Development of a value based pricing index for new drugs in metastatic colorectal cancer
- Authors: Dranitsaris, George
- Date: 2012
- Subjects: Drug -- Prices , Prescription pricing , Pharmaceutical industry -- Prices
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:10140 , http://hdl.handle.net/10948/d1009310 , Drug -- Prices , Prescription pricing , Pharmaceutical industry -- Prices
- Description: Background: Worldwide, prices for cancer drugs have been under downward pressure where several governments have mandated price cuts of branded and generic products. A better alternative to mandated price cuts would be the estimation of a launch price based on drug performance, cost effectiveness and a country’s ability to pay. In this study, the development of a global pricing index for new drugs that encompasses all of these attributes in patients with metastatic colorectal cancer (mCRC) is described. Methods: A pharmacoeconomic model was developed to simulate clinical outcomes in mCRC patients receiving chemotherapy with the addition of a “new drug” that improves survival by 1.4, 3 and 6 months. Cost and health state utility data were obtained from cancer centers and oncology nurses (total n=112) in Canada (n=24), Spain (n=24), India (n=24), South Africa (n=16) and Malaysia (n=24). A price per dose was estimated for each survival increment using a target value threshold of three times the per capita gross domestic product (GDP) for each country, as recommended by the World Health Organisation (WHO). Multivariable analysis was then used to develop the pricing index, which considers survival benefit, per capita GDP and income dispersion as measured by the Gini coefficient as predictor variables. Results: Higher survival benefits were associated with elevated drug prices, especially in wealthier countries such as Canada and Spain. For a nation like Argentina with a per capita GDP of $15,000 and a Gini coefficient of 51, it is estimated that for a drug which provides a 4 month survival benefit in mCRC, the value based price would be $US 630 per dose. In contrast, the same drug in a wealthier country like Norway could command a price of $US 2,775 and still be considered cost effective according to the WHO criteria. Conclusions: A global pricing index was presented that can be used to estimate a value based price in different countries for new drugs in mCRC. The application of this index to estimate a price based on cost effectiveness would be a good starting point for opening dialogue between the key stakeholders and a better alternative to governments’ mandated price cuts.
- Full Text:
- Date Issued: 2012
- Authors: Dranitsaris, George
- Date: 2012
- Subjects: Drug -- Prices , Prescription pricing , Pharmaceutical industry -- Prices
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:10140 , http://hdl.handle.net/10948/d1009310 , Drug -- Prices , Prescription pricing , Pharmaceutical industry -- Prices
- Description: Background: Worldwide, prices for cancer drugs have been under downward pressure where several governments have mandated price cuts of branded and generic products. A better alternative to mandated price cuts would be the estimation of a launch price based on drug performance, cost effectiveness and a country’s ability to pay. In this study, the development of a global pricing index for new drugs that encompasses all of these attributes in patients with metastatic colorectal cancer (mCRC) is described. Methods: A pharmacoeconomic model was developed to simulate clinical outcomes in mCRC patients receiving chemotherapy with the addition of a “new drug” that improves survival by 1.4, 3 and 6 months. Cost and health state utility data were obtained from cancer centers and oncology nurses (total n=112) in Canada (n=24), Spain (n=24), India (n=24), South Africa (n=16) and Malaysia (n=24). A price per dose was estimated for each survival increment using a target value threshold of three times the per capita gross domestic product (GDP) for each country, as recommended by the World Health Organisation (WHO). Multivariable analysis was then used to develop the pricing index, which considers survival benefit, per capita GDP and income dispersion as measured by the Gini coefficient as predictor variables. Results: Higher survival benefits were associated with elevated drug prices, especially in wealthier countries such as Canada and Spain. For a nation like Argentina with a per capita GDP of $15,000 and a Gini coefficient of 51, it is estimated that for a drug which provides a 4 month survival benefit in mCRC, the value based price would be $US 630 per dose. In contrast, the same drug in a wealthier country like Norway could command a price of $US 2,775 and still be considered cost effective according to the WHO criteria. Conclusions: A global pricing index was presented that can be used to estimate a value based price in different countries for new drugs in mCRC. The application of this index to estimate a price based on cost effectiveness would be a good starting point for opening dialogue between the key stakeholders and a better alternative to governments’ mandated price cuts.
- Full Text:
- Date Issued: 2012
Development of a visible light active, photo-catalytic and antimicrobial nanocomposite of titanium dioxide and silicon dioxide for water treatment
- Authors: Mungondori, Henry Heroe
- Date: 2012
- Subjects: Titanium dioxide , Silica , Catalysis , Nanocomposites (Materials) , Water -- Purification
- Language: English
- Type: Thesis , Masters , MSc (Chemistry)
- Identifier: vital:11335 , http://hdl.handle.net/10353/471 , Titanium dioxide , Silica , Catalysis , Nanocomposites (Materials) , Water -- Purification
- Description: The aim of this study was to prepare composite materials based on titanium dioxide (TiO2) and silicon dioxide (SiO2), and to evaluate their photo-catalytic and antimicrobial properties. Carbon and nitrogen doped TiO2nano-particles were prepared via a sol gel synthesis, which is a simple hydrolysis and condensation technique. In situ doping was carried out using glucose and urea as carbon and nitrogen sources respectively. Doping increased the spectral response of titanium dioxide photo-catalyst, allowing it to utilise the visible region which is much wider than the UV region (about 40 % of the solar spectrum), thus making it a more efficient photo-catalyst. The carbon and nitrogen doped TiO2-SiO2nano-particles were immobilized on glass support material to allow for easy separation of the spent photo-catalyst after the photo-degradation process. Tetraethyl orthosilicate (TEOS) was employed as both a binder and precursor for silicon dioxide. A mixture of TiO2 and TEOS in a 1:1 ratio was allowed to polymerize on a glass support which had been treated with hydrofluoric acid to introduce OH groups. The prepared photo-catalytic material was characterized by FT-IR, XRD, DRS, TEM, EDX, and BET analyses. Carbon was found to be more effective as a dopant than nitrogen. It brought about a band gap reduction of 0.30 eV and a BET surface area of 95.4 m2g-1 on the photo-catalyst as compared to a gap reduction of 0.2 eV and surface area of 52.2 m2g-1 for nitrogen doped TiO2. On the other hand, introduction of SiO2 allowed utilization of visible light by the TiO2-SiO2 nano-composite leading to an improved rate of photo-degradation of both methyl orange and phenol red. However, the immobilization of TiO2 on support material made it less effective towards inactivation of E. coli ATCC 25922 bacterial cells when compared to powdered TiO2 which was able to inactivate about 98 % of the bacterial cells within an hour of treatment.
- Full Text:
- Date Issued: 2012
- Authors: Mungondori, Henry Heroe
- Date: 2012
- Subjects: Titanium dioxide , Silica , Catalysis , Nanocomposites (Materials) , Water -- Purification
- Language: English
- Type: Thesis , Masters , MSc (Chemistry)
- Identifier: vital:11335 , http://hdl.handle.net/10353/471 , Titanium dioxide , Silica , Catalysis , Nanocomposites (Materials) , Water -- Purification
- Description: The aim of this study was to prepare composite materials based on titanium dioxide (TiO2) and silicon dioxide (SiO2), and to evaluate their photo-catalytic and antimicrobial properties. Carbon and nitrogen doped TiO2nano-particles were prepared via a sol gel synthesis, which is a simple hydrolysis and condensation technique. In situ doping was carried out using glucose and urea as carbon and nitrogen sources respectively. Doping increased the spectral response of titanium dioxide photo-catalyst, allowing it to utilise the visible region which is much wider than the UV region (about 40 % of the solar spectrum), thus making it a more efficient photo-catalyst. The carbon and nitrogen doped TiO2-SiO2nano-particles were immobilized on glass support material to allow for easy separation of the spent photo-catalyst after the photo-degradation process. Tetraethyl orthosilicate (TEOS) was employed as both a binder and precursor for silicon dioxide. A mixture of TiO2 and TEOS in a 1:1 ratio was allowed to polymerize on a glass support which had been treated with hydrofluoric acid to introduce OH groups. The prepared photo-catalytic material was characterized by FT-IR, XRD, DRS, TEM, EDX, and BET analyses. Carbon was found to be more effective as a dopant than nitrogen. It brought about a band gap reduction of 0.30 eV and a BET surface area of 95.4 m2g-1 on the photo-catalyst as compared to a gap reduction of 0.2 eV and surface area of 52.2 m2g-1 for nitrogen doped TiO2. On the other hand, introduction of SiO2 allowed utilization of visible light by the TiO2-SiO2 nano-composite leading to an improved rate of photo-degradation of both methyl orange and phenol red. However, the immobilization of TiO2 on support material made it less effective towards inactivation of E. coli ATCC 25922 bacterial cells when compared to powdered TiO2 which was able to inactivate about 98 % of the bacterial cells within an hour of treatment.
- Full Text:
- Date Issued: 2012
Development of corona-based power supplies for remote repeater stations for overhead HVDC power transmission systems
- Authors: Kaseke, R
- Date: 2012
- Language: English
- Type: Thesis , Doctoral , PhD (Physics)
- Identifier: vital:11595 , http://hdl.handle.net/10353/d1006787
- Description: More and more people worldwide are becoming “carbon conscious”. This means they are becoming increasingly aware of the imminent adverse effects of global warming. Of late there has been an urgent drive for governments to be on the forefront of all carbon mitigation initiatives. One such drive involves the United Nations Framework Convention on Climate Change whose parties have been meeting regularly under the banner of Conference of Parties (COP) since 1995. At this conference, parties to the convention review progress made in dealing with climate change. Also key to the deliberations in such meetings are better ways of developing cleaner “carbon free” energy sources. Energy sources of this nature are commonly known as renewable energy sources. In essence global energy trends are constantly moving towards development of more renewable energy sources. It is an undeniable fact that some of viable renewable energy sources especially those with bulk capacity are usually located remotely from load centers. This inevitable reality necessitates the construction of long distance bulk power transmission corridors to link generation sites with load centers. Due to its many inherent advantages over High Voltage Alternate Current (HVAC) for long distance power transmission, High Voltage Direct Current (HVDC) is gradually winning the favor of many utilities. In fact, recent advances in HVDC technology have encouraged many utilities to explore the possibility of harnessing remotely located renewable energy sources which would have otherwise not been viable with HVAC transmission. Through the unfortunate and inevitable phenomenon known as corona effect, overhead HVDC conductors suffer real power losses to the air dielectric surrounding them. Through corona, part of the energy carried on the transmission line is expended through ionization and movement of charges in the air dielectric. This study combined physics, mathematical as well engineering concepts to review corona phenomenon around HVDC lines with specific emphasis on space charge generation and motion within ionized DC fields as well as the influence of temperature on corona discharge or power loss. Also, unlike HVAC, performance of an HVDC system relies heavily on the availability of a reliable and robust telecommunication system. One of the key ways of ensuring reliability of a telecommunication system is by making sure that reliable power supplies are in place to power remote repeater stations. A novel concept of quasi-autonomous corona-based power supply (or QC power supply in short) that works on the principle of magnetohydrodymic (MHD) power generation was developed. A small scale experiment was then designed to assess the feasibility of such power supplies. The experiment was conducted with DC supply of a maximum rated voltage of 30 kVDC and generated up to 6 VDC at an optimum ambient temperature of 23°C. These results have confirmed that with further development QC power supplies have the potential of proving reliable power to remotely located repeaters or any other small critical loads along the stretch of the HVDC transmission line. Practical HVDC transmission systems operate voltages in the excess of 500 kV. By linear extrapolation of the above mentioned results; one would expect to yield up to 100-, 120- and 160-VDC from a 500-, 600- and 800- kV HVDC system, respectively. Although the study succeeded in conceptualizing a CMHD idea upon which the novel QC power supply was developed, quite extensive and rigorous design, modeling, prototyping and experimentation processes are still required before the first QC power supply can be commissioned on a practical HVDC line
- Full Text:
- Date Issued: 2012
- Authors: Kaseke, R
- Date: 2012
- Language: English
- Type: Thesis , Doctoral , PhD (Physics)
- Identifier: vital:11595 , http://hdl.handle.net/10353/d1006787
- Description: More and more people worldwide are becoming “carbon conscious”. This means they are becoming increasingly aware of the imminent adverse effects of global warming. Of late there has been an urgent drive for governments to be on the forefront of all carbon mitigation initiatives. One such drive involves the United Nations Framework Convention on Climate Change whose parties have been meeting regularly under the banner of Conference of Parties (COP) since 1995. At this conference, parties to the convention review progress made in dealing with climate change. Also key to the deliberations in such meetings are better ways of developing cleaner “carbon free” energy sources. Energy sources of this nature are commonly known as renewable energy sources. In essence global energy trends are constantly moving towards development of more renewable energy sources. It is an undeniable fact that some of viable renewable energy sources especially those with bulk capacity are usually located remotely from load centers. This inevitable reality necessitates the construction of long distance bulk power transmission corridors to link generation sites with load centers. Due to its many inherent advantages over High Voltage Alternate Current (HVAC) for long distance power transmission, High Voltage Direct Current (HVDC) is gradually winning the favor of many utilities. In fact, recent advances in HVDC technology have encouraged many utilities to explore the possibility of harnessing remotely located renewable energy sources which would have otherwise not been viable with HVAC transmission. Through the unfortunate and inevitable phenomenon known as corona effect, overhead HVDC conductors suffer real power losses to the air dielectric surrounding them. Through corona, part of the energy carried on the transmission line is expended through ionization and movement of charges in the air dielectric. This study combined physics, mathematical as well engineering concepts to review corona phenomenon around HVDC lines with specific emphasis on space charge generation and motion within ionized DC fields as well as the influence of temperature on corona discharge or power loss. Also, unlike HVAC, performance of an HVDC system relies heavily on the availability of a reliable and robust telecommunication system. One of the key ways of ensuring reliability of a telecommunication system is by making sure that reliable power supplies are in place to power remote repeater stations. A novel concept of quasi-autonomous corona-based power supply (or QC power supply in short) that works on the principle of magnetohydrodymic (MHD) power generation was developed. A small scale experiment was then designed to assess the feasibility of such power supplies. The experiment was conducted with DC supply of a maximum rated voltage of 30 kVDC and generated up to 6 VDC at an optimum ambient temperature of 23°C. These results have confirmed that with further development QC power supplies have the potential of proving reliable power to remotely located repeaters or any other small critical loads along the stretch of the HVDC transmission line. Practical HVDC transmission systems operate voltages in the excess of 500 kV. By linear extrapolation of the above mentioned results; one would expect to yield up to 100-, 120- and 160-VDC from a 500-, 600- and 800- kV HVDC system, respectively. Although the study succeeded in conceptualizing a CMHD idea upon which the novel QC power supply was developed, quite extensive and rigorous design, modeling, prototyping and experimentation processes are still required before the first QC power supply can be commissioned on a practical HVDC line
- Full Text:
- Date Issued: 2012
Development of molecularly imprinted polymer based solid phase extraction sorbents for the selective cleanup of food and pharmaceutical residue samples
- Authors: Batlokwa, Bareki Shima
- Date: 2012
- Subjects: Sorbents -- Research Nanofibers -- Research Aflatoxins -- Research Electrospinning -- Research Extraction (Chemistry) -- Research
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:4309 , http://hdl.handle.net/10962/d1004967
- Description: This thesis presents the development of chlorophyll, cholic acid, aflatoxin B1 molecularly imprinted polymer (MIP) particles and cholic acid MIP nanofibers for application as selective solid phase extraction (SPE) sorbents. The particles were prepared by bulk polymerization and the nanofibers by a novel approach combining molecular imprinting and electrospinning technology. The AFB1 MIP particles were compared with an aflatoxin specific immunoextraction sorbent in cleaning-up and pre-concentrating aflatoxins from nut extracts. They both recorded high extraction efficiencies (EEs) of > 97 % in selectively extracting the aflatoxins (AFB1, AFB2, AFG1 and AFG2). High reproducibility marked by the low %RSDs of < 1% and low LODs of ≤ 0.02 ng/g were calculated in all cases. The LODs were within the monitoring requirements of the European Commission. The results were validated with a peanut butter certified reference material. The chlorophyll MIP on the other hand selectively removed chlorophyll that would otherwise interfere during pesticide residue analysis (PRA) from > 0.6 to <0.09 Au in green plants extracts. The extracted chlorophyll was removed to far below the level of ≥ 0.399 Au that is usually associated with interference during PRA. Furthermore, the MIP demonstrated better selectivity by removing only chlorophyll (> 99%) in the presence of planar pesticides than the currently employed graphitized carbon black (GCB) that removed both the chlorophyll (> 88%) and planar pesticides (> 89%). For the interfering cholic acid during drug residue analysis, cholic acid MIP electrospun nanofibers demonstrated to be more sensitive and possessing higher loading capacity than the MIP particles. 100% cholic acid was removed by the nanofibers from standard solutions relative to 80% by the particles. This showed that the nanofibers have better performance than the micro particles and as such have potential to replace the particle based SPE sorbents that are currently in use. All the templates were optimally removed from the prepared MIPs by employing a novel pressurized hot water extraction template removal method that was used for the first time in this thesis. The method employed only water, an environmentally friendly solvent to remove templates to ≥ 99.6% with template residual bleeding of ≤ 0.02%.
- Full Text:
- Date Issued: 2012
- Authors: Batlokwa, Bareki Shima
- Date: 2012
- Subjects: Sorbents -- Research Nanofibers -- Research Aflatoxins -- Research Electrospinning -- Research Extraction (Chemistry) -- Research
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:4309 , http://hdl.handle.net/10962/d1004967
- Description: This thesis presents the development of chlorophyll, cholic acid, aflatoxin B1 molecularly imprinted polymer (MIP) particles and cholic acid MIP nanofibers for application as selective solid phase extraction (SPE) sorbents. The particles were prepared by bulk polymerization and the nanofibers by a novel approach combining molecular imprinting and electrospinning technology. The AFB1 MIP particles were compared with an aflatoxin specific immunoextraction sorbent in cleaning-up and pre-concentrating aflatoxins from nut extracts. They both recorded high extraction efficiencies (EEs) of > 97 % in selectively extracting the aflatoxins (AFB1, AFB2, AFG1 and AFG2). High reproducibility marked by the low %RSDs of < 1% and low LODs of ≤ 0.02 ng/g were calculated in all cases. The LODs were within the monitoring requirements of the European Commission. The results were validated with a peanut butter certified reference material. The chlorophyll MIP on the other hand selectively removed chlorophyll that would otherwise interfere during pesticide residue analysis (PRA) from > 0.6 to <0.09 Au in green plants extracts. The extracted chlorophyll was removed to far below the level of ≥ 0.399 Au that is usually associated with interference during PRA. Furthermore, the MIP demonstrated better selectivity by removing only chlorophyll (> 99%) in the presence of planar pesticides than the currently employed graphitized carbon black (GCB) that removed both the chlorophyll (> 88%) and planar pesticides (> 89%). For the interfering cholic acid during drug residue analysis, cholic acid MIP electrospun nanofibers demonstrated to be more sensitive and possessing higher loading capacity than the MIP particles. 100% cholic acid was removed by the nanofibers from standard solutions relative to 80% by the particles. This showed that the nanofibers have better performance than the micro particles and as such have potential to replace the particle based SPE sorbents that are currently in use. All the templates were optimally removed from the prepared MIPs by employing a novel pressurized hot water extraction template removal method that was used for the first time in this thesis. The method employed only water, an environmentally friendly solvent to remove templates to ≥ 99.6% with template residual bleeding of ≤ 0.02%.
- Full Text:
- Date Issued: 2012
Development, assessment and optimisation of oral famciclovir formulations for paediatric use
- Authors: Magnus, Laura
- Date: 2012
- Subjects: Drugs -- Dosage forms , Drugs -- Analysis , Capsules (Pharmacy) , Antiviral agents , Pediatrics
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:3870 , http://hdl.handle.net/10962/d1018244
- Description: Many Active Pharmaceutical Ingredients (API) such as the antiviral agent famciclovir (FCV) are required for paediatric treatment but are not commercially available in age-appropriate dosage forms. It is common practice to prepare oral liquid dosage forms using commercially available tablets, capsules or powdered API and then dispersing or dissolving the crushed and/or powdered materials in a vehicle that the patient can swallow. Vehicles that are commonly used for this purpose include methylcellulose, syrup or combinations of these carriers where possible or commercially available suspending agents such as Ora-Sweet®, if available, can be used. However, several critical factors are overlooked when manufacturing extemporaneous formulations including, but not limited to, physical and chemical properties of the API, excipients, compatibility, stability and bioavailability issues. A stability-indicating High Performance Liquid Chromatography (HPLC) method for the analysis of FCV was developed and validated according to the International Conference on Harmonization (ICH) guidelines. The method is sensitive, selective, precise, accurate and linear over the concentration range 2-120 μg/ml. The stability of 25 mg/ml FCV formulations was assessed in vehicles manufactured from syrup simplex, hydroxypropyl methylcellulose (HPMC), Ora-Sweet® and an aqueous buffer (pH 6) following storage at 25 °C/60% RH and 40 °C/75% RH over six (6) to eight (8) weeks. The shelf life of the products was calculated as the longest period of storage for approximately 90% of the added FCV to be recovered. Formulations were manufactured using syrup simplex or HPMC with methylparaben and propylparaben individually or in combination and with sodium metabisulphite, ascorbic acid or citric acid as antioxidants. The resultant products were subject to quality control analysis for API content, viscosity, pH and appearance and the resultant data were subject to statistical analysis. The degradation rates were calculated for each product and a degradation profile plotted. The degradation rates of FCV in extemporaneous formulations were compared to those of FCV manufactured using a commercially available suspending agent and a buffered vehicle. FCV undergoes major degradation in the presence of sucrose, as observed for formulations in which the vehicle was syrup and Ora-Sweet®. FCV was found to be most stable when dissolved/dispersed in an HPMC vehicle incorporating sodium metabisulphite and a combination of parabens. The formulation that exhibited the maximum stability was manufactured using an aqueous solution buffered to pH 6. Due to the enhanced stability of FCV when added to a buffered vehicle a formulation in which an HPMC vehicle buffered to pH 6 with sodium metabisulphite, methylparaben and propylparaben was selected for optimisation using a Central Composite Design approach (CCD). In this way it was possible to establish a relationship between input variables such as pH, % w/v HPMC, % w/v antioxidant and % w/v preservative and the responses selected for monitoring by means of response surface modelling. A quadratic model was found to be the most appropriate to describe the relationship between input and output variables. Thirty batches of product were randomly manufactured according to the CCD and analysed to establish the stability in respect of viscosity, pH and the amount of FCV remaining following storage and the data were fitted to models using Design-Expert® software. A correlation between input variables and the responses was best described by a quadratic polynomial model. Analysis of Variance indicated that the response surface models were significant (P-value < 0.0001). The pH to which a FCV formulation was buffered was the most significant factor to effect the % drug content and the ultimate pH of the formulation, while the % w/v HPMC had the most significant effect on the viscosity of the product. The optimum composition for the manufacture of an oral liquid FCV formulation was predicted using the optimisation function of the Design-Expert® software. A low % error of prediction was established, indicating that the model is robust and that RSM is an appropriate formulation optimisation tool as it has a high prognostic ability. A liquid FCV formulation was developed, optimised and found to be suitable for its intended purpose. However further optimisation is required in respect of colourants, sweeteners and/or flavourants. The approach followed is useful in ensuring the development of quality products and can be applied in future.
- Full Text:
- Date Issued: 2012
- Authors: Magnus, Laura
- Date: 2012
- Subjects: Drugs -- Dosage forms , Drugs -- Analysis , Capsules (Pharmacy) , Antiviral agents , Pediatrics
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:3870 , http://hdl.handle.net/10962/d1018244
- Description: Many Active Pharmaceutical Ingredients (API) such as the antiviral agent famciclovir (FCV) are required for paediatric treatment but are not commercially available in age-appropriate dosage forms. It is common practice to prepare oral liquid dosage forms using commercially available tablets, capsules or powdered API and then dispersing or dissolving the crushed and/or powdered materials in a vehicle that the patient can swallow. Vehicles that are commonly used for this purpose include methylcellulose, syrup or combinations of these carriers where possible or commercially available suspending agents such as Ora-Sweet®, if available, can be used. However, several critical factors are overlooked when manufacturing extemporaneous formulations including, but not limited to, physical and chemical properties of the API, excipients, compatibility, stability and bioavailability issues. A stability-indicating High Performance Liquid Chromatography (HPLC) method for the analysis of FCV was developed and validated according to the International Conference on Harmonization (ICH) guidelines. The method is sensitive, selective, precise, accurate and linear over the concentration range 2-120 μg/ml. The stability of 25 mg/ml FCV formulations was assessed in vehicles manufactured from syrup simplex, hydroxypropyl methylcellulose (HPMC), Ora-Sweet® and an aqueous buffer (pH 6) following storage at 25 °C/60% RH and 40 °C/75% RH over six (6) to eight (8) weeks. The shelf life of the products was calculated as the longest period of storage for approximately 90% of the added FCV to be recovered. Formulations were manufactured using syrup simplex or HPMC with methylparaben and propylparaben individually or in combination and with sodium metabisulphite, ascorbic acid or citric acid as antioxidants. The resultant products were subject to quality control analysis for API content, viscosity, pH and appearance and the resultant data were subject to statistical analysis. The degradation rates were calculated for each product and a degradation profile plotted. The degradation rates of FCV in extemporaneous formulations were compared to those of FCV manufactured using a commercially available suspending agent and a buffered vehicle. FCV undergoes major degradation in the presence of sucrose, as observed for formulations in which the vehicle was syrup and Ora-Sweet®. FCV was found to be most stable when dissolved/dispersed in an HPMC vehicle incorporating sodium metabisulphite and a combination of parabens. The formulation that exhibited the maximum stability was manufactured using an aqueous solution buffered to pH 6. Due to the enhanced stability of FCV when added to a buffered vehicle a formulation in which an HPMC vehicle buffered to pH 6 with sodium metabisulphite, methylparaben and propylparaben was selected for optimisation using a Central Composite Design approach (CCD). In this way it was possible to establish a relationship between input variables such as pH, % w/v HPMC, % w/v antioxidant and % w/v preservative and the responses selected for monitoring by means of response surface modelling. A quadratic model was found to be the most appropriate to describe the relationship between input and output variables. Thirty batches of product were randomly manufactured according to the CCD and analysed to establish the stability in respect of viscosity, pH and the amount of FCV remaining following storage and the data were fitted to models using Design-Expert® software. A correlation between input variables and the responses was best described by a quadratic polynomial model. Analysis of Variance indicated that the response surface models were significant (P-value < 0.0001). The pH to which a FCV formulation was buffered was the most significant factor to effect the % drug content and the ultimate pH of the formulation, while the % w/v HPMC had the most significant effect on the viscosity of the product. The optimum composition for the manufacture of an oral liquid FCV formulation was predicted using the optimisation function of the Design-Expert® software. A low % error of prediction was established, indicating that the model is robust and that RSM is an appropriate formulation optimisation tool as it has a high prognostic ability. A liquid FCV formulation was developed, optimised and found to be suitable for its intended purpose. However further optimisation is required in respect of colourants, sweeteners and/or flavourants. The approach followed is useful in ensuring the development of quality products and can be applied in future.
- Full Text:
- Date Issued: 2012
Diagnosing organizational effectiveness in the tourism sector of Zanzibar
- Authors: Raja, Sanjay Kanji
- Date: 2012
- Subjects: Organizational effectiveness -- Zanzibar Management by objectives -- Zanzibar Tourism -- Zanzibar Tourism -- Management -- Zanzibar Job satisfaction -- Zanzibar Employee motivation -- Zanzibar
- Language: English
- Type: Thesis , Masters , MBA
- Identifier: vital:780 , http://hdl.handle.net/10962/d1003901
- Description: The tourism sector in Zanzibar Tanzania has emerged strongly in the past 15 years, helping the development of other Industries that support it. As a result, Industries such as telecommunication, IT, transport and hospitality have also emerged recently. It is, however, speculated that organizations in the tourism sector in Zanzibar generally lack the effective performance that is required of them to compete in the contemporary complex and turbulent market environment. This research thus set out to explore and diagnose the organizational effectiveness of the accommodation units of the tourism sector in Zanzibar. The research had specific objectives of diagnosing and finding the gap between the current and the optimal organizational performance in two particular units of accommodation as well as determining the factors affecting organizational performance in these units. The study furthermore set out to recommend implementation of suitable intervention activities to improve organizational performance in the units analyzed. In order to achieve the above objectives the research deployed an action research strategy with the Weisbord’s six box model as a framework to diagnose two five star grade accommodation units in Zanzibar. A qualitative method was used to collect data. Key findings of the research are briefly presented below: - The service output of the accommodation units analyzed was not very consistent and fell short of the expectation of their customers. This showed a gap in terms of the organizations’ performance. - Factors affecting organizational effectiveness were found to be mainly in the Purpose and Rewards functions of the organizations. - The specific areas in the Purpose function that appeared to have substantial problems were: -- Goals of the organization were not clearly stated -- Employees did not understand the purpose of the organization -- Employees were not involved in deciding their work unit goals -- Employees were not in agreement with the goals of their work units. -- Employees did not understand priorities of the organization The specific areas in the Reward function that appeared to have substantial problems were: -- The pay scale and benefits of the organization did not treat employees equitably. -- Employees felt that the salary they received was not commensurate with the jobs they performed. -- Not all tasks to be accomplished were associated with incentives. Following the diagnostics findings above, the research suggested the following intervention activities that could possibly help to address the above mentioned problems: - A Management by Objectives (MBO) process was suggested to redress the problems indicated in the Purpose function. This would help to set clearly agreed goals at all levels of the organizations. Employees and resources would then be directed towards achieving these goals that would enable the organizations to perform more effectively. - Revision of the current reward system was suggested to redress the problems indicated in the Reward function. The reward system should be implemented in a manner that creates a feeling of both internal as well as external (market) equity among employees. Furthermore, rewards should be linked to performance in order to direct behaviour and motivation among employees. The performance based reward system can also help to achieve the MBO process proposed above since rewards will be designated for achievement of individual, departmental and finally organizational objectives, thus increasing organizational effectiveness.
- Full Text:
- Date Issued: 2012
- Authors: Raja, Sanjay Kanji
- Date: 2012
- Subjects: Organizational effectiveness -- Zanzibar Management by objectives -- Zanzibar Tourism -- Zanzibar Tourism -- Management -- Zanzibar Job satisfaction -- Zanzibar Employee motivation -- Zanzibar
- Language: English
- Type: Thesis , Masters , MBA
- Identifier: vital:780 , http://hdl.handle.net/10962/d1003901
- Description: The tourism sector in Zanzibar Tanzania has emerged strongly in the past 15 years, helping the development of other Industries that support it. As a result, Industries such as telecommunication, IT, transport and hospitality have also emerged recently. It is, however, speculated that organizations in the tourism sector in Zanzibar generally lack the effective performance that is required of them to compete in the contemporary complex and turbulent market environment. This research thus set out to explore and diagnose the organizational effectiveness of the accommodation units of the tourism sector in Zanzibar. The research had specific objectives of diagnosing and finding the gap between the current and the optimal organizational performance in two particular units of accommodation as well as determining the factors affecting organizational performance in these units. The study furthermore set out to recommend implementation of suitable intervention activities to improve organizational performance in the units analyzed. In order to achieve the above objectives the research deployed an action research strategy with the Weisbord’s six box model as a framework to diagnose two five star grade accommodation units in Zanzibar. A qualitative method was used to collect data. Key findings of the research are briefly presented below: - The service output of the accommodation units analyzed was not very consistent and fell short of the expectation of their customers. This showed a gap in terms of the organizations’ performance. - Factors affecting organizational effectiveness were found to be mainly in the Purpose and Rewards functions of the organizations. - The specific areas in the Purpose function that appeared to have substantial problems were: -- Goals of the organization were not clearly stated -- Employees did not understand the purpose of the organization -- Employees were not involved in deciding their work unit goals -- Employees were not in agreement with the goals of their work units. -- Employees did not understand priorities of the organization The specific areas in the Reward function that appeared to have substantial problems were: -- The pay scale and benefits of the organization did not treat employees equitably. -- Employees felt that the salary they received was not commensurate with the jobs they performed. -- Not all tasks to be accomplished were associated with incentives. Following the diagnostics findings above, the research suggested the following intervention activities that could possibly help to address the above mentioned problems: - A Management by Objectives (MBO) process was suggested to redress the problems indicated in the Purpose function. This would help to set clearly agreed goals at all levels of the organizations. Employees and resources would then be directed towards achieving these goals that would enable the organizations to perform more effectively. - Revision of the current reward system was suggested to redress the problems indicated in the Reward function. The reward system should be implemented in a manner that creates a feeling of both internal as well as external (market) equity among employees. Furthermore, rewards should be linked to performance in order to direct behaviour and motivation among employees. The performance based reward system can also help to achieve the MBO process proposed above since rewards will be designated for achievement of individual, departmental and finally organizational objectives, thus increasing organizational effectiveness.
- Full Text:
- Date Issued: 2012
Differential regulation of monocyte cytokine release by αV and β2 integrins that bind CD23:
- Edkins, Adrienne L, Borland, Gillian, Acharya, Mridu, Cogdell, Richard, Ozanne, Bradford W, Cushley, William
- Authors: Edkins, Adrienne L , Borland, Gillian , Acharya, Mridu , Cogdell, Richard , Ozanne, Bradford W , Cushley, William
- Date: 2012
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/165153 , vital:41213 , DOI: 10.1111/j.1365-2567.2012.03576.x
- Description: The human soluble CD23 (sCD23) protein displays highly pleiotropic cytokine‐like activity. Monocytic cells express the sCD23‐binding integrins αVβ3, αVβ5, αMβ2 and αXβ2, but it is unclear which of these four integrins most acutely regulates sCD23‐driven cytokine release. The hypothesis that ligation of different sCD23‐binding integrins promoted release of distinct subsets of cytokines was tested. Lipopolysaccharide (LPS) and sCD23 promoted release of distinct groups of cytokines from the THP‐1 model cell line.
- Full Text:
- Date Issued: 2012
- Authors: Edkins, Adrienne L , Borland, Gillian , Acharya, Mridu , Cogdell, Richard , Ozanne, Bradford W , Cushley, William
- Date: 2012
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/165153 , vital:41213 , DOI: 10.1111/j.1365-2567.2012.03576.x
- Description: The human soluble CD23 (sCD23) protein displays highly pleiotropic cytokine‐like activity. Monocytic cells express the sCD23‐binding integrins αVβ3, αVβ5, αMβ2 and αXβ2, but it is unclear which of these four integrins most acutely regulates sCD23‐driven cytokine release. The hypothesis that ligation of different sCD23‐binding integrins promoted release of distinct subsets of cytokines was tested. Lipopolysaccharide (LPS) and sCD23 promoted release of distinct groups of cytokines from the THP‐1 model cell line.
- Full Text:
- Date Issued: 2012
Difficulties experienced by small business managers in marketing their businesses
- Authors: Kpalou, Jean-Yves Gaba
- Date: 2012
- Subjects: Marketing , Small business
- Language: English
- Type: Thesis , Masters , MTech
- Identifier: vital:9016 , http://hdl.handle.net/10948/d1018635
- Description: The small business sector in today‘s world is considered seriously by researchers, scholars, policy-makers and governments as an important answer in addressing problems of unemployment, poverty alleviation, and redistribution of wealth. Promoting and encouraging the development of the small business sector is without any doubt a key factor for economic growth. However, this sector faced a high rate of businesses failure due to the many challenges among them, for example, the lack of marketing strategy and implementation in the conduct of the business. Several researches show the important role of marketing in a business but unfortunately it is still not a strong component in many organisations especially within the small business sector.For this reason the aim of this study was to investigate the difficulties experienced by small business managers in marketing their businesses. Taking the aim of this study into consideration, the primary objectives were to firstly look at the practice of marketing in small businesses and secondly to identify the difficulties of marketing experienced by small business managers.The literature study provided a brief overview of the small business sector, followed by a presentation of the practice of marketing in an organisation especially within small business enterprises. Moreover a discussion of the difficulties experienced by small business managers in marketing their businesses was also addressed through the literature review. The literature classified those difficulties into two types; (a)internal factors (lack of marketing planning and strategy, cost of marketing, lack of marketing expertise, perception of marketing) and (b) external factors (lack of knowledge of the market environment).The empirical study was conducted to evaluate the practice of marketing in small businesses and to see what marketing difficulties were experienced by small business owners and/or managers. Data were collected by means of a survey, using a questionnaire. Respondents were identified using the snowball sampling technique through the database of the Nelson Mandela Bay Chamber of Commerce. The data gathered from 67 usable questionnaires were analysed and interpreted. The results of the empirical study revealed that the biggest problems experienced by small business managers in the sample were the heavy cost of marketing followed by the lack of marketing expertise and finally the lack of marketing segmentation strategy. This study contributes to the enhancement of the literature on small business marketing with a focus on the difficulties experienced by owners and/or managers in implementing marketing. As a result this study presents recommendations and suggestions to assist managers in marketing their businesses.
- Full Text:
- Date Issued: 2012
- Authors: Kpalou, Jean-Yves Gaba
- Date: 2012
- Subjects: Marketing , Small business
- Language: English
- Type: Thesis , Masters , MTech
- Identifier: vital:9016 , http://hdl.handle.net/10948/d1018635
- Description: The small business sector in today‘s world is considered seriously by researchers, scholars, policy-makers and governments as an important answer in addressing problems of unemployment, poverty alleviation, and redistribution of wealth. Promoting and encouraging the development of the small business sector is without any doubt a key factor for economic growth. However, this sector faced a high rate of businesses failure due to the many challenges among them, for example, the lack of marketing strategy and implementation in the conduct of the business. Several researches show the important role of marketing in a business but unfortunately it is still not a strong component in many organisations especially within the small business sector.For this reason the aim of this study was to investigate the difficulties experienced by small business managers in marketing their businesses. Taking the aim of this study into consideration, the primary objectives were to firstly look at the practice of marketing in small businesses and secondly to identify the difficulties of marketing experienced by small business managers.The literature study provided a brief overview of the small business sector, followed by a presentation of the practice of marketing in an organisation especially within small business enterprises. Moreover a discussion of the difficulties experienced by small business managers in marketing their businesses was also addressed through the literature review. The literature classified those difficulties into two types; (a)internal factors (lack of marketing planning and strategy, cost of marketing, lack of marketing expertise, perception of marketing) and (b) external factors (lack of knowledge of the market environment).The empirical study was conducted to evaluate the practice of marketing in small businesses and to see what marketing difficulties were experienced by small business owners and/or managers. Data were collected by means of a survey, using a questionnaire. Respondents were identified using the snowball sampling technique through the database of the Nelson Mandela Bay Chamber of Commerce. The data gathered from 67 usable questionnaires were analysed and interpreted. The results of the empirical study revealed that the biggest problems experienced by small business managers in the sample were the heavy cost of marketing followed by the lack of marketing expertise and finally the lack of marketing segmentation strategy. This study contributes to the enhancement of the literature on small business marketing with a focus on the difficulties experienced by owners and/or managers in implementing marketing. As a result this study presents recommendations and suggestions to assist managers in marketing their businesses.
- Full Text:
- Date Issued: 2012
Difficulties experienced by small businesses in accessing finance
- Kouadio, Gbogbo Nina Marie-Laure
- Authors: Kouadio, Gbogbo Nina Marie-Laure
- Date: 2012
- Subjects: Economics , Small business
- Language: English
- Type: Thesis , Masters , MTech
- Identifier: vital:9015 , http://hdl.handle.net/10948/d1018633
- Description: Small and Medium Enterprises (SMEs) significantly contribute to the growth of the economy and the employment sector. However, it is indicated that SMEs lack access to the financial products and services that are critical to their growth. Therefore, the primary objective of this study was to investigate the difficulties experienced by small businesses in accessing finance. An online questionnaire survey was considered an appropriate measurement method for this study. The targeted population of the study included all small businesses operating in the Nelson Mandela Bay Metropole. Thus, some 208 companies were identified as part of the study sampling frame. A total number of 66 questionnaires were returned out of the 208 targeted companies - giving a response rate of 29 percent. The quantitative data were processed using a STATISTICA program, leading to appropriate descriptive statistical analyses, including frequencies, means, medians and standard deviations. In order to obtain a better understanding of the difficulties experienced by small businesses in accessing finance, hypotheses were also formulated and a t-test was used to establish the statistical significance of certain demographic variables and company characteristics regarding the problems experienced by small businesses in accessing finance. The results of the empirical study revealed that the major difficulties faced by small businesses in their access to finance were the lack of collateral and security, the high cost of borrowing interest and the delay in feedback from the financial institutions. Further, by testing the hypotheses, it was also revealed that the ethnic group of the applicant, the total years of business experience of the applicant and the annual turnover of the business have an impact on the access to finance. Based on the relevant literature study and the empirical results, recommendations were made in order to address the identified problems. However, the unavailability of an exhaustive small business database in the Nelson Mandela Bay Metropole did not allow the research to draw on a larger representative sample. Thus, this limitation has impeded in-depth statistical analysis that would have allowed the research to obtain more accurate findings. Further studies could investigate the reasons why in many cases financial institutions reject the funding of small businesses.
- Full Text:
- Date Issued: 2012
- Authors: Kouadio, Gbogbo Nina Marie-Laure
- Date: 2012
- Subjects: Economics , Small business
- Language: English
- Type: Thesis , Masters , MTech
- Identifier: vital:9015 , http://hdl.handle.net/10948/d1018633
- Description: Small and Medium Enterprises (SMEs) significantly contribute to the growth of the economy and the employment sector. However, it is indicated that SMEs lack access to the financial products and services that are critical to their growth. Therefore, the primary objective of this study was to investigate the difficulties experienced by small businesses in accessing finance. An online questionnaire survey was considered an appropriate measurement method for this study. The targeted population of the study included all small businesses operating in the Nelson Mandela Bay Metropole. Thus, some 208 companies were identified as part of the study sampling frame. A total number of 66 questionnaires were returned out of the 208 targeted companies - giving a response rate of 29 percent. The quantitative data were processed using a STATISTICA program, leading to appropriate descriptive statistical analyses, including frequencies, means, medians and standard deviations. In order to obtain a better understanding of the difficulties experienced by small businesses in accessing finance, hypotheses were also formulated and a t-test was used to establish the statistical significance of certain demographic variables and company characteristics regarding the problems experienced by small businesses in accessing finance. The results of the empirical study revealed that the major difficulties faced by small businesses in their access to finance were the lack of collateral and security, the high cost of borrowing interest and the delay in feedback from the financial institutions. Further, by testing the hypotheses, it was also revealed that the ethnic group of the applicant, the total years of business experience of the applicant and the annual turnover of the business have an impact on the access to finance. Based on the relevant literature study and the empirical results, recommendations were made in order to address the identified problems. However, the unavailability of an exhaustive small business database in the Nelson Mandela Bay Metropole did not allow the research to draw on a larger representative sample. Thus, this limitation has impeded in-depth statistical analysis that would have allowed the research to obtain more accurate findings. Further studies could investigate the reasons why in many cases financial institutions reject the funding of small businesses.
- Full Text:
- Date Issued: 2012
Discrimination against women under customary law in South Africa with reference to inheritance and succession
- Mashalaba, Siyabulela Welcome
- Authors: Mashalaba, Siyabulela Welcome
- Date: 2012
- Subjects: Inheritance and succession -- South Africa , Customary law -- South Africa , Sex discrimination -- South Africa
- Language: English
- Type: Thesis , Masters , MA (Human Rights)
- Identifier: vital:11099 , http://hdl.handle.net/10353/505 , Inheritance and succession -- South Africa , Customary law -- South Africa , Sex discrimination -- South Africa
- Description: In South Africa, it is evident that women are uniformed of their essential human rights, especially their inheritance and succession rights, including protection of such rights. Human rights are international norms that protect individuals everywhere from the states’ political, legal and social abuse. Human rights are entitlements which human beings have in order to enhance their human condition. They are the fundamental entitlements or minimum standards to be met for individual so that they live with dignity. This study focused on discrimination of women under customary law in South Africa with reference to inheritance and succession. The study validated the findings of other researchers on the impact of cultural practices on women’s rights to inheritance and succession. In addition the findings revealed that efforts t eliminate traditional practices, should foremost come from men and from communities that hold such destructive attitudes towards women. The outcomes and recommendations of this study would assist the government and other institutions to adopt effective measures to empower women and especially educate them so that they can assert and defend their human rights
- Full Text:
- Date Issued: 2012
- Authors: Mashalaba, Siyabulela Welcome
- Date: 2012
- Subjects: Inheritance and succession -- South Africa , Customary law -- South Africa , Sex discrimination -- South Africa
- Language: English
- Type: Thesis , Masters , MA (Human Rights)
- Identifier: vital:11099 , http://hdl.handle.net/10353/505 , Inheritance and succession -- South Africa , Customary law -- South Africa , Sex discrimination -- South Africa
- Description: In South Africa, it is evident that women are uniformed of their essential human rights, especially their inheritance and succession rights, including protection of such rights. Human rights are international norms that protect individuals everywhere from the states’ political, legal and social abuse. Human rights are entitlements which human beings have in order to enhance their human condition. They are the fundamental entitlements or minimum standards to be met for individual so that they live with dignity. This study focused on discrimination of women under customary law in South Africa with reference to inheritance and succession. The study validated the findings of other researchers on the impact of cultural practices on women’s rights to inheritance and succession. In addition the findings revealed that efforts t eliminate traditional practices, should foremost come from men and from communities that hold such destructive attitudes towards women. The outcomes and recommendations of this study would assist the government and other institutions to adopt effective measures to empower women and especially educate them so that they can assert and defend their human rights
- Full Text:
- Date Issued: 2012
Domestic workers: discussion document 27-29 March 2012
- Congress of South African Trade Unions (COSATU)
- Authors: Congress of South African Trade Unions (COSATU)
- Date: 2012
- Subjects: Labor unions South Africa , Household employees South Africa , Cosatu
- Language: English
- Type: book , text
- Identifier: http://hdl.handle.net/10962/68711 , vital:29307
- Description: The 5th Cosatu Congress resolved that a research be commissioned by the CEC and conducted by Naledi on the need for establishment of advice centres for servicing and assisting domestic workers. Again, part of the resolution indicated that we should consider finding a viable home for domestic workers. As we move towards the 11th Cosatu Gender Conference, we need to reflect and take stock of the previous resolutions passed on domestic workers, assess the strategies/ steps taken for implementation and make a way forward. This paper has arisen as a follow-up of the afore-mentioned resolution including the commitment made by Cosatu on the Summit held between 27-28 August 2011 which the federation hosted in partnership with the South African Domestic Services and Allied Workers Union (SADSAWU) and the South African Office of the ILO. The aim is to stimulate and resuscitate discussions on domestic work acknowledging the positive steps taken at international level of adoption of ILO Convention 189 (C189) on Decent Work for Domestic Workers and its Recommendation 201 (R201).
- Full Text:
- Date Issued: 2012
- Authors: Congress of South African Trade Unions (COSATU)
- Date: 2012
- Subjects: Labor unions South Africa , Household employees South Africa , Cosatu
- Language: English
- Type: book , text
- Identifier: http://hdl.handle.net/10962/68711 , vital:29307
- Description: The 5th Cosatu Congress resolved that a research be commissioned by the CEC and conducted by Naledi on the need for establishment of advice centres for servicing and assisting domestic workers. Again, part of the resolution indicated that we should consider finding a viable home for domestic workers. As we move towards the 11th Cosatu Gender Conference, we need to reflect and take stock of the previous resolutions passed on domestic workers, assess the strategies/ steps taken for implementation and make a way forward. This paper has arisen as a follow-up of the afore-mentioned resolution including the commitment made by Cosatu on the Summit held between 27-28 August 2011 which the federation hosted in partnership with the South African Domestic Services and Allied Workers Union (SADSAWU) and the South African Office of the ILO. The aim is to stimulate and resuscitate discussions on domestic work acknowledging the positive steps taken at international level of adoption of ILO Convention 189 (C189) on Decent Work for Domestic Workers and its Recommendation 201 (R201).
- Full Text:
- Date Issued: 2012
Dragging young people down the drain: the mobile phone, gossip mobile website Outoilet and the creation of a mobile ghetto
- Authors: Schoon, Alette
- Date: 2012
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/147858 , vital:38679 , DOI: 10.1080/02560046.2012.744723
- Description: This qualitative study uses the domestication model to describe how a geographically based gossip mobile website, Outoilet (old toilet), helped to shape the meanings of everyday life for young adults in Hooggenoeg, a poor black low-income urban settlement in Grahamstown, South Africa. All the residents here know one another and there is very little privacy, and the mobile phone, during the period of this research, reinforced the lack of privacy through gossip. Such gossip promoted an inward-looking collective sociability. As this article demonstrates, subjects of gossip avoided the streets to escape collective surveillance. Outoilet's explicit sexual language seemed to target those who attempted social mobility by replicating local discourses of respectability and shame. Contrary to findings from other contexts, the mobile phone here thus promoted a collective sociability and may have discouraged mobility as well as economic development.
- Full Text:
- Date Issued: 2012
- Authors: Schoon, Alette
- Date: 2012
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/147858 , vital:38679 , DOI: 10.1080/02560046.2012.744723
- Description: This qualitative study uses the domestication model to describe how a geographically based gossip mobile website, Outoilet (old toilet), helped to shape the meanings of everyday life for young adults in Hooggenoeg, a poor black low-income urban settlement in Grahamstown, South Africa. All the residents here know one another and there is very little privacy, and the mobile phone, during the period of this research, reinforced the lack of privacy through gossip. Such gossip promoted an inward-looking collective sociability. As this article demonstrates, subjects of gossip avoided the streets to escape collective surveillance. Outoilet's explicit sexual language seemed to target those who attempted social mobility by replicating local discourses of respectability and shame. Contrary to findings from other contexts, the mobile phone here thus promoted a collective sociability and may have discouraged mobility as well as economic development.
- Full Text:
- Date Issued: 2012
Dreams, sexuality and fantasy: a psychoanalytic reading of K. Sello Duiker’s novels
- Authors: Kirton-Els, Teneille
- Date: 2012
- Language: English
- Type: Thesis , Doctoral , DLitt et Phil
- Identifier: vital:11890 , http://hdl.handle.net/10353/d1020154
- Description: The primary aim of this thesis is to provide a text-based literary study exploring the characters and themes created by K. Sello Duiker in the three novels, Thirteen Cents, The Quiet Violence of Dreams and The Hidden Star. Duiker’s work is significant because it highlights prominent societal challenges prevalent in post-apartheid society. By analysing Duiker’s novels one acquires a better understanding of this author, an understanding of the world that contributed to the creation of his texts and his contribution to South African literature. Insight into Duiker’s fictional world allows for a careful investigation of the prominent societal issues prevalent in Duiker’s work - a world riddled with violence, issues of sexuality and psychological distress. For this purpose this thesis is premised on the notion that underpinning K. Sello Duiker’s oeuvre is a central focus on dreams, sexuality and fantasy. Logically, therefore, the main focus of the study is specifically on the inner working of the characters’ minds and how they deal/ or are unable to cope with contemporary social concerns, often resulting in psychological turmoil and dysfunctionality. For this reason, prominent themes examined in this study are the interpretation of dreams, an exploration of sexuality and an examination of fantasy in the three novels. Psychoanalytic literary theory, with the main focus being specifically on the theories presented by Sigmund Freud is used as an analytic tool to read Duiker’s texts. Psychoanalytic theory is arguably the most appropriate for analysing Duiker’s novels as it allows one to investigate the characters’ psyches and the psychological effect of societal influences on these characters. In addition, one is also able to examine how the characters are able/ unable to deal with the trauma caused by the contemporary issues in society – issues of violence, sexuality and psychological distress. Thus, one is able to grasp an overall understanding of the characters’ behaviour and actions. Furthermore, the characters’ experiences are based on the behaviour and incidents of real people, people suffering from psychological dysfunctionality, sexuality issues and identity crisis. The first chapter discusses post-apartheid literature, and provides a brief background on Duiker, his works and his conception as a writer. Chapter two provides an overview of psychoanalytic theory and on the relevant theories of Sigmund Freud. Chapter three offers a reading of Thirteen Cents, a novel that pays particular attention to the lives of children living on the streets of Cape Town. In the next chapter The Quiet Violence of Dreams is examined with a special focus on Duiker’s experimentation with form in the construction of this novel. Aspects pertaining to sexuality and dreams are also examined. Chapter five pays particular attention to magical realism and fantasy in The Hidden Star.
- Full Text:
- Date Issued: 2012
- Authors: Kirton-Els, Teneille
- Date: 2012
- Language: English
- Type: Thesis , Doctoral , DLitt et Phil
- Identifier: vital:11890 , http://hdl.handle.net/10353/d1020154
- Description: The primary aim of this thesis is to provide a text-based literary study exploring the characters and themes created by K. Sello Duiker in the three novels, Thirteen Cents, The Quiet Violence of Dreams and The Hidden Star. Duiker’s work is significant because it highlights prominent societal challenges prevalent in post-apartheid society. By analysing Duiker’s novels one acquires a better understanding of this author, an understanding of the world that contributed to the creation of his texts and his contribution to South African literature. Insight into Duiker’s fictional world allows for a careful investigation of the prominent societal issues prevalent in Duiker’s work - a world riddled with violence, issues of sexuality and psychological distress. For this purpose this thesis is premised on the notion that underpinning K. Sello Duiker’s oeuvre is a central focus on dreams, sexuality and fantasy. Logically, therefore, the main focus of the study is specifically on the inner working of the characters’ minds and how they deal/ or are unable to cope with contemporary social concerns, often resulting in psychological turmoil and dysfunctionality. For this reason, prominent themes examined in this study are the interpretation of dreams, an exploration of sexuality and an examination of fantasy in the three novels. Psychoanalytic literary theory, with the main focus being specifically on the theories presented by Sigmund Freud is used as an analytic tool to read Duiker’s texts. Psychoanalytic theory is arguably the most appropriate for analysing Duiker’s novels as it allows one to investigate the characters’ psyches and the psychological effect of societal influences on these characters. In addition, one is also able to examine how the characters are able/ unable to deal with the trauma caused by the contemporary issues in society – issues of violence, sexuality and psychological distress. Thus, one is able to grasp an overall understanding of the characters’ behaviour and actions. Furthermore, the characters’ experiences are based on the behaviour and incidents of real people, people suffering from psychological dysfunctionality, sexuality issues and identity crisis. The first chapter discusses post-apartheid literature, and provides a brief background on Duiker, his works and his conception as a writer. Chapter two provides an overview of psychoanalytic theory and on the relevant theories of Sigmund Freud. Chapter three offers a reading of Thirteen Cents, a novel that pays particular attention to the lives of children living on the streets of Cape Town. In the next chapter The Quiet Violence of Dreams is examined with a special focus on Duiker’s experimentation with form in the construction of this novel. Aspects pertaining to sexuality and dreams are also examined. Chapter five pays particular attention to magical realism and fantasy in The Hidden Star.
- Full Text:
- Date Issued: 2012
Drug abuse in selected Grahamstown schools
- Authors: Rungani, Judith
- Date: 2012
- Subjects: High school students -- Substance use -- South Africa -- Eastern Cape , School management and organization , Teenagers -- Drug abuse , Substance abuse -- Youth -- Grahamstown (South Africa)
- Language: English
- Type: Thesis , Masters , M SW
- Identifier: vital:11759 , http://hdl.handle.net/10353/d1004784 , High school students -- Substance use -- South Africa -- Eastern Cape , School management and organization , Teenagers -- Drug abuse , Substance abuse -- Youth -- Grahamstown (South Africa)
- Description: The study explores drug abuse by learners in selected Grahamstown high schools. The study`s main concern is that drug abuse by learners is on the rise but yet there is less research on the drugs which are being used and the factors which motivate the learners to use such drugs. There are several drug abuse prevention strategies which are being implemented but yet they seem not to be very effective. It is in this frame of reference that this study saw it vital to focus on drug abuse by high school learners in Grahamstown. The study aims to identify the most commonly abused drugs by learners in the high schools of Grahamstown and the reasons why they use these drugs. The study made use of the mixed method research that is making use of both qualitative and quantitative research. The questionnaire was the instrument of data collection in quantitative data and interviews for the qualitative data. The packages which were used for the analysis of data include the Statistical Analysis System (SAS) V8 which was used to provide descriptive analysis and correlations. The findings of the study establish that the commonly abused drugs by learners are: alcohol with 58%, followed by cigarettes 22%, hookah-pipe 9%, dagga 7%. The main reasons why learners use drugs are: peer pressure, role models, availability, environment, and curiosity. Differences in drug use between male and female learners were noted. Twenty-five percent of the male learners and 16% of the female learners reported to be using drugs. In the view of these results, the researcher recommends that a comprehensive drug abuse prevention framework be formulated which focuses on preventing drug abuse at individual, family and community levels.
- Full Text:
- Date Issued: 2012
- Authors: Rungani, Judith
- Date: 2012
- Subjects: High school students -- Substance use -- South Africa -- Eastern Cape , School management and organization , Teenagers -- Drug abuse , Substance abuse -- Youth -- Grahamstown (South Africa)
- Language: English
- Type: Thesis , Masters , M SW
- Identifier: vital:11759 , http://hdl.handle.net/10353/d1004784 , High school students -- Substance use -- South Africa -- Eastern Cape , School management and organization , Teenagers -- Drug abuse , Substance abuse -- Youth -- Grahamstown (South Africa)
- Description: The study explores drug abuse by learners in selected Grahamstown high schools. The study`s main concern is that drug abuse by learners is on the rise but yet there is less research on the drugs which are being used and the factors which motivate the learners to use such drugs. There are several drug abuse prevention strategies which are being implemented but yet they seem not to be very effective. It is in this frame of reference that this study saw it vital to focus on drug abuse by high school learners in Grahamstown. The study aims to identify the most commonly abused drugs by learners in the high schools of Grahamstown and the reasons why they use these drugs. The study made use of the mixed method research that is making use of both qualitative and quantitative research. The questionnaire was the instrument of data collection in quantitative data and interviews for the qualitative data. The packages which were used for the analysis of data include the Statistical Analysis System (SAS) V8 which was used to provide descriptive analysis and correlations. The findings of the study establish that the commonly abused drugs by learners are: alcohol with 58%, followed by cigarettes 22%, hookah-pipe 9%, dagga 7%. The main reasons why learners use drugs are: peer pressure, role models, availability, environment, and curiosity. Differences in drug use between male and female learners were noted. Twenty-five percent of the male learners and 16% of the female learners reported to be using drugs. In the view of these results, the researcher recommends that a comprehensive drug abuse prevention framework be formulated which focuses on preventing drug abuse at individual, family and community levels.
- Full Text:
- Date Issued: 2012
Dynamics of a lattice Universe : the dust approximation in cosmology
- Bruneton, J-P, Larena, Julien
- Authors: Bruneton, J-P , Larena, Julien
- Date: 2012
- Language: English
- Type: Article
- Identifier: vital:6789 , http://hdl.handle.net/10962/d1006941
- Description: We find a solution to Einstein field equations for a regular toroidal lattice of size L with equal masses M at the centre of each cell; this solution is exact at order M/L. Such a solution is convenient to study the dynamics of an assembly of galaxy-like objects. We find that the solution is expanding (or contracting) in exactly the same way as the solution of a Friedman–Lemaître–Robertson–Walker Universe with dust having the same average density as our model. This points towards the absence of backreaction in a Universe filled with an infinite number of objects, and this validates the fluid approximation, as far as dynamics is concerned, and at the level of approximation considered in this work.
- Full Text:
- Date Issued: 2012
- Authors: Bruneton, J-P , Larena, Julien
- Date: 2012
- Language: English
- Type: Article
- Identifier: vital:6789 , http://hdl.handle.net/10962/d1006941
- Description: We find a solution to Einstein field equations for a regular toroidal lattice of size L with equal masses M at the centre of each cell; this solution is exact at order M/L. Such a solution is convenient to study the dynamics of an assembly of galaxy-like objects. We find that the solution is expanding (or contracting) in exactly the same way as the solution of a Friedman–Lemaître–Robertson–Walker Universe with dust having the same average density as our model. This points towards the absence of backreaction in a Universe filled with an infinite number of objects, and this validates the fluid approximation, as far as dynamics is concerned, and at the level of approximation considered in this work.
- Full Text:
- Date Issued: 2012
E-democracy through mobile monitoring: participatory journalism
- Reinecke, Romi, Coulson, Debbie, Thinyane, Hannah
- Authors: Reinecke, Romi , Coulson, Debbie , Thinyane, Hannah
- Date: 2012
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/454671 , vital:75364 , https://hdl.handle.net/10520/EJC134096
- Description: The councillor promised her ward an end to the humiliation of the buck-et system and the building of suitable sanitation facilities. It's why she voted for him. And while it has taken four years, today the building ma-terial for 40 toilets, one of which will be hers, has arrived. Of course, Eunice cannot be certain all 40 toilets will be built to the planned speci-fications and timeline; that's why she's monitoring the municipality's service delivery. Eunice has her phone ready and is counting the bricks and bags of cement that will become toilets for her street under her watchful eye and with the help of a mobile application, MobiSAM, and a local newspaper.
- Full Text:
- Date Issued: 2012
- Authors: Reinecke, Romi , Coulson, Debbie , Thinyane, Hannah
- Date: 2012
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/454671 , vital:75364 , https://hdl.handle.net/10520/EJC134096
- Description: The councillor promised her ward an end to the humiliation of the buck-et system and the building of suitable sanitation facilities. It's why she voted for him. And while it has taken four years, today the building ma-terial for 40 toilets, one of which will be hers, has arrived. Of course, Eunice cannot be certain all 40 toilets will be built to the planned speci-fications and timeline; that's why she's monitoring the municipality's service delivery. Eunice has her phone ready and is counting the bricks and bags of cement that will become toilets for her street under her watchful eye and with the help of a mobile application, MobiSAM, and a local newspaper.
- Full Text:
- Date Issued: 2012
Educational perspectives on social learning theory: antecedents and starting points for research
- Lotz-Sisitka, Heila, Mukute, Mutizwa, Belay, Million
- Authors: Lotz-Sisitka, Heila , Mukute, Mutizwa , Belay, Million
- Date: 2012
- Subjects: To be catalogued
- Language: English
- Type: text , report
- Identifier: http://hdl.handle.net/10962/436612 , vital:73286 , ISBN 978-1-919991-81-8 , https://transformativelearning.education/wp-content/uploads/2013/01/reviews-on-social-learning-literature.pdf
- Description: This paper contributes to the social learning literature. It argues that there is a need to give attention to the antecedent literatures that inform understandings of the social in social learning; and the learning in social learning. These antecedent literatures (drawn mainly from sociocultural psychology, learning theory and realist social theory in this paper) are necessary in social learning research, if we are to avoid the problem of ontological collapse in social learning research. The concept of ontologi-cal collapse (after Sfard, 2006) refers to a tendency in modern sciences to objectify social processes. It is used in this paper to draw attention to the need to understand the complex social processes involved in social learn-ing (and the antecedent literatures that may enable us to do so). As such, it warns against reification in social learning research; and also warns against turning social learning into an object, devoid of complex learning processes and agentive reflexions, decision making and practices. To clar-ify this concept, the paper shares examples of instances of ontological collapse, showing that at times, the social learning literature itself can fall victim to the problem of ontological collapse. Drawing on the literature review work in two cases studies of social learning research that work carefully with the antecedent literatures, the paper demonstrates the im-portance of engaging carefully with these literatures to avoid ontological collapse in social learning research in the fields of environmental education and natural resources management.
- Full Text:
- Date Issued: 2012
- Authors: Lotz-Sisitka, Heila , Mukute, Mutizwa , Belay, Million
- Date: 2012
- Subjects: To be catalogued
- Language: English
- Type: text , report
- Identifier: http://hdl.handle.net/10962/436612 , vital:73286 , ISBN 978-1-919991-81-8 , https://transformativelearning.education/wp-content/uploads/2013/01/reviews-on-social-learning-literature.pdf
- Description: This paper contributes to the social learning literature. It argues that there is a need to give attention to the antecedent literatures that inform understandings of the social in social learning; and the learning in social learning. These antecedent literatures (drawn mainly from sociocultural psychology, learning theory and realist social theory in this paper) are necessary in social learning research, if we are to avoid the problem of ontological collapse in social learning research. The concept of ontologi-cal collapse (after Sfard, 2006) refers to a tendency in modern sciences to objectify social processes. It is used in this paper to draw attention to the need to understand the complex social processes involved in social learn-ing (and the antecedent literatures that may enable us to do so). As such, it warns against reification in social learning research; and also warns against turning social learning into an object, devoid of complex learning processes and agentive reflexions, decision making and practices. To clar-ify this concept, the paper shares examples of instances of ontological collapse, showing that at times, the social learning literature itself can fall victim to the problem of ontological collapse. Drawing on the literature review work in two cases studies of social learning research that work carefully with the antecedent literatures, the paper demonstrates the im-portance of engaging carefully with these literatures to avoid ontological collapse in social learning research in the fields of environmental education and natural resources management.
- Full Text:
- Date Issued: 2012
Educational transformation and curriculum reform: teachers' perceptions of their roles as change agents
- Authors: Ngqondi, Kholisile Phillip
- Date: 2012
- Subjects: Educational change -- South Africa -- Eastern Cape , Teachers -- Training of -- South Africa -- Eastern Cape , Curriculum change -- South Africa -- Eastern Cape , Education -- Political aspects -- South Africa -- Eastern Cape
- Language: English
- Type: Thesis , Masters , MEd
- Identifier: vital:9460 , http://hdl.handle.net/10948/d1020136
- Description: Since 1994, the educational landscape in South Africa has been subjected to on-going policy changes. The national Curriculum and Assessment Policy Statement (CAPS) which has been promulgated recently, is the third version of a post-apartheid national school curriculum. Teachers, in particular, fulfil critical roles as change agents during a process of educational transformation, as they need to facilitate the change by implementing the new national school curriculum. This study aimed to ascertain teacher experiences of continuous curriculum change, by focusing in particular on the views of selected FET teachers. Focus group interviews were conducted with teachers employed at secondary schools in an urban township in the Eastern Cape. The data revealed that the teachers‟ responses could be categorised into four broad themes, namely CAPS itself, the learners in relation to CAPS, the teacher in relation to CAPS and the Department of Education in relation to CAPS. Despite several frustrations and uncertainties, it was clear that the teachers wanted to assume agency as they expressed a commitment towards change and a willingness to implement CAPS to the best of their ability. This study however concludes that the FET teachers who participated struggled to assume full agency, due to restrictive and disabling conditions which are mostly beyond their control.
- Full Text:
- Date Issued: 2012
- Authors: Ngqondi, Kholisile Phillip
- Date: 2012
- Subjects: Educational change -- South Africa -- Eastern Cape , Teachers -- Training of -- South Africa -- Eastern Cape , Curriculum change -- South Africa -- Eastern Cape , Education -- Political aspects -- South Africa -- Eastern Cape
- Language: English
- Type: Thesis , Masters , MEd
- Identifier: vital:9460 , http://hdl.handle.net/10948/d1020136
- Description: Since 1994, the educational landscape in South Africa has been subjected to on-going policy changes. The national Curriculum and Assessment Policy Statement (CAPS) which has been promulgated recently, is the third version of a post-apartheid national school curriculum. Teachers, in particular, fulfil critical roles as change agents during a process of educational transformation, as they need to facilitate the change by implementing the new national school curriculum. This study aimed to ascertain teacher experiences of continuous curriculum change, by focusing in particular on the views of selected FET teachers. Focus group interviews were conducted with teachers employed at secondary schools in an urban township in the Eastern Cape. The data revealed that the teachers‟ responses could be categorised into four broad themes, namely CAPS itself, the learners in relation to CAPS, the teacher in relation to CAPS and the Department of Education in relation to CAPS. Despite several frustrations and uncertainties, it was clear that the teachers wanted to assume agency as they expressed a commitment towards change and a willingness to implement CAPS to the best of their ability. This study however concludes that the FET teachers who participated struggled to assume full agency, due to restrictive and disabling conditions which are mostly beyond their control.
- Full Text:
- Date Issued: 2012
Educator perceptions of the impact of the departmental matric intervention strategies on selected under-performing schools in the Queenstown district
- Authors: Mrali, Amos Mzoxolo
- Date: 2012
- Subjects: High school teachers -- South Africa -- Eastern Cape , High school students -- South Africa -- Eastern Cape , Teacher effectiveness -- South Africa -- Eastern Cape , High schools -- South Africa -- Eastern Cape -- Examinations , Academic achievement -- South Africa -- Eastern Cape , School improvement programs -- South Africa -- Eastern Cape , School crisis management -- South Africa -- Eastern Cape
- Language: English
- Type: Thesis , Masters , M Ed
- Identifier: vital:16180 , http://hdl.handle.net/10353/d1006232 , High school teachers -- South Africa -- Eastern Cape , High school students -- South Africa -- Eastern Cape , Teacher effectiveness -- South Africa -- Eastern Cape , High schools -- South Africa -- Eastern Cape -- Examinations , Academic achievement -- South Africa -- Eastern Cape , School improvement programs -- South Africa -- Eastern Cape , School crisis management -- South Africa -- Eastern Cape
- Description: The problem of school under-performance as defined by the level of pass rates of learners in the matric examinations has been a point of educational debate in South Africa for a number of years, especially after the attainment of democracy. In the Eastern Cape, Matric Intervention Strategies (MIS) have been used to address the problem. The aim of this study was to investigate educator perceptions of the impact of the MIS on selected under-performing high schools in the Queenstown District.Two case study schools classified as consistent under-performers participated in the study. Data was collected through in-depth interviews of key educators in these schools. There were five main findings. First, educators felt that Departmental intervention strategies had not made any significant improvement in addressing underperformance in the two case study schools. Second, participants saw underperformance by schools as caused by a myriad of factors which include those related to leadership and management at school and district levels and educator and learner factors, as well as teacher union interference. They did not see MIS as being able to address the causes simultaneously. Third, the implementation of the (MIS) at school level was poorly monitored by the Departmental officials. It was reported that under-performing schools were hardly visited and supported by the subject advisors and (MIO)s. Fourth, educators perceived the role of subject advisors to be limited to CASS moderation as they did not provide any developmental support to educators experiencing content gaps. Finally, educators saw the MIS as a money making scheme for certain educators and district officials. They claimed this was linked to corrupt practices during the appointment of tutors. The teachers did not have confidence in the appointment procedures used by the district for tutors.It can be concluded that the Matric Intervention Strategies in the two schools arenot likely to achieve the intended results as long as educators do not think thatthe strategies are addressing the problems they face. Another conclusion is that the Matric Intervention Strategies are seen as ‘quick fix’ responses to what arereally deep-seated and systemic problems in education. Given the findings of this study, it is recommended that the impact of Matric Intervention Strategies be the focus of a survey research for which a probability sample must be drawn that can generate findings that are generalisable across the participating target population. For the delivery of the MIS it is recommended that the weaknesses identified by educators of the two schools be further investigated so that new implementation plans can be developed.
- Full Text:
- Date Issued: 2012
- Authors: Mrali, Amos Mzoxolo
- Date: 2012
- Subjects: High school teachers -- South Africa -- Eastern Cape , High school students -- South Africa -- Eastern Cape , Teacher effectiveness -- South Africa -- Eastern Cape , High schools -- South Africa -- Eastern Cape -- Examinations , Academic achievement -- South Africa -- Eastern Cape , School improvement programs -- South Africa -- Eastern Cape , School crisis management -- South Africa -- Eastern Cape
- Language: English
- Type: Thesis , Masters , M Ed
- Identifier: vital:16180 , http://hdl.handle.net/10353/d1006232 , High school teachers -- South Africa -- Eastern Cape , High school students -- South Africa -- Eastern Cape , Teacher effectiveness -- South Africa -- Eastern Cape , High schools -- South Africa -- Eastern Cape -- Examinations , Academic achievement -- South Africa -- Eastern Cape , School improvement programs -- South Africa -- Eastern Cape , School crisis management -- South Africa -- Eastern Cape
- Description: The problem of school under-performance as defined by the level of pass rates of learners in the matric examinations has been a point of educational debate in South Africa for a number of years, especially after the attainment of democracy. In the Eastern Cape, Matric Intervention Strategies (MIS) have been used to address the problem. The aim of this study was to investigate educator perceptions of the impact of the MIS on selected under-performing high schools in the Queenstown District.Two case study schools classified as consistent under-performers participated in the study. Data was collected through in-depth interviews of key educators in these schools. There were five main findings. First, educators felt that Departmental intervention strategies had not made any significant improvement in addressing underperformance in the two case study schools. Second, participants saw underperformance by schools as caused by a myriad of factors which include those related to leadership and management at school and district levels and educator and learner factors, as well as teacher union interference. They did not see MIS as being able to address the causes simultaneously. Third, the implementation of the (MIS) at school level was poorly monitored by the Departmental officials. It was reported that under-performing schools were hardly visited and supported by the subject advisors and (MIO)s. Fourth, educators perceived the role of subject advisors to be limited to CASS moderation as they did not provide any developmental support to educators experiencing content gaps. Finally, educators saw the MIS as a money making scheme for certain educators and district officials. They claimed this was linked to corrupt practices during the appointment of tutors. The teachers did not have confidence in the appointment procedures used by the district for tutors.It can be concluded that the Matric Intervention Strategies in the two schools arenot likely to achieve the intended results as long as educators do not think thatthe strategies are addressing the problems they face. Another conclusion is that the Matric Intervention Strategies are seen as ‘quick fix’ responses to what arereally deep-seated and systemic problems in education. Given the findings of this study, it is recommended that the impact of Matric Intervention Strategies be the focus of a survey research for which a probability sample must be drawn that can generate findings that are generalisable across the participating target population. For the delivery of the MIS it is recommended that the weaknesses identified by educators of the two schools be further investigated so that new implementation plans can be developed.
- Full Text:
- Date Issued: 2012
Educators perceptions of implementing guidelines on HIV/AIDS interventions in the Department of Educations Port Elizabeth District
- Authors: Heynes, Arnelle
- Date: 2012
- Subjects: Educators -- South Africa , Port Elizabeth (South Africa) -- Education , Communicable diseases
- Language: English
- Type: Thesis , Masters , MA
- Identifier: vital:9895 , http://hdl.handle.net/10948/d1009319 , Educators -- South Africa , Port Elizabeth (South Africa) -- Education , Communicable diseases
- Description: The development and implementation of policy guidelines remains a contentious issue. Over the past few years, difficulty still exists in implementing the Department of Education (DoE) 1999, National Education Policy Act, 1996 (No. 27 of 1996): National Policy on HIV/AIDS for learners and educators in public schools, and students and educators in further education and training institutions [here after referred to as DoE HIV/AIDS policy (1999)], while at the same time trying to transform the entire education system. This research explored the perceptions of educators in the Port Elizabeth District regarding the implementation of DoE HIV/AIDS (1999) policy guidelines. A secondary objective was to provide a reflection of how the implementation of guidelines on HIV/AIDS interventions within the schools of the Port Elizabeth District either conformed to or deviated from the guidelines outlined in the DoE HIV/AIDS policy (1999). The study was executed within the paradigm of qualitative research and employed an exploratory, descriptive and contextual design. The researcher conducted a pilot study to enhance the trustworthiness of the study. Purposive sampling was employed to recruit research participants, consisting of 12 educators from 10 schools in the Port Elizabeth District where HIV/AIDS interventions were being implemented. Data was gathered through semi-structured interviewing and analysed using Tesch’s (1990) in De Vos, Strydom, Fouché & Delport (2005:340-341) framework for analysis of qualitative data. Guba’s model (in Krefting, 1991) was used to ensure the trustworthiness of the study. Three themes emerged from the results of the in-depth semi-structured interviews: (1) Educators’ views on the DoE HIV/AIDS policy (1999) guidelines and its implementation (2) Gaps or shortcomings in implementation of the DoE HIV/AIDS policy (1999) and (3) Educator suggestions’ to inform implementation of the DoE HIV/AIDS policy (1999) in schools. The results from the study indicate that there is inconsistency in the policy implementation approach employed by DoE district level representatives and there is a need for knowledge and capacity development at district and school level. The value of the study is outlined as well as recommendations.
- Full Text:
- Date Issued: 2012
- Authors: Heynes, Arnelle
- Date: 2012
- Subjects: Educators -- South Africa , Port Elizabeth (South Africa) -- Education , Communicable diseases
- Language: English
- Type: Thesis , Masters , MA
- Identifier: vital:9895 , http://hdl.handle.net/10948/d1009319 , Educators -- South Africa , Port Elizabeth (South Africa) -- Education , Communicable diseases
- Description: The development and implementation of policy guidelines remains a contentious issue. Over the past few years, difficulty still exists in implementing the Department of Education (DoE) 1999, National Education Policy Act, 1996 (No. 27 of 1996): National Policy on HIV/AIDS for learners and educators in public schools, and students and educators in further education and training institutions [here after referred to as DoE HIV/AIDS policy (1999)], while at the same time trying to transform the entire education system. This research explored the perceptions of educators in the Port Elizabeth District regarding the implementation of DoE HIV/AIDS (1999) policy guidelines. A secondary objective was to provide a reflection of how the implementation of guidelines on HIV/AIDS interventions within the schools of the Port Elizabeth District either conformed to or deviated from the guidelines outlined in the DoE HIV/AIDS policy (1999). The study was executed within the paradigm of qualitative research and employed an exploratory, descriptive and contextual design. The researcher conducted a pilot study to enhance the trustworthiness of the study. Purposive sampling was employed to recruit research participants, consisting of 12 educators from 10 schools in the Port Elizabeth District where HIV/AIDS interventions were being implemented. Data was gathered through semi-structured interviewing and analysed using Tesch’s (1990) in De Vos, Strydom, Fouché & Delport (2005:340-341) framework for analysis of qualitative data. Guba’s model (in Krefting, 1991) was used to ensure the trustworthiness of the study. Three themes emerged from the results of the in-depth semi-structured interviews: (1) Educators’ views on the DoE HIV/AIDS policy (1999) guidelines and its implementation (2) Gaps or shortcomings in implementation of the DoE HIV/AIDS policy (1999) and (3) Educator suggestions’ to inform implementation of the DoE HIV/AIDS policy (1999) in schools. The results from the study indicate that there is inconsistency in the policy implementation approach employed by DoE district level representatives and there is a need for knowledge and capacity development at district and school level. The value of the study is outlined as well as recommendations.
- Full Text:
- Date Issued: 2012