A critique of multilingualism in South Africa’s post-democratic parliament with particular reference to the use of selected minority languages
- Authors: Masombuka, Elizabeth Lucy
- Date: 2018
- Subjects: Multilingualism -- South Africa , Language policy -- South Africa , Language and languages -- Political aspects , Linguistic minorities -- South Africa , Linguistic rights -- South Africa , South Africa. Parliament (1994- ). Parliamentary Communication Services , Hansard Society Commission on the Communication of Parliamentary Democracy
- Language: English
- Type: text , Thesis , Masters , MA
- Identifier: http://hdl.handle.net/10962/61984 , vital:28092
- Description: Language is an essential tool in effecting transformation in a community, society as well as in a culturally diverse institution like the Parliament of South Africa. This study is undertaken to establish the progress made in the use of official languages in the Parliament of South Africa. This study critically looks at the use of eleven South African official languages by the Parliament of South Africa in its daily debates in ensuring transformation to a multilingual parliament. The focus of the study is on the publication of Hansard in all official languages, with specific reference to previously marginalised languages as declared by the Constitution. The study was done in the Language Service Section of the Parliament of South Africa. Firstly, the study looked at the History of Parliament and Hansard publications in relation to the sittings and debates of MP’s since the beginning of Parliament in South Africa. Secondly, a literature review was done on Language Policy implementation, monitoring and promotion of languages in South Africa. Review of legislative frameworks on language matters was undertaken in order to find out the compliance of parliament in using official languages in the publication of Hansard. The study evaluates the recognition of languages as well as the parliamentary in-House Language Policy (Operational Language Policy) in relation to the prescriptions of the Constitution. Findings of the study are indicated in chapter 5 of the thesis. The presentation of data comprises of the work experience of the languages practitioners in parliament, availability and critique of the Language Policy Operational Policy in Parliament, as well as findings in the published Hansard Volumes since the first parliament. The study further tries to look at challenges that hinder the use, and promotion of all languages in parliament, including the use of these languages in the publication of Hansard. The study focuses on minority languages and previously marginalised languages. Recommendations are provided as a means of helping to improve the situation regarding the implementation of the language policy that will assist parliament to transform in order to become truly multilingual. This will allow parliament to be in a position to develop previously marginalised languages.
- Full Text:
- Date Issued: 2018
- Authors: Masombuka, Elizabeth Lucy
- Date: 2018
- Subjects: Multilingualism -- South Africa , Language policy -- South Africa , Language and languages -- Political aspects , Linguistic minorities -- South Africa , Linguistic rights -- South Africa , South Africa. Parliament (1994- ). Parliamentary Communication Services , Hansard Society Commission on the Communication of Parliamentary Democracy
- Language: English
- Type: text , Thesis , Masters , MA
- Identifier: http://hdl.handle.net/10962/61984 , vital:28092
- Description: Language is an essential tool in effecting transformation in a community, society as well as in a culturally diverse institution like the Parliament of South Africa. This study is undertaken to establish the progress made in the use of official languages in the Parliament of South Africa. This study critically looks at the use of eleven South African official languages by the Parliament of South Africa in its daily debates in ensuring transformation to a multilingual parliament. The focus of the study is on the publication of Hansard in all official languages, with specific reference to previously marginalised languages as declared by the Constitution. The study was done in the Language Service Section of the Parliament of South Africa. Firstly, the study looked at the History of Parliament and Hansard publications in relation to the sittings and debates of MP’s since the beginning of Parliament in South Africa. Secondly, a literature review was done on Language Policy implementation, monitoring and promotion of languages in South Africa. Review of legislative frameworks on language matters was undertaken in order to find out the compliance of parliament in using official languages in the publication of Hansard. The study evaluates the recognition of languages as well as the parliamentary in-House Language Policy (Operational Language Policy) in relation to the prescriptions of the Constitution. Findings of the study are indicated in chapter 5 of the thesis. The presentation of data comprises of the work experience of the languages practitioners in parliament, availability and critique of the Language Policy Operational Policy in Parliament, as well as findings in the published Hansard Volumes since the first parliament. The study further tries to look at challenges that hinder the use, and promotion of all languages in parliament, including the use of these languages in the publication of Hansard. The study focuses on minority languages and previously marginalised languages. Recommendations are provided as a means of helping to improve the situation regarding the implementation of the language policy that will assist parliament to transform in order to become truly multilingual. This will allow parliament to be in a position to develop previously marginalised languages.
- Full Text:
- Date Issued: 2018
A Cross-cultural analysis of the normative indicators of the Beck Depression Inventory II(BDI-II) and the Beck Anxiety Inventory (BAI) amongst young adults in the Eastern Cape,South Africa
- Fourie, Claire https://orcid.org/0000-0002-0255-204X
- Authors: Fourie, Claire https://orcid.org/0000-0002-0255-204X
- Date: 2018
- Subjects: Stress (Psychology) , Depression, Mental
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10353/25117 , vital:63979
- Description: Mental illness rates are climbing, locally and globally. The World Health Organization (2001) has claimed that one in four people will be affected by a psychiatric disorder during their lifetime. With this in mind, there is an array of psychometric assessment measures that are used as tools to assist in the mental health care field. Two such measures are the Beck Anxiety Inventory (BAI) and the Beck Depression Inventory-II (BDI-II). These measures are used globally to assist with the diagnosis and treatment of depression and anxiety. However, in South Africa, a paucity of normative indicators exists. This research set out to determine if there are significant differences in performance on the BAI and BDI-II when comparing a sample from the Eastern Cape, South Africa, to the international norms. It was found that performances on the BAI between the local sample and the international sample did not differ significantly. The local sample, on average, performed 4.76 points lower on the BDI-II than those assessed in the international norms. A series of theoretical models are explored in elucidating the findings in this study. , Thesis (MSoc) -- Faculty of Social Sciences and Humanities, 2018
- Full Text:
- Date Issued: 2018
- Authors: Fourie, Claire https://orcid.org/0000-0002-0255-204X
- Date: 2018
- Subjects: Stress (Psychology) , Depression, Mental
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10353/25117 , vital:63979
- Description: Mental illness rates are climbing, locally and globally. The World Health Organization (2001) has claimed that one in four people will be affected by a psychiatric disorder during their lifetime. With this in mind, there is an array of psychometric assessment measures that are used as tools to assist in the mental health care field. Two such measures are the Beck Anxiety Inventory (BAI) and the Beck Depression Inventory-II (BDI-II). These measures are used globally to assist with the diagnosis and treatment of depression and anxiety. However, in South Africa, a paucity of normative indicators exists. This research set out to determine if there are significant differences in performance on the BAI and BDI-II when comparing a sample from the Eastern Cape, South Africa, to the international norms. It was found that performances on the BAI between the local sample and the international sample did not differ significantly. The local sample, on average, performed 4.76 points lower on the BDI-II than those assessed in the international norms. A series of theoretical models are explored in elucidating the findings in this study. , Thesis (MSoc) -- Faculty of Social Sciences and Humanities, 2018
- Full Text:
- Date Issued: 2018
A derivation of the the black-scholes equation using martingales
- Authors: Nyarko , Ebenezer Narh
- Date: 2018
- Subjects: Mathematical models
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: http://hdl.handle.net/10353/14572 , vital:40016
- Description: This work focuses on the application of stochastic differential equations, with martingales, in finance. The emphasis is on the derivation of the Black-Scholes model for the valuation of options. A theoretical framework in stochastic analysis, together with Itô calculus (Kiyoshi Itô), is explored. The Girsanov Theorem is applied in order to transform a modelled stochastic equation based, on predetermined stock and bond prices, into equivalent martingale measures. A replication strategy is then adopted to solve the two equations analytically, by finding the natural logarithm of the expectation of the solution to the stochastic models. We finally compute the resulting solution based on a standard, normal distribution to get the desired outcome of the Black-Scholes model.
- Full Text:
- Date Issued: 2018
- Authors: Nyarko , Ebenezer Narh
- Date: 2018
- Subjects: Mathematical models
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: http://hdl.handle.net/10353/14572 , vital:40016
- Description: This work focuses on the application of stochastic differential equations, with martingales, in finance. The emphasis is on the derivation of the Black-Scholes model for the valuation of options. A theoretical framework in stochastic analysis, together with Itô calculus (Kiyoshi Itô), is explored. The Girsanov Theorem is applied in order to transform a modelled stochastic equation based, on predetermined stock and bond prices, into equivalent martingale measures. A replication strategy is then adopted to solve the two equations analytically, by finding the natural logarithm of the expectation of the solution to the stochastic models. We finally compute the resulting solution based on a standard, normal distribution to get the desired outcome of the Black-Scholes model.
- Full Text:
- Date Issued: 2018
A Flexible Approach for the Application of Immersive Audio to an Installation Performance:
- Devonport, Sean, Foss, Richard
- Authors: Devonport, Sean , Foss, Richard
- Date: 2018
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/426720 , vital:72385 , https://www.isea-international.org/symposia/1988-2022/
- Description: This paper investigates the use of the ImmerGo spatial audio system and Ethernet AVB as a platform for the creation and deployment of immersive audio content. An analysis of Ethernet AVB and ImmerGo’s features is given. This is followed by a practical implementation of ImmerGo within an installation setting of a choreographed performance. This approach provided key features such as user control from a mobile device to render positions of audio tracks and control DAW transport. The Ethernet AVB network allowed for real-time synchronized audio streaming, audio device interoperability, distributed endpoint processing and simple audio routing schemes.
- Full Text:
- Date Issued: 2018
- Authors: Devonport, Sean , Foss, Richard
- Date: 2018
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/426720 , vital:72385 , https://www.isea-international.org/symposia/1988-2022/
- Description: This paper investigates the use of the ImmerGo spatial audio system and Ethernet AVB as a platform for the creation and deployment of immersive audio content. An analysis of Ethernet AVB and ImmerGo’s features is given. This is followed by a practical implementation of ImmerGo within an installation setting of a choreographed performance. This approach provided key features such as user control from a mobile device to render positions of audio tracks and control DAW transport. The Ethernet AVB network allowed for real-time synchronized audio streaming, audio device interoperability, distributed endpoint processing and simple audio routing schemes.
- Full Text:
- Date Issued: 2018
A formative intervention for developing Learner Representative Council (LRC) voice and leadership in a newly established school in Namibia
- Authors: Amadhila, Linda
- Date: 2018
- Subjects: School management and organization -- Namibia , Educational leadership -- Namibia , Education, Secondary -- Namibia , Student government -- Namibia , Student participation in administration -- Namibia
- Language: English
- Type: text , Thesis , Masters , MEd
- Identifier: http://hdl.handle.net/10962/61744 , vital:28054
- Description: In Namibian schools, learner voice and leadership are being promoted through the policy document entitled the Education Act 16 of2001 which provides an opportunity to establish Learner Representative Councils (LRCs) in secondary schools. However, recent studies have found that this body of learner leaders do not function all that effectively and sometimes exist for the sake of adhering to the policy. This prompted me to conduct an activity theoretical interventionist case- study within the critical paradigm, to develop LRC voice and leadership in a newly established Namibian school. Framed by Cultural Historical Activity Theory, the study was divided into two phases to answer the over-arching question: How can LRC voice and leadership be developed in a school? Phase one was largely interpretive, the contextual profiling phase, where document analysis, individual interviews, questionnaires and observations were used to generate data to answer the following research sub-questions: How is learner leadership understood in the school? What leadership development opportunities for the LRC currently exist in the school? What underlying factors constrain the development of LRC voice and leadership in the newly established school? Phase two of the study was the expansive learning phase, which consisted of three intervention workshops. The Change Laboratory method and a focus group interview were used to generate data in response to the last research sub-question: In what ways can LRC participation in a Change Laboratory process contribute to their leadership development? Data generated were inductively and deductively analysed, using the activity theoretical principles of contradictions and double stimulation. Data revealed that learner leadership was largely understood as managerial roles carried out by the LRC in the school. Unlike many schools in Namibia, this case-study school offered numerous leadership development opportunities for the LRC. The community networking events such as: School Exchange Programmes, Town Council breakfast and Junior Regional Council, were opportunities offered to the LRC to solicit information, exchange ideas and discuss matters of common interest with the LRCs of the fully established schools. However, there were a number of challenges that constrained LRC voice and leadership development, the major one being the fact that this was a newly established school. Of significance was that LRC participation in the Change Laboratory process contributed positively to the development of voice and leadership in learners. During this Change Laboratory process, the LRC developed a new artefact - the vision and mission statement of the school - this signified that the learners expansively transformed the object of their activity. Recommendations emerging out of the study included that the School Management Team see the ‘newly established’ status of the school as an opportunity for development, rather than a limitation, and therefore invite the LRC to participate in the different leadership practices as the school becomes established. A significant recommendation for school leadership research is to use the third generation of CHAT to expand the unit of analysis, in order to understand the leadership relations and power dynamics between multiple activity systems in schools as complex organisations.
- Full Text:
- Date Issued: 2018
- Authors: Amadhila, Linda
- Date: 2018
- Subjects: School management and organization -- Namibia , Educational leadership -- Namibia , Education, Secondary -- Namibia , Student government -- Namibia , Student participation in administration -- Namibia
- Language: English
- Type: text , Thesis , Masters , MEd
- Identifier: http://hdl.handle.net/10962/61744 , vital:28054
- Description: In Namibian schools, learner voice and leadership are being promoted through the policy document entitled the Education Act 16 of2001 which provides an opportunity to establish Learner Representative Councils (LRCs) in secondary schools. However, recent studies have found that this body of learner leaders do not function all that effectively and sometimes exist for the sake of adhering to the policy. This prompted me to conduct an activity theoretical interventionist case- study within the critical paradigm, to develop LRC voice and leadership in a newly established Namibian school. Framed by Cultural Historical Activity Theory, the study was divided into two phases to answer the over-arching question: How can LRC voice and leadership be developed in a school? Phase one was largely interpretive, the contextual profiling phase, where document analysis, individual interviews, questionnaires and observations were used to generate data to answer the following research sub-questions: How is learner leadership understood in the school? What leadership development opportunities for the LRC currently exist in the school? What underlying factors constrain the development of LRC voice and leadership in the newly established school? Phase two of the study was the expansive learning phase, which consisted of three intervention workshops. The Change Laboratory method and a focus group interview were used to generate data in response to the last research sub-question: In what ways can LRC participation in a Change Laboratory process contribute to their leadership development? Data generated were inductively and deductively analysed, using the activity theoretical principles of contradictions and double stimulation. Data revealed that learner leadership was largely understood as managerial roles carried out by the LRC in the school. Unlike many schools in Namibia, this case-study school offered numerous leadership development opportunities for the LRC. The community networking events such as: School Exchange Programmes, Town Council breakfast and Junior Regional Council, were opportunities offered to the LRC to solicit information, exchange ideas and discuss matters of common interest with the LRCs of the fully established schools. However, there were a number of challenges that constrained LRC voice and leadership development, the major one being the fact that this was a newly established school. Of significance was that LRC participation in the Change Laboratory process contributed positively to the development of voice and leadership in learners. During this Change Laboratory process, the LRC developed a new artefact - the vision and mission statement of the school - this signified that the learners expansively transformed the object of their activity. Recommendations emerging out of the study included that the School Management Team see the ‘newly established’ status of the school as an opportunity for development, rather than a limitation, and therefore invite the LRC to participate in the different leadership practices as the school becomes established. A significant recommendation for school leadership research is to use the third generation of CHAT to expand the unit of analysis, in order to understand the leadership relations and power dynamics between multiple activity systems in schools as complex organisations.
- Full Text:
- Date Issued: 2018
A framework for aligning ICT service providers' products and services to the needs of SME customers
- Authors: Mhlongo, Sizwe
- Date: 2018
- Subjects: Small business -- Computer networks , Business enterprises -- information technology Consumer behavior
- Language: English
- Type: Thesis , Masters , MBA
- Identifier: http://hdl.handle.net/10948/31911 , vital:31861
- Description: Small and medium-sized enterprises (SMEs) have the potential to enhance economic growth and innovation, create jobs, and stimulate competition in the economy. However, SMEs face several challenges that influence their longevity, growth, and success. Information Communication Technology (ICT) adoption has the potential to alleviate some of these challenges faced by SMEs and to enhance their competitiveness. The adoption and use of ICT can bring benefits in terms of increasing their efficiency, innovation, growth and competitive advantages. However, SMEs are currently not taking full advantage of exploiting the potential of ICT products and services. Mostly, SMEs depend on the advice provided by their ICT service providers regarding the best ICT products and services they should adopt due to the lack of in-house ICT skills and capabilities. This treatise investigates the approach and critical success factors for ICT service providers to align their products and services to the needs of SMEs. To evaluate the conceptual framework that was proposed by this study based on the literature review, an empirical study was conducted among the SME respondents within the Gauteng province of South Africa. The questionnaire used for this study collected data to measure the SMEs’ perceptions on the availability, awareness, usage and the value added by the adoption of ICT products and services and the level of the satisfaction of the ICT needs of SMEs. The findings of this study indicate that gaps and misalignments exist between the ICT needs of SMEs and the ICT service providers’ products and services targeted to SMEs. The major discovery from the conducted empirical study revealed that ICT service providers mostly fulfil only the basic level needs of SMEs such as ICT infrastructure needs but do not fully address the higher level needs such as the digital transformation needs of SMEs. In conclusion, this study recommends that it is crucial for ICT services providers to align their products and services to the needs of SMEs in order to successfully target and market to the SME segment.
- Full Text:
- Date Issued: 2018
- Authors: Mhlongo, Sizwe
- Date: 2018
- Subjects: Small business -- Computer networks , Business enterprises -- information technology Consumer behavior
- Language: English
- Type: Thesis , Masters , MBA
- Identifier: http://hdl.handle.net/10948/31911 , vital:31861
- Description: Small and medium-sized enterprises (SMEs) have the potential to enhance economic growth and innovation, create jobs, and stimulate competition in the economy. However, SMEs face several challenges that influence their longevity, growth, and success. Information Communication Technology (ICT) adoption has the potential to alleviate some of these challenges faced by SMEs and to enhance their competitiveness. The adoption and use of ICT can bring benefits in terms of increasing their efficiency, innovation, growth and competitive advantages. However, SMEs are currently not taking full advantage of exploiting the potential of ICT products and services. Mostly, SMEs depend on the advice provided by their ICT service providers regarding the best ICT products and services they should adopt due to the lack of in-house ICT skills and capabilities. This treatise investigates the approach and critical success factors for ICT service providers to align their products and services to the needs of SMEs. To evaluate the conceptual framework that was proposed by this study based on the literature review, an empirical study was conducted among the SME respondents within the Gauteng province of South Africa. The questionnaire used for this study collected data to measure the SMEs’ perceptions on the availability, awareness, usage and the value added by the adoption of ICT products and services and the level of the satisfaction of the ICT needs of SMEs. The findings of this study indicate that gaps and misalignments exist between the ICT needs of SMEs and the ICT service providers’ products and services targeted to SMEs. The major discovery from the conducted empirical study revealed that ICT service providers mostly fulfil only the basic level needs of SMEs such as ICT infrastructure needs but do not fully address the higher level needs such as the digital transformation needs of SMEs. In conclusion, this study recommends that it is crucial for ICT services providers to align their products and services to the needs of SMEs in order to successfully target and market to the SME segment.
- Full Text:
- Date Issued: 2018
A framework for designing ambient assisted living services for disabled individuals
- Authors: Kyazze, Michael
- Date: 2018
- Subjects: Assistive computer technology , Computers and people with disabilities Self-help devices for people with disabilities People with disabilities -- Means of communication -- Technological innovations Communication devices for people with disabilities
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10948/31240 , vital:31347
- Description: Physically disabled individuals face a number of challenges when carrying out their everyday activities such as moving around, communicating with others, and their personal care. One way of overcoming these challenges is by using personal assistants. An alternative is to enable independence through assistive technology. This research aimed to investigate how physically disabled individuals experience these challenges, and how assistive technology can enable them to be more independent. In order to achieve the goal of this research, existing literature was reviewed on disability, assisted living, and interaction techniques. The literature study on disability identified some of the challenges faced by disabled individuals in their daily lives. In order to contextualize these challenges, interview studies with eighteen disabled individuals, and twelve personal assistants were carried out in Kampala, Uganda and Port Elizabeth, South Africa. The participants from both Uganda and South Africa were limited to those living in urban areas. The Ugandan participants noted that, whereas technology may assist their daily lives, their most essential needs are basic disability support aids such as wheelchairs and better long canes. This was in contrast with the South African participants, who have access to basic disability support aids. The South African participants identified their key needs as controlling an electronic environment without assistance, e.g. house lights, using a mobile phone, and using a computer without assistance. The interviews narrowed down the scope to focus on individuals with quadriplegia, specifically individuals who have limited hand use, but can comfortably speak and move their heads, and make gestures such as head shake and nod. Literature on assisted living technologies and frameworks, provided the technical foundation for the research. The literature review of interaction techniques identified a number of possible ways in which individuals with quadriplegia can interact with technology. An appropriate set of interaction techniques, namely head shake and nod, voice, and facial feature tracking were identified. Evaluations of the interaction techniques excluded head shake and nod, because of an inconsistency in detecting an individual’s head pose in different lighting conditions, when using a Microsoft Kinect. Voice and facial feature tracking using a standard computer camera were identified as the most suitable interaction techniques for this study. A framework for designing assisted living software services was developed. The framework allows disability researchers and solution developers to understand the needs of a given disability group, and design relevant solutions. To demonstrate that the proposed framework iii | P a g e addresses the main aim of this research, a prototype was developed that enables users to control smart lights (Phillips hue), a Smart TV (Samsung), and carry out basic navigation and webbrowsing on a computer. Users could interact with the software using voice and facial feature commands. A usability study was carried out with fifteen physically disabled individuals in Port Elizabeth, South Africa. The results of the evaluation study were highly positive. The successful evaluation of the prototype provided empirical evidence that the proposed framework does assist in the design of relevant and useful software services, to meet the unique needs of physically disabled individuals.
- Full Text:
- Date Issued: 2018
- Authors: Kyazze, Michael
- Date: 2018
- Subjects: Assistive computer technology , Computers and people with disabilities Self-help devices for people with disabilities People with disabilities -- Means of communication -- Technological innovations Communication devices for people with disabilities
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10948/31240 , vital:31347
- Description: Physically disabled individuals face a number of challenges when carrying out their everyday activities such as moving around, communicating with others, and their personal care. One way of overcoming these challenges is by using personal assistants. An alternative is to enable independence through assistive technology. This research aimed to investigate how physically disabled individuals experience these challenges, and how assistive technology can enable them to be more independent. In order to achieve the goal of this research, existing literature was reviewed on disability, assisted living, and interaction techniques. The literature study on disability identified some of the challenges faced by disabled individuals in their daily lives. In order to contextualize these challenges, interview studies with eighteen disabled individuals, and twelve personal assistants were carried out in Kampala, Uganda and Port Elizabeth, South Africa. The participants from both Uganda and South Africa were limited to those living in urban areas. The Ugandan participants noted that, whereas technology may assist their daily lives, their most essential needs are basic disability support aids such as wheelchairs and better long canes. This was in contrast with the South African participants, who have access to basic disability support aids. The South African participants identified their key needs as controlling an electronic environment without assistance, e.g. house lights, using a mobile phone, and using a computer without assistance. The interviews narrowed down the scope to focus on individuals with quadriplegia, specifically individuals who have limited hand use, but can comfortably speak and move their heads, and make gestures such as head shake and nod. Literature on assisted living technologies and frameworks, provided the technical foundation for the research. The literature review of interaction techniques identified a number of possible ways in which individuals with quadriplegia can interact with technology. An appropriate set of interaction techniques, namely head shake and nod, voice, and facial feature tracking were identified. Evaluations of the interaction techniques excluded head shake and nod, because of an inconsistency in detecting an individual’s head pose in different lighting conditions, when using a Microsoft Kinect. Voice and facial feature tracking using a standard computer camera were identified as the most suitable interaction techniques for this study. A framework for designing assisted living software services was developed. The framework allows disability researchers and solution developers to understand the needs of a given disability group, and design relevant solutions. To demonstrate that the proposed framework iii | P a g e addresses the main aim of this research, a prototype was developed that enables users to control smart lights (Phillips hue), a Smart TV (Samsung), and carry out basic navigation and webbrowsing on a computer. Users could interact with the software using voice and facial feature commands. A usability study was carried out with fifteen physically disabled individuals in Port Elizabeth, South Africa. The results of the evaluation study were highly positive. The successful evaluation of the prototype provided empirical evidence that the proposed framework does assist in the design of relevant and useful software services, to meet the unique needs of physically disabled individuals.
- Full Text:
- Date Issued: 2018
A framework for financing public transport infrastructure in South Africa
- Authors: Nobaza, Lwazi Bruce
- Date: 2018
- Subjects: Local transit -- South Africa -- Finance , Urban transportation -- South Africa -- Finance Transportation and state -- South Africa
- Language: English
- Type: Thesis , Masters , MBA
- Identifier: http://hdl.handle.net/10948/22703 , vital:30059
- Description: South African cities are faced with still challenges of economic and spatial exclusion due to the legacy of apartheid, growing need for housing opportunities, high transport costs, long commuting times between work and home, and poor integration of different modes of public transport. Although there is a strong association between public transport infrastructure investment and socio-spatial transformation, the current backlog of public transport infrastructure and the inability of public funds to address such backlog inhibit spatial transformation and socio-economic integration. Notably, public transport has a potential to expedite spatial transformation and social integration and also stimulate the economy but it is still underfunded. There are numerous alternative and innovative mechanisms that are applied internationally, that can help with financing of public transport infrastructure financing, but few or none have been applied in a South African context. The purpose of this study is to explore alternative funding mechanisms and provide a conceptual framework for that will ensure availability of finances that are critical for financing public transport infrastructure in South Africa. Literature review provides international best practices in the financing of public transport infrastructure that can be replicated in South Africa. This resulted in the identification of six independent variables, namely government funding, external financing, public private partnerships, risk management, property value capture and institutional environment and two intervening variables, namely feasibility and viability. These variables were then utilised to develop a conceptual framework with suggested hypotheses on the financing of public transport infrastructure in South Africa. Primary data was then statistically analysed to test the proposed conceptual framework and hypothesised relationships. The empirical study provides little evidence of significant relationships between dependent variables of the study, namely perceived success of financing public transport infrastructure in South Africa and the independent and intervening variables. However, the study highlights that feasibility and financial viability are preconditions for sustainable investments into public transport infrastructure. These can be only achieved in an investment climate with a conducive policy and legislative framework that does not only protect interests of various investors but also utilises government funding to leverage private sector finance. This will ensure that long term objectives spatial transformation of urban areas is achieved.
- Full Text:
- Date Issued: 2018
- Authors: Nobaza, Lwazi Bruce
- Date: 2018
- Subjects: Local transit -- South Africa -- Finance , Urban transportation -- South Africa -- Finance Transportation and state -- South Africa
- Language: English
- Type: Thesis , Masters , MBA
- Identifier: http://hdl.handle.net/10948/22703 , vital:30059
- Description: South African cities are faced with still challenges of economic and spatial exclusion due to the legacy of apartheid, growing need for housing opportunities, high transport costs, long commuting times between work and home, and poor integration of different modes of public transport. Although there is a strong association between public transport infrastructure investment and socio-spatial transformation, the current backlog of public transport infrastructure and the inability of public funds to address such backlog inhibit spatial transformation and socio-economic integration. Notably, public transport has a potential to expedite spatial transformation and social integration and also stimulate the economy but it is still underfunded. There are numerous alternative and innovative mechanisms that are applied internationally, that can help with financing of public transport infrastructure financing, but few or none have been applied in a South African context. The purpose of this study is to explore alternative funding mechanisms and provide a conceptual framework for that will ensure availability of finances that are critical for financing public transport infrastructure in South Africa. Literature review provides international best practices in the financing of public transport infrastructure that can be replicated in South Africa. This resulted in the identification of six independent variables, namely government funding, external financing, public private partnerships, risk management, property value capture and institutional environment and two intervening variables, namely feasibility and viability. These variables were then utilised to develop a conceptual framework with suggested hypotheses on the financing of public transport infrastructure in South Africa. Primary data was then statistically analysed to test the proposed conceptual framework and hypothesised relationships. The empirical study provides little evidence of significant relationships between dependent variables of the study, namely perceived success of financing public transport infrastructure in South Africa and the independent and intervening variables. However, the study highlights that feasibility and financial viability are preconditions for sustainable investments into public transport infrastructure. These can be only achieved in an investment climate with a conducive policy and legislative framework that does not only protect interests of various investors but also utilises government funding to leverage private sector finance. This will ensure that long term objectives spatial transformation of urban areas is achieved.
- Full Text:
- Date Issued: 2018
A framework for improving construction workers’ health and safety practices in Lagos, Nigeria
- Authors: Kukoyi, Patricia Omega
- Date: 2018
- Subjects: Construction industry -- Health aspects -- Lagos -- Nigeria , Industrial safety -- Lagos -- Nigeria Sustainable construction -- Lagos -- Nigeria
- Language: English
- Type: Thesis , Doctoral , DPhil
- Identifier: http://hdl.handle.net/10948/30962 , vital:31235
- Description: The construction sector is known for its poor health and safety (H&S) record. This situation contributes to the poor performance of construction projects and poor worker productivity. In view of this, the research was undertaken to improve workers’ H&S practices. This study determined how the systems thinking approach will mitigate unhealthy and unsafe construction practices in Lagos, Nigeria by developing interventions, and proposing a model for improved H&S practices. The study utilised a mixed research method approach. Both quantitative and qualitative methods were used specifically the concurrent embedded method to obtain and analyse the data. The sample size for the quantitative study was 375 respondents and a total of 40 respondents were engaged in the qualitative study. The sample consisted of designers, contractors, clients, quantity surveyors, project managers, construction managers, supervisors, and construction workers (masons, carpenters, painters, roofers, electricians) based in Lagos, Nigeria. The findings reveal that there is inadequate consideration for H&S during the procurement of construction projects. Furthermore, the absence of H&S regulations relating to the construction sector was observed. Unsafe practices at construction sites in Nigeria can be attributed to this discovery. The study reveals that the regulatory system, the organisation, the individual and the work environment all have an impact on H&S work practices. Although the contractors are mainly responsible for H&S at construction sites, other construction stakeholders (such as clients, consultants, etc.) influence H&S practices. The findings highlight the need for the adoption of a holistic approach to facilitate improvement in H&S practices on construction sites. The research has contributed to the body of knowledge by developing a framework for improving workers’ H&S performance on construction sites.
- Full Text:
- Date Issued: 2018
- Authors: Kukoyi, Patricia Omega
- Date: 2018
- Subjects: Construction industry -- Health aspects -- Lagos -- Nigeria , Industrial safety -- Lagos -- Nigeria Sustainable construction -- Lagos -- Nigeria
- Language: English
- Type: Thesis , Doctoral , DPhil
- Identifier: http://hdl.handle.net/10948/30962 , vital:31235
- Description: The construction sector is known for its poor health and safety (H&S) record. This situation contributes to the poor performance of construction projects and poor worker productivity. In view of this, the research was undertaken to improve workers’ H&S practices. This study determined how the systems thinking approach will mitigate unhealthy and unsafe construction practices in Lagos, Nigeria by developing interventions, and proposing a model for improved H&S practices. The study utilised a mixed research method approach. Both quantitative and qualitative methods were used specifically the concurrent embedded method to obtain and analyse the data. The sample size for the quantitative study was 375 respondents and a total of 40 respondents were engaged in the qualitative study. The sample consisted of designers, contractors, clients, quantity surveyors, project managers, construction managers, supervisors, and construction workers (masons, carpenters, painters, roofers, electricians) based in Lagos, Nigeria. The findings reveal that there is inadequate consideration for H&S during the procurement of construction projects. Furthermore, the absence of H&S regulations relating to the construction sector was observed. Unsafe practices at construction sites in Nigeria can be attributed to this discovery. The study reveals that the regulatory system, the organisation, the individual and the work environment all have an impact on H&S work practices. Although the contractors are mainly responsible for H&S at construction sites, other construction stakeholders (such as clients, consultants, etc.) influence H&S practices. The findings highlight the need for the adoption of a holistic approach to facilitate improvement in H&S practices on construction sites. The research has contributed to the body of knowledge by developing a framework for improving workers’ H&S performance on construction sites.
- Full Text:
- Date Issued: 2018
A framework for malicious host fingerprinting using distributed network sensors
- Authors: Hunter, Samuel Oswald
- Date: 2018
- Subjects: Computer networks -- Security measures , Malware (Computer software) , Multisensor data fusion , Distributed Sensor Networks , Automated Reconnaissance Framework , Latency Based Multilateration
- Language: English
- Type: text , Thesis , Masters , MSc
- Identifier: http://hdl.handle.net/10962/60653 , vital:27811
- Description: Numerous software agents exist and are responsible for increasing volumes of malicious traffic that is observed on the Internet today. From a technical perspective the existing techniques for monitoring malicious agents and traffic were not developed to allow for the interrogation of the source of malicious traffic. This interrogation or reconnaissance would be considered active analysis as opposed to existing, mostly passive analysis. Unlike passive analysis, the active techniques are time-sensitive and their results become increasingly inaccurate as time delta between observation and interrogation increases. In addition to this, some studies had shown that the geographic separation of hosts on the Internet have resulted in pockets of different malicious agents and traffic targeting victims. As such it would be important to perform any kind of data collection over various source and in distributed IP address space. The data gathering and exposure capabilities of sensors such as honeypots and network telescopes were extended through the development of near-realtime Distributed Sensor Network modules that allowed for the near-realtime analysis of malicious traffic from distributed, heterogeneous monitoring sensors. In order to utilise the data exposed by the near-realtime Distributed Sensor Network modules an Automated Reconnaissance Framework was created, this framework was tasked with active and passive information collection and analysis of data in near-realtime and was designed from an adapted Multi Sensor Data Fusion model. The hypothesis was made that if sufficiently different characteristics of a host could be identified; combined they could act as a unique fingerprint for that host, potentially allowing for the re-identification of that host, even if its IP address had changed. To this end the concept of Latency Based Multilateration was introduced, acting as an additional metric for remote host fingerprinting. The vast amount of information gathered by the AR-Framework required the development of visualisation tools which could illustrate this data in near-realtime and also provided various degrees of interaction to accommodate human interpretation of such data. Ultimately the data collected through the application of the near-realtime Distributed Sensor Network and AR-Framework provided a unique perspective of a malicious host demographic. Allowing for new correlations to be drawn between attributes such as common open ports and operating systems, location, and inferred intent of these malicious hosts. The result of which expands our current understanding of malicious hosts on the Internet and enables further research in the area.
- Full Text:
- Date Issued: 2018
- Authors: Hunter, Samuel Oswald
- Date: 2018
- Subjects: Computer networks -- Security measures , Malware (Computer software) , Multisensor data fusion , Distributed Sensor Networks , Automated Reconnaissance Framework , Latency Based Multilateration
- Language: English
- Type: text , Thesis , Masters , MSc
- Identifier: http://hdl.handle.net/10962/60653 , vital:27811
- Description: Numerous software agents exist and are responsible for increasing volumes of malicious traffic that is observed on the Internet today. From a technical perspective the existing techniques for monitoring malicious agents and traffic were not developed to allow for the interrogation of the source of malicious traffic. This interrogation or reconnaissance would be considered active analysis as opposed to existing, mostly passive analysis. Unlike passive analysis, the active techniques are time-sensitive and their results become increasingly inaccurate as time delta between observation and interrogation increases. In addition to this, some studies had shown that the geographic separation of hosts on the Internet have resulted in pockets of different malicious agents and traffic targeting victims. As such it would be important to perform any kind of data collection over various source and in distributed IP address space. The data gathering and exposure capabilities of sensors such as honeypots and network telescopes were extended through the development of near-realtime Distributed Sensor Network modules that allowed for the near-realtime analysis of malicious traffic from distributed, heterogeneous monitoring sensors. In order to utilise the data exposed by the near-realtime Distributed Sensor Network modules an Automated Reconnaissance Framework was created, this framework was tasked with active and passive information collection and analysis of data in near-realtime and was designed from an adapted Multi Sensor Data Fusion model. The hypothesis was made that if sufficiently different characteristics of a host could be identified; combined they could act as a unique fingerprint for that host, potentially allowing for the re-identification of that host, even if its IP address had changed. To this end the concept of Latency Based Multilateration was introduced, acting as an additional metric for remote host fingerprinting. The vast amount of information gathered by the AR-Framework required the development of visualisation tools which could illustrate this data in near-realtime and also provided various degrees of interaction to accommodate human interpretation of such data. Ultimately the data collected through the application of the near-realtime Distributed Sensor Network and AR-Framework provided a unique perspective of a malicious host demographic. Allowing for new correlations to be drawn between attributes such as common open ports and operating systems, location, and inferred intent of these malicious hosts. The result of which expands our current understanding of malicious hosts on the Internet and enables further research in the area.
- Full Text:
- Date Issued: 2018
A framework for managing the impact of information communication technology on employee well-being
- Authors: Ackerman, Richard
- Date: 2018
- Subjects: Work environment -- Psychological aspects , Work -- Technological innovations Employees -- Mental health Job stress Flextime
- Language: English
- Type: Thesis , Masters , MBA
- Identifier: http://hdl.handle.net/10948/21449 , vital:29523
- Description: Employees who work with Information Communication Technology (hereafter referred to as ICT) face a risk in a rise of portable work. This in turn provides a means for employees to be connected to work, even when at home. Flexible work solutions and ability to work any hour of the week creates non-standard work schedules, which in turn can lead to a condition of work-a-holism. In most cases, this phenomena is driven by the belief that being constantly available to work demonstrates a devotion to one’s career and employer. The higher demands placed on employees, are in most cases at the expense of employees’ health, work-life balance and overall well-being. The primary objective of this study is therefore to establish whether the use of ICT outside of normal working hours affects employee well-being, as measured in terms of work-life balance. The second objective of this study is to provide the Target Company within the automotive component supply industry located in Port Elizabeth, in the Republic of South Africa, with a framework for managing the impact of ICT on employee well-being. The research paper has been prompted by the Target Company having recently introduced flexible working solutions for its employees. Research on the topic of alternative forms of work schedules, has shown flexible working arrangements gives employees more choice and control over where, when and by how much they work. Flexibility allows employees to actively shape their working conditions which helps them solve the demands of integrating personal life and work commitments. Whether management should encourage or permit the use of ICT amongst its employees to extend beyond normal working hours however remains unclear. In order to answer the research questions, this study has applied a quantitative, positivistic and deductive research based methodology. The approach applied within this study included conducting an extensive literature review on the effects of ICT use after hours on employee well-being. Thereafter using literature as a foundation, a measuring instrument was constructed in the form of an online questionnaire. The questionnaire was emailed to respondents to collect primary data, in order to measure the dependent and independent variables in terms of the hypothesised relationships. Testing of the variables followed, in order to establish whether the use of ICT use after hours negatively impacts employee well-being as measured in terms of work-life balance and stress. Secondly, the study set out to establish whether flexible working conditions linked to ICT use after hours negatively impacts on employee work-life balance. Thirdly, the relationship between physiological aspects such as age, gender and ethnicity were interrogated to establish an employees’ ability to adapt to changing work conditions, brought about as a direct result of ICT. Lastly, this study set out to establish which ICT tool (email, cellular phone, smartphone or other) has the highest impact on employee wellness. The data collection process yielded a sample of 103 respondents in middle and senior management levels of the Target Company, with 97% being recipients of employer provided ICT tools. These respondents represented the employees who are most likely to be affected by the phenomena under investigation. The survey data was captured and analysed using descriptive statistical techniques. The interpretation revealed aspects which formed the basis for managerial recommendations in the form of a proposed framework to manage the impact of ICT on employee well-being. The findings of the study found that the use of ICT outside of normal working hours has a negative influence on employee well-being as measured in terms of work-life balance and stress. The literature review findings were confirmed as supporting the statement that flexible working conditions linked to ICT use after hours having a positive influence on employee work-life balance. A further finding of the study was the confirmation of physiological aspects affects an employees’ ability to adapt to changing working conditions, thereby having a negative influence on employee work-life balance. Lastly, to the question of which ICT tool has the biggest impact on well-being, it was found that differing ICT tools (email, cellular, smartphone, or other) do not have a negative influence on employee wellness. These findings formed the basis for the recommendations in the form of a framework which has been proposed to manage the impact of ICT on employee well-being. The most pertinent aspect of the framework includes the employer communicating a well-defined ICT usage policy, which clearly outlines a standard operating procedure in relation to ICT use to all its employees. The findings furthermore propose that the employer should take the time to explain and train its employees as to what is considered acceptable and non-acceptable use of ICT devices, especially in relation to after hour use and leave absences from work. To ensure employee well-being, employees should be encouraged to implement defined time blocks for when they are available for work and when they are not. This can be applied through the act of switching off their ICT devices, which constitutes a boundary work tactic as an action in order to prevent work-related interruptions in the private sphere. While the employer can take described measures, it should also be noted that there is responsibility on the part of the employee to ensure personal wellness, including regular exercise, relaxation, and taking appropriate breaks when necessary. Moreover, employees can apply work and life boundary management techniques through the selective use of devices. By not applying automatic work email updates on ICT devices such as smart phones is yet another boundary management technique which can be utilised by employees. There are a range of practical suggestions which are proposed as a method to minimize the risk of ICT use on employee well-being within this research document. The above proposals have only served to highlight a select few aspects. While it is acknowledged that there are important advantages associated with the development and use of ICT, it is equally important to allow employees to recharge their batteries in the form of appropriate downtime to regain perspective, thus allowing the organisation to maintain its competitive advantage, with the well-being of its employees taken to heart.
- Full Text:
- Date Issued: 2018
- Authors: Ackerman, Richard
- Date: 2018
- Subjects: Work environment -- Psychological aspects , Work -- Technological innovations Employees -- Mental health Job stress Flextime
- Language: English
- Type: Thesis , Masters , MBA
- Identifier: http://hdl.handle.net/10948/21449 , vital:29523
- Description: Employees who work with Information Communication Technology (hereafter referred to as ICT) face a risk in a rise of portable work. This in turn provides a means for employees to be connected to work, even when at home. Flexible work solutions and ability to work any hour of the week creates non-standard work schedules, which in turn can lead to a condition of work-a-holism. In most cases, this phenomena is driven by the belief that being constantly available to work demonstrates a devotion to one’s career and employer. The higher demands placed on employees, are in most cases at the expense of employees’ health, work-life balance and overall well-being. The primary objective of this study is therefore to establish whether the use of ICT outside of normal working hours affects employee well-being, as measured in terms of work-life balance. The second objective of this study is to provide the Target Company within the automotive component supply industry located in Port Elizabeth, in the Republic of South Africa, with a framework for managing the impact of ICT on employee well-being. The research paper has been prompted by the Target Company having recently introduced flexible working solutions for its employees. Research on the topic of alternative forms of work schedules, has shown flexible working arrangements gives employees more choice and control over where, when and by how much they work. Flexibility allows employees to actively shape their working conditions which helps them solve the demands of integrating personal life and work commitments. Whether management should encourage or permit the use of ICT amongst its employees to extend beyond normal working hours however remains unclear. In order to answer the research questions, this study has applied a quantitative, positivistic and deductive research based methodology. The approach applied within this study included conducting an extensive literature review on the effects of ICT use after hours on employee well-being. Thereafter using literature as a foundation, a measuring instrument was constructed in the form of an online questionnaire. The questionnaire was emailed to respondents to collect primary data, in order to measure the dependent and independent variables in terms of the hypothesised relationships. Testing of the variables followed, in order to establish whether the use of ICT use after hours negatively impacts employee well-being as measured in terms of work-life balance and stress. Secondly, the study set out to establish whether flexible working conditions linked to ICT use after hours negatively impacts on employee work-life balance. Thirdly, the relationship between physiological aspects such as age, gender and ethnicity were interrogated to establish an employees’ ability to adapt to changing work conditions, brought about as a direct result of ICT. Lastly, this study set out to establish which ICT tool (email, cellular phone, smartphone or other) has the highest impact on employee wellness. The data collection process yielded a sample of 103 respondents in middle and senior management levels of the Target Company, with 97% being recipients of employer provided ICT tools. These respondents represented the employees who are most likely to be affected by the phenomena under investigation. The survey data was captured and analysed using descriptive statistical techniques. The interpretation revealed aspects which formed the basis for managerial recommendations in the form of a proposed framework to manage the impact of ICT on employee well-being. The findings of the study found that the use of ICT outside of normal working hours has a negative influence on employee well-being as measured in terms of work-life balance and stress. The literature review findings were confirmed as supporting the statement that flexible working conditions linked to ICT use after hours having a positive influence on employee work-life balance. A further finding of the study was the confirmation of physiological aspects affects an employees’ ability to adapt to changing working conditions, thereby having a negative influence on employee work-life balance. Lastly, to the question of which ICT tool has the biggest impact on well-being, it was found that differing ICT tools (email, cellular, smartphone, or other) do not have a negative influence on employee wellness. These findings formed the basis for the recommendations in the form of a framework which has been proposed to manage the impact of ICT on employee well-being. The most pertinent aspect of the framework includes the employer communicating a well-defined ICT usage policy, which clearly outlines a standard operating procedure in relation to ICT use to all its employees. The findings furthermore propose that the employer should take the time to explain and train its employees as to what is considered acceptable and non-acceptable use of ICT devices, especially in relation to after hour use and leave absences from work. To ensure employee well-being, employees should be encouraged to implement defined time blocks for when they are available for work and when they are not. This can be applied through the act of switching off their ICT devices, which constitutes a boundary work tactic as an action in order to prevent work-related interruptions in the private sphere. While the employer can take described measures, it should also be noted that there is responsibility on the part of the employee to ensure personal wellness, including regular exercise, relaxation, and taking appropriate breaks when necessary. Moreover, employees can apply work and life boundary management techniques through the selective use of devices. By not applying automatic work email updates on ICT devices such as smart phones is yet another boundary management technique which can be utilised by employees. There are a range of practical suggestions which are proposed as a method to minimize the risk of ICT use on employee well-being within this research document. The above proposals have only served to highlight a select few aspects. While it is acknowledged that there are important advantages associated with the development and use of ICT, it is equally important to allow employees to recharge their batteries in the form of appropriate downtime to regain perspective, thus allowing the organisation to maintain its competitive advantage, with the well-being of its employees taken to heart.
- Full Text:
- Date Issued: 2018
A framework for selecting NoSQL Databases:a NetFlow use case
- Authors: Rheeder, Leon Albertus
- Date: 2018
- Subjects: Non-relational databases , Database management Information technology Computer science
- Language: English
- Type: Thesis , Masters , MIT
- Identifier: http://hdl.handle.net/10948/35061 , vital:33611
- Description: Making decisions regarding technology is difficult for IT practitioners, especially when they lack formal guidance. Ad hoc decisions are prone to be influenced by biases. This research study specifically considered decisions regarding NoSQL. The primary objective of this study was to develop a framework that can assist IT practitioners with decisions regarding NoSQL technologies. An investigation into typical decision-making problems encountered when having to make technology-based decisions provided an understanding of the problem context. The application context was explored through a literature study of the four NoSQL families. This study produces a framework to assist IT practitioners in making decisions regarding technology. The framework comprises two models. Firstly, a weighted decision model combines several constructs, thereby providing a general method of making decisions. Secondly, a 6-step process model that can be used to adapt the weighted decision-model to a specific type of technology and a specific use case is proposed. The feasibility and utility of the proposed framework are demonstrated by applying the framework to a NetFlow use case. If NetFlow data is to be used for analytical decision-making, the data must be stored long-term. NoSQL databases have increased in popularity, especially in decision-making contexts. Therefore, NoSQL is a logical storage choice. However, which NoSQL family to use is not self-evident. Therefore, the decision-maker may require assistance to make the right decision. To assist with this decision, the framework was adapted to be used in the NoSQL context. A set of criteria was developed to allow various NoSQL options to be uniformly compared. Furthermore, the four NoSQL families were graded based on this set of criteria. After adaptation, experts provided input regarding the requirements of the NetFlow use case. This resulted in the weighting of the criteria for this specific use case. Finally, a weighted score was calculated for each family. For the NetFlow use case, the model suggests that a document-based NoSQL database be used. The framework ensures that all NoSQL technologies are systematically investigated, thereby reducing the effect of biases. Thus, the problem identified in this study is addressed. The proposed model can also serve as a foundation for future research
- Full Text:
- Date Issued: 2018
- Authors: Rheeder, Leon Albertus
- Date: 2018
- Subjects: Non-relational databases , Database management Information technology Computer science
- Language: English
- Type: Thesis , Masters , MIT
- Identifier: http://hdl.handle.net/10948/35061 , vital:33611
- Description: Making decisions regarding technology is difficult for IT practitioners, especially when they lack formal guidance. Ad hoc decisions are prone to be influenced by biases. This research study specifically considered decisions regarding NoSQL. The primary objective of this study was to develop a framework that can assist IT practitioners with decisions regarding NoSQL technologies. An investigation into typical decision-making problems encountered when having to make technology-based decisions provided an understanding of the problem context. The application context was explored through a literature study of the four NoSQL families. This study produces a framework to assist IT practitioners in making decisions regarding technology. The framework comprises two models. Firstly, a weighted decision model combines several constructs, thereby providing a general method of making decisions. Secondly, a 6-step process model that can be used to adapt the weighted decision-model to a specific type of technology and a specific use case is proposed. The feasibility and utility of the proposed framework are demonstrated by applying the framework to a NetFlow use case. If NetFlow data is to be used for analytical decision-making, the data must be stored long-term. NoSQL databases have increased in popularity, especially in decision-making contexts. Therefore, NoSQL is a logical storage choice. However, which NoSQL family to use is not self-evident. Therefore, the decision-maker may require assistance to make the right decision. To assist with this decision, the framework was adapted to be used in the NoSQL context. A set of criteria was developed to allow various NoSQL options to be uniformly compared. Furthermore, the four NoSQL families were graded based on this set of criteria. After adaptation, experts provided input regarding the requirements of the NetFlow use case. This resulted in the weighting of the criteria for this specific use case. Finally, a weighted score was calculated for each family. For the NetFlow use case, the model suggests that a document-based NoSQL database be used. The framework ensures that all NoSQL technologies are systematically investigated, thereby reducing the effect of biases. Thus, the problem identified in this study is addressed. The proposed model can also serve as a foundation for future research
- Full Text:
- Date Issued: 2018
A framework for the integration of mobile technology into adventure sport for the purpose of increasing participant safety
- Authors: Mills, Craig John
- Date: 2018
- Subjects: Mobile communication systems , Health promotion -- Technological innovations Sports -- Technological innovations Cell phones -- Health aspects
- Language: English
- Type: Thesis , Masters , MIT
- Identifier: http://hdl.handle.net/10948/32099 , vital:31958
- Description: The sporting industry has seen incredible advancements with the use of information technology. Technology is used in the sporting industry for training, coaching and even as a deciding factor of a game result. There are certain sports which require individuals to venture into isolated environments, these sports have been termed adventure or extreme sports. Due to the extreme environmental factors that can occur with adventure sport, it is possible for an individual to experience an emergency situation. Emergency situations can occur at any time, and this is especially true in adventure sport. Adventure sport such as ocean and river kayaking require individuals to venture into isolated environments, where if an emergency situation occurs could result in an individual left stranded waiting for emergency rescue. Adventure sport participants and Event Organizers are aware of the dangers associated with this type of adventure sport, but there is currently no requirement to have a mobile technology device present during kayaking events. The main purpose of this dissertation was to evaluate the current use of mobile technology in adventure sport in the Eastern Cape province of South Africa. To accomplish this two literature reviews were conducted which identi_ed information on the two main themes which are adventure sport and mobile technology. To produce information from the ocean and river kayaking community an online questionnaire was distributed to several kayaking clubs in the Eastern Cape province of South Africa. This dissertation also presents a framework that proposes the use of mobile technology hardware and software by participants and event organisers in an attempt to increase the safety of events in this form of adventure sport. It is hoped that the framework for using mobile technology to increase the safety of adventure sport proposed in this research, may provide clear guidance for the achievement of a safer sporting experience for the participants of ocean and river kayaking.
- Full Text:
- Date Issued: 2018
- Authors: Mills, Craig John
- Date: 2018
- Subjects: Mobile communication systems , Health promotion -- Technological innovations Sports -- Technological innovations Cell phones -- Health aspects
- Language: English
- Type: Thesis , Masters , MIT
- Identifier: http://hdl.handle.net/10948/32099 , vital:31958
- Description: The sporting industry has seen incredible advancements with the use of information technology. Technology is used in the sporting industry for training, coaching and even as a deciding factor of a game result. There are certain sports which require individuals to venture into isolated environments, these sports have been termed adventure or extreme sports. Due to the extreme environmental factors that can occur with adventure sport, it is possible for an individual to experience an emergency situation. Emergency situations can occur at any time, and this is especially true in adventure sport. Adventure sport such as ocean and river kayaking require individuals to venture into isolated environments, where if an emergency situation occurs could result in an individual left stranded waiting for emergency rescue. Adventure sport participants and Event Organizers are aware of the dangers associated with this type of adventure sport, but there is currently no requirement to have a mobile technology device present during kayaking events. The main purpose of this dissertation was to evaluate the current use of mobile technology in adventure sport in the Eastern Cape province of South Africa. To accomplish this two literature reviews were conducted which identi_ed information on the two main themes which are adventure sport and mobile technology. To produce information from the ocean and river kayaking community an online questionnaire was distributed to several kayaking clubs in the Eastern Cape province of South Africa. This dissertation also presents a framework that proposes the use of mobile technology hardware and software by participants and event organisers in an attempt to increase the safety of events in this form of adventure sport. It is hoped that the framework for using mobile technology to increase the safety of adventure sport proposed in this research, may provide clear guidance for the achievement of a safer sporting experience for the participants of ocean and river kayaking.
- Full Text:
- Date Issued: 2018
A framework to address the shortage of registered nurses in South Africa in alignment with the national health insurance requirement
- Authors: Venturini, Ronwyn
- Date: 2018
- Subjects: Nursing -- South Africa , Nursing -- Manpower -- South Africa Nursing services -- South Africa -- Administration Skilled labor -- South Africa Labor supply -- South Africa Manpower planning -- South Africa
- Language: English
- Type: Thesis , Masters , MBA
- Identifier: http://hdl.handle.net/10948/36782 , vital:34054
- Description: In South Africa, there is a dire need for good quality healthcare in the public and private sectors. To achieve the aforementioned, the shortage of medical personnel is of utmost concern and the ability to retain these qualified individuals an even greater dilemma. The Department of Health in South Africa has embarked on a National Health Insurance model they want to introduce similar to the first world countries such as the British and American systems whereby medical insurance is free for all and not a single citizen is left unattended in their time of need. The primary purpose of this study was to identify a framework that will enable the South African government to implement a successful National Health Insurance system. Key theoretical factors (remuneration and rewards, work climate, stress, job satisfaction, recognition and bedside nursing) were investigated to ascertain what the key contributors are regarding the shortage of registered nurses. The identification of pertinent factors will promote the retention of nurses, which represent the population of this study. A questionnaire was designed by the researcher to collect the data from the sample, which consisted of 99 registered nurses in both public and the private sectors in South Africa across the provinces namely Gauteng, Eastern Cape, Western Cape Kwa-Zulu Natal, Free State, Limpopo and North West. The data collection process included electronic and hard copies of the questionnaires that were administered using the self-selected sampling and snowball non-probability sampling strategies. Descriptive statistics were conducted on the empirical data collected; and inferential statistics in the form of multiple regression analysis was used to test the hypotheses formulated. The study found that recognition is the only contributor that is directly related to the shortage of registered nurses. The framework established should assist policy makers and government to understand the contributing factors exacerbating the shortage of registered nurses.
- Full Text:
- Date Issued: 2018
- Authors: Venturini, Ronwyn
- Date: 2018
- Subjects: Nursing -- South Africa , Nursing -- Manpower -- South Africa Nursing services -- South Africa -- Administration Skilled labor -- South Africa Labor supply -- South Africa Manpower planning -- South Africa
- Language: English
- Type: Thesis , Masters , MBA
- Identifier: http://hdl.handle.net/10948/36782 , vital:34054
- Description: In South Africa, there is a dire need for good quality healthcare in the public and private sectors. To achieve the aforementioned, the shortage of medical personnel is of utmost concern and the ability to retain these qualified individuals an even greater dilemma. The Department of Health in South Africa has embarked on a National Health Insurance model they want to introduce similar to the first world countries such as the British and American systems whereby medical insurance is free for all and not a single citizen is left unattended in their time of need. The primary purpose of this study was to identify a framework that will enable the South African government to implement a successful National Health Insurance system. Key theoretical factors (remuneration and rewards, work climate, stress, job satisfaction, recognition and bedside nursing) were investigated to ascertain what the key contributors are regarding the shortage of registered nurses. The identification of pertinent factors will promote the retention of nurses, which represent the population of this study. A questionnaire was designed by the researcher to collect the data from the sample, which consisted of 99 registered nurses in both public and the private sectors in South Africa across the provinces namely Gauteng, Eastern Cape, Western Cape Kwa-Zulu Natal, Free State, Limpopo and North West. The data collection process included electronic and hard copies of the questionnaires that were administered using the self-selected sampling and snowball non-probability sampling strategies. Descriptive statistics were conducted on the empirical data collected; and inferential statistics in the form of multiple regression analysis was used to test the hypotheses formulated. The study found that recognition is the only contributor that is directly related to the shortage of registered nurses. The framework established should assist policy makers and government to understand the contributing factors exacerbating the shortage of registered nurses.
- Full Text:
- Date Issued: 2018
A framework to enhance the appreciation and motivation of employees in an automotive factory
- Authors: Parsons, Paul Benjamin
- Date: 2018
- Subjects: Employee motivation , Work ethic Incentive awards Employees|xRating of Motor vehicle industry -- Psychological aspects
- Language: English
- Type: Thesis , Masters , MBA
- Identifier: http://hdl.handle.net/10948/23059 , vital:30402
- Description: Manufacturing in South Africa is constantly under pressure to produce more for less, and the automotive industry is no exception. Well known initiatives like “just-in-time” (JIT) manufacturing; “flexible manufacturing systems” (FMS); and “lean manufacturing”, are some of the strategies that manufacturing adopted to increase productivity. Due to the comparative extremely high capital investments that need to be spent before a single unit is built, manufacturing can only be competitive by exploring economics of scale; in doing this, manufacturers recoup capital outflow and start showing profit. Should this require that an employee be treated in the same way: used as an input into the production process? Human capital theory has been around for many decades, proclaiming that employees are more than just labourers. Gone are the days when work was an exchange between labour and money. Both parties demand more from each other. Employers want more commitment, efficiency and flexibility; employees, on the other hand, want more autonomy, purpose and appreciation. Employees are a company‟s biggest assets if treated and motivated correctly. Employee motivation is not a new concept – theorists and likeminded people have tried to dissect and understand the topic over millennia. It seems, however, that whenever a theory is formulated people‟s perception changes (almost like trying to hit a moving target). Some theorists claim that a totally new rule set is required to motivate employees in the information age. The bottom line seems to be that in order for companies to gain advantage from human capital, the area-specific motivational environment needs to be understood. Only when this is accomplished, can policies and incentives be aligned, resulting in a more committed, efficient and flexible employee. It is therefore imperative for an employer to understand both what motivates his or her employees, and what these employees recognise as appreciation.
- Full Text:
- Date Issued: 2018
- Authors: Parsons, Paul Benjamin
- Date: 2018
- Subjects: Employee motivation , Work ethic Incentive awards Employees|xRating of Motor vehicle industry -- Psychological aspects
- Language: English
- Type: Thesis , Masters , MBA
- Identifier: http://hdl.handle.net/10948/23059 , vital:30402
- Description: Manufacturing in South Africa is constantly under pressure to produce more for less, and the automotive industry is no exception. Well known initiatives like “just-in-time” (JIT) manufacturing; “flexible manufacturing systems” (FMS); and “lean manufacturing”, are some of the strategies that manufacturing adopted to increase productivity. Due to the comparative extremely high capital investments that need to be spent before a single unit is built, manufacturing can only be competitive by exploring economics of scale; in doing this, manufacturers recoup capital outflow and start showing profit. Should this require that an employee be treated in the same way: used as an input into the production process? Human capital theory has been around for many decades, proclaiming that employees are more than just labourers. Gone are the days when work was an exchange between labour and money. Both parties demand more from each other. Employers want more commitment, efficiency and flexibility; employees, on the other hand, want more autonomy, purpose and appreciation. Employees are a company‟s biggest assets if treated and motivated correctly. Employee motivation is not a new concept – theorists and likeminded people have tried to dissect and understand the topic over millennia. It seems, however, that whenever a theory is formulated people‟s perception changes (almost like trying to hit a moving target). Some theorists claim that a totally new rule set is required to motivate employees in the information age. The bottom line seems to be that in order for companies to gain advantage from human capital, the area-specific motivational environment needs to be understood. Only when this is accomplished, can policies and incentives be aligned, resulting in a more committed, efficient and flexible employee. It is therefore imperative for an employer to understand both what motivates his or her employees, and what these employees recognise as appreciation.
- Full Text:
- Date Issued: 2018
A gender based analysis of the Amalima Programme in empowering married women within households in rural Gwanda, Zimbabwe
- Authors: Sibanda, Patience
- Date: 2018
- Subjects: Non-governmental organizations Zimbabwe Matabeleland South Province , Power (Social sciences) Zimbabwe Matabeleland South Province , Women Zimbabwe Social conditions , Women's rights Zimbabwe , Patriarchy Zimbabwe Matabeleland South Province
- Language: English
- Type: text , Thesis , Masters , MA
- Identifier: http://hdl.handle.net/10962/63682 , vital:28470
- Description: Non-Governmental Organisations (NGOs) have occupied a prominent role in the socio-economic development of rural areas of Zimbabwe since the time of the country’s independence in 1980, including a focus on improving the conditions and status of women in communal areas. These NGOs adopt a participatory methodology in their development programmes and projects, as they try to ensure that the active participation of women in rural development facilitates women’s access to resources and the realisation of their rights. These initiatives are important given the pronounced system of patriarchy which exists in communal areas. In the context of local patriarchies, NGOs also often claim that they empower women. This thesis focuses on the work of one particular NGO programme, namely the Amalima programme, with a particular focus on three wards in the communal areas in Gwanda, Zimbabwe. From a gendered perspective concerned with questions of women’s empowerment, the main objective of the thesis is to provide a critical analysis of the Amalima programme with particular reference to married women in Gwanda. Based on original fieldwork (including interviews with men, women and NGO practitioners), the thesis concludes that the outcomes of the Amalima programme in empowering married women in Gwanda are uneven and that, overall, the local system of patriarchy (including at household level) remains largely intact.
- Full Text:
- Date Issued: 2018
- Authors: Sibanda, Patience
- Date: 2018
- Subjects: Non-governmental organizations Zimbabwe Matabeleland South Province , Power (Social sciences) Zimbabwe Matabeleland South Province , Women Zimbabwe Social conditions , Women's rights Zimbabwe , Patriarchy Zimbabwe Matabeleland South Province
- Language: English
- Type: text , Thesis , Masters , MA
- Identifier: http://hdl.handle.net/10962/63682 , vital:28470
- Description: Non-Governmental Organisations (NGOs) have occupied a prominent role in the socio-economic development of rural areas of Zimbabwe since the time of the country’s independence in 1980, including a focus on improving the conditions and status of women in communal areas. These NGOs adopt a participatory methodology in their development programmes and projects, as they try to ensure that the active participation of women in rural development facilitates women’s access to resources and the realisation of their rights. These initiatives are important given the pronounced system of patriarchy which exists in communal areas. In the context of local patriarchies, NGOs also often claim that they empower women. This thesis focuses on the work of one particular NGO programme, namely the Amalima programme, with a particular focus on three wards in the communal areas in Gwanda, Zimbabwe. From a gendered perspective concerned with questions of women’s empowerment, the main objective of the thesis is to provide a critical analysis of the Amalima programme with particular reference to married women in Gwanda. Based on original fieldwork (including interviews with men, women and NGO practitioners), the thesis concludes that the outcomes of the Amalima programme in empowering married women in Gwanda are uneven and that, overall, the local system of patriarchy (including at household level) remains largely intact.
- Full Text:
- Date Issued: 2018
A gold–chitosan composite with low symmetry zinc phthalocyanine for enhanced singlet oxygen generation and improved photodynamic therapy activity
- Dube, Edith, Oluwole, David O, Prinsloo, Earl, Nyokong, Tebello
- Authors: Dube, Edith , Oluwole, David O , Prinsloo, Earl , Nyokong, Tebello
- Date: 2018
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/233397 , vital:50087 , xlink:href="https://doi.org/10.1039/C8NJ00801A"
- Description: Novel zinc(II) 3-(4-((3,17,23-tris(4-(benzo[d]thiazol-2-yl)phenoxy)phthalocyanine-9-yl)oxy)phenyl)propanoic acid (complex 3) was synthesised. Complex 3 was subsequently reacted with gold nanoparticles (AuNPs), chitosan (CT) and a gold–chitosan (AuCT) hybrid to form 3-AuNPs, 3-CT and 3-AuCT, respectively. The conjugates afforded a decrease in fluorescence quantum yield with a corresponding increase in the triplet and singlet quantum yields compared to complex 3. The in vitro dark cytotoxicity and photodynamic therapy activity (PDT) of complex 3 and 3-AuCT composites were investigated against epithelial breast cancer cells (MCF-7) with both the samples showing minimum dark cytotoxicity. They both accounted for a cell viability of ≥90% at a concentration of ≤59.2 μg mL−1. 3-AuCT showed better PDT activity (compared to 3 alone) with less than 50% viable cells at a concentration of ≥29.6 μg mL−1 making it potentially applicable for PDT. On the other hand, AuCT displayed some activity against cancer cells, probably due to photothermal activity since gold is a light absorber, however it had more than 50% viable cells at a concentration of ≤59.2 μg mL−1.
- Full Text:
- Date Issued: 2018
- Authors: Dube, Edith , Oluwole, David O , Prinsloo, Earl , Nyokong, Tebello
- Date: 2018
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/233397 , vital:50087 , xlink:href="https://doi.org/10.1039/C8NJ00801A"
- Description: Novel zinc(II) 3-(4-((3,17,23-tris(4-(benzo[d]thiazol-2-yl)phenoxy)phthalocyanine-9-yl)oxy)phenyl)propanoic acid (complex 3) was synthesised. Complex 3 was subsequently reacted with gold nanoparticles (AuNPs), chitosan (CT) and a gold–chitosan (AuCT) hybrid to form 3-AuNPs, 3-CT and 3-AuCT, respectively. The conjugates afforded a decrease in fluorescence quantum yield with a corresponding increase in the triplet and singlet quantum yields compared to complex 3. The in vitro dark cytotoxicity and photodynamic therapy activity (PDT) of complex 3 and 3-AuCT composites were investigated against epithelial breast cancer cells (MCF-7) with both the samples showing minimum dark cytotoxicity. They both accounted for a cell viability of ≥90% at a concentration of ≤59.2 μg mL−1. 3-AuCT showed better PDT activity (compared to 3 alone) with less than 50% viable cells at a concentration of ≥29.6 μg mL−1 making it potentially applicable for PDT. On the other hand, AuCT displayed some activity against cancer cells, probably due to photothermal activity since gold is a light absorber, however it had more than 50% viable cells at a concentration of ≤59.2 μg mL−1.
- Full Text:
- Date Issued: 2018
A longitudinal investigation into employability : student transition and experiences from tertiary education into the labour market
- Authors: Harry, Tinashe Timothy
- Date: 2018
- Subjects: Employability Graduate students Labor market
- Language: English
- Type: Thesis , Doctoral , DCom
- Identifier: http://hdl.handle.net/10353/11053 , vital:37015
- Description: Orientation: Several policies have been formulated by the government to redress the inequalities of apartheid. However, the policies have not yielded any positive results as many graduates from Historically Disadvantaged Institutes (HDIs) continue to struggle in the open labour market as compared to graduates from Historically Advantaged Institutes (HAIs). This has been mainly attributed to the legacy of apartheid in several previous studies. As a result, most of these previously disadvantaged individuals (mostly Black Africans) struggle to make the transition from higher education into the world of work. Research Purpose: This study thus explores the journeys of these Black African students from HDIs to understand the transition and experiences from tertiary education into the labour market. Further, the research sought to understand how these transitions and experiences manifest in a context of high unemployment. Finally, the resolution tactics used by students in such a context are given attention. Research approach, design and method: A longitudinal qualitative approach was deemed appropriate for the study as the aim was to understand the changes that occurred over time. The data was collected over a two-year period. A narrative inquiry was utilized as it allowed the participants to share their perceptions without limitations. A total of 30 participants partook in the study. The participants were selected using a purposive sampling to ensure the right participants were involved in the study. The main criteria for selection to participate was that the participants had to be enrolled with a HDI. Main findings: The narratives of the participants led to the formulation of six main themes that were regarded as affecting the transitions and experiences of the Black graduates from HDIs; namely, (1) socio-economic background, (2) education system, (3) labour market experiences, (4) geographical location, (5) social capital and (6) student resolutions to the challenges of employability. A previously disadvantaged background resulted in the participants being recipients of poor education quality, no social networks or information to navigate the labour market and limited access to the labour market due to secluded residential areas. Subsequently, most participants were unable to take responsibility of enhancing their own employability. Contribution: It is not the sole responsibility of the higher education institutes to produce employable graduates, but it's a process that should also involve government, students and employers. As long as the social inequality remains an issue in the country all the efforts to improve employability and transition into the open labour market will be in vain. Furthermore, employers must work together with higher education institutes by offering programs such as internships and career expos to enhance the employability of the graduates. A Graduate Transition Model (GTM) is suggested based on the findings of this research.
- Full Text:
- Date Issued: 2018
- Authors: Harry, Tinashe Timothy
- Date: 2018
- Subjects: Employability Graduate students Labor market
- Language: English
- Type: Thesis , Doctoral , DCom
- Identifier: http://hdl.handle.net/10353/11053 , vital:37015
- Description: Orientation: Several policies have been formulated by the government to redress the inequalities of apartheid. However, the policies have not yielded any positive results as many graduates from Historically Disadvantaged Institutes (HDIs) continue to struggle in the open labour market as compared to graduates from Historically Advantaged Institutes (HAIs). This has been mainly attributed to the legacy of apartheid in several previous studies. As a result, most of these previously disadvantaged individuals (mostly Black Africans) struggle to make the transition from higher education into the world of work. Research Purpose: This study thus explores the journeys of these Black African students from HDIs to understand the transition and experiences from tertiary education into the labour market. Further, the research sought to understand how these transitions and experiences manifest in a context of high unemployment. Finally, the resolution tactics used by students in such a context are given attention. Research approach, design and method: A longitudinal qualitative approach was deemed appropriate for the study as the aim was to understand the changes that occurred over time. The data was collected over a two-year period. A narrative inquiry was utilized as it allowed the participants to share their perceptions without limitations. A total of 30 participants partook in the study. The participants were selected using a purposive sampling to ensure the right participants were involved in the study. The main criteria for selection to participate was that the participants had to be enrolled with a HDI. Main findings: The narratives of the participants led to the formulation of six main themes that were regarded as affecting the transitions and experiences of the Black graduates from HDIs; namely, (1) socio-economic background, (2) education system, (3) labour market experiences, (4) geographical location, (5) social capital and (6) student resolutions to the challenges of employability. A previously disadvantaged background resulted in the participants being recipients of poor education quality, no social networks or information to navigate the labour market and limited access to the labour market due to secluded residential areas. Subsequently, most participants were unable to take responsibility of enhancing their own employability. Contribution: It is not the sole responsibility of the higher education institutes to produce employable graduates, but it's a process that should also involve government, students and employers. As long as the social inequality remains an issue in the country all the efforts to improve employability and transition into the open labour market will be in vain. Furthermore, employers must work together with higher education institutes by offering programs such as internships and career expos to enhance the employability of the graduates. A Graduate Transition Model (GTM) is suggested based on the findings of this research.
- Full Text:
- Date Issued: 2018
A medicinal chemistry study in nitrogen containing heterocycles
- Authors: Lunga, Mayibongwe Junior
- Date: 2018
- Subjects: Indole , Tetrazoles , Antimalarials , Heat shock proteins , Plasmodium falciparum
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/63521 , vital:28430
- Description: Heterocyclic structures have found extensive utility in the field of medicinal chemistry, as prominent regions of pharmacophores resulting in numerous drug treatments for many diseases. Accordingly, in this project we explored the respective antimalarial and anticancer activity exhibited by compounds featuring nitrogen containing indole and tetrazole heterocycles respectively. This thesis therefore comprises of two distinct parts. Part 1. Following the development of resistance towards traditional antimalarial therapy such as chloroquine and emerging resistance towards artemisinin combination therapies, the WHO reported the urgent need for new, effective drugs and identification of new drug targets to combat the Plasmodium falciparum parasite. In 2015 the parasite was the cause of 429 000 deaths, the majority occurring in the sub-Saharan region of Africa. This highlights the failing effectiveness of vector control strategies, reiterating the need to develop alternative control and treatment strategies. In response to this need we wanted to expand and further describe the SAR of the indole based series, indolyl-3-ethanone-α- thioethers, previously synthesized in our laboratory. These compounds were found to exhibit antimalarial activity with compounds 2.26 and 2.27 exhibiting activity against P. falciparum 3D7 in the nanomolar range. Based on these compounds we synthesized compounds 3.21 and 3.24 – 3.32 following a three step reaction pathway. Our results in this study, indicate that compound 3.28, a pnitrothiophenol analogue of 2.27 was the most active of the compounds we synthesized and furthermore was superior in activity against Plasmodium compared to 2.27. This result indicated that the presence of p-NO2 is important in enhancing anti-plasmodial activity. Comparing compounds 3.25 and 3.26 with an oxygen on the ether bridge to compounds 3.29 and 3.30 with a sulfur, we observed an increase in hydrophilicity coupled to a decrease in anti-plasmodial activity in the compounds, thus, highlighting the importance of sulfur for enhanced activity. Furthermore, we investigated bioisosteric replacement of the 5-chloro substituent present in hit compounds 2.27 and 3.28, with an electron withdrawing nitrile (3.27) and electron donating methyl (3.29) and methoxy (3.31) substituents. These substituents decreased anti-plasmodial activity, confirming that a chlorine substituent is optimal for biological activity. This study furthered our understanding of the SAR of indolyl-3-ethanone-α- thioethers for the development of potent anti-plasmodial lead compounds. Part 2. Triple negative breast cancer (TNBC), which disproportionately affects women of sub-Saharan Africa, is unresponsive to hormone-based therapies. This emergence presents a population of patients devoid of effective drug treatment, signaling the urgent need to develop new effective therapies with novel drug targets. Therefore, we identified our target in TNBC cells as the protein-protein interaction between the co-chaperones HOP and HSP90. We reasoned that a disruption of this interaction would ultimately result in cancer cell death via the degradation of essential oncogenic client proteins. Following a fragment screening campaign, which identified several acid and tetrazole containing hits (4.56 – 4.58) which bound to HOP, with low anticancer activity, we sought to develop synthetic methodology to elaborate our fragment hits synthesizing tetrazole containing fragments to target TNBC cell lines. We therefore proceeded to synthesize a range of multi substituted fragments (4.59 – 4.63), utilizing a nitrile (4.66) to access tetrazoles via 1,3-cycloaddition and an acid by nitrile hydrolysis. We successfully synthesized the tetrazole and acid fragments which are currently undergoing characterization for activity against TNBC. , Thesis (MSc) -- Faculty of Pharmacy, Pharmacy, 2018
- Full Text:
- Date Issued: 2018
- Authors: Lunga, Mayibongwe Junior
- Date: 2018
- Subjects: Indole , Tetrazoles , Antimalarials , Heat shock proteins , Plasmodium falciparum
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/63521 , vital:28430
- Description: Heterocyclic structures have found extensive utility in the field of medicinal chemistry, as prominent regions of pharmacophores resulting in numerous drug treatments for many diseases. Accordingly, in this project we explored the respective antimalarial and anticancer activity exhibited by compounds featuring nitrogen containing indole and tetrazole heterocycles respectively. This thesis therefore comprises of two distinct parts. Part 1. Following the development of resistance towards traditional antimalarial therapy such as chloroquine and emerging resistance towards artemisinin combination therapies, the WHO reported the urgent need for new, effective drugs and identification of new drug targets to combat the Plasmodium falciparum parasite. In 2015 the parasite was the cause of 429 000 deaths, the majority occurring in the sub-Saharan region of Africa. This highlights the failing effectiveness of vector control strategies, reiterating the need to develop alternative control and treatment strategies. In response to this need we wanted to expand and further describe the SAR of the indole based series, indolyl-3-ethanone-α- thioethers, previously synthesized in our laboratory. These compounds were found to exhibit antimalarial activity with compounds 2.26 and 2.27 exhibiting activity against P. falciparum 3D7 in the nanomolar range. Based on these compounds we synthesized compounds 3.21 and 3.24 – 3.32 following a three step reaction pathway. Our results in this study, indicate that compound 3.28, a pnitrothiophenol analogue of 2.27 was the most active of the compounds we synthesized and furthermore was superior in activity against Plasmodium compared to 2.27. This result indicated that the presence of p-NO2 is important in enhancing anti-plasmodial activity. Comparing compounds 3.25 and 3.26 with an oxygen on the ether bridge to compounds 3.29 and 3.30 with a sulfur, we observed an increase in hydrophilicity coupled to a decrease in anti-plasmodial activity in the compounds, thus, highlighting the importance of sulfur for enhanced activity. Furthermore, we investigated bioisosteric replacement of the 5-chloro substituent present in hit compounds 2.27 and 3.28, with an electron withdrawing nitrile (3.27) and electron donating methyl (3.29) and methoxy (3.31) substituents. These substituents decreased anti-plasmodial activity, confirming that a chlorine substituent is optimal for biological activity. This study furthered our understanding of the SAR of indolyl-3-ethanone-α- thioethers for the development of potent anti-plasmodial lead compounds. Part 2. Triple negative breast cancer (TNBC), which disproportionately affects women of sub-Saharan Africa, is unresponsive to hormone-based therapies. This emergence presents a population of patients devoid of effective drug treatment, signaling the urgent need to develop new effective therapies with novel drug targets. Therefore, we identified our target in TNBC cells as the protein-protein interaction between the co-chaperones HOP and HSP90. We reasoned that a disruption of this interaction would ultimately result in cancer cell death via the degradation of essential oncogenic client proteins. Following a fragment screening campaign, which identified several acid and tetrazole containing hits (4.56 – 4.58) which bound to HOP, with low anticancer activity, we sought to develop synthetic methodology to elaborate our fragment hits synthesizing tetrazole containing fragments to target TNBC cell lines. We therefore proceeded to synthesize a range of multi substituted fragments (4.59 – 4.63), utilizing a nitrile (4.66) to access tetrazoles via 1,3-cycloaddition and an acid by nitrile hydrolysis. We successfully synthesized the tetrazole and acid fragments which are currently undergoing characterization for activity against TNBC. , Thesis (MSc) -- Faculty of Pharmacy, Pharmacy, 2018
- Full Text:
- Date Issued: 2018
A micro-ethnography: exploring relations between Somali and South African traders in Clarehill, Cape Town
- Authors: Solomon, Kelly Michelle
- Date: 2018
- Subjects: Immigrants South Africa , Immigrants Social conditions , Xenophobia South Africa , Social capital (Sociology) South Africa , Somalis Migrations , Identity (Philosophical concept) , South Africa Race relations
- Language: English
- Type: text , Thesis , Masters , MA
- Identifier: http://hdl.handle.net/10962/61277 , vital:27999 , https://doi.org/10.21504/10962/61277
- Description: Xenophobia has become a dominant narrative in contemporary South Africa. In this thesis, I hone in on a micro, informal economic market that functions cohesively and convivially with both South African and Somali transmigrant traders in it. Religion is one of the key ways through which migrants are able to access social networks and social capital. Islam, the dominant practised religion in the market, thus forms a foundation for strong, emotionally supportive, caring relationships between Somali transmigrants and South Africans The relationships between South African traders and Somali transmigrants are mutually constitutive, as they lean on one another for stability during a time that is unstable for both groups. The closeness of their relationships is evident through the way in which they tease and joke with one another, and the many ways in which they offer intangible support to each other. This thesis illustrates that despite the dominant xenophobic narrative, a close social kinship is formed in the Roelof Street market between South Africans and Somali transmigrants.
- Full Text:
- Date Issued: 2018
- Authors: Solomon, Kelly Michelle
- Date: 2018
- Subjects: Immigrants South Africa , Immigrants Social conditions , Xenophobia South Africa , Social capital (Sociology) South Africa , Somalis Migrations , Identity (Philosophical concept) , South Africa Race relations
- Language: English
- Type: text , Thesis , Masters , MA
- Identifier: http://hdl.handle.net/10962/61277 , vital:27999 , https://doi.org/10.21504/10962/61277
- Description: Xenophobia has become a dominant narrative in contemporary South Africa. In this thesis, I hone in on a micro, informal economic market that functions cohesively and convivially with both South African and Somali transmigrant traders in it. Religion is one of the key ways through which migrants are able to access social networks and social capital. Islam, the dominant practised religion in the market, thus forms a foundation for strong, emotionally supportive, caring relationships between Somali transmigrants and South Africans The relationships between South African traders and Somali transmigrants are mutually constitutive, as they lean on one another for stability during a time that is unstable for both groups. The closeness of their relationships is evident through the way in which they tease and joke with one another, and the many ways in which they offer intangible support to each other. This thesis illustrates that despite the dominant xenophobic narrative, a close social kinship is formed in the Roelof Street market between South Africans and Somali transmigrants.
- Full Text:
- Date Issued: 2018