Chemical studies of 1,5-benzodioxepanones

Title: Chemical studies of 1,5-benzodioxepanones
Creator: Gelebe, Aifheli Carlson
Subject: Biochemistry
Subject: Pigments (Biology)
Subject: Benzopyrans
Date Issued: 1991
Date: 1991
Type: Thesis
Type: Masters
Type: MSc
Identifier: vital:4423
Identifier: http://hdl.handle.net/10962/d1006895
Identifier: Biochemistry
Identifier: Pigments (Biology)
Identifier: Benzopyrans
Description: Chromone and flavanone derivatives were prepared by condensation of the corresponding 2-hydroxyacetophenones (with diethyl oxalate or the appropriate aromatic aldehyde respectively) and cyclisation of the condensation products. Saeyer-Villiger rearrangement of these flavanones, with MCPBA, resulted in expansion of the C-ring. Spectroscopic techniques have been used to establish the regioselectivity of the rearrangement and hence, the identity of the rearranged products as 1,5-benzodioxepan-4-ones. The 1,5-benzodioxepan-4-ones were subjected to detailed ¹H and ¹³C n.m.r. analysis and a combination of low and high resolution mass spectrometry has been used to study the mass fragmentation pathways of these ring-expanded products.
Format: 111 p.
Format: pdf
Publisher: Rhodes University
Publisher: Faculty of Science, Chemistry
Language: English
Rights: Gelebe, Aifheli Carlson

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