- Title
- Development and in vitro biological studies of polymer-based wound dressings with a high haemostatic ability for the management of wounds
- Creator
- Nqoro, Xhamla https://orcid.org/0000-0002-2065-3629
- Subject
- Wound healing
- Subject
- Surgical wound infections
- Subject
- Wound treatment equipment industry
- Date Issued
- 2022
- Date
- 2022
- Type
- Doctoral theses
- Type
- text
- Identifier
- http://hdl.handle.net/10353/27970
- Identifier
- vital:71404
- Description
- Wounds are usually accompanied by complications such as excessive bleeding and bacteria invasion. The design of wound dressings that rapidly stop excessive bleeding and inhibit bacterial invasion is crucial to promoting accelerated wound healing. To meet the abovementioned requirements in wound dressings, topical gels were prepared from sodium alginate SA and carboxymethylcellulose CMC. The wound dressings were loaded with an antifibrinolytic agent, tranexamic acid TA, essential oils, and a variety of metal-based nanoparticles, and carbon-based biomaterials. The scanning electron microscopy SEM and X-ray diffraction XRD confirmed the successful formation of the nanoparticles. The prepared formulations exhibited in vitro drug release kinetics that best fitted with the Korsmeyer-Peppas model. These gels exhibited good spreadability and viscosity, showing a shear-thinning behaviour with pH between 6.7 and 7.3, signifying suitability for skin application and ease of application. The prepared topical gels exhibited significant antibacterial effects against gram-negative and gram-positive strains of bacteria. SA EO-based formulations showed high antibacterial activity across all bacterial strains, followed by SA-based formulations compared to CMC-based formulations, which exhibited moderate antibacterial activity. Moreover, the prepared gels showed good cytocompatibility, promoted cell proliferation, and exhibited 80 percent wound closure on day 3 compared to the untreated group, which showed a 38 percent wound reduction in vitro. Excellent blood clotting properties were observed with CMC-based gels compared to other formulations. However, all the prepared formulations exhibited outstanding blood clotting ability compared to the control, showing that they can promote rapid blood coagulation. The features presented by the prepared gels reveal that they are suitable for rapid wound healing
- Description
- Thesis (PhD) -- Faculty of Science and Agriculture, 2022
- Format
- computer
- Format
- online resource
- Format
- application/pdf
- Format
- 1 online resource (xiii, 147 leaves)
- Format
- Publisher
- University of Fort Hare
- Publisher
- Faculty of Science and Agriculture
- Language
- English
- Rights
- University of Fort Hare
- Rights
- All Rights Reserved
- Rights
- Open Access
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UFH Department of Chemistry
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | SOURCE1 | Nqoro X201300305 Thesis Final xxx.pdf | 4 MB | Adobe Acrobat PDF | View Details Download |