturable absorption (RSA) in 1(4),8(11),15(18),22(25)-tetrakis-(4-pyridyloxy)phthalocyaninato lead(II) 4, 1(4)-mono-(2-pyridyloxy)phthalocyaninato lead(II) 7, and 1(4)-mono-(4-pyridyloxy)phthalocyaninato lead(II) 8, with large two-photon absorption cross-section, high hyperpolarizability and high third-order susceptibility values in the range of 4.53 × 10−43–5.33 × 10−42 cm4 s per photon, 1.61 × 10−28–1.89 × 10−27 esu and 9.73 × 10−12–7.05 × 10−11 esu respectively. , Original publication is available at http://dx.doi.org/10.1039/C3DT52462K , Arbortext Advanced Print Publisher 9.1.520/W Unicode , Acrobat Distiller 10.0.0 (Windows); modified using iText� 5.3.3 �2000-2012 1T3XT BVBA (AGPL-version)
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Optical properties and electronic structures of axially-ligated group 9 porphyrins

  • Authors: Wang, Bei-Bei , Zuo, Huiping , Mack, John , Majumdar, Poulomi , Nyokong, Tebello , Chan, Kin Shing , Shen, Zhen
  • Language: English
  • Type: Article
  • Identifier: vital:7295 , http://hdl.handle.net/10962/d1020358
  • Description: A series of group 9 metal tetra-(p-tolyl)-porphyrin (M(ttp), M = Co(II), Rh(III), Ir(III)) complexes with axial phenyl substituents have been synthesized and characterized. An aryl bromide cleavage reaction of transition metal complexes was used to prepare the complexes from Co(ttp), Rh(ttp)Cl and Ir(ttp)COCl, respectively. Magnetic circular dichroism (MCD) spectroscopy and TD-DFT calculations have been used to study trends in the optical spectra and electronic structures. The effect of introducing different para-substituents on the phenyl substituents was examined. During fluorescence emission studies, phosphorescence was observed for the Ir(III) complexes in the near infrared (NIR) region. , Original publication is available at http://dx.doi.org/10.1142/S108842461550073X
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