But is it publishable? Mastering the MMed message
- Authors: A G Parrish , E S Grossman,
- Date: 202
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/11260/3353 , vital:43318 , http://www.samj.org.za/index.php/samj/article/view/13033
- Description: The research requirement for South African specialist registration offers opportunities and challenges. For some clinicians it may spark a lifelong interest in clinical investigation, while for many others it may provide a potential publication opportunity. Integrating the specific requirements of an MMed mini-dissertation with those of standard medical publications can be difficult for first-time authors and their supervisors; published guidance caters to full-length laboratory Master’s or doctoral research. We suggest that research is more likely to be publishable if it is locally relevant, has a clear clinical message and is coherently presented.
- Full Text:
- Date Issued: 202
- Authors: A G Parrish , E S Grossman,
- Date: 202
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/11260/3353 , vital:43318 , http://www.samj.org.za/index.php/samj/article/view/13033
- Description: The research requirement for South African specialist registration offers opportunities and challenges. For some clinicians it may spark a lifelong interest in clinical investigation, while for many others it may provide a potential publication opportunity. Integrating the specific requirements of an MMed mini-dissertation with those of standard medical publications can be difficult for first-time authors and their supervisors; published guidance caters to full-length laboratory Master’s or doctoral research. We suggest that research is more likely to be publishable if it is locally relevant, has a clear clinical message and is coherently presented.
- Full Text:
- Date Issued: 202
Essential medicine selection during the COVID-19 pandemic: Enabling access in uncharted territory
- Authors: A G Parrish
- Date: 2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/11260/3364 , vital:43319 , http://www.samj.org.za/index.php/samj/article/view/13086
- Description: The COVID-19 pandemic requires urgent decisions regarding treatment policy in the face of rapidly evolving evidence. In response, the South African Essential Medicines List Committee established a subcommittee to systematically review and appraise emerging evidence, within very short timelines, in order to inform the National Department of Health COVID-19 treatment guidelines. To date, the subcommittee has reviewed 14 potential treatments, and made recommendations based on local context, feasibility, resource requirements and equity. Here we describe the rapid review and evidence-to-decision process, using remdesivir and dexamethasone as examples. Our experience is that conducting rapid reviews is a practical and efficient way to address medicine policy questions under pandemic conditions.
- Full Text:
- Date Issued: 2020
- Authors: A G Parrish
- Date: 2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/11260/3364 , vital:43319 , http://www.samj.org.za/index.php/samj/article/view/13086
- Description: The COVID-19 pandemic requires urgent decisions regarding treatment policy in the face of rapidly evolving evidence. In response, the South African Essential Medicines List Committee established a subcommittee to systematically review and appraise emerging evidence, within very short timelines, in order to inform the National Department of Health COVID-19 treatment guidelines. To date, the subcommittee has reviewed 14 potential treatments, and made recommendations based on local context, feasibility, resource requirements and equity. Here we describe the rapid review and evidence-to-decision process, using remdesivir and dexamethasone as examples. Our experience is that conducting rapid reviews is a practical and efficient way to address medicine policy questions under pandemic conditions.
- Full Text:
- Date Issued: 2020
Effects of an eight-week lumbar stabilization exercise programme on selected variables of patients with chronic low back pain:
- Abass, Ademola O, Alli, Abiola R, Olagbegi, Oladapo M, Christie, Candice J, Bolarinde, Olufemi S
- Authors: Abass, Ademola O , Alli, Abiola R , Olagbegi, Oladapo M , Christie, Candice J , Bolarinde, Olufemi S
- Date: 2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/150307 , vital:38966 , DOI: https://doi.org/10.3329/bjms.v19i3.45864
- Description: Lumbar stabilisation exercise has been shown to reduce pain and disability in patients with low back pain but information on its potential benefits in term of back muscle endurance is scarce. This study was aimed at investigating the effects of augmenting conventional physiotherapy with lumbar stabilization exercises on selected variables of patients with non-specific chronic low back pain (NSCLBP).
- Full Text:
- Date Issued: 2020
- Authors: Abass, Ademola O , Alli, Abiola R , Olagbegi, Oladapo M , Christie, Candice J , Bolarinde, Olufemi S
- Date: 2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/150307 , vital:38966 , DOI: https://doi.org/10.3329/bjms.v19i3.45864
- Description: Lumbar stabilisation exercise has been shown to reduce pain and disability in patients with low back pain but information on its potential benefits in term of back muscle endurance is scarce. This study was aimed at investigating the effects of augmenting conventional physiotherapy with lumbar stabilization exercises on selected variables of patients with non-specific chronic low back pain (NSCLBP).
- Full Text:
- Date Issued: 2020
Temperature tolerance and humidity requirements of select entomopathogenic fungal isolates for future use in citrus IPM programmes
- Acheampong, M A, Coombes, Candice A, Moore, Sean D, Hill, Martin P
- Authors: Acheampong, M A , Coombes, Candice A , Moore, Sean D , Hill, Martin P
- Date: 2020
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/419399 , vital:71641 , xlink:href="https://doi.org/10.1016/j.jip.2020.107436"
- Description: Several isolates of Beauveria bassiana (Balsamo-Crivelli) Vuillemin (Hypocreales: Cordycipitacae) and Metarhizium anisopliae (Metchnikoff) Sorokin (Hypocreales: Clavicipitacae) have been investigated as possible microbial control agents of key citrus pests in South Africa. Although laboratory results have been promising, field trials against foliar pests have shown limited success. These findings highlighted the need to investigate other biological attributes of these fungal isolates besides virulence in order to select candidates that may be better suited for the foliar environment. Thus, this study investigated the influence of temperature on the in vitro growth of seven indigenous local isolates and the humidity requirements necessary to promote successful infection, in comparison with two commercial isolates (B. bassiana PPRI 5339 and M. anisopliae ICIPE 69). All the fungal isolates grew across a range of temperatures (8–34 °C) and optimally between 26 and 28 °C. Similarly, fungal infection of Thaumatotibia leucotreta Meyrick (Lepidoptera: Tortricidae) fifth instars occurred across a range of humidity levels (12%, 43%, 75%, 98%) regardless of fungal concentration, although external sporulation was restricted to treatments exposed to 98% relative humidity. It was concluded that neither temperature nor humidity, when considered alone, is likely to significantly influence the efficacy of any of the isolates in the field, given that they are active within temperature and humidity ranges experienced in South African citrus orchards.
- Full Text:
- Date Issued: 2020
- Authors: Acheampong, M A , Coombes, Candice A , Moore, Sean D , Hill, Martin P
- Date: 2020
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/419399 , vital:71641 , xlink:href="https://doi.org/10.1016/j.jip.2020.107436"
- Description: Several isolates of Beauveria bassiana (Balsamo-Crivelli) Vuillemin (Hypocreales: Cordycipitacae) and Metarhizium anisopliae (Metchnikoff) Sorokin (Hypocreales: Clavicipitacae) have been investigated as possible microbial control agents of key citrus pests in South Africa. Although laboratory results have been promising, field trials against foliar pests have shown limited success. These findings highlighted the need to investigate other biological attributes of these fungal isolates besides virulence in order to select candidates that may be better suited for the foliar environment. Thus, this study investigated the influence of temperature on the in vitro growth of seven indigenous local isolates and the humidity requirements necessary to promote successful infection, in comparison with two commercial isolates (B. bassiana PPRI 5339 and M. anisopliae ICIPE 69). All the fungal isolates grew across a range of temperatures (8–34 °C) and optimally between 26 and 28 °C. Similarly, fungal infection of Thaumatotibia leucotreta Meyrick (Lepidoptera: Tortricidae) fifth instars occurred across a range of humidity levels (12%, 43%, 75%, 98%) regardless of fungal concentration, although external sporulation was restricted to treatments exposed to 98% relative humidity. It was concluded that neither temperature nor humidity, when considered alone, is likely to significantly influence the efficacy of any of the isolates in the field, given that they are active within temperature and humidity ranges experienced in South African citrus orchards.
- Full Text:
- Date Issued: 2020
Policies to reduce single-use plastic marine pollution in West Africa:
- Adam, Issahaku, Walker, Tony R, Bezerra, Joana Carlos, Clayton, Andrea
- Authors: Adam, Issahaku , Walker, Tony R , Bezerra, Joana Carlos , Clayton, Andrea
- Date: 2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/150196 , vital:38948 , https://doi.org/10.1016/j.marpol.2020.103928
- Description: Countries in Africa are increasingly adopting policies to reduce single-use plastic (SUP) pollution, yet there has been limited analysis of policies adopted by African countries. This paper reviews SUP reduction policies, specifically in West Africa.
- Full Text:
- Date Issued: 2020
- Authors: Adam, Issahaku , Walker, Tony R , Bezerra, Joana Carlos , Clayton, Andrea
- Date: 2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/150196 , vital:38948 , https://doi.org/10.1016/j.marpol.2020.103928
- Description: Countries in Africa are increasingly adopting policies to reduce single-use plastic (SUP) pollution, yet there has been limited analysis of policies adopted by African countries. This paper reviews SUP reduction policies, specifically in West Africa.
- Full Text:
- Date Issued: 2020
Patient acceptance of HIV testing services in rural emergency departments in South Africa
- Aditi Rao, Caitlin Kennedy, Pamela Mda, Thomas C. Quinn, David Stead, Bhakti Hansoti
- Authors: Aditi Rao , Caitlin Kennedy , Pamela Mda , Thomas C. Quinn , David Stead , Bhakti Hansoti
- Date: 2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/11260/3270 , vital:43287 , https://doi.org/10.4102/sajhivmed.v21i1.1105
- Description: Background: South Africa faces the highest burden of HIV infection globally. The National Strategic Plan on HIV recommends provider-initiated HIV counselling and testing (HCT) in all healthcare facilities. However, HIV continues to overwhelm the healthcare system. Emergency department (ED)-based HCT could address unmet testing needs. Objectives: This study examines the reasons for accepting or declining HCT in South African EDs to inform the development of HCT implementation strategies. Method: We conducted a prospective observational study in two rural EDs, from June to September 2017. Patients presenting to the ED were systematically approached and offered a point-of-care test in accordance with national guidelines. Patients demographics, presenting compaint, medical history and reasons for accepting/declining testing, were recorded. A pooled analysis is presented. Results: Across sites, 2074 adult, non-critical patients in the ED were approached; 1880 were enrolled in the study. Of those enrolled, 19.7% had a previously known positive diagnosis, and 80.3% were unaware of their HIV status. Of those unaware, 90% patients accepted and 10% declined testing. The primary reasons for declining testing were ‘does not want to know status’ (37.6%), ‘in too much pain’ (34%) and ‘does not believe they are at risk’ (19.9%). Conclusions: Despite national guidelines, a high proportion of individuals remain undiagnosed, of which a majority are young men. Our study demonstrated high patient acceptance of ED-based HCT. There is a need for investment and innovation regarding effective pain management and confidential service delivery to address patient barriers. Findings support a routine, non-targeted HCT strategy in EDs. Keywords: HIV counselling and testing; South Africa; emergency department; patient acceptance; implementation research; linkage to care.
- Full Text:
- Date Issued: 2020
- Authors: Aditi Rao , Caitlin Kennedy , Pamela Mda , Thomas C. Quinn , David Stead , Bhakti Hansoti
- Date: 2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/11260/3270 , vital:43287 , https://doi.org/10.4102/sajhivmed.v21i1.1105
- Description: Background: South Africa faces the highest burden of HIV infection globally. The National Strategic Plan on HIV recommends provider-initiated HIV counselling and testing (HCT) in all healthcare facilities. However, HIV continues to overwhelm the healthcare system. Emergency department (ED)-based HCT could address unmet testing needs. Objectives: This study examines the reasons for accepting or declining HCT in South African EDs to inform the development of HCT implementation strategies. Method: We conducted a prospective observational study in two rural EDs, from June to September 2017. Patients presenting to the ED were systematically approached and offered a point-of-care test in accordance with national guidelines. Patients demographics, presenting compaint, medical history and reasons for accepting/declining testing, were recorded. A pooled analysis is presented. Results: Across sites, 2074 adult, non-critical patients in the ED were approached; 1880 were enrolled in the study. Of those enrolled, 19.7% had a previously known positive diagnosis, and 80.3% were unaware of their HIV status. Of those unaware, 90% patients accepted and 10% declined testing. The primary reasons for declining testing were ‘does not want to know status’ (37.6%), ‘in too much pain’ (34%) and ‘does not believe they are at risk’ (19.9%). Conclusions: Despite national guidelines, a high proportion of individuals remain undiagnosed, of which a majority are young men. Our study demonstrated high patient acceptance of ED-based HCT. There is a need for investment and innovation regarding effective pain management and confidential service delivery to address patient barriers. Findings support a routine, non-targeted HCT strategy in EDs. Keywords: HIV counselling and testing; South Africa; emergency department; patient acceptance; implementation research; linkage to care.
- Full Text:
- Date Issued: 2020
Enhanced Light-Driven Antimicrobial Activity of Cationic Poly (oxanorbornene) s by Phthalocyanine Incorporation into Polymer as Pendants
- Ahmetali, Erem, Sen, Pinar, Süer, N Ceren, Aksu, Burak, Nyokong, Tebello, Eren, Tarik, Sener, Kasim M
- Authors: Ahmetali, Erem , Sen, Pinar , Süer, N Ceren , Aksu, Burak , Nyokong, Tebello , Eren, Tarik , Sener, Kasim M
- Date: 2020
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/185976 , vital:44453 , xlink:href=" https://doi.org/10.1002/macp.202000386"
- Description: Amphiphilic poly(oxanorbornene)s are promising synthetic polymers that mimic the structural properties and antimicrobial functions of naturally occurring antimicrobial peptides. Here, poly(oxanorbornene)s bearing pendant zinc(II) phthalocyanine and triphenyl(ethyl) phosphonium functionalities are synthesized by ring-opening metathesis polymerization (ROMP). Fluorescence, singlet oxygen and triplet quantum yields of polymers are measured in dimethyl sulfoxide and aqueous medium. The singlet oxygen quantum yields of copolymers with the highest triphenyl and triethyl phosphonium content are found to be 0.29 and 0.41, respectively. Then, antimicrobial activities of polymers against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) are investigated under both dark and light conditions. Synergistic effect of zinc(II) phthalocyanine and phosphonium-containing poly(oxanorbornene) is observed that the conjugate possessing the most triphenyl phosphonium side chains has the highest activity under light against both gram-positive and gram-negative bacterial strains after 80 min irradiation, reducing the survival of E. coli or S. aureus by 99.9999%. Hemolytic concentrations of the copolymers are found between 8 and 512 µg mL−1. Scanning electron microscopy (SEM) proves that the bacteria membrane deforms after contacting with the biocidal polymer.
- Full Text:
- Date Issued: 2020
- Authors: Ahmetali, Erem , Sen, Pinar , Süer, N Ceren , Aksu, Burak , Nyokong, Tebello , Eren, Tarik , Sener, Kasim M
- Date: 2020
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/185976 , vital:44453 , xlink:href=" https://doi.org/10.1002/macp.202000386"
- Description: Amphiphilic poly(oxanorbornene)s are promising synthetic polymers that mimic the structural properties and antimicrobial functions of naturally occurring antimicrobial peptides. Here, poly(oxanorbornene)s bearing pendant zinc(II) phthalocyanine and triphenyl(ethyl) phosphonium functionalities are synthesized by ring-opening metathesis polymerization (ROMP). Fluorescence, singlet oxygen and triplet quantum yields of polymers are measured in dimethyl sulfoxide and aqueous medium. The singlet oxygen quantum yields of copolymers with the highest triphenyl and triethyl phosphonium content are found to be 0.29 and 0.41, respectively. Then, antimicrobial activities of polymers against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) are investigated under both dark and light conditions. Synergistic effect of zinc(II) phthalocyanine and phosphonium-containing poly(oxanorbornene) is observed that the conjugate possessing the most triphenyl phosphonium side chains has the highest activity under light against both gram-positive and gram-negative bacterial strains after 80 min irradiation, reducing the survival of E. coli or S. aureus by 99.9999%. Hemolytic concentrations of the copolymers are found between 8 and 512 µg mL−1. Scanning electron microscopy (SEM) proves that the bacteria membrane deforms after contacting with the biocidal polymer.
- Full Text:
- Date Issued: 2020
Host stage preference and performance of Dolichogenidea gelechiidivoris (Hymenoptera: Braconidae), a candidate for classical biological control of Tuta absoluta in Africa
- Aigbedion-Atalor, Pascal O, Mohamed, Samira A, Hill, Martin P, Zalucki, Myron P, Azrag, Abdelmutalab G A, Srinivasan, Ramasamy, Ekesi, Sunday
- Authors: Aigbedion-Atalor, Pascal O , Mohamed, Samira A , Hill, Martin P , Zalucki, Myron P , Azrag, Abdelmutalab G A , Srinivasan, Ramasamy , Ekesi, Sunday
- Date: 2020
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/423516 , vital:72068 , xlink:href="https://doi.org/10.1016/j.biocontrol.2020.104215"
- Description: Tuta absoluta (Meyrick) (Lepidoptera: Gelechiidae) is native to South America but has invaded the Afro-Eurasian supercontinent where it is currently the most devastating invasive arthropod pest of tomato. As a part of the first classical biological control programme against T. absoluta in Africa, a larval parasitoid, Dolichogenidea gelechiidivoris Marsh. (Syn.: Apanteles gelechiidivoris Marsh) (Hymenoptera: Braconidae), of T. absoluta was imported from Peru into the quarantine facility of the International Centre of Insect Physiology and Ecology, Kenya. We report on the host larval preference of D. gelechiidivoris and the host suitability, and the parasitoid’s reproductive strategy, including lifetime fecundity and egg maturation dynamics. Dolichogenidea gelechiidivoris females preferentially oviposited in early (1st and 2nd) larval instars of T. absoluta but parasitized and completed development in all four instars of the host. Host instar did not affect D. gelechiidivoris sex-ratio but females reared on the first instar had significantly fewer eggs than when reared in late larval instars (3rd and 4th). Females of the parasitoid emerged with a high mature egg load which peaked 2 d post eclosion. The females of D. gelechiidivoris survived 8.51 ± 0.65 d and produced 103 ± 8 offspring per female at 26 ± 4 °C (range: 24 to 29 °C) and 50–70% relative humidity (RH) with males present and fed honey-water (80% honey). Increasing maternal age decreased the proportion of female offspring. Under the aforementioned laboratory conditions, the Gross and Net reproductive rates were 72 and 39.5 respectively, while the mean generation time was 20 d. The potential intrinsic rate of natural increase was 0.18. This study shows that D. gelechiidivoris is a potential biological control agent of T. absoluta and should be considered for release in Kenya and across Africa following host specificity testing and risk assessments.
- Full Text:
- Date Issued: 2020
- Authors: Aigbedion-Atalor, Pascal O , Mohamed, Samira A , Hill, Martin P , Zalucki, Myron P , Azrag, Abdelmutalab G A , Srinivasan, Ramasamy , Ekesi, Sunday
- Date: 2020
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/423516 , vital:72068 , xlink:href="https://doi.org/10.1016/j.biocontrol.2020.104215"
- Description: Tuta absoluta (Meyrick) (Lepidoptera: Gelechiidae) is native to South America but has invaded the Afro-Eurasian supercontinent where it is currently the most devastating invasive arthropod pest of tomato. As a part of the first classical biological control programme against T. absoluta in Africa, a larval parasitoid, Dolichogenidea gelechiidivoris Marsh. (Syn.: Apanteles gelechiidivoris Marsh) (Hymenoptera: Braconidae), of T. absoluta was imported from Peru into the quarantine facility of the International Centre of Insect Physiology and Ecology, Kenya. We report on the host larval preference of D. gelechiidivoris and the host suitability, and the parasitoid’s reproductive strategy, including lifetime fecundity and egg maturation dynamics. Dolichogenidea gelechiidivoris females preferentially oviposited in early (1st and 2nd) larval instars of T. absoluta but parasitized and completed development in all four instars of the host. Host instar did not affect D. gelechiidivoris sex-ratio but females reared on the first instar had significantly fewer eggs than when reared in late larval instars (3rd and 4th). Females of the parasitoid emerged with a high mature egg load which peaked 2 d post eclosion. The females of D. gelechiidivoris survived 8.51 ± 0.65 d and produced 103 ± 8 offspring per female at 26 ± 4 °C (range: 24 to 29 °C) and 50–70% relative humidity (RH) with males present and fed honey-water (80% honey). Increasing maternal age decreased the proportion of female offspring. Under the aforementioned laboratory conditions, the Gross and Net reproductive rates were 72 and 39.5 respectively, while the mean generation time was 20 d. The potential intrinsic rate of natural increase was 0.18. This study shows that D. gelechiidivoris is a potential biological control agent of T. absoluta and should be considered for release in Kenya and across Africa following host specificity testing and risk assessments.
- Full Text:
- Date Issued: 2020
Optically stimulated luminescence and spectral emission features of radioluminescence and thermoluminescence of natural kunzite:
- Alatishe, M A, Ogundare, F O, Folley, Damilola E, Chithambo, Makaiko L, Chikwembani, S
- Authors: Alatishe, M A , Ogundare, F O , Folley, Damilola E , Chithambo, Makaiko L , Chikwembani, S
- Date: 2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/160478 , vital:40449 , https://doi.org/10.1016/j.radmeas.2020.106457
- Description: Features of luminescence optically stimulated from natural kunzite using 470 nm blue light are reported. Preparatory measurements of its X-ray excited radioluminescence and thermoluminescence show that the sample has two main bands centered at 360 nm and 600 nm. The optically stimulated luminescence discussed in this report was monitored in the UV region and is presumed to be the same 360 nm emission that appears in the radioluminescence and thermoluminescence spectra. The glow curve shows at least three peaks at 74, 202, 432 oC for heating at 1 oC and the third one is a composite of two. Only the first two peaks are deduced to contribute most of the optically stimulated luminescence.
- Full Text:
- Date Issued: 2020
- Authors: Alatishe, M A , Ogundare, F O , Folley, Damilola E , Chithambo, Makaiko L , Chikwembani, S
- Date: 2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/160478 , vital:40449 , https://doi.org/10.1016/j.radmeas.2020.106457
- Description: Features of luminescence optically stimulated from natural kunzite using 470 nm blue light are reported. Preparatory measurements of its X-ray excited radioluminescence and thermoluminescence show that the sample has two main bands centered at 360 nm and 600 nm. The optically stimulated luminescence discussed in this report was monitored in the UV region and is presumed to be the same 360 nm emission that appears in the radioluminescence and thermoluminescence spectra. The glow curve shows at least three peaks at 74, 202, 432 oC for heating at 1 oC and the third one is a composite of two. Only the first two peaks are deduced to contribute most of the optically stimulated luminescence.
- Full Text:
- Date Issued: 2020
Chemical archeoceanography:
- Albarede, Francis, Thibon, Fanny, Blichert-Toft, Janne, Tsikos, Harilaos
- Authors: Albarede, Francis , Thibon, Fanny , Blichert-Toft, Janne , Tsikos, Harilaos
- Date: 2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/149065 , vital:38801 , https://doi.org/10.1016/j.chemgeo.2020.119625
- Description: Elemental fluxes to the ocean are expected to increase with the surface area of continental exposure to weathering and atmospheric PCO2. The record of phosphorus in sediments, which has no notable source within the ocean, and the radiogenic strontium isotopes in Archean carbonates indicate that, prior to the Great Oxidation Event (GOE), subaerial expanses represented only about 20% of the modern continental surface area, i.e. 7% of the surface of the Earth. Because these simple first-order observations, in contrast to the low oxygen content of the pre-GOE atmosphere, have so far received only little attention in the appraisal of the marine chemistry of the early Earth, a reassessment of the chemistry of the pre-GOE ocean is warranted. Here we discuss some of the geochemical cycles of the Archean world, including protons, alkalinity, electrons, and other electrolytes, and attempt to build a first conceptual framework for Chemical Archeoceanography.
- Full Text:
- Date Issued: 2020
- Authors: Albarede, Francis , Thibon, Fanny , Blichert-Toft, Janne , Tsikos, Harilaos
- Date: 2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/149065 , vital:38801 , https://doi.org/10.1016/j.chemgeo.2020.119625
- Description: Elemental fluxes to the ocean are expected to increase with the surface area of continental exposure to weathering and atmospheric PCO2. The record of phosphorus in sediments, which has no notable source within the ocean, and the radiogenic strontium isotopes in Archean carbonates indicate that, prior to the Great Oxidation Event (GOE), subaerial expanses represented only about 20% of the modern continental surface area, i.e. 7% of the surface of the Earth. Because these simple first-order observations, in contrast to the low oxygen content of the pre-GOE atmosphere, have so far received only little attention in the appraisal of the marine chemistry of the early Earth, a reassessment of the chemistry of the pre-GOE ocean is warranted. Here we discuss some of the geochemical cycles of the Archean world, including protons, alkalinity, electrons, and other electrolytes, and attempt to build a first conceptual framework for Chemical Archeoceanography.
- Full Text:
- Date Issued: 2020
The influence of citrus orchard age on the ecology of entomopathogenic fungi and nematodes
- Albertyn ,Sonnica, Moore, Sean D, Marsberg, Tamryn, Coombes, Candice A, Hill, Martin P
- Authors: Albertyn ,Sonnica , Moore, Sean D , Marsberg, Tamryn , Coombes, Candice A , Hill, Martin P
- Date: 2020
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/417545 , vital:71462 , xlink:href="https://hdl.handle.net/10520/ejc-cristal-v10-n1-a7"
- Description: A three-year survey of the ecology of entomopathogenic nematodes (EPN) and entomopathogenic fungi (EPF) was undertaken on soils from citrus orchards of different ages to determine the influence of orchard age on the ecology of entomopathogenic fungi and nematodes. The influence of mulch and irrigation method on the occurrence of EPN and EPF was also determined. Most of the isolates recovered (n = 810) were Beauveria sp. (87.88% of all isolates), followed by Metarhizium sp. (11.87% of all isolates). Only 0.24% of soil samples collected during this study tested positive for EPN. All EPN isolates recovered were Heterorhabditis bacteriophora. No significant differences in EPF occurrence were recorded between orchards under drip and micro-sprinkler irrigation. EPF occurrence was significantly lower (P = 0.016) in orchards covered by mulch (31.85% ± 2.07% occurrence) than in orchards with no covering (38.57% ± 1.57% occurrence). EPF occurrence of 40.33 ± 2.13% was highest in non-bearing orchards, followed by mature orchards (nine years or older) (36.76 ± 2.05% of samples) with the lowest EPF occurrence of 25.30 ± 2.02% reported in juvenile orchards (four to eight years old). Juvenile orchards sustain significantly less EPF than mature and non-bearing orchards because of the combined negative impact of less favourable environmental conditions (lower shade density) and fungicide applications.
- Full Text:
- Date Issued: 2020
- Authors: Albertyn ,Sonnica , Moore, Sean D , Marsberg, Tamryn , Coombes, Candice A , Hill, Martin P
- Date: 2020
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/417545 , vital:71462 , xlink:href="https://hdl.handle.net/10520/ejc-cristal-v10-n1-a7"
- Description: A three-year survey of the ecology of entomopathogenic nematodes (EPN) and entomopathogenic fungi (EPF) was undertaken on soils from citrus orchards of different ages to determine the influence of orchard age on the ecology of entomopathogenic fungi and nematodes. The influence of mulch and irrigation method on the occurrence of EPN and EPF was also determined. Most of the isolates recovered (n = 810) were Beauveria sp. (87.88% of all isolates), followed by Metarhizium sp. (11.87% of all isolates). Only 0.24% of soil samples collected during this study tested positive for EPN. All EPN isolates recovered were Heterorhabditis bacteriophora. No significant differences in EPF occurrence were recorded between orchards under drip and micro-sprinkler irrigation. EPF occurrence was significantly lower (P = 0.016) in orchards covered by mulch (31.85% ± 2.07% occurrence) than in orchards with no covering (38.57% ± 1.57% occurrence). EPF occurrence of 40.33 ± 2.13% was highest in non-bearing orchards, followed by mature orchards (nine years or older) (36.76 ± 2.05% of samples) with the lowest EPF occurrence of 25.30 ± 2.02% reported in juvenile orchards (four to eight years old). Juvenile orchards sustain significantly less EPF than mature and non-bearing orchards because of the combined negative impact of less favourable environmental conditions (lower shade density) and fungicide applications.
- Full Text:
- Date Issued: 2020
The privacy paradox applies to IoT devices too: a Saudi Arabian study
- Aleisa, Noura, Renaud, Karen, Bongiovanni, Ivano
- Authors: Aleisa, Noura , Renaud, Karen , Bongiovanni, Ivano
- Date: 2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/150252 , vital:38953 , https://doi.org/10.1016/j.cose.2020.101897
- Description: The “privacy paradox” is the term used to describe the disconnect between self-reported privacy value attributions and actions actually taken to protect and preserve personal privacy. This phenomenon has been investigated in a number of domains and we extend the body of research with an investigation in the IoT domain. We presented participants with evidence of a specific IoT device’s (smart plug) privacy violations and then measured changes in privacy concerns and trust, as well as uptake of a range of behavioural responses. Our Saudi Arabian participants, despite expressing high levels of privacy concerns, generally chose not to respond to this evidence with preventative action.
- Full Text:
- Date Issued: 2020
- Authors: Aleisa, Noura , Renaud, Karen , Bongiovanni, Ivano
- Date: 2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/150252 , vital:38953 , https://doi.org/10.1016/j.cose.2020.101897
- Description: The “privacy paradox” is the term used to describe the disconnect between self-reported privacy value attributions and actions actually taken to protect and preserve personal privacy. This phenomenon has been investigated in a number of domains and we extend the body of research with an investigation in the IoT domain. We presented participants with evidence of a specific IoT device’s (smart plug) privacy violations and then measured changes in privacy concerns and trust, as well as uptake of a range of behavioural responses. Our Saudi Arabian participants, despite expressing high levels of privacy concerns, generally chose not to respond to this evidence with preventative action.
- Full Text:
- Date Issued: 2020
The Privacy Paradox applies to IoT devices too: a Saudi Arabian study
- Aleisa, Noura, Renaud, Karen, Bongiovanni, Ivano
- Authors: Aleisa, Noura , Renaud, Karen , Bongiovanni, Ivano
- Date: 2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/158350 , vital:40176 , https://doi.org/10.1016/j.cose.2020.101897
- Description: The “privacy paradox” is the term used to describe the disconnect between self-reported privacy value attributions and actions actually taken to protect and preserve personal privacy. This phenomenon has been investigated in a number of domains and we extend the body of research with an investigation in the IoT domain. We presented participants with evidence of a specific IoT device’s (smart plug) privacy violations and then measured changes in privacy concerns and trust, as well as uptake of a range of behavioural responses.
- Full Text:
- Date Issued: 2020
- Authors: Aleisa, Noura , Renaud, Karen , Bongiovanni, Ivano
- Date: 2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/158350 , vital:40176 , https://doi.org/10.1016/j.cose.2020.101897
- Description: The “privacy paradox” is the term used to describe the disconnect between self-reported privacy value attributions and actions actually taken to protect and preserve personal privacy. This phenomenon has been investigated in a number of domains and we extend the body of research with an investigation in the IoT domain. We presented participants with evidence of a specific IoT device’s (smart plug) privacy violations and then measured changes in privacy concerns and trust, as well as uptake of a range of behavioural responses.
- Full Text:
- Date Issued: 2020
Integrated computational approaches and tools for allosteric drug discovery:
- Amamuddy, Olivier S, Veldman, Wade, Manyumwa, Colleen, Khairallah, Afrah, Agajanian, Steve, Oluyemi, Odeyemi, Verkhivker, Gennady M, Tastan Bishop, Özlem
- Authors: Amamuddy, Olivier S , Veldman, Wade , Manyumwa, Colleen , Khairallah, Afrah , Agajanian, Steve , Oluyemi, Odeyemi , Verkhivker, Gennady M , Tastan Bishop, Özlem
- Date: 2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/163012 , vital:41004 , https://doi.org/10.3390/ijms21030847
- Description: Understanding molecular mechanisms underlying the complexity of allosteric regulation in proteins has attracted considerable attention in drug discovery due to the benefits and versatility of allosteric modulators in providing desirable selectivity against protein targets while minimizing toxicity and other side effects. The proliferation of novel computational approaches for predicting ligand–protein interactions and binding using dynamic and network-centric perspectives has led to new insights into allosteric mechanisms and facilitated computer-based discovery of allosteric drugs. Although no absolute method of experimental and in silico allosteric drug/site discovery exists, current methods are still being improved. As such, the critical analysis and integration of established approaches into robust, reproducible, and customizable computational pipelines with experimental feedback could make allosteric drug discovery more efficient and reliable. In this article, we review computational approaches for allosteric drug discovery and discuss how these tools can be utilized to develop consensus workflows for in silico identification of allosteric sites and modulators with some applications to pathogen resistance and precision medicine. The emerging realization that allosteric modulators can exploit distinct regulatory mechanisms and can provide access to targeted modulation of protein activities could open opportunities for probing biological processes and in silico design of drug combinations with improved therapeutic indices and a broad range of activities.
- Full Text:
- Date Issued: 2020
- Authors: Amamuddy, Olivier S , Veldman, Wade , Manyumwa, Colleen , Khairallah, Afrah , Agajanian, Steve , Oluyemi, Odeyemi , Verkhivker, Gennady M , Tastan Bishop, Özlem
- Date: 2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/163012 , vital:41004 , https://doi.org/10.3390/ijms21030847
- Description: Understanding molecular mechanisms underlying the complexity of allosteric regulation in proteins has attracted considerable attention in drug discovery due to the benefits and versatility of allosteric modulators in providing desirable selectivity against protein targets while minimizing toxicity and other side effects. The proliferation of novel computational approaches for predicting ligand–protein interactions and binding using dynamic and network-centric perspectives has led to new insights into allosteric mechanisms and facilitated computer-based discovery of allosteric drugs. Although no absolute method of experimental and in silico allosteric drug/site discovery exists, current methods are still being improved. As such, the critical analysis and integration of established approaches into robust, reproducible, and customizable computational pipelines with experimental feedback could make allosteric drug discovery more efficient and reliable. In this article, we review computational approaches for allosteric drug discovery and discuss how these tools can be utilized to develop consensus workflows for in silico identification of allosteric sites and modulators with some applications to pathogen resistance and precision medicine. The emerging realization that allosteric modulators can exploit distinct regulatory mechanisms and can provide access to targeted modulation of protein activities could open opportunities for probing biological processes and in silico design of drug combinations with improved therapeutic indices and a broad range of activities.
- Full Text:
- Date Issued: 2020
Impact of emerging mutations on the dynamic properties the SARS-CoV-2 main protease: an in silico investigation
- Amamuddy, Olivier S, Verkhivker, Gennady M, Tastan Bishop, Özlem
- Authors: Amamuddy, Olivier S , Verkhivker, Gennady M , Tastan Bishop, Özlem
- Date: 2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/163035 , vital:41006 , doi: 10.1021/acs.jcim.0c00634
- Description: The new coronavirus (SARS-CoV-2) is a global threat to world health and its economy. Its main protease (Mpro), which functions as a dimer, cleaves viral precursor proteins in the process of viral maturation. It is a good candidate for drug development owing to its conservation and the absence of a human homolog. An improved understanding of the protein behaviour can accelerate the discovery of effective therapies in order to reduce mortality. 100 ns all-atom molecular dynamics simulations of 50 homology modelled mutant Mpro dimers were performed at pH 7 from filtered sequences obtained from the GISAID database. Protease dynamics were analysed using RMSD, RMSF, Rg, the averaged betweenness centrality and geometry calculations. Domains from each Mpro protomer were found to generally have independent motions, while the dimer-stabilising N-finger region was found to be flexible in most mutants.
- Full Text:
- Date Issued: 2020
- Authors: Amamuddy, Olivier S , Verkhivker, Gennady M , Tastan Bishop, Özlem
- Date: 2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/163035 , vital:41006 , doi: 10.1021/acs.jcim.0c00634
- Description: The new coronavirus (SARS-CoV-2) is a global threat to world health and its economy. Its main protease (Mpro), which functions as a dimer, cleaves viral precursor proteins in the process of viral maturation. It is a good candidate for drug development owing to its conservation and the absence of a human homolog. An improved understanding of the protein behaviour can accelerate the discovery of effective therapies in order to reduce mortality. 100 ns all-atom molecular dynamics simulations of 50 homology modelled mutant Mpro dimers were performed at pH 7 from filtered sequences obtained from the GISAID database. Protease dynamics were analysed using RMSD, RMSF, Rg, the averaged betweenness centrality and geometry calculations. Domains from each Mpro protomer were found to generally have independent motions, while the dimer-stabilising N-finger region was found to be flexible in most mutants.
- Full Text:
- Date Issued: 2020
Impact of early pandemic stage mutations on molecular dynamics of SARS-CoV-2 Mpro:
- Amamuddy, Olivier S, Verkhivker, Gennady M, Tastan Bishop, Özlem
- Authors: Amamuddy, Olivier S , Verkhivker, Gennady M , Tastan Bishop, Özlem
- Date: 2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/162330 , vital:40835 , https://0-doi.org.wam.seals.ac.za/10.1021/acs.jcim.0c00634
- Description: A new coronavirus (SARS-CoV-2) is a global threat to world health and economy. Its dimeric main protease (Mpro), which is required for the proteolytic cleavage of viral precursor proteins, is a good candidate for drug development owing to its conservation and the absence of a human homolog. Improving our understanding of Mpro behavior can accelerate the discovery of effective therapies to reduce mortality. All-atom molecular dynamics (MD) simulations (100 ns) of 50 mutant Mpro dimers obtained from filtered sequences from the GISAID database were analyzed using root-mean-square deviation, root-mean-square fluctuation, Rg, averaged betweenness centrality, and geometry calculations.
- Full Text:
- Date Issued: 2020
- Authors: Amamuddy, Olivier S , Verkhivker, Gennady M , Tastan Bishop, Özlem
- Date: 2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/162330 , vital:40835 , https://0-doi.org.wam.seals.ac.za/10.1021/acs.jcim.0c00634
- Description: A new coronavirus (SARS-CoV-2) is a global threat to world health and economy. Its dimeric main protease (Mpro), which is required for the proteolytic cleavage of viral precursor proteins, is a good candidate for drug development owing to its conservation and the absence of a human homolog. Improving our understanding of Mpro behavior can accelerate the discovery of effective therapies to reduce mortality. All-atom molecular dynamics (MD) simulations (100 ns) of 50 mutant Mpro dimers obtained from filtered sequences from the GISAID database were analyzed using root-mean-square deviation, root-mean-square fluctuation, Rg, averaged betweenness centrality, and geometry calculations.
- Full Text:
- Date Issued: 2020
Determining the unbinding events and conserved motions associated with the pyrazinamide release due to resistance mutations of Mycobacterium tuberculosis pyrazinamidase:
- Amamuddy, Olivier S, Musyoka, Thommas M, Boateng, Rita A, Zabo, Sophakama, Tastan Bishop, Özlem
- Authors: Amamuddy, Olivier S , Musyoka, Thommas M , Boateng, Rita A , Zabo, Sophakama , Tastan Bishop, Özlem
- Date: 2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/148869 , vital:38781 , https://doi.org/10.1016/j.csbj.2020.05.0099
- Description: Pyrazinamide (PZA) is the only first-line antitubercular drug active against latent Mycobacterium tuberculosis (Mtb). It is activated to pyrazinoic acid by the pncA-encoded pyrazinamidase enzyme (PZase). Despite the emergence of PZA drug resistance, the underlying mechanisms of resistance remain unclear. This study investigated part of these mechanisms by modelling a PZA-bound wild type and 82 mutant PZase structures before applying molecular dynamics (MD) with an accurate Fe2+ cofactor coordination geometry.
- Full Text:
- Date Issued: 2020
- Authors: Amamuddy, Olivier S , Musyoka, Thommas M , Boateng, Rita A , Zabo, Sophakama , Tastan Bishop, Özlem
- Date: 2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/148869 , vital:38781 , https://doi.org/10.1016/j.csbj.2020.05.0099
- Description: Pyrazinamide (PZA) is the only first-line antitubercular drug active against latent Mycobacterium tuberculosis (Mtb). It is activated to pyrazinoic acid by the pncA-encoded pyrazinamidase enzyme (PZase). Despite the emergence of PZA drug resistance, the underlying mechanisms of resistance remain unclear. This study investigated part of these mechanisms by modelling a PZA-bound wild type and 82 mutant PZase structures before applying molecular dynamics (MD) with an accurate Fe2+ cofactor coordination geometry.
- Full Text:
- Date Issued: 2020
Understanding the Pyrimethamine drug resistance mechanism via combined molecular dynamics and dynamic residue network analysis:
- Amusengeri, Arnold, Tata, Rolland B, Tastan Bishop, Özlem
- Authors: Amusengeri, Arnold , Tata, Rolland B , Tastan Bishop, Özlem
- Date: 2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/163022 , vital:41005 , https://doi.org/10.3390/molecules25040904
- Description: In this era of precision medicine, insights into the resistance mechanism of drugs are integral for the development of potent therapeutics. Here, we sought to understand the contribution of four point mutations (N51I, C59R, S108N, and I164L) within the active site of the malaria parasite enzyme dihydrofolate reductase (DHFR) towards the resistance of the antimalarial drug pyrimethamine. Homology modeling was used to obtain full-length models of wild type (WT) and mutant DHFR. Molecular docking was employed to dock pyrimethamine onto the generated structures. Subsequent all-atom molecular dynamics (MD) simulations and binding free-energy computations highlighted that pyrimethamine’s stability and affinity inversely relates to the number of mutations within its binding site and, hence, resistance severity.
- Full Text:
- Date Issued: 2020
- Authors: Amusengeri, Arnold , Tata, Rolland B , Tastan Bishop, Özlem
- Date: 2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/163022 , vital:41005 , https://doi.org/10.3390/molecules25040904
- Description: In this era of precision medicine, insights into the resistance mechanism of drugs are integral for the development of potent therapeutics. Here, we sought to understand the contribution of four point mutations (N51I, C59R, S108N, and I164L) within the active site of the malaria parasite enzyme dihydrofolate reductase (DHFR) towards the resistance of the antimalarial drug pyrimethamine. Homology modeling was used to obtain full-length models of wild type (WT) and mutant DHFR. Molecular docking was employed to dock pyrimethamine onto the generated structures. Subsequent all-atom molecular dynamics (MD) simulations and binding free-energy computations highlighted that pyrimethamine’s stability and affinity inversely relates to the number of mutations within its binding site and, hence, resistance severity.
- Full Text:
- Date Issued: 2020
Screening for small molecule modulators of Trypanosoma brucei Hsp70 chaperone activity based upon alcyonarian coral-derived natural products
- Andreassend, Sarah K, Bentley, Stephen, Blatch, Gregory L, Boshoff, Aileen, Keyzers, Robert A
- Authors: Andreassend, Sarah K , Bentley, Stephen , Blatch, Gregory L , Boshoff, Aileen , Keyzers, Robert A
- Date: 2020
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/426045 , vital:72309 , xlink:href="https://doi.org/10.3390/md18020081"
- Description: The Trypanosoma brucei Hsp70/J-protein machinery plays an essential role in survival, differentiation, and pathogenesis of the protozoan parasite, and is an emerging target against African Trypanosomiasis. This study evaluated a set of small molecules, inspired by the malonganenones and nuttingins, as modulators of the chaperone activity of the cytosolic heat inducible T. brucei Hsp70 and constitutive TbHsp70.4 proteins. The compounds were assessed for cytotoxicity on both the bloodstream form of T. b. brucei parasites and a mammalian cell line. The compounds were then investigated for their modulatory effect on the aggregation suppression and ATPase activities of the TbHsp70 proteins. A structure–activity relationship for the malonganenone-class of alkaloids is proposed based upon these results.
- Full Text:
- Date Issued: 2020
- Authors: Andreassend, Sarah K , Bentley, Stephen , Blatch, Gregory L , Boshoff, Aileen , Keyzers, Robert A
- Date: 2020
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/426045 , vital:72309 , xlink:href="https://doi.org/10.3390/md18020081"
- Description: The Trypanosoma brucei Hsp70/J-protein machinery plays an essential role in survival, differentiation, and pathogenesis of the protozoan parasite, and is an emerging target against African Trypanosomiasis. This study evaluated a set of small molecules, inspired by the malonganenones and nuttingins, as modulators of the chaperone activity of the cytosolic heat inducible T. brucei Hsp70 and constitutive TbHsp70.4 proteins. The compounds were assessed for cytotoxicity on both the bloodstream form of T. b. brucei parasites and a mammalian cell line. The compounds were then investigated for their modulatory effect on the aggregation suppression and ATPase activities of the TbHsp70 proteins. A structure–activity relationship for the malonganenone-class of alkaloids is proposed based upon these results.
- Full Text:
- Date Issued: 2020
Using Translanguaging in Higher Education to Empower Students' Voices and Enable Epistemological Becoming
- Asfour, Fouad-Martin, Ndabula, Yanela, Chakona, Gamuchirai, Mason, Paul, Oluwole, David O
- Authors: Asfour, Fouad-Martin , Ndabula, Yanela , Chakona, Gamuchirai , Mason, Paul , Oluwole, David O
- Date: 2020
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/425506 , vital:72251 , xlink:href="https://doi.org/10.29086/2519-5476/2020/sp31a4"
- Description: This article is based on research conducted by a group of plurilingual postgraduate students from different disciplines who facilitated writing groups at the Centre for Postgraduate Studies at Rhodes University over the past two years. It is based on self-reflective writing of language biographies and aims to raise attention about, and to open up a discussion on, the impact of social and personal language practices. We approach the role of language not only as complex interrogation of academic identity, but also as sense of embodied self, an active element in the formation of geo- and body-politics of knowledge which has been highlighted in recent literature focussing on translanguaging in education and decolonising the curricula of Higher Education. Following selfguided research, we engaged in a critical reflection on the use of home languages in education and consulted relevant literature that argues for the inclusion of translanguaging practices in Higher Education. Our research, therefore, focuses on new epistemologies afforded by a shift away from the monolingual habitus and from the concept of multilingualism towards plurilingualism and translanguaging. Our data suggests that a plurilingual approach towards teaching and learning in Higher Education can afford epistemological access to learners across faculties and disciplines in Higher Education, and we argue that the role of languages of tuition in curricula need to be strategically re-evaluated.
- Full Text:
- Date Issued: 2020
- Authors: Asfour, Fouad-Martin , Ndabula, Yanela , Chakona, Gamuchirai , Mason, Paul , Oluwole, David O
- Date: 2020
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/425506 , vital:72251 , xlink:href="https://doi.org/10.29086/2519-5476/2020/sp31a4"
- Description: This article is based on research conducted by a group of plurilingual postgraduate students from different disciplines who facilitated writing groups at the Centre for Postgraduate Studies at Rhodes University over the past two years. It is based on self-reflective writing of language biographies and aims to raise attention about, and to open up a discussion on, the impact of social and personal language practices. We approach the role of language not only as complex interrogation of academic identity, but also as sense of embodied self, an active element in the formation of geo- and body-politics of knowledge which has been highlighted in recent literature focussing on translanguaging in education and decolonising the curricula of Higher Education. Following selfguided research, we engaged in a critical reflection on the use of home languages in education and consulted relevant literature that argues for the inclusion of translanguaging practices in Higher Education. Our research, therefore, focuses on new epistemologies afforded by a shift away from the monolingual habitus and from the concept of multilingualism towards plurilingualism and translanguaging. Our data suggests that a plurilingual approach towards teaching and learning in Higher Education can afford epistemological access to learners across faculties and disciplines in Higher Education, and we argue that the role of languages of tuition in curricula need to be strategically re-evaluated.
- Full Text:
- Date Issued: 2020