Procedural meanings of well in a corpus of Xhosa English
- Authors: De Klerk, Vivian A
- Date: 2005
- Language: English
- Type: Article
- Identifier: vital:6128 , http://hdl.handle.net/10962/d1011579
- Description: This article explores the use of the pragmatic marker well in a large corpus of the discourse of non-mother tongue speakers of Xhosa English, which is a sub-variety of Black South African English. A brief overview of discourse markers in general and of well in particular is provided, and the problems they pose to linguists in terms of difficulties in defining their syntactic, semantic and pragmatic properties are examined. After a brief description of the nature of the corpus of Xhosa English on which the study is based, and of the methodological approach which was followed, the rest of the article focuses on a fairly detailed exposition of the overall trends in contextualised uses and procedural meanings of well in the corpus, along with examples. Some (limited) parallels are drawn between the use of well in XE and other English corpora, in order to highlight the problems experienced by L2 learners in acquiring discourse markers.
- Full Text:
- Date Issued: 2005
- Authors: De Klerk, Vivian A
- Date: 2005
- Language: English
- Type: Article
- Identifier: vital:6128 , http://hdl.handle.net/10962/d1011579
- Description: This article explores the use of the pragmatic marker well in a large corpus of the discourse of non-mother tongue speakers of Xhosa English, which is a sub-variety of Black South African English. A brief overview of discourse markers in general and of well in particular is provided, and the problems they pose to linguists in terms of difficulties in defining their syntactic, semantic and pragmatic properties are examined. After a brief description of the nature of the corpus of Xhosa English on which the study is based, and of the methodological approach which was followed, the rest of the article focuses on a fairly detailed exposition of the overall trends in contextualised uses and procedural meanings of well in the corpus, along with examples. Some (limited) parallels are drawn between the use of well in XE and other English corpora, in order to highlight the problems experienced by L2 learners in acquiring discourse markers.
- Full Text:
- Date Issued: 2005
The Revolutionary Road to Liberation
- Date: 1991-01
- Subjects: Government, Resistance to -- South Africa , South Africa -- History -- 20th century , South Africa -- Politics and government
- Language: English
- Type: text , Article
- Identifier: http://hdl.handle.net/10948/33887 , vital:33094 , Bulk File 7
- Description: This is one of many individual publications put out by the New Unity Movement.
- Full Text: false
- Date Issued: 1991-01
- Date: 1991-01
- Subjects: Government, Resistance to -- South Africa , South Africa -- History -- 20th century , South Africa -- Politics and government
- Language: English
- Type: text , Article
- Identifier: http://hdl.handle.net/10948/33887 , vital:33094 , Bulk File 7
- Description: This is one of many individual publications put out by the New Unity Movement.
- Full Text: false
- Date Issued: 1991-01
In defence of freedom
- NUM
- Authors: NUM
- Date: 1995
- Subjects: NUM
- Language: English
- Type: text
- Identifier: http://hdl.handle.net/10962/149565 , vital:38864
- Description: This book was produced to respond to questions asked by our members during the president’s national RDP mass education tour. It covers our struggle history from as early as 1652 up until the time when Nelson Mandela was inaugurated the first president of a democratic South Africa. The book also attempts to assist comrades to understand what the RDP is and find ways of rebuilding our country after the hard years of apartheid. Workers, particularly from the mining industry will be able to use this book in understanding how their contribution will assist in creating jobs, building more houses etc. We would like you to read this book over and over again and discuss the content with comrades in your branch. The committee will appriaciate any suggestions that you may come up with.
- Full Text:
- Date Issued: 1995
- Authors: NUM
- Date: 1995
- Subjects: NUM
- Language: English
- Type: text
- Identifier: http://hdl.handle.net/10962/149565 , vital:38864
- Description: This book was produced to respond to questions asked by our members during the president’s national RDP mass education tour. It covers our struggle history from as early as 1652 up until the time when Nelson Mandela was inaugurated the first president of a democratic South Africa. The book also attempts to assist comrades to understand what the RDP is and find ways of rebuilding our country after the hard years of apartheid. Workers, particularly from the mining industry will be able to use this book in understanding how their contribution will assist in creating jobs, building more houses etc. We would like you to read this book over and over again and discuss the content with comrades in your branch. The committee will appriaciate any suggestions that you may come up with.
- Full Text:
- Date Issued: 1995
A decade later: follow-up review of South African research on the consequences of and contributory factors in teen-aged pregnancy
- Macleod, Catriona I, Tracey, Tiffany
- Authors: Macleod, Catriona I , Tracey, Tiffany
- Date: 2010
- Language: English
- Type: Article
- Identifier: vital:6276 , http://hdl.handle.net/10962/d1008276 , http://journals.sagepub.com/doi/abs/10.1177/008124631004000103
- Description: In this paper, we review South African research conducted in the last 10 years on the consequences of and contributory factors in teen-aged pregnancy. We discuss research into the rates of teen-aged pregnancy, the intentionality and wantedness of pregnancy, the disruption of schooling, health issues, consequences for the children, welfare concerns, knowledge and use of contraception, timing of sexual debut, age of partner, coercive sexual relations, cultural factors and health service provision. We compare this discussion to the reviews on the same topic appearing in the South African Journal of Psychology a decade ago. We find that there are several changes in focus in the research on pregnancy amongst young women. We conclude that, in general, there has been an improvement in the breadth of data available, mostly as a result of representative national and local surveys. A better teasing out of nuances around particular issues and a grappling with theoretical issues are also evident in recent research.
- Full Text:
- Date Issued: 2010
- Authors: Macleod, Catriona I , Tracey, Tiffany
- Date: 2010
- Language: English
- Type: Article
- Identifier: vital:6276 , http://hdl.handle.net/10962/d1008276 , http://journals.sagepub.com/doi/abs/10.1177/008124631004000103
- Description: In this paper, we review South African research conducted in the last 10 years on the consequences of and contributory factors in teen-aged pregnancy. We discuss research into the rates of teen-aged pregnancy, the intentionality and wantedness of pregnancy, the disruption of schooling, health issues, consequences for the children, welfare concerns, knowledge and use of contraception, timing of sexual debut, age of partner, coercive sexual relations, cultural factors and health service provision. We compare this discussion to the reviews on the same topic appearing in the South African Journal of Psychology a decade ago. We find that there are several changes in focus in the research on pregnancy amongst young women. We conclude that, in general, there has been an improvement in the breadth of data available, mostly as a result of representative national and local surveys. A better teasing out of nuances around particular issues and a grappling with theoretical issues are also evident in recent research.
- Full Text:
- Date Issued: 2010
Contrasting spatial heterogeneity of sessile organisms within mussel (Perna perna L.) beds in relation to topographic variability
- Erlandsson, J, McQuaid, Christopher D, Kostylev, V E
- Authors: Erlandsson, J , McQuaid, Christopher D , Kostylev, V E
- Date: 2005
- Language: English
- Type: Article
- Identifier: vital:6949 , http://hdl.handle.net/10962/d1011979
- Description: We examined the spatial heterogeneity in three sessile rocky shore organisms, the mussel Perna perna, the barnacle Octomeris angulosa (Sowerby) and the red alga Gelidium pristoides (Turn.) at a range of continuous local scales along horizontal transects within mid- and upper mussel beds of South African shores. We also examined the relationships between variability of organisms and topographic features (rock depressions, slope, aspect), and between mussel, barnacle and algal variability over the same scales. To estimate spatial heterogeneity, we analyzed scaling properties of semivariograms using a fractal approach. Relationships between different variables at the different scales were examined by cross-semivariograms. Spatial dependence of P. perna variability increased with spatial dependence of topographic variability, so that scaling regions of mussel and topographic distributions corresponded well. This relationship often improved with larger local scales (mussel cover increased with depressions, steeper slope and aspect towards waves), while at smaller spatial scales, variability in mussel cover was less well explained by variability in topography. The variability of the barnacle O. angulosa exhibited spatial dependence, even on topographically unstructured shores. In contrast, the distribution of the alga G. pristoides revealed high fractal dimensions, showing spatial independence on topographically unstructured shores. Algae also showed a very strong negative relationship with mussels at most local scales, and a negative relationship with barnacles in upper zones, especially at larger local scales. Barnacles may show clear spatial dependence because of hydrodynamics (at larger local scales) and the need to find a future mate in close proximity (at smaller local scales), while algae may show a strong negative relationship with mussels because of competition for space.
- Full Text:
- Date Issued: 2005
- Authors: Erlandsson, J , McQuaid, Christopher D , Kostylev, V E
- Date: 2005
- Language: English
- Type: Article
- Identifier: vital:6949 , http://hdl.handle.net/10962/d1011979
- Description: We examined the spatial heterogeneity in three sessile rocky shore organisms, the mussel Perna perna, the barnacle Octomeris angulosa (Sowerby) and the red alga Gelidium pristoides (Turn.) at a range of continuous local scales along horizontal transects within mid- and upper mussel beds of South African shores. We also examined the relationships between variability of organisms and topographic features (rock depressions, slope, aspect), and between mussel, barnacle and algal variability over the same scales. To estimate spatial heterogeneity, we analyzed scaling properties of semivariograms using a fractal approach. Relationships between different variables at the different scales were examined by cross-semivariograms. Spatial dependence of P. perna variability increased with spatial dependence of topographic variability, so that scaling regions of mussel and topographic distributions corresponded well. This relationship often improved with larger local scales (mussel cover increased with depressions, steeper slope and aspect towards waves), while at smaller spatial scales, variability in mussel cover was less well explained by variability in topography. The variability of the barnacle O. angulosa exhibited spatial dependence, even on topographically unstructured shores. In contrast, the distribution of the alga G. pristoides revealed high fractal dimensions, showing spatial independence on topographically unstructured shores. Algae also showed a very strong negative relationship with mussels at most local scales, and a negative relationship with barnacles in upper zones, especially at larger local scales. Barnacles may show clear spatial dependence because of hydrodynamics (at larger local scales) and the need to find a future mate in close proximity (at smaller local scales), while algae may show a strong negative relationship with mussels because of competition for space.
- Full Text:
- Date Issued: 2005
A hand to mouth existence: hurdles emanating from the COVID 19 Pandemic for Women Survivalist Entrepreneurs in Johannesburg, South Africa
- Mapuranga, Miston, Maziriri, Eugine Tafadzwa, Rukuni, Tarisai Fritz
- Authors: Mapuranga, Miston , Maziriri, Eugine Tafadzwa , Rukuni, Tarisai Fritz
- Date: 2021-09-13
- Subjects: Covid-19 (Disease) , Women-owned business enterprises , Entrepreneurship
- Language: English
- Type: article
- Identifier: http://hdl.handle.net/11260/7460 , vital:53960 , https://doi.org/10.31920/2634-3622/2021/v10n3a6
- Description: There are many women survivalist entrepreneurs in South Africa, many of whom work in the informal sector. The emergence of theCOVID-19 pandemic has a devastating effect on their entrepreneurial projects. While both the public and private sectors have initiated various measures to ease the blow, obstacles continue to confront them. This study sought to examine the challenges faced by women survivalist entrepreneurs in South Africa’s Johannesburg metropolitan area. The researchers gathered qualitative data using a qualitative research approach by conducting semi-structured face-to-face interviews. The data was analysed using thematic analyses. The themes that emerged from the findings include; a lack of capital for reinvestment, no government grant support, a decline in the demand for products by the market, rotting agricultural produce or stock, a battle for strategic selling points and numerous confrontations with police as a result of not meeting the regulatory rules relating to COVID-19. The present research provides theoretical implications for academics in entrepreneurship by enhancing the understanding of the hurdles that these entrepreneurs have experienced because of COVID-19. On the practitioners’ side, this work offers avenues for women survivalist entrepreneurs to improve their entrepreneurial ventures and eventually eliminate the challenges they face when running their ventures. This study also offers policy implications. For example, existing government policies can be amended to make the working conditions of women survivalist entrepreneurs better or make the rules under which they operate simpler. This study contributes to entrepreneurship literature by uncovering the difficulties faced by women survivalist entrepreneurs due to the COVID-19 pandemic. It will assist other scholars in further developing this research field. As such, this research is important for women survivalist entrepreneurs because most of them endeavour to enhance entrepreneurial performance for the betterment of their lives. Governments may also use the study to develop interventions aimed at facilitating the growth and development of women survivalist entrepreneurs.
- Full Text:
- Date Issued: 2021-09-13
- Authors: Mapuranga, Miston , Maziriri, Eugine Tafadzwa , Rukuni, Tarisai Fritz
- Date: 2021-09-13
- Subjects: Covid-19 (Disease) , Women-owned business enterprises , Entrepreneurship
- Language: English
- Type: article
- Identifier: http://hdl.handle.net/11260/7460 , vital:53960 , https://doi.org/10.31920/2634-3622/2021/v10n3a6
- Description: There are many women survivalist entrepreneurs in South Africa, many of whom work in the informal sector. The emergence of theCOVID-19 pandemic has a devastating effect on their entrepreneurial projects. While both the public and private sectors have initiated various measures to ease the blow, obstacles continue to confront them. This study sought to examine the challenges faced by women survivalist entrepreneurs in South Africa’s Johannesburg metropolitan area. The researchers gathered qualitative data using a qualitative research approach by conducting semi-structured face-to-face interviews. The data was analysed using thematic analyses. The themes that emerged from the findings include; a lack of capital for reinvestment, no government grant support, a decline in the demand for products by the market, rotting agricultural produce or stock, a battle for strategic selling points and numerous confrontations with police as a result of not meeting the regulatory rules relating to COVID-19. The present research provides theoretical implications for academics in entrepreneurship by enhancing the understanding of the hurdles that these entrepreneurs have experienced because of COVID-19. On the practitioners’ side, this work offers avenues for women survivalist entrepreneurs to improve their entrepreneurial ventures and eventually eliminate the challenges they face when running their ventures. This study also offers policy implications. For example, existing government policies can be amended to make the working conditions of women survivalist entrepreneurs better or make the rules under which they operate simpler. This study contributes to entrepreneurship literature by uncovering the difficulties faced by women survivalist entrepreneurs due to the COVID-19 pandemic. It will assist other scholars in further developing this research field. As such, this research is important for women survivalist entrepreneurs because most of them endeavour to enhance entrepreneurial performance for the betterment of their lives. Governments may also use the study to develop interventions aimed at facilitating the growth and development of women survivalist entrepreneurs.
- Full Text:
- Date Issued: 2021-09-13
I.U.F EDUCATION PROGRAM
- UIF
- Authors: UIF
- Date: 1983
- Subjects: UIF
- Language: English
- Type: text
- Identifier: http://hdl.handle.net/10962/174123 , vital:42444
- Description: THIS IS INFORMATION MATERIAL CONCERNING STUDIES IN STUDY CIRCLES. IT IS AIMED, PRIMARILY, AT BEING A GUIDE TO THOSE WHO HAVE NOT PREVIOUSLY TAKEN PART IN SUCH STUDIES. THE MATERIAL WAS PREPARED BY THE IUF EDUCATION SECRETARIES JOINTLY WITH PARTICIPANTS IN THE IUF STUDY CIRCLE LEADERS' SEMINAR IN THE PHILIPPINES, IN AUTUMN 1981. THE MATERIAL GIVES A THOROUGH INTRODUCTION OF THE STUDY CIRCLE METHOD. IT ALSO DEALS WITH THE ROLE OF THE CIRCLE LEADER AND THE PARTICIPANT AS WELL AS THE REQUIREMENTS OF MATERIAL "DESIGN”.
- Full Text:
- Date Issued: 1983
- Authors: UIF
- Date: 1983
- Subjects: UIF
- Language: English
- Type: text
- Identifier: http://hdl.handle.net/10962/174123 , vital:42444
- Description: THIS IS INFORMATION MATERIAL CONCERNING STUDIES IN STUDY CIRCLES. IT IS AIMED, PRIMARILY, AT BEING A GUIDE TO THOSE WHO HAVE NOT PREVIOUSLY TAKEN PART IN SUCH STUDIES. THE MATERIAL WAS PREPARED BY THE IUF EDUCATION SECRETARIES JOINTLY WITH PARTICIPANTS IN THE IUF STUDY CIRCLE LEADERS' SEMINAR IN THE PHILIPPINES, IN AUTUMN 1981. THE MATERIAL GIVES A THOROUGH INTRODUCTION OF THE STUDY CIRCLE METHOD. IT ALSO DEALS WITH THE ROLE OF THE CIRCLE LEADER AND THE PARTICIPANT AS WELL AS THE REQUIREMENTS OF MATERIAL "DESIGN”.
- Full Text:
- Date Issued: 1983
Psycho-medical discourse in South African research on teenage pregnancy
- Macleod, Catriona I, Durrheim, Kevin
- Authors: Macleod, Catriona I , Durrheim, Kevin
- Date: 2003
- Language: English
- Type: Article
- Identifier: vital:6257 , http://hdl.handle.net/10962/d1007875
- Description: Catriona Macleod and Kevin Durrheim apply a Foucauldian analysis to the scientific literature on teenage pregnancy.
- Full Text:
- Date Issued: 2003
- Authors: Macleod, Catriona I , Durrheim, Kevin
- Date: 2003
- Language: English
- Type: Article
- Identifier: vital:6257 , http://hdl.handle.net/10962/d1007875
- Description: Catriona Macleod and Kevin Durrheim apply a Foucauldian analysis to the scientific literature on teenage pregnancy.
- Full Text:
- Date Issued: 2003
Conscientious objection to performing same-sex marriage in South Africa
- Authors: Kruuse, Helen
- Date: 2014
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/129186 , vital:36228 , https://doi.org/10.1093/lawfam/ebu001
- Description: This article considers whether public servants should be exempt from South Africa’s equality provisions and anti-discrimination legislation in solemnizing same-sex marriages. In order to deal with this question, the article analyses the treatment of freedom of conscience and conscientious objection by comparing the solemnization of same-sex marriage by public servants, with another public service: that of terminations of pregnancy. While each situation will inevitably turn on the particular circumstances of the case, I argue that there should be a content-neutral guiding principle (as well as consistency) in dealing with these situations. The issue in each situation is narrowed to whether a civil servant’s personal convictions can override the state’s secular obligations in providing a service, and whether there is room for a qualified right to conscientious objection. By analysing the matter in this way, it is clear that the unqualified statutory exemption clause in South Africa’s Civil Union Act is constitutionally objectionable.
- Full Text: false
- Date Issued: 2014
- Authors: Kruuse, Helen
- Date: 2014
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/129186 , vital:36228 , https://doi.org/10.1093/lawfam/ebu001
- Description: This article considers whether public servants should be exempt from South Africa’s equality provisions and anti-discrimination legislation in solemnizing same-sex marriages. In order to deal with this question, the article analyses the treatment of freedom of conscience and conscientious objection by comparing the solemnization of same-sex marriage by public servants, with another public service: that of terminations of pregnancy. While each situation will inevitably turn on the particular circumstances of the case, I argue that there should be a content-neutral guiding principle (as well as consistency) in dealing with these situations. The issue in each situation is narrowed to whether a civil servant’s personal convictions can override the state’s secular obligations in providing a service, and whether there is room for a qualified right to conscientious objection. By analysing the matter in this way, it is clear that the unqualified statutory exemption clause in South Africa’s Civil Union Act is constitutionally objectionable.
- Full Text: false
- Date Issued: 2014
Creating a virtual classroom: evaluating the use of online discussion forums to increase teaching and learning activities in an introductory accounting class
- Authors: Bezuidenhout, L Peta
- Date: 2008
- Language: English
- Type: Conference paper
- Identifier: vital:6082 , http://hdl.handle.net/10962/d1008586
- Description: In teaching large classes, the educationally beneficial informal interaction between students and between lecturer and students is generally reduced, while effective use of both students' and lecturer's time is often a challenge. During student consultations, especially over the already stressful test and examination periods, many of the questions asked by the students are the same or similar. The lecturer needs to respond to each query by providing the same detailed explanation for the problem, resulting in ineffective use of time for the lecturer, while students waste time waiting for an appointment, or more often, simply don't bother to follow up on any queries they may have. Having a social presence is important for students' cognitive development, but in a large class posing questions or interrogating issues during a lecture appears to be challenging for many students. It is often not easy for students to initiate discussions or establish relationships with peers or the lecturer due to feelings of vulnerability and due to the size and impersonal atmosphere of the lecture theatre. This paper deals with the introduction of online discussion forums in an introductory accounting course and the benefits and problems experienced by the students, tutors and lecturer as a result thereof. Feedback received from these participants is discussed. The introduction and use of these forums resulted in a virtual classroom being created, where significantly more teaching and learning activities took place, to the benefit of all participants. Participation could have been peripheral - in the form of simply reading discussions; or active – through posting questions, or responding to questions.
- Full Text:
- Date Issued: 2008
- Authors: Bezuidenhout, L Peta
- Date: 2008
- Language: English
- Type: Conference paper
- Identifier: vital:6082 , http://hdl.handle.net/10962/d1008586
- Description: In teaching large classes, the educationally beneficial informal interaction between students and between lecturer and students is generally reduced, while effective use of both students' and lecturer's time is often a challenge. During student consultations, especially over the already stressful test and examination periods, many of the questions asked by the students are the same or similar. The lecturer needs to respond to each query by providing the same detailed explanation for the problem, resulting in ineffective use of time for the lecturer, while students waste time waiting for an appointment, or more often, simply don't bother to follow up on any queries they may have. Having a social presence is important for students' cognitive development, but in a large class posing questions or interrogating issues during a lecture appears to be challenging for many students. It is often not easy for students to initiate discussions or establish relationships with peers or the lecturer due to feelings of vulnerability and due to the size and impersonal atmosphere of the lecture theatre. This paper deals with the introduction of online discussion forums in an introductory accounting course and the benefits and problems experienced by the students, tutors and lecturer as a result thereof. Feedback received from these participants is discussed. The introduction and use of these forums resulted in a virtual classroom being created, where significantly more teaching and learning activities took place, to the benefit of all participants. Participation could have been peripheral - in the form of simply reading discussions; or active – through posting questions, or responding to questions.
- Full Text:
- Date Issued: 2008
Software engineering: inaugural lecture delivered at Rhodes University
- Authors: Williams, M H
- Date: 1979
- Subjects: Computer programming , Programming languages (Electronic computers)
- Language: English
- Type: Text
- Identifier: vital:680 , http://hdl.handle.net/10962/d1020749 , ISBN 0868100102
- Description: Inaugural lecture delivered at Rhodes University , Rhodes University Libraries (Digitisation)
- Full Text:
- Date Issued: 1979
- Authors: Williams, M H
- Date: 1979
- Subjects: Computer programming , Programming languages (Electronic computers)
- Language: English
- Type: Text
- Identifier: vital:680 , http://hdl.handle.net/10962/d1020749 , ISBN 0868100102
- Description: Inaugural lecture delivered at Rhodes University , Rhodes University Libraries (Digitisation)
- Full Text:
- Date Issued: 1979
Establishing computational approaches towards identifying malarial allosteric modulators: a case study of plasmodium falciparum hsp70s
- Amusengeri, Arnold, Astl, Lindy, Lobb, Kevin A, Verkhivker, Gennady M, Tastan Bishop, Özlem
- Authors: Amusengeri, Arnold , Astl, Lindy , Lobb, Kevin A , Verkhivker, Gennady M , Tastan Bishop, Özlem
- Date: 2019
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/163000 , vital:41003 , https://doi.org/10.3390/ijms20225574
- Description: Combating malaria is almost a never-ending battle, as Plasmodium parasites develop resistance to the drugs used against them, as observed recently in artemisinin-based combination therapies. The main concern now is if the resistant parasite strains spread from Southeast Asia to Africa, the continent hosting most malaria cases. To prevent catastrophic results, we need to find non-conventional approaches. Allosteric drug targeting sites and modulators might be a new hope for malarial treatments. Heat shock proteins (HSPs) are potential malarial drug targets and have complex allosteric control mechanisms. Yet, studies on designing allosteric modulators against them are limited. Here, we identified allosteric modulators (SANC190 and SANC651) against P. falciparum Hsp70-1 and Hsp70-x, affecting the conformational dynamics of the proteins, delicately balanced by the endogenous ligands. Previously, we established a pipeline to identify allosteric sites and modulators. This study also further investigated alternative approaches to speed up the process by comparing all atom molecular dynamics simulations and dynamic residue network analysis with the coarse-grained (CG) versions of the calculations. Betweenness centrality (BC) profiles for PfHsp70-1 and PfHsp70-x derived from CG simulations not only revealed similar trends but also pointed to the same functional regions and specific residues corresponding to BC profile peaks.
- Full Text:
- Date Issued: 2019
- Authors: Amusengeri, Arnold , Astl, Lindy , Lobb, Kevin A , Verkhivker, Gennady M , Tastan Bishop, Özlem
- Date: 2019
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/163000 , vital:41003 , https://doi.org/10.3390/ijms20225574
- Description: Combating malaria is almost a never-ending battle, as Plasmodium parasites develop resistance to the drugs used against them, as observed recently in artemisinin-based combination therapies. The main concern now is if the resistant parasite strains spread from Southeast Asia to Africa, the continent hosting most malaria cases. To prevent catastrophic results, we need to find non-conventional approaches. Allosteric drug targeting sites and modulators might be a new hope for malarial treatments. Heat shock proteins (HSPs) are potential malarial drug targets and have complex allosteric control mechanisms. Yet, studies on designing allosteric modulators against them are limited. Here, we identified allosteric modulators (SANC190 and SANC651) against P. falciparum Hsp70-1 and Hsp70-x, affecting the conformational dynamics of the proteins, delicately balanced by the endogenous ligands. Previously, we established a pipeline to identify allosteric sites and modulators. This study also further investigated alternative approaches to speed up the process by comparing all atom molecular dynamics simulations and dynamic residue network analysis with the coarse-grained (CG) versions of the calculations. Betweenness centrality (BC) profiles for PfHsp70-1 and PfHsp70-x derived from CG simulations not only revealed similar trends but also pointed to the same functional regions and specific residues corresponding to BC profile peaks.
- Full Text:
- Date Issued: 2019
Introduction to Psychology: PSY 122
- Van, Heerden, R, Sandlana, N S
- Authors: Van, Heerden, R , Sandlana, N S
- Date: 2010-01
- Subjects: Psychology
- Language: English
- Type: Examination paper
- Identifier: vital:17981 , http://hdl.handle.net/10353/d1010553
- Description: Introduction to Psychology: PSY 122, supplementary examination January 2010.
- Full Text: false
- Date Issued: 2010-01
- Authors: Van, Heerden, R , Sandlana, N S
- Date: 2010-01
- Subjects: Psychology
- Language: English
- Type: Examination paper
- Identifier: vital:17981 , http://hdl.handle.net/10353/d1010553
- Description: Introduction to Psychology: PSY 122, supplementary examination January 2010.
- Full Text: false
- Date Issued: 2010-01
Media consumption and everyday life
- Authors: Strelitz, Larry N
- Date: 2008
- Language: English
- Type: text , Conference paper
- Identifier: vital:6324 , http://hdl.handle.net/10962/d1008550
- Description: I see this inaugural lecture as an opportunity to trace my journey into the field of media studies, showing how significant youthful experiences with the media set me off on my particular research trajectory. In this address I will use the umbrella term ‘mass media’ to cover both the traditional news media as well as forms of popular culture such as soap operas, popular music and so on. Sometimes we use the terms ‘popular culture’ and ‘mass media’ interchangeably as they both constitute the cultural life of ordinary people.
- Full Text:
- Date Issued: 2008
- Authors: Strelitz, Larry N
- Date: 2008
- Language: English
- Type: text , Conference paper
- Identifier: vital:6324 , http://hdl.handle.net/10962/d1008550
- Description: I see this inaugural lecture as an opportunity to trace my journey into the field of media studies, showing how significant youthful experiences with the media set me off on my particular research trajectory. In this address I will use the umbrella term ‘mass media’ to cover both the traditional news media as well as forms of popular culture such as soap operas, popular music and so on. Sometimes we use the terms ‘popular culture’ and ‘mass media’ interchangeably as they both constitute the cultural life of ordinary people.
- Full Text:
- Date Issued: 2008
Quality of life and positive youth development in Grahamstown East, South Africa
- Authors: Moller, Valerie
- Date: 2003
- Language: English
- Type: Article
- Identifier: http://hdl.handle.net/10962/2363 , vital:20281
- Description: Quality-of-life studies are ideally suited to fulfilling the new international youth research agenda, which focuses on ‘positive youth development’ to make recommendations for policy and practice. The paper reports a South African case study conducted among disadvantaged youth for this purpose. A sample survey of close on 900 African youth, aged 15-24 years, sought to identify indicators of positive development to serve as goals of youth and community work in Grahamstown East/Rini, in the Eastern Cape province of South Africa. The setting is unique. This mainly rural province is among the poorest, least developed, and has one of highest unemployment rates. Nevertheless, Grahamstown may offer special development opportunities for local youth due to the proximity of the city centre and diverse extension projects for youth. The survey found that development opportunities were unequally distributed with the materially advantaged youth being more exposed to development opportunities through their schools, spare time activities, and community contacts. They were more ambitious than others and more aware of risks facing contemporary youth. Advantaged youth also reported higher levels of subjective well-being and optimism, findings consistent with earlier studies conducted among adult populations, which report remarkable congruence between material and subjective well-being among South Africans. The analysis used overall life satisfaction as key indicator of successful youth development to learn more about major youth aspirations and goals. In conclusion, the study was able to identify a youth development initiative based on the aspirations of the youth, which might be pursued as a researcher-practitioner partnership project in line with the new international youth research agenda.
- Full Text:
- Date Issued: 2003
- Authors: Moller, Valerie
- Date: 2003
- Language: English
- Type: Article
- Identifier: http://hdl.handle.net/10962/2363 , vital:20281
- Description: Quality-of-life studies are ideally suited to fulfilling the new international youth research agenda, which focuses on ‘positive youth development’ to make recommendations for policy and practice. The paper reports a South African case study conducted among disadvantaged youth for this purpose. A sample survey of close on 900 African youth, aged 15-24 years, sought to identify indicators of positive development to serve as goals of youth and community work in Grahamstown East/Rini, in the Eastern Cape province of South Africa. The setting is unique. This mainly rural province is among the poorest, least developed, and has one of highest unemployment rates. Nevertheless, Grahamstown may offer special development opportunities for local youth due to the proximity of the city centre and diverse extension projects for youth. The survey found that development opportunities were unequally distributed with the materially advantaged youth being more exposed to development opportunities through their schools, spare time activities, and community contacts. They were more ambitious than others and more aware of risks facing contemporary youth. Advantaged youth also reported higher levels of subjective well-being and optimism, findings consistent with earlier studies conducted among adult populations, which report remarkable congruence between material and subjective well-being among South Africans. The analysis used overall life satisfaction as key indicator of successful youth development to learn more about major youth aspirations and goals. In conclusion, the study was able to identify a youth development initiative based on the aspirations of the youth, which might be pursued as a researcher-practitioner partnership project in line with the new international youth research agenda.
- Full Text:
- Date Issued: 2003
Phenylpropanolamine hydrochloride
- Kanfer, Isadore, Haigh, John M, Dowse, Roslind
- Authors: Kanfer, Isadore , Haigh, John M , Dowse, Roslind
- Date: 1983
- Language: English
- Type: Article
- Identifier: vital:6385 , http://hdl.handle.net/10962/d1006306
- Description: Phenylpropanolamine hydrochloride belongs to the sympathomimetic amine class of drugs and is structurally related to ephedrine hydrochloride. Its synthesis was first reported in 1910 and the first American patent was registered in 1939. The effects of phenylpropanolamine hydrochloride are largely the result of alpha-adrenergic agonist activity resulting from both direct stimulation of adrenergic receptors and release of neuronal norepinephrine. The principal adverse effect of phenylpropanolamine hydrochloride is dose-related hypertension and ventricular arrhythmia has been described. Phenylpropanolamine hydrochloride is widely used as a decongestant and it has been used as an anorectic agent for over 40 years. A report in 1939 described its effect as an hypertensive agent when administered parenterally.
- Full Text:
- Date Issued: 1983
- Authors: Kanfer, Isadore , Haigh, John M , Dowse, Roslind
- Date: 1983
- Language: English
- Type: Article
- Identifier: vital:6385 , http://hdl.handle.net/10962/d1006306
- Description: Phenylpropanolamine hydrochloride belongs to the sympathomimetic amine class of drugs and is structurally related to ephedrine hydrochloride. Its synthesis was first reported in 1910 and the first American patent was registered in 1939. The effects of phenylpropanolamine hydrochloride are largely the result of alpha-adrenergic agonist activity resulting from both direct stimulation of adrenergic receptors and release of neuronal norepinephrine. The principal adverse effect of phenylpropanolamine hydrochloride is dose-related hypertension and ventricular arrhythmia has been described. Phenylpropanolamine hydrochloride is widely used as a decongestant and it has been used as an anorectic agent for over 40 years. A report in 1939 described its effect as an hypertensive agent when administered parenterally.
- Full Text:
- Date Issued: 1983
Stop privatisation - Join the campaign
- COSATU
- Authors: COSATU
- Date: June 1991
- Subjects: COSATU
- Language: English
- Type: text
- Identifier: http://hdl.handle.net/10962/135389 , vital:37263
- Description: Privatisation is when government hands over the management or assets of government services to private interests. Privatised services don't provide well for the poor, who can't pay, because private interests must make profits. Government says it will ensure the poor get good services through contracts and regulations - but it doesn't have capacity to enforce them. Privatisation makes it harder to maintain cross subsidies. Cross subsidies mean rich communities or industry pay more, so that poor households can pay less. Getting rid of cross-subsidies tends to make the prices for services for the poor go up. Privatised companies don't take the broader economic needs of the country into account, for instance by buying goods locally as a way to create jobs, and providing affordable services in remote regions.
- Full Text:
- Date Issued: June 1991
- Authors: COSATU
- Date: June 1991
- Subjects: COSATU
- Language: English
- Type: text
- Identifier: http://hdl.handle.net/10962/135389 , vital:37263
- Description: Privatisation is when government hands over the management or assets of government services to private interests. Privatised services don't provide well for the poor, who can't pay, because private interests must make profits. Government says it will ensure the poor get good services through contracts and regulations - but it doesn't have capacity to enforce them. Privatisation makes it harder to maintain cross subsidies. Cross subsidies mean rich communities or industry pay more, so that poor households can pay less. Getting rid of cross-subsidies tends to make the prices for services for the poor go up. Privatised companies don't take the broader economic needs of the country into account, for instance by buying goods locally as a way to create jobs, and providing affordable services in remote regions.
- Full Text:
- Date Issued: June 1991
Racializing teenage pregnancy : ‘culture’ and ‘tradition’ in the South African scientific literature
- Macleod, Catriona I, Durrheim, Kevin
- Authors: Macleod, Catriona I , Durrheim, Kevin
- Date: 2002
- Language: English
- Type: Article
- Identifier: vital:6260 , http://hdl.handle.net/10962/d1007878
- Description: The signifiers, ‘race’, ‘culture’ or ‘ethnicity’ are utilized in the teenage pregnancy literature (1) to highlight ‘differences’ in adolescent sexual and reproductive behaviour and (2) as explanatory tools. When ‘white’ teenagers are the focus of research, psychological explanations are usually invoked, while for ‘black’ teenagers, explanations are socio-cultural in nature. In this paper, we explore how, through a process of racialization, the psycho-medical literature on teenage pregnancy in South Africa contributes to the entrenchment of ‘race’, ‘culture’ and ‘ethnicity’ as fixed, ‘natural’ signifiers. We utilize Derrida’s notion of différance, together with Phoenix and Woollett’s adaptation – ‘normalized absence/pathologized presence’ – to indicate how ‘black’ people are cast as the Other, the pathologized presence which relies on the normalized absent trace, ‘whiteness’, for definition. We analyse how the notions of ‘tradition’ and ‘culture’ are deployed to sanitize or disguise the underlying racializing project. ‘Black’ is exoticized and rendered strange and thus open to scrutiny, monitoring and intervention. ‘Culture’ and ‘tradition’ appeal to the myth of origin, thus providing pseudo-historical explanations which essentialize and naturalize racialized collectivities. , Rhodes University
- Full Text:
- Date Issued: 2002
Racializing teenage pregnancy : ‘culture’ and ‘tradition’ in the South African scientific literature
- Authors: Macleod, Catriona I , Durrheim, Kevin
- Date: 2002
- Language: English
- Type: Article
- Identifier: vital:6260 , http://hdl.handle.net/10962/d1007878
- Description: The signifiers, ‘race’, ‘culture’ or ‘ethnicity’ are utilized in the teenage pregnancy literature (1) to highlight ‘differences’ in adolescent sexual and reproductive behaviour and (2) as explanatory tools. When ‘white’ teenagers are the focus of research, psychological explanations are usually invoked, while for ‘black’ teenagers, explanations are socio-cultural in nature. In this paper, we explore how, through a process of racialization, the psycho-medical literature on teenage pregnancy in South Africa contributes to the entrenchment of ‘race’, ‘culture’ and ‘ethnicity’ as fixed, ‘natural’ signifiers. We utilize Derrida’s notion of différance, together with Phoenix and Woollett’s adaptation – ‘normalized absence/pathologized presence’ – to indicate how ‘black’ people are cast as the Other, the pathologized presence which relies on the normalized absent trace, ‘whiteness’, for definition. We analyse how the notions of ‘tradition’ and ‘culture’ are deployed to sanitize or disguise the underlying racializing project. ‘Black’ is exoticized and rendered strange and thus open to scrutiny, monitoring and intervention. ‘Culture’ and ‘tradition’ appeal to the myth of origin, thus providing pseudo-historical explanations which essentialize and naturalize racialized collectivities. , Rhodes University
- Full Text:
- Date Issued: 2002
We are all the public
- Authors: Pithouse, Richard, 1970-
- Date: 2009
- Language: English
- Type: Article
- Identifier: vital:6198 , http://hdl.handle.net/10962/d1008562
- Description: [from introduction]: Across the country the most vulnerable people in our society are being subject to brazenly unlawful and often violent action at the hands of the state. Homeless people, refugees, sex workers, street traders and shack dwellers are all being taught, in the most literal sense of the term, to know their place. But state illegality is not only aimed at the segregation of physical space. It is also about ensuring that the people on the margins of society know their political place.
- Full Text:
- Date Issued: 2009
- Authors: Pithouse, Richard, 1970-
- Date: 2009
- Language: English
- Type: Article
- Identifier: vital:6198 , http://hdl.handle.net/10962/d1008562
- Description: [from introduction]: Across the country the most vulnerable people in our society are being subject to brazenly unlawful and often violent action at the hands of the state. Homeless people, refugees, sex workers, street traders and shack dwellers are all being taught, in the most literal sense of the term, to know their place. But state illegality is not only aimed at the segregation of physical space. It is also about ensuring that the people on the margins of society know their political place.
- Full Text:
- Date Issued: 2009
Constructing a cardinal measure of democratic development in a transition polity: the Nigerian example
- Dinneya, Godson E, Tsegaye, Asrat
- Authors: Dinneya, Godson E , Tsegaye, Asrat
- Date: 2004
- Language: English
- Type: Article
- Identifier: vital:6076 , http://hdl.handle.net/10962/d1003837
- Description: Existing measures of the level of democracy present in a given state treat democracy as a product and therefore place undue emphasis on actual freedoms enjoyed by the citizens of the country. In transition polities where the actual levels of freedom are low despite continuing efforts to democratize, democracy should be seen as a process rather than a product. A measure that dilutes the end product to capture today's struggles against undemocratic structures and policies does so in order to recognize the foundations these inputs lay for future democratic development. Nigeria exemplifies the many polities in transition on the African continent. This essay looks at the major political events that typify the processes of power change, quality of governance, political environment and democratic dividends, and uses them to construct democratization indices to determine the pattern and level of democratization in Nigeria since political independence. This exercise sets the stage for assessing the impacts of various dimensions of democratization on the performance of the Nigerian economy.
- Full Text:
- Date Issued: 2004
- Authors: Dinneya, Godson E , Tsegaye, Asrat
- Date: 2004
- Language: English
- Type: Article
- Identifier: vital:6076 , http://hdl.handle.net/10962/d1003837
- Description: Existing measures of the level of democracy present in a given state treat democracy as a product and therefore place undue emphasis on actual freedoms enjoyed by the citizens of the country. In transition polities where the actual levels of freedom are low despite continuing efforts to democratize, democracy should be seen as a process rather than a product. A measure that dilutes the end product to capture today's struggles against undemocratic structures and policies does so in order to recognize the foundations these inputs lay for future democratic development. Nigeria exemplifies the many polities in transition on the African continent. This essay looks at the major political events that typify the processes of power change, quality of governance, political environment and democratic dividends, and uses them to construct democratization indices to determine the pattern and level of democratization in Nigeria since political independence. This exercise sets the stage for assessing the impacts of various dimensions of democratization on the performance of the Nigerian economy.
- Full Text:
- Date Issued: 2004