Cardiometabolic risk factors and early indicators of vascular dysfunction: a cross-sectional cohort study in South African adolescents
- Letswalo, Boitumelo Prescilla, Schmid-Zalaudek, Karin, Brix, Bianca, Matjuda, Edna Ngoakoana, Klosz, Fabian, Obernhumer, Natalie, Gaisl, Michael, Engwa, Godwill Azeh, Sewani-Rusike, Constance, Fredriksen, Per Morten, Nkeh-Chungag, Benedicta, Goswami, Nandu
- Authors: Letswalo, Boitumelo Prescilla , Schmid-Zalaudek, Karin , Brix, Bianca , Matjuda, Edna Ngoakoana , Klosz, Fabian , Obernhumer, Natalie , Gaisl, Michael , Engwa, Godwill Azeh , Sewani-Rusike, Constance , Fredriksen, Per Morten , Nkeh-Chungag, Benedicta , Goswami, Nandu
- Date: 2021
- Language: English
- Type: Journal article
- Identifier: http://hdl.handle.net/11260/3864 , vital:43959
- Full Text:
- Authors: Letswalo, Boitumelo Prescilla , Schmid-Zalaudek, Karin , Brix, Bianca , Matjuda, Edna Ngoakoana , Klosz, Fabian , Obernhumer, Natalie , Gaisl, Michael , Engwa, Godwill Azeh , Sewani-Rusike, Constance , Fredriksen, Per Morten , Nkeh-Chungag, Benedicta , Goswami, Nandu
- Date: 2021
- Language: English
- Type: Journal article
- Identifier: http://hdl.handle.net/11260/3864 , vital:43959
- Full Text:
Insufficient iodine nutrition status and the risk of pre-eclampsia: a protocol for systematic review and meta-analysis
- Charles Bitamazire Businge, Namhla Madini, Benjamin Longo-Mbenza, A P Kengne
- Authors: Charles Bitamazire Businge , Namhla Madini , Benjamin Longo-Mbenza , A P Kengne
- Date: 2021
- Language: English
- Type: Journal Article
- Identifier: http://hdl.handle.net/11260/4602 , vital:44141
- Full Text:
- Authors: Charles Bitamazire Businge , Namhla Madini , Benjamin Longo-Mbenza , A P Kengne
- Date: 2021
- Language: English
- Type: Journal Article
- Identifier: http://hdl.handle.net/11260/4602 , vital:44141
- Full Text:
Insufficient iodine nutrition status and the risk of pre-eclampsia: a systemic review and meta-analysis
- Charles Bitamazire Businge, Anthony Usenbo, Benjamin Longo-Mbenza, AP Kengne
- Authors: Charles Bitamazire Businge , Anthony Usenbo , Benjamin Longo-Mbenza , AP Kengne
- Date: 2021
- Language: English
- Type: Journal article
- Identifier: http://hdl.handle.net/11260/3876 , vital:43961
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- Authors: Charles Bitamazire Businge , Anthony Usenbo , Benjamin Longo-Mbenza , AP Kengne
- Date: 2021
- Language: English
- Type: Journal article
- Identifier: http://hdl.handle.net/11260/3876 , vital:43961
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Neuropsychiatric Genetics of African Populations-Psychosis (NeuroGAPPsychosis): a case-control study protocol and GWAS in Ethiopia, Kenya, South Africa and Uganda
- Stevenson, Anne, Zingela, Zukiswa, Akena, Dickens, Stroud, Rocky E, Atwoli, Lukoye, Campbell, Megan M, Chibnik, Lori B, Kwobah, Edith, Kariuki, Symon M, Martin, Alicia R, de Menil, Victoria, Newton, Charles R J C, Sibeko, Goodman, Stein, Dan J, Teferra, Solomon, Koenen, Karestan C
- Authors: Stevenson, Anne , Zingela, Zukiswa , Akena, Dickens , Stroud, Rocky E , Atwoli, Lukoye , Campbell, Megan M , Chibnik, Lori B , Kwobah, Edith , Kariuki, Symon M , Martin, Alicia R , de Menil, Victoria , Newton, Charles R J C , Sibeko, Goodman , Stein, Dan J , Teferra, Solomon , Koenen, Karestan C
- Date: 2021
- Language: English
- Type: Journal Article
- Identifier: http://hdl.handle.net/11260/4594 , vital:44137
- Full Text:
- Authors: Stevenson, Anne , Zingela, Zukiswa , Akena, Dickens , Stroud, Rocky E , Atwoli, Lukoye , Campbell, Megan M , Chibnik, Lori B , Kwobah, Edith , Kariuki, Symon M , Martin, Alicia R , de Menil, Victoria , Newton, Charles R J C , Sibeko, Goodman , Stein, Dan J , Teferra, Solomon , Koenen, Karestan C
- Date: 2021
- Language: English
- Type: Journal Article
- Identifier: http://hdl.handle.net/11260/4594 , vital:44137
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Umbilical cord interleukin-6 predicts outcome in very low birthweight infants in a high HIV-burden setting: a prospective cohort study
- Mackay , Cheryl Anne, Smit, James Stephanus, Khan, Farhaad, Dessai, Fazana, Connolly, Catherine, Masekela, Refiloe
- Authors: Mackay , Cheryl Anne , Smit, James Stephanus , Khan, Farhaad , Dessai, Fazana , Connolly, Catherine , Masekela, Refiloe
- Date: 2020
- Language: English
- Type: Journal Article
- Identifier: http://hdl.handle.net/11260/6376 , vital:45384
- Description: Objectives South Africa has a double burden of high neonatal mortality and maternal HIV prevalence. Common to both is a proinflammatory in utero and perinatal milieu. The aim of this study was to determine cytokine profiles in HIV exposed (HE) and HIV unexposed (HU) very low birthweight (VLBW) infants and to determine whether these were associated with predischarge outcomes. Design Single-centre, prospective cohort study conducted from 1 June 2017 to 31 January 2019. Patients Inborn infants with birth weight of <1500 g were enrolled and cord blood was collected for interleukin (IL)-6 and tumour necrosis factor alpha (TNF-α) assays. Participants provided informed consent and ethics approval was obtained. Outcome measures The primary outcome was umbilical cord cytokine levels according to maternal HIV status. Secondary outcomes included death and/or serious neonatal infection, necrotising enterocolitis, intraventricular haemorrhage, periventricular leucomalacia, chronic lung disease and haemodynamically significant patent ductus arteriosus before discharge. Results A total of 279 cases were included with 269 cytokine assays performed on 122 HEs and 147 HUs. Median IL-6 levels were 53.0 pg/mL in HEs and 21.0 pg/ mL in HUs (p=0.07). Median TNF-α levels were 7.2 pg/ mL in HEs and 6.5 pg/mL in HUs (p=0.6). There was significantly more late-onset sepsis in the HE group compared with the HU group (41.2% vs 27.9%) (p=0.03). IL-6 levels were significantly higher for those with any adverse outcome (p=0.006) and death and/or any adverse outcome (p=0.0001). TNF-α levels did not differ according to predischarge outcomes. Conclusion There is no significant difference in IL-6 and TNF-α levels in cord blood of HE compared with HU VLBWs. However, IL-6 levels are significantly higher in VLBWs with adverse predischarge outcomes, and VLBW HEs are at increased risk of adverse predischarge outcomes compared with HUs, particularly late-onset sepsis.
- Full Text:
- Authors: Mackay , Cheryl Anne , Smit, James Stephanus , Khan, Farhaad , Dessai, Fazana , Connolly, Catherine , Masekela, Refiloe
- Date: 2020
- Language: English
- Type: Journal Article
- Identifier: http://hdl.handle.net/11260/6376 , vital:45384
- Description: Objectives South Africa has a double burden of high neonatal mortality and maternal HIV prevalence. Common to both is a proinflammatory in utero and perinatal milieu. The aim of this study was to determine cytokine profiles in HIV exposed (HE) and HIV unexposed (HU) very low birthweight (VLBW) infants and to determine whether these were associated with predischarge outcomes. Design Single-centre, prospective cohort study conducted from 1 June 2017 to 31 January 2019. Patients Inborn infants with birth weight of <1500 g were enrolled and cord blood was collected for interleukin (IL)-6 and tumour necrosis factor alpha (TNF-α) assays. Participants provided informed consent and ethics approval was obtained. Outcome measures The primary outcome was umbilical cord cytokine levels according to maternal HIV status. Secondary outcomes included death and/or serious neonatal infection, necrotising enterocolitis, intraventricular haemorrhage, periventricular leucomalacia, chronic lung disease and haemodynamically significant patent ductus arteriosus before discharge. Results A total of 279 cases were included with 269 cytokine assays performed on 122 HEs and 147 HUs. Median IL-6 levels were 53.0 pg/mL in HEs and 21.0 pg/ mL in HUs (p=0.07). Median TNF-α levels were 7.2 pg/ mL in HEs and 6.5 pg/mL in HUs (p=0.6). There was significantly more late-onset sepsis in the HE group compared with the HU group (41.2% vs 27.9%) (p=0.03). IL-6 levels were significantly higher for those with any adverse outcome (p=0.006) and death and/or any adverse outcome (p=0.0001). TNF-α levels did not differ according to predischarge outcomes. Conclusion There is no significant difference in IL-6 and TNF-α levels in cord blood of HE compared with HU VLBWs. However, IL-6 levels are significantly higher in VLBWs with adverse predischarge outcomes, and VLBW HEs are at increased risk of adverse predischarge outcomes compared with HUs, particularly late-onset sepsis.
- Full Text:
Insufficient iodine nutrition status and the risk of pre-eclampsia: a protocol for systematic review and meta-analysis
- Authors: Charles Bitamazire Businge
- Date: 2017
- Language: English
- Type: Journal
- Identifier: http://hdl.handle.net/11260/5729 , vital:44637
- Full Text:
- Authors: Charles Bitamazire Businge
- Date: 2017
- Language: English
- Type: Journal
- Identifier: http://hdl.handle.net/11260/5729 , vital:44637
- Full Text:
Social epidemiology of hypertension in Buffalo City Metropolitan Municipality (BCMM): cross-sectional study of determinants of prevalence, awareness, treatment and control among South African adults
- Authors: Oladele Vincent Adeniyi
- Date: 2017
- Language: English
- Type: Journal
- Identifier: http://hdl.handle.net/11260/5734 , vital:44636
- Full Text:
- Authors: Oladele Vincent Adeniyi
- Date: 2017
- Language: English
- Type: Journal
- Identifier: http://hdl.handle.net/11260/5734 , vital:44636
- Full Text:
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