A best practice guideline for screening and managing chorioamnionitis
- Authors: Du Plessis, Allison Herlene
- Date: 2020
- Subjects: Bacterial diseases
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10948/46374 , vital:39575
- Description: Due to the complex nature of chorioamnionitis, women are often misdiagnosed, undiagnosed or only diagnosed after birth when it is too late to prevent maternal and neonatal complications. A lack of a comprehensive best practice guidelinefor screening and managing women withchorioamnionitis resultsin delayed treatment and management that could minimise maternal and neonatal complications. Saving Babiesreported that unexplained intra-uterine deathsremained the main primary (obstetric) cause of death for babies with a weight above 1000g (24.4%of all deaths). Of these unexplained uterine deaths, 33% are of normal birth weight (>2500g), and,therefore,most likely term gestation. Saving Babies further reported that 22.9% of all live births in South Africa was premature and 22.8% of birthswere unexplained intra-uterine deaths. Prematurity is one major complication of chorioamnionitis. When susceptibility for chorioamnionitis is considered during early pregnancy, it is possible to intervene and prevent or even reduce the incidences and complications of chorioamnionitis.A qualitative research study was conducted in three phases. In Phase One(Part One), a theoretically constructed patient scenario of chorioamnionitis was presented to ten midwives,and semi-structured individual interviews were done to elicit information regarding how they screen for and manage chorioamnionitis. In Phase One(Part Two), experienced medical practitioners in the field of obstetrics and gynaecology were individually interviewed, also using semi-structured individual interviewsto gain their views regarding chorioamnionitis as a contributing factor to maternal morbidity and mortality. Qualitative findings in Phase Oneindicated that there is a general lack of knowledge regarding chorioamnionitis among midwives, resulting ininadequate screening, misdiagnosis and mismanagement of the condition. Experienced medical practitioners confirmed that chorioamnionitis is underdiagnosed, misdiagnosed or undiagnosed and underreported,and they hold views that it is difficult to treat and control pregnancy-related infections according to current practice.An integrative literature review was conductedin Phase Twoand literature regarding diagnostic biomarkers, screening options to diagnose chorioamnionitis and management of chorioamnionitis were extracted. After evidence synthesisofPhase Oneand Phase Twodata, a best practice guidelinefor screening and managing viiwomen withchorioamnionitiswas developed usingthe National Institute for Health and Clinical Excellence guideline development approach in Phase Three. The purpose of the best practice guideline for screening and managing women with chorioamnionitis was to provide a guideline onhow to manage women who are at risk and those who present with signs and symptoms of chorioamnionitis at any stage during their pregnancy. Five recommendations were made that involve screening for chorioamnionitisand causative factors, biomarkers to diagnose chorioamnionitis, management of chorioamnionitis that includes pharmacological and non-pharmacological management, and health education to women.Ethics for this research study were guided by the ethical principles and guidelines of the Belmont Report. The trustworthiness of this research study was adopted from Ravitch and Carl,and was based on criticality, reflexivity, collaboration, and rigour. An independent coder and reviewer wereto verify the data that were included in the best practice guideline. Expert reviewersappraised the best practice guidelineusing Appraisal of Guidelines for Research and Evaluation II tools.
- Full Text:
- Date Issued: 2020
- Authors: Du Plessis, Allison Herlene
- Date: 2020
- Subjects: Bacterial diseases
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10948/46374 , vital:39575
- Description: Due to the complex nature of chorioamnionitis, women are often misdiagnosed, undiagnosed or only diagnosed after birth when it is too late to prevent maternal and neonatal complications. A lack of a comprehensive best practice guidelinefor screening and managing women withchorioamnionitis resultsin delayed treatment and management that could minimise maternal and neonatal complications. Saving Babiesreported that unexplained intra-uterine deathsremained the main primary (obstetric) cause of death for babies with a weight above 1000g (24.4%of all deaths). Of these unexplained uterine deaths, 33% are of normal birth weight (>2500g), and,therefore,most likely term gestation. Saving Babies further reported that 22.9% of all live births in South Africa was premature and 22.8% of birthswere unexplained intra-uterine deaths. Prematurity is one major complication of chorioamnionitis. When susceptibility for chorioamnionitis is considered during early pregnancy, it is possible to intervene and prevent or even reduce the incidences and complications of chorioamnionitis.A qualitative research study was conducted in three phases. In Phase One(Part One), a theoretically constructed patient scenario of chorioamnionitis was presented to ten midwives,and semi-structured individual interviews were done to elicit information regarding how they screen for and manage chorioamnionitis. In Phase One(Part Two), experienced medical practitioners in the field of obstetrics and gynaecology were individually interviewed, also using semi-structured individual interviewsto gain their views regarding chorioamnionitis as a contributing factor to maternal morbidity and mortality. Qualitative findings in Phase Oneindicated that there is a general lack of knowledge regarding chorioamnionitis among midwives, resulting ininadequate screening, misdiagnosis and mismanagement of the condition. Experienced medical practitioners confirmed that chorioamnionitis is underdiagnosed, misdiagnosed or undiagnosed and underreported,and they hold views that it is difficult to treat and control pregnancy-related infections according to current practice.An integrative literature review was conductedin Phase Twoand literature regarding diagnostic biomarkers, screening options to diagnose chorioamnionitis and management of chorioamnionitis were extracted. After evidence synthesisofPhase Oneand Phase Twodata, a best practice guidelinefor screening and managing viiwomen withchorioamnionitiswas developed usingthe National Institute for Health and Clinical Excellence guideline development approach in Phase Three. The purpose of the best practice guideline for screening and managing women with chorioamnionitis was to provide a guideline onhow to manage women who are at risk and those who present with signs and symptoms of chorioamnionitis at any stage during their pregnancy. Five recommendations were made that involve screening for chorioamnionitisand causative factors, biomarkers to diagnose chorioamnionitis, management of chorioamnionitis that includes pharmacological and non-pharmacological management, and health education to women.Ethics for this research study were guided by the ethical principles and guidelines of the Belmont Report. The trustworthiness of this research study was adopted from Ravitch and Carl,and was based on criticality, reflexivity, collaboration, and rigour. An independent coder and reviewer wereto verify the data that were included in the best practice guideline. Expert reviewersappraised the best practice guidelineusing Appraisal of Guidelines for Research and Evaluation II tools.
- Full Text:
- Date Issued: 2020
A framework for price tariffs in the costing structures of South African private hospitals
- Authors: Botha, Gideon
- Date: 2020
- Subjects: Hospitals, Proprietary
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10948/47489 , vital:40126
- Description: The increase of South African health care costs can be extrapolated into the global healthcare cost challenge, with various factors contributing to this problem. One of the factors viewed as being central to the rising cost of health care is the inability of health care provider organisations to accurately measure unit costs of resources used to treat a patient for their medical condition and patient outcomes. The measurement of an accurate unit cost and patient outcomes is imperative to improving value, which is seen as an improvement in outcomes for every rand spent. The determination of price tariffs and the price tariff payment model used to onward bill the price tariff for medical services have also been identified as having a central role in improving value in health care. In order for price tariffs to improve value, they should be reflective and be based on an accurate unit cost that reflects the cost of resources used to provide efficient and effective care for a patient’s medical condition. For the price tariff payment model to improve value, it needs to reward providers for delivering superior patient outcomes at a lower cost by making price tariffs contingent on achieving specified outcomes as well as incorporating performance payments or holdbacks based on outcomes achieved. This study provides a framework for price tariffs in the costing structures of South African private hospitals. Secondary research was conducted in the form of a comprehensive literature search in order to do an interpretative analysis of the strengths and weaknesses of the various combinations of unit costing models and price tariff payment models used to determine prices in private hospitals. The literature review was followed by primary research that involved three phases, all of which used a qualitative research approach. In Phase 1, primary data were collected using unobtrusive measures that consisted of a data request first, followed by unstructured interviews with representatives of Hospital A and Hospital B to obtain an analysis of the combinations of unit costing model and price tariff payment model used for a laparoscopic appendectomy. In Phase 2, data were collected by means of an unstructured interview with a surgeon describing a laparoscopic appendectomy procedure in detail and based on this process description, the approximate costs for the various resources that were sourced from different suppliers could be calculated. The data analysis and interpretation were done in three phases, with each phase having different research objectives. The data were first coded and then interpreted. In the first primary research phase, the combinations of unit costing models and price tariff payment models used by private Hospital A and Hospital B were evaluated. In the second phase, the recommended combination of unit costing model and price tariff payment model was applied to a hypothetical example and evaluated. In the final phase, based on the outcome of the first and second research phases, a combination of unit costing model and price tariff payment model for private hospitals was recommended. The results showed that the recommended combination of unit costing and price tariff payment model namely time-driven activity-based costing with the global fee price tariff payment model was the most appropriate to determine price tariffs in private hospitals when compared to the unit costing models and price tariff payment models used by Hospital A and Hospital B for a laparoscopic appendectomy. Furthermore, the recommended combination of unit costing model and price tariff payment model was found to be usable for the determination of price tariffs in the costing structures of private hospitals. The time-driven activity-based costing model and global fee price tariff payment model should be adopted or used as guidelines for determining price tariffs in private hospitals in South Africa. Price tariffs would be more transparent as they would reflect the actual resource cost of treating the patient and the resources used and treatment provided could then be assessed against the delivery value chain that charts the principal activities involved in a patient’s care for a medical condition to ensure that patient best-practice protocols are followed. The proposed framework enables the determination of price tariffs based on an accurate unit cost reflecting the actual resources used to provide efficient and effective care and also improve value for the patient.
- Full Text:
- Date Issued: 2020
- Authors: Botha, Gideon
- Date: 2020
- Subjects: Hospitals, Proprietary
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10948/47489 , vital:40126
- Description: The increase of South African health care costs can be extrapolated into the global healthcare cost challenge, with various factors contributing to this problem. One of the factors viewed as being central to the rising cost of health care is the inability of health care provider organisations to accurately measure unit costs of resources used to treat a patient for their medical condition and patient outcomes. The measurement of an accurate unit cost and patient outcomes is imperative to improving value, which is seen as an improvement in outcomes for every rand spent. The determination of price tariffs and the price tariff payment model used to onward bill the price tariff for medical services have also been identified as having a central role in improving value in health care. In order for price tariffs to improve value, they should be reflective and be based on an accurate unit cost that reflects the cost of resources used to provide efficient and effective care for a patient’s medical condition. For the price tariff payment model to improve value, it needs to reward providers for delivering superior patient outcomes at a lower cost by making price tariffs contingent on achieving specified outcomes as well as incorporating performance payments or holdbacks based on outcomes achieved. This study provides a framework for price tariffs in the costing structures of South African private hospitals. Secondary research was conducted in the form of a comprehensive literature search in order to do an interpretative analysis of the strengths and weaknesses of the various combinations of unit costing models and price tariff payment models used to determine prices in private hospitals. The literature review was followed by primary research that involved three phases, all of which used a qualitative research approach. In Phase 1, primary data were collected using unobtrusive measures that consisted of a data request first, followed by unstructured interviews with representatives of Hospital A and Hospital B to obtain an analysis of the combinations of unit costing model and price tariff payment model used for a laparoscopic appendectomy. In Phase 2, data were collected by means of an unstructured interview with a surgeon describing a laparoscopic appendectomy procedure in detail and based on this process description, the approximate costs for the various resources that were sourced from different suppliers could be calculated. The data analysis and interpretation were done in three phases, with each phase having different research objectives. The data were first coded and then interpreted. In the first primary research phase, the combinations of unit costing models and price tariff payment models used by private Hospital A and Hospital B were evaluated. In the second phase, the recommended combination of unit costing model and price tariff payment model was applied to a hypothetical example and evaluated. In the final phase, based on the outcome of the first and second research phases, a combination of unit costing model and price tariff payment model for private hospitals was recommended. The results showed that the recommended combination of unit costing and price tariff payment model namely time-driven activity-based costing with the global fee price tariff payment model was the most appropriate to determine price tariffs in private hospitals when compared to the unit costing models and price tariff payment models used by Hospital A and Hospital B for a laparoscopic appendectomy. Furthermore, the recommended combination of unit costing model and price tariff payment model was found to be usable for the determination of price tariffs in the costing structures of private hospitals. The time-driven activity-based costing model and global fee price tariff payment model should be adopted or used as guidelines for determining price tariffs in private hospitals in South Africa. Price tariffs would be more transparent as they would reflect the actual resource cost of treating the patient and the resources used and treatment provided could then be assessed against the delivery value chain that charts the principal activities involved in a patient’s care for a medical condition to ensure that patient best-practice protocols are followed. The proposed framework enables the determination of price tariffs based on an accurate unit cost reflecting the actual resources used to provide efficient and effective care and also improve value for the patient.
- Full Text:
- Date Issued: 2020
A psychobiographical case study: Amelia Dyer in a search for glory
- Authors: April, Heather
- Date: 2020
- Subjects: Serial murderers--Psychology
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10948/50857 , vital:43008
- Description: The study is a psychobiographical case study based on the life of a Victorian baby farmer Amelia Dyer (1837-1896). She was executed for the murder of babies who were placed in her care over a period of 30 years. Psychobiography is a qualitative method of enquiry which explores the life of a unique individual subject through the lens of a psychological theory for the purpose of creating a coherent psychological case study. The psychoanalytic theoretical lens of Karen Horney was used to trace the evolution of Amelia Dyer’s sense of self within the Victorian culture of respectability. Baby farming referred to an unregulated business of adoption and fostering of infants, mostly illegitimate infants for a fee. Insufficient social structures and support for unwed mothers and children encouraged the business practice as women had very little choice for childcare. Baby farming was open to abuse and exploitation and hundreds of babies lost their lives due to insufficient care or infanticide. Amelia Dyer showed special talents and creativity from a young age, was ambitious and wanted to be self-reliant in a culture that did not provide women with opportunities to live out their ambitions. Baby farming became a business venture for her in the early stages of her life which later evolved into sadistic abuse and murder of the infants. Her evolution from a creative and hardworking young girl to a sadistic murderer of children is what qualifies her as a suitable subject for the exploration of Karen Horney’s dynamic theory of neuroses and the development of the neurotic self within culture. Extensive biographical data was collected and processed into salient themes. The study integrates the theory of Karen Horney, the life experiences of Amelia Dyer and Victorian respectability and demonstrates the value of using psychobiography as the method of inquiry into the exploration of the unique individual. The findings of the study demonstrated that Amelia Dyer and her social context were inextricably bound by a vicious cycle of psychic and emotional vi conflicts related to fear, control and self-hatred by the internalization of gender stereotypes and norms. The contribution of the study as a whole rests with its demonstration of the value of a holistic and reflexive exploration of the unique individual woman. It demonstrates the value of Horney’s in-depth theoretical understanding of the ambivalent core of selfhood that lies behind observable acts of behavior. The study as a whole contributes towards building upon holistic and integrative therapeutic frameworks in the understanding of diversity amongst women and mothers in culture.
- Full Text:
- Date Issued: 2020
- Authors: April, Heather
- Date: 2020
- Subjects: Serial murderers--Psychology
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10948/50857 , vital:43008
- Description: The study is a psychobiographical case study based on the life of a Victorian baby farmer Amelia Dyer (1837-1896). She was executed for the murder of babies who were placed in her care over a period of 30 years. Psychobiography is a qualitative method of enquiry which explores the life of a unique individual subject through the lens of a psychological theory for the purpose of creating a coherent psychological case study. The psychoanalytic theoretical lens of Karen Horney was used to trace the evolution of Amelia Dyer’s sense of self within the Victorian culture of respectability. Baby farming referred to an unregulated business of adoption and fostering of infants, mostly illegitimate infants for a fee. Insufficient social structures and support for unwed mothers and children encouraged the business practice as women had very little choice for childcare. Baby farming was open to abuse and exploitation and hundreds of babies lost their lives due to insufficient care or infanticide. Amelia Dyer showed special talents and creativity from a young age, was ambitious and wanted to be self-reliant in a culture that did not provide women with opportunities to live out their ambitions. Baby farming became a business venture for her in the early stages of her life which later evolved into sadistic abuse and murder of the infants. Her evolution from a creative and hardworking young girl to a sadistic murderer of children is what qualifies her as a suitable subject for the exploration of Karen Horney’s dynamic theory of neuroses and the development of the neurotic self within culture. Extensive biographical data was collected and processed into salient themes. The study integrates the theory of Karen Horney, the life experiences of Amelia Dyer and Victorian respectability and demonstrates the value of using psychobiography as the method of inquiry into the exploration of the unique individual. The findings of the study demonstrated that Amelia Dyer and her social context were inextricably bound by a vicious cycle of psychic and emotional vi conflicts related to fear, control and self-hatred by the internalization of gender stereotypes and norms. The contribution of the study as a whole rests with its demonstration of the value of a holistic and reflexive exploration of the unique individual woman. It demonstrates the value of Horney’s in-depth theoretical understanding of the ambivalent core of selfhood that lies behind observable acts of behavior. The study as a whole contributes towards building upon holistic and integrative therapeutic frameworks in the understanding of diversity amongst women and mothers in culture.
- Full Text:
- Date Issued: 2020
A psychobiography of Viktor Emil Frankl
- Authors: Bushkin, Hanan
- Date: 2020
- Subjects: Frankl, Viktor Emil
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10948/46440 , vital:39566
- Description: The first study conducted in South Africa of a prominent figure traces back as far as 1939. Since then, extensive research has been done in the field of psychobiography, resulting in a growing interest in this field and evolving into an established research genre in South Africa. Despite the increase in the use of psychobiographies as a research approach internationally and specifically in South Africa, its use is still considered relatively under-utilised and, therefore, the pursuit of further development of psychobiographies in South Africa is required. In light of South Africa’s effort to promote and advance the use of psychobiographies, South African researchers may be motivated to continue studying significant and exceptional lives in South Africa and abroad. Viktor Frankl was selected for this study based on his uniqueness, significance and his interesting life. He is also considered an exceptional individual who has shaped modern psychological thinking. Frankl had written over 40 books on his theory and many studies have been conducted based on his existential theory. Frankl’s contribution to the academic world has been recognised and acknowledged by significant institutions through his own and others’ research. Although much has been written on the life and work of Frankl, none of the literature utilises specific psychological focus and no psychobiographical study of the life of Frankl exists. Therefore, the researcher selected Frankl as the subject for this psychobiography through purposive sampling. The aim of the study was to provide a psychological exploration and description of Frankl’s life against the backdrop of his socio-cultural context. In order to achieve this aim, the researcher employed two psychological frameworks to guide in the description and exploration of his life. The psychological frameworks included Levinson’s life structure theory of adult development and Frankl’s existential theory. The study aimed to describe Frankl’s development with the use of Levinson’s theory while describing how he attained meaning in his life with the use of his own existential theory. Due to the exploratory-descriptive nature of this study, the objective fell within the inductive research approach. The researcher utilised a systematic coding method to arrange the data. The theoretical framework of Levinson’s life structure theory guided the coding system, as well as the key concepts of Frankl’s existential theory. In addition, the researcher utilised Alexander’s guidelines for the extraction of salient data, together with McAdam’s methods and recommendations for managing the data. Lastly, the researcher followed the 12-step method of conducting a psychobiography, as proposed by Du Plessis. Findings from this study found a correlation between Frankl’s life and the eras and transitional periods as theorised by Levinson’s theory. The findings of this study, therefore, support the use of Levinson’s theory with regards to the time frames and its use in understanding Frankl’s development. Also, the researcher found that Levinson’s theory was useful in understanding Frankl’s personality development within his context throughout his lifespan. With regards to Frankl’s existential theory, the researcher found that the use of the theory was suitable in understanding Frankl’s search for meaning. Frankl’s concepts of freedom of will, will to meaning, meaning of life, existential vacuum, supra-meaning, dimensional ontology, the three triads and noö-dynamics assisted in explaining Frankl’s drive to find meaning in his life, take responsibility to attain such meaning and to strive for transcendence beyond his suffering. The researcher found Frankl’s theory useful in explaining his drive, motives, needs and patterns of behaviour within this context. The holistic and integrative approach of the study allowed for an in-depth exploration and description of Frankl’s life and development within his socio-historical context. In addition to contributing to the existing body of knowledge on Frankl, his life and his theory, the study also contributed to the growing field of psychobiographical research. The study acknowledged and highlighted that further in-depth examination of the lives of extraordinary personalities could significantly contribute to psychobiographical studies. Based on the psychological frameworks used to explore and describe Frankl’s life, recommendations are made for future research.
- Full Text:
- Date Issued: 2020
- Authors: Bushkin, Hanan
- Date: 2020
- Subjects: Frankl, Viktor Emil
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10948/46440 , vital:39566
- Description: The first study conducted in South Africa of a prominent figure traces back as far as 1939. Since then, extensive research has been done in the field of psychobiography, resulting in a growing interest in this field and evolving into an established research genre in South Africa. Despite the increase in the use of psychobiographies as a research approach internationally and specifically in South Africa, its use is still considered relatively under-utilised and, therefore, the pursuit of further development of psychobiographies in South Africa is required. In light of South Africa’s effort to promote and advance the use of psychobiographies, South African researchers may be motivated to continue studying significant and exceptional lives in South Africa and abroad. Viktor Frankl was selected for this study based on his uniqueness, significance and his interesting life. He is also considered an exceptional individual who has shaped modern psychological thinking. Frankl had written over 40 books on his theory and many studies have been conducted based on his existential theory. Frankl’s contribution to the academic world has been recognised and acknowledged by significant institutions through his own and others’ research. Although much has been written on the life and work of Frankl, none of the literature utilises specific psychological focus and no psychobiographical study of the life of Frankl exists. Therefore, the researcher selected Frankl as the subject for this psychobiography through purposive sampling. The aim of the study was to provide a psychological exploration and description of Frankl’s life against the backdrop of his socio-cultural context. In order to achieve this aim, the researcher employed two psychological frameworks to guide in the description and exploration of his life. The psychological frameworks included Levinson’s life structure theory of adult development and Frankl’s existential theory. The study aimed to describe Frankl’s development with the use of Levinson’s theory while describing how he attained meaning in his life with the use of his own existential theory. Due to the exploratory-descriptive nature of this study, the objective fell within the inductive research approach. The researcher utilised a systematic coding method to arrange the data. The theoretical framework of Levinson’s life structure theory guided the coding system, as well as the key concepts of Frankl’s existential theory. In addition, the researcher utilised Alexander’s guidelines for the extraction of salient data, together with McAdam’s methods and recommendations for managing the data. Lastly, the researcher followed the 12-step method of conducting a psychobiography, as proposed by Du Plessis. Findings from this study found a correlation between Frankl’s life and the eras and transitional periods as theorised by Levinson’s theory. The findings of this study, therefore, support the use of Levinson’s theory with regards to the time frames and its use in understanding Frankl’s development. Also, the researcher found that Levinson’s theory was useful in understanding Frankl’s personality development within his context throughout his lifespan. With regards to Frankl’s existential theory, the researcher found that the use of the theory was suitable in understanding Frankl’s search for meaning. Frankl’s concepts of freedom of will, will to meaning, meaning of life, existential vacuum, supra-meaning, dimensional ontology, the three triads and noö-dynamics assisted in explaining Frankl’s drive to find meaning in his life, take responsibility to attain such meaning and to strive for transcendence beyond his suffering. The researcher found Frankl’s theory useful in explaining his drive, motives, needs and patterns of behaviour within this context. The holistic and integrative approach of the study allowed for an in-depth exploration and description of Frankl’s life and development within his socio-historical context. In addition to contributing to the existing body of knowledge on Frankl, his life and his theory, the study also contributed to the growing field of psychobiographical research. The study acknowledged and highlighted that further in-depth examination of the lives of extraordinary personalities could significantly contribute to psychobiographical studies. Based on the psychological frameworks used to explore and describe Frankl’s life, recommendations are made for future research.
- Full Text:
- Date Issued: 2020
An evaluation of programme management with reference to inner -city problem buildings: The case of Nelson Mandela Bay Metropolitan Municipality ,South Africa
- Conradie, Hendrik Francois, Shaidi,Walter
- Authors: Conradie, Hendrik Francois , Shaidi,Walter
- Date: 2020
- Subjects: Municipal government -- South Africa -- Port Elizabeth , Finance,Public --South Africa --Port Elizabeth
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10948/46670 , vital:39607
- Description: This research study is qualitative and cross-sectional in nature. Programme management by South African city governments is investigated and evaluated, as related to inner-city decay and problem (derelict; hijacked; dilapidated; overcrowded) buildings. A case study approach, focusing on the Nelson Mandela Bay Municipality in Port Elizabeth, South Africa, is utilised to understand the phenomenon, and to answer the research question. The significant challenge of inner-city and central business district problem buildings in major South African cities has prompted the study; no scientific research has previously been conducted or published on this topic The study started out with this research question, asked in a case study context: to what extent are programmes dealing with inner-city problem buildings and decay managed effectively by city government in South Africa? In the literature review the researcher focused on programme management theory, emphasising the usefulness of project management principles and practice in public sector programme management contexts. In a subsequent chapter the applicable constitutional and legislative frameworks were presented. The researcher developed, as outcome, strategic remedial legal options available to city governments when dealing with transgressing owners of problematic buildings. Problem building by-laws were dealt with in detail. A qualitative research approach, including semi-structured in-depth interviews with political and managerial leaders at the case study city government, assisted the researcher in effective data generation. Data analysis was performed with vigour, based on thematic content analysis.relevant coding practices were utilised in analysis and interpretation of data.
- Full Text:
- Date Issued: 2020
- Authors: Conradie, Hendrik Francois , Shaidi,Walter
- Date: 2020
- Subjects: Municipal government -- South Africa -- Port Elizabeth , Finance,Public --South Africa --Port Elizabeth
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10948/46670 , vital:39607
- Description: This research study is qualitative and cross-sectional in nature. Programme management by South African city governments is investigated and evaluated, as related to inner-city decay and problem (derelict; hijacked; dilapidated; overcrowded) buildings. A case study approach, focusing on the Nelson Mandela Bay Municipality in Port Elizabeth, South Africa, is utilised to understand the phenomenon, and to answer the research question. The significant challenge of inner-city and central business district problem buildings in major South African cities has prompted the study; no scientific research has previously been conducted or published on this topic The study started out with this research question, asked in a case study context: to what extent are programmes dealing with inner-city problem buildings and decay managed effectively by city government in South Africa? In the literature review the researcher focused on programme management theory, emphasising the usefulness of project management principles and practice in public sector programme management contexts. In a subsequent chapter the applicable constitutional and legislative frameworks were presented. The researcher developed, as outcome, strategic remedial legal options available to city governments when dealing with transgressing owners of problematic buildings. Problem building by-laws were dealt with in detail. A qualitative research approach, including semi-structured in-depth interviews with political and managerial leaders at the case study city government, assisted the researcher in effective data generation. Data analysis was performed with vigour, based on thematic content analysis.relevant coding practices were utilised in analysis and interpretation of data.
- Full Text:
- Date Issued: 2020
An investigation of the link between Financial sector development and economic growth in Zimbabwe from 1980 -2016
- Authors: Machokoto, Sydney
- Date: 2020
- Subjects: Financial institutions-- Zimbambwe , Economic growth, development,planning -- Zimbabwe
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10948/49894 , vital:41814
- Description: This study investigated the link between financial sector development and economic growth in Zimbabwe from 1980 to 2016 using the Auto Regressive Distributed Lag model. Market capitalization as a ratio of gross domestic product (GDP), bank credit to the private sector as a ratio of GDP and financial assets of microfinance as a ratio of GDP were used as proxy variables for financial sector development. Economic growth was measured by real GDP. The Granger causality test indicated bi-directional causality between access to financial services and economic growth in Zimbabwe in the long run. Market capitalization and bank credit to the private sector did not Granger cause economic growth in Zimbabwe. It was recommended that the government should promote the functioning of the capital market as it is the conduit for providing long term capital to businesses. Bank credit to the private sector was found to be statistically significant. It was recommended that the government should promote decentralization of the banking sector to rural areas. The proxy variables of financial development used were statistically significant in influencing economic growth. The findings from the study led to the recommendation to open additional microfinance companies in remote areas and to increase the supply of financial services and products. Empirical evidence indicates that the link between financial development and economic growth depends on the proxy variables of financial sector development used in econometric modelling. The model was tested for heteroscedasticity, serial correlation, stability and normality. The econometric tests conducted were all satisfactory. This made the model ideal for policy formulation and recommendation.
- Full Text:
- Date Issued: 2020
- Authors: Machokoto, Sydney
- Date: 2020
- Subjects: Financial institutions-- Zimbambwe , Economic growth, development,planning -- Zimbabwe
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10948/49894 , vital:41814
- Description: This study investigated the link between financial sector development and economic growth in Zimbabwe from 1980 to 2016 using the Auto Regressive Distributed Lag model. Market capitalization as a ratio of gross domestic product (GDP), bank credit to the private sector as a ratio of GDP and financial assets of microfinance as a ratio of GDP were used as proxy variables for financial sector development. Economic growth was measured by real GDP. The Granger causality test indicated bi-directional causality between access to financial services and economic growth in Zimbabwe in the long run. Market capitalization and bank credit to the private sector did not Granger cause economic growth in Zimbabwe. It was recommended that the government should promote the functioning of the capital market as it is the conduit for providing long term capital to businesses. Bank credit to the private sector was found to be statistically significant. It was recommended that the government should promote decentralization of the banking sector to rural areas. The proxy variables of financial development used were statistically significant in influencing economic growth. The findings from the study led to the recommendation to open additional microfinance companies in remote areas and to increase the supply of financial services and products. Empirical evidence indicates that the link between financial development and economic growth depends on the proxy variables of financial sector development used in econometric modelling. The model was tested for heteroscedasticity, serial correlation, stability and normality. The econometric tests conducted were all satisfactory. This made the model ideal for policy formulation and recommendation.
- Full Text:
- Date Issued: 2020
Applied phylogeography : mapping the genetic resource of Honeybush across the Cape Floristic Region
- Authors: Galuszynski, Nicholas C
- Date: 2020
- Subjects: Phylogeography -- South Africa
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10948/46771 , vital:39655
- Description: Aim: Honeybush tea is a herbal infusion made from members of the Cape Floristic Region (CFR) endemic Cyclopia Vent. Consting of 21 extant species, six are anthropogenically redistributed across the CFR for Honeybush cultivation. However, with no information regarding the distribution and levels of genetic diversity among wild Honeybush populations, anthropogenic translocation of cultivated genotypes may risk disrupting natural genetic diversity patterns. In this thesis, an applied phylogeographic approach is used to provide baseline insights into the spatial structuring of Honeybush genetic diversity. Location: The Cape Floristic Region (CFR), located along the southern Cape of South Africa. Methods: Spatial structuring of evolutionary lineages within Cyclopia are explored at a genus level using data generated from the combination of Anchored Hybrid Enrichment library preparation and high through put sequencing. A High Resolution Melt analysis (HRM) toolkit is then developed to screen haplotype variation across three non-coding chloroplast loci. This HRM toolkit coupled with haplotype confirmation Sanger sequencing is then applied to describe the spatial structuring of genetic diversity in wild populations for two Honeybush species (C. intermedia and C. subternata) and to compare genetic diversity among wild and cultivated populations of three Honeybush species (C. intermedia, C. subternata, and C. longifolia). A reanalysis of published phylogeographic data focusing on CFR plant taxa is used to test if phylogeographic breaks occur across the boundaries among adjacent Centers of Endemism (CoEs). Finally, the low-copy nuclear data set generated via AHE and high throughput sequencing is summarized. Results: Phylogeographic structuring was detected at the inter- and intraspecific levels in Cyclopia. The genus level analysis revealed a strong phylogenetic split between western CFR and eastern CFR endemic species in the nuclear and chloroplast genomes. At the intraspecific level, HRM proved to be a high throughput and accurate tool for haplotype detection, revealing phylogeographic structuring of genetic diversity in C.intermediaand C.subternata. This genetic diversity and structuring was not detected in cultivated Honeybush populations, which appear to have originated from a small number of founding individuals and have experienced a genetic bottleneck. Spatial structuring of genetic lineages is common among CFR plant taxa and the reanalysis of existing data found a significant trend for phylogeographic breaks tooccuracrosstheboundariesamongadjacentCoEs. Finally, over200000baseswere sequenced across 445 low-copy nuclear loci for 14 Cyclopia species. Conclusions: This thesis provides important baseline information on the spatial distribution of wild Honeybush genetic diversity. Phylogeographic structuring is present in wild Honeybush populations. This however is not accounted for in cultivated populations, which may place wild genetic diversity at risk of being disrupted if geneflow among wild and cultivated populations occurs. The results from this thesis should therefore be used to develop precautionary guidelines for the anthropogenic redistribution of Honeybush genetic material for cultivation. Furthermore, the novel insights into regional patterns of phylogeohraphic structuring of plant populations should encourage more efficient and hypothesis driven sampling designs in future phylogeographic work in the CFR. The high throughput sequence data generated in this thesis should transform Cyclopia to a model organism for the study of molecular evolution in the CFR.
- Full Text:
- Date Issued: 2020
- Authors: Galuszynski, Nicholas C
- Date: 2020
- Subjects: Phylogeography -- South Africa
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10948/46771 , vital:39655
- Description: Aim: Honeybush tea is a herbal infusion made from members of the Cape Floristic Region (CFR) endemic Cyclopia Vent. Consting of 21 extant species, six are anthropogenically redistributed across the CFR for Honeybush cultivation. However, with no information regarding the distribution and levels of genetic diversity among wild Honeybush populations, anthropogenic translocation of cultivated genotypes may risk disrupting natural genetic diversity patterns. In this thesis, an applied phylogeographic approach is used to provide baseline insights into the spatial structuring of Honeybush genetic diversity. Location: The Cape Floristic Region (CFR), located along the southern Cape of South Africa. Methods: Spatial structuring of evolutionary lineages within Cyclopia are explored at a genus level using data generated from the combination of Anchored Hybrid Enrichment library preparation and high through put sequencing. A High Resolution Melt analysis (HRM) toolkit is then developed to screen haplotype variation across three non-coding chloroplast loci. This HRM toolkit coupled with haplotype confirmation Sanger sequencing is then applied to describe the spatial structuring of genetic diversity in wild populations for two Honeybush species (C. intermedia and C. subternata) and to compare genetic diversity among wild and cultivated populations of three Honeybush species (C. intermedia, C. subternata, and C. longifolia). A reanalysis of published phylogeographic data focusing on CFR plant taxa is used to test if phylogeographic breaks occur across the boundaries among adjacent Centers of Endemism (CoEs). Finally, the low-copy nuclear data set generated via AHE and high throughput sequencing is summarized. Results: Phylogeographic structuring was detected at the inter- and intraspecific levels in Cyclopia. The genus level analysis revealed a strong phylogenetic split between western CFR and eastern CFR endemic species in the nuclear and chloroplast genomes. At the intraspecific level, HRM proved to be a high throughput and accurate tool for haplotype detection, revealing phylogeographic structuring of genetic diversity in C.intermediaand C.subternata. This genetic diversity and structuring was not detected in cultivated Honeybush populations, which appear to have originated from a small number of founding individuals and have experienced a genetic bottleneck. Spatial structuring of genetic lineages is common among CFR plant taxa and the reanalysis of existing data found a significant trend for phylogeographic breaks tooccuracrosstheboundariesamongadjacentCoEs. Finally, over200000baseswere sequenced across 445 low-copy nuclear loci for 14 Cyclopia species. Conclusions: This thesis provides important baseline information on the spatial distribution of wild Honeybush genetic diversity. Phylogeographic structuring is present in wild Honeybush populations. This however is not accounted for in cultivated populations, which may place wild genetic diversity at risk of being disrupted if geneflow among wild and cultivated populations occurs. The results from this thesis should therefore be used to develop precautionary guidelines for the anthropogenic redistribution of Honeybush genetic material for cultivation. Furthermore, the novel insights into regional patterns of phylogeohraphic structuring of plant populations should encourage more efficient and hypothesis driven sampling designs in future phylogeographic work in the CFR. The high throughput sequence data generated in this thesis should transform Cyclopia to a model organism for the study of molecular evolution in the CFR.
- Full Text:
- Date Issued: 2020
Attention-deficit/hyperactivity disorder (ADHD) in South Africa: diagnosis and treatment from childhood to adulthood
- Munasur-Naidoo, Ashmitha Premchand
- Authors: Munasur-Naidoo, Ashmitha Premchand
- Date: 2020
- Subjects: Attention-deficit hyperactivity disorder
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10948/46398 , vital:39603
- Description: Background: Historically Attention-Deficit/hyperactivity disorder (ADHD) was, considered to be a condition that affected mainly children. Over a period of time, there has been a greater understanding to recognize that this condition is also present in the adult population. Globally, treatment for adults has been established as is evident from the various guidelines available. In South Africa, however,healthcare is split into the public and private sectors, which results in differences in the extent of diagnosis and treatment for adults with ADHD.Aim: The primary aim of the study was to evaluate ADHD in South Africa from childhood to adulthood and to determine to what extent adults are being diagnosed and treated.Method: This study comprised of two facets, namely, a drug utilization review and a questionnaire survey. The first part comprised of a retrospective drug utilization study evaluating the consumption and cost of medication used in the treatment of ADHD. The questionnaire was undertaken using a survey methodology amongst selected healthcare professionals in South Africa involved in the diagnosis and treatment of adult ADHD. The data generated from this study together with available guidelines was assessed and a proposed framework for the treatment and diagnosis of adult ADHD was developed for use in the South African public healthcare sector. Results: Based on the registered medication available to treat ADHD, the consumption of methylphenidate and atomoxetine in the private healthcare sector using the Intercontinental Marketing Service database from 2013 to 2016was established. Despite the controversy regarding stimulant medication, methylphenidate was shown to be the medication of choice in South Africa. The consumption of methylphenidate (95.85%) was higher when compared to atomoxetine (4.15%) in 2013 and very slight changes were observed in 2016 were the consumption was 96.40% and 3.60%, respectively. Similarly, over a four-year period, the spend on ADHD medication increased in 2013 to 2016 by 62.63%. Furthermore, the market share for ADHD is dominated by extended-release methylphenidate tablets (59.53%). The questionnaire survey amongst selected healthcare professionals in South Africa involved in the diagnosis and treatment of adult ADHDhighlighted the tools used for diagnosis, pharmacological and non-pharmacological treatment options, which treatment has been found to be most successful, difference in treatment between genders, incorporation of supplementation into the management of patients, difficulties experienced by patients and which co-morbid conditions were also prevalent with ADHD. Based on the data collated in this study and an evaluation of the available guidelines, a framework for treatment of adult patients in the public healthcare sector has been proposed for South Africa at a provincial and national level. Conclusion: In South Africa treatment for ADHD is increasing in the private healthcare sector. The cost and consumption of methylphenidate and atomoxetine has risen over a short period. The treatment of adults in the private sector has also garnered interest, however, the public sector has not yet published guidelines enabling access to diagnosis and treatment for these adult patients. Given the chronic, costly, and debilitating nature of this condition more needs to be done to assist those affected by it. Further studies in this area of neuropsychiatry in South Africa is required to enable access to diagnosis and treatment in the public healthcare sector.
- Full Text:
- Date Issued: 2020
- Authors: Munasur-Naidoo, Ashmitha Premchand
- Date: 2020
- Subjects: Attention-deficit hyperactivity disorder
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10948/46398 , vital:39603
- Description: Background: Historically Attention-Deficit/hyperactivity disorder (ADHD) was, considered to be a condition that affected mainly children. Over a period of time, there has been a greater understanding to recognize that this condition is also present in the adult population. Globally, treatment for adults has been established as is evident from the various guidelines available. In South Africa, however,healthcare is split into the public and private sectors, which results in differences in the extent of diagnosis and treatment for adults with ADHD.Aim: The primary aim of the study was to evaluate ADHD in South Africa from childhood to adulthood and to determine to what extent adults are being diagnosed and treated.Method: This study comprised of two facets, namely, a drug utilization review and a questionnaire survey. The first part comprised of a retrospective drug utilization study evaluating the consumption and cost of medication used in the treatment of ADHD. The questionnaire was undertaken using a survey methodology amongst selected healthcare professionals in South Africa involved in the diagnosis and treatment of adult ADHD. The data generated from this study together with available guidelines was assessed and a proposed framework for the treatment and diagnosis of adult ADHD was developed for use in the South African public healthcare sector. Results: Based on the registered medication available to treat ADHD, the consumption of methylphenidate and atomoxetine in the private healthcare sector using the Intercontinental Marketing Service database from 2013 to 2016was established. Despite the controversy regarding stimulant medication, methylphenidate was shown to be the medication of choice in South Africa. The consumption of methylphenidate (95.85%) was higher when compared to atomoxetine (4.15%) in 2013 and very slight changes were observed in 2016 were the consumption was 96.40% and 3.60%, respectively. Similarly, over a four-year period, the spend on ADHD medication increased in 2013 to 2016 by 62.63%. Furthermore, the market share for ADHD is dominated by extended-release methylphenidate tablets (59.53%). The questionnaire survey amongst selected healthcare professionals in South Africa involved in the diagnosis and treatment of adult ADHDhighlighted the tools used for diagnosis, pharmacological and non-pharmacological treatment options, which treatment has been found to be most successful, difference in treatment between genders, incorporation of supplementation into the management of patients, difficulties experienced by patients and which co-morbid conditions were also prevalent with ADHD. Based on the data collated in this study and an evaluation of the available guidelines, a framework for treatment of adult patients in the public healthcare sector has been proposed for South Africa at a provincial and national level. Conclusion: In South Africa treatment for ADHD is increasing in the private healthcare sector. The cost and consumption of methylphenidate and atomoxetine has risen over a short period. The treatment of adults in the private sector has also garnered interest, however, the public sector has not yet published guidelines enabling access to diagnosis and treatment for these adult patients. Given the chronic, costly, and debilitating nature of this condition more needs to be done to assist those affected by it. Further studies in this area of neuropsychiatry in South Africa is required to enable access to diagnosis and treatment in the public healthcare sector.
- Full Text:
- Date Issued: 2020
Commercial maritime higher education needs in South Africa
- Authors: Allison, Lee-Ann
- Date: 2020
- Subjects: Marine resources
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10948/47496 , vital:40117
- Description: Seaborne cargo trade accounts for over 80% of the physical volume of global trade. Maritime transport thus fulfills an integral function in the economy of the world. South Africa generates approximately 3.5% of the world’s seaborne trade by value and 1.61% by tonnage, but the business of shipping all that cargo is undertaken by foreign firms. Operation Phakisa, the Comprehensive Maritime Transport Policy, and the South African Maritime Road Map, in pursuance of the National Development Plan, aim to revive the commercial maritime sector. In order to meet the demand for the skills and innovative abilities sought at executive and managerial levels in the commercial maritime sector, higher education in the knowledge of maritime business is increasingly becoming a prerequisite. Investment in higher education of quality and relevance in the maritime field would contribute to achieving the goals of the government for harnessing the potential of South Africa’s blue economy. The literature is researched in order to establish an authoritative view that the knowledge and the inspiration for entrepreneurial activity in the maritime sector can be imparted through higher education; and for example, that a viable shipping sector can contribute to the growth of a country’s economy. The South African maritime sector is then described. The commercial maritime higher education available at universities and other institutions of higher learning in South Africa, as well as in other African countries and elsewhere in the world, is examined, in order to be able to identify the degree and diploma courses available. Maritime courses imply not only the content of the educational material, but also the method whereby the knowledge is instilled in learners, and which extends well beyond the classroom. A survey, by way of the personal interviews of leaders in maritime business, maritime government affairs, and academics teaching maritime topics, is then undertaken to ascertain their views on the education required to promote the maritime sector in South Africa, using the list of subjects available for study worldwide, to assist their choice. The literature research and the interview survey by design also enable the secondary aims of the study to be achieved. Those aims include determining how awareness of the maritime domain could be raised and how co-operation between academia, business, and government, known as the triple helix could be organized, to promote the growth of the maritime sector. The results of the survey are analyzed and tabulated, in order to illustrate the extent of the agreement between those interviewed and the conclusions reached. These conclusions establish: (i) that the commercial maritime education currently available in South Africa, is inadequate to meet the aim of the government to the sector; (ii) that a post-graduate degree iv in the specified maritime studies incorporating a period of internship, and following on the first degree in business subjects, is required; (iii) that a triple helix of co-operation between academia, business, and the government is essential to grow the commercial maritime sector in which South African entrepreneurs educated in such business will have the advantage; (iv) that greater awareness of the maritime domain is essential in South Africa if entrepreneurship in maritime business is to be cultivated; and (v)that such awareness can be cultivated in various ways; but it should start by including more maritime topics in the current school curricula.
- Full Text:
- Date Issued: 2020
- Authors: Allison, Lee-Ann
- Date: 2020
- Subjects: Marine resources
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10948/47496 , vital:40117
- Description: Seaborne cargo trade accounts for over 80% of the physical volume of global trade. Maritime transport thus fulfills an integral function in the economy of the world. South Africa generates approximately 3.5% of the world’s seaborne trade by value and 1.61% by tonnage, but the business of shipping all that cargo is undertaken by foreign firms. Operation Phakisa, the Comprehensive Maritime Transport Policy, and the South African Maritime Road Map, in pursuance of the National Development Plan, aim to revive the commercial maritime sector. In order to meet the demand for the skills and innovative abilities sought at executive and managerial levels in the commercial maritime sector, higher education in the knowledge of maritime business is increasingly becoming a prerequisite. Investment in higher education of quality and relevance in the maritime field would contribute to achieving the goals of the government for harnessing the potential of South Africa’s blue economy. The literature is researched in order to establish an authoritative view that the knowledge and the inspiration for entrepreneurial activity in the maritime sector can be imparted through higher education; and for example, that a viable shipping sector can contribute to the growth of a country’s economy. The South African maritime sector is then described. The commercial maritime higher education available at universities and other institutions of higher learning in South Africa, as well as in other African countries and elsewhere in the world, is examined, in order to be able to identify the degree and diploma courses available. Maritime courses imply not only the content of the educational material, but also the method whereby the knowledge is instilled in learners, and which extends well beyond the classroom. A survey, by way of the personal interviews of leaders in maritime business, maritime government affairs, and academics teaching maritime topics, is then undertaken to ascertain their views on the education required to promote the maritime sector in South Africa, using the list of subjects available for study worldwide, to assist their choice. The literature research and the interview survey by design also enable the secondary aims of the study to be achieved. Those aims include determining how awareness of the maritime domain could be raised and how co-operation between academia, business, and government, known as the triple helix could be organized, to promote the growth of the maritime sector. The results of the survey are analyzed and tabulated, in order to illustrate the extent of the agreement between those interviewed and the conclusions reached. These conclusions establish: (i) that the commercial maritime education currently available in South Africa, is inadequate to meet the aim of the government to the sector; (ii) that a post-graduate degree iv in the specified maritime studies incorporating a period of internship, and following on the first degree in business subjects, is required; (iii) that a triple helix of co-operation between academia, business, and the government is essential to grow the commercial maritime sector in which South African entrepreneurs educated in such business will have the advantage; (iv) that greater awareness of the maritime domain is essential in South Africa if entrepreneurship in maritime business is to be cultivated; and (v)that such awareness can be cultivated in various ways; but it should start by including more maritime topics in the current school curricula.
- Full Text:
- Date Issued: 2020
Comprehensive characterization of the antidiabetic potential of selected plants and macrofungi from Africa using an in vitro target-directed screening platform and cellomics
- Authors: Pringle, Nadine Alex
- Date: 2020
- Subjects: Hypoglycemic agents
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10948/46750 , vital:39653
- Description: Several synthetic antidiabetic drugs have been developed to date, however, most are accompanied by adverse side-effects while remaining expensive and largely inaccessible to the vast majority of those who need it. To provide enough scientific evidence to support the inclusion of more affordable African antidiabetic medicinal plants and macrofungi into healthcare programs, this study sought out to develop a comprehensive in vitro antidiabetic target-directed screening platform incorporating high content screening and analysis/ cellomics. To test the success of this model, the potential antidiabetic mechanisms of five plants (Aspalathus linearis, Brachylaena discolor, Carpobrotus deliciosus, Sutherlandia frutescens and Tarchonanthus camphoratus) and two macrofungal species (Ganoderma lucidum and Hericium erinaceus) were explored. The screening model consisted of approximately 22 assays exploring the antidiabetic effects of selected aqueous and ethanolic extracts in five well-characterised antidiabetic targets: the intestine, liver, skeletal muscle, adipose tissue/ obesity and pancreatic β-cells. These targets were further categorised and scored under three mechanistic classes/ therapeutic targets (postprandial hyperglycaemia; insulin resistance and inflammation; pancreatic β-cell function) to elucidate their potential mechanisms of action and select appropriate animal models for future studies. Almost any normal or diabetic rodent model would be suitable to explore the antidiabetic potential of extracts such as A. linearis, B. discolor ethanol, C. deliciosus ethanol or T. camphoratus which obtained high cumulative scores under postprandial hyperglycaemia while high fat diet and genetic models of obesity appear more suited towards extracts such as H. erinaceus aqueous that obtained their highest cumulative score under insulin resistance. In general, a combination of rodent models ranging from non-obese models to models of obesity and β-cell destruction presenting symptoms from all three mechanistic classes should be considered due to the pleiotropic nature of the tested extracts, however, establishing appropriate experimental designs is crucial. To demonstrate the versatility of the screening platform and emphasise the importance of in vitro screening pertaining to diabetic complications, a more detailed biochemical investigation into the potential therapeutic benefits of A. linearis in the treatment of diabetic wounds was conducted. Several properties supporting the therapeutic potential of rooibos were highlighted with the green and fermented extracts presenting distinctly different characteristics. The pro-inflammatory nature of fermented rooibos may have therapeutic value for wounds characterised with a delayed initial inflammatory phase, such as early diabetic wounds while the green extract appears more suited to wounds burdened with excessive inflammation as it attenuated COX-2 levels and effectively protected fibroblasts against oxidative stress. To date, this appears to be the most comprehensive antidiabetic screening platform in existence and consequently provides the only feasible solution that will enable natural product antidiabetic research to progress to the point where natural products can be commercialised and incorporated into meaningful healthcare programs. Future research should be focussed towards further expanding this model by incorporating additional targets, more sophisticated cell culturing techniques, multiplexed high content screening assays and carrying out combination treatments that explore the antidiabetic effects of two or more crude extracts to establish whether they are capable of acting in a synergistic manner.
- Full Text:
- Date Issued: 2020
- Authors: Pringle, Nadine Alex
- Date: 2020
- Subjects: Hypoglycemic agents
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10948/46750 , vital:39653
- Description: Several synthetic antidiabetic drugs have been developed to date, however, most are accompanied by adverse side-effects while remaining expensive and largely inaccessible to the vast majority of those who need it. To provide enough scientific evidence to support the inclusion of more affordable African antidiabetic medicinal plants and macrofungi into healthcare programs, this study sought out to develop a comprehensive in vitro antidiabetic target-directed screening platform incorporating high content screening and analysis/ cellomics. To test the success of this model, the potential antidiabetic mechanisms of five plants (Aspalathus linearis, Brachylaena discolor, Carpobrotus deliciosus, Sutherlandia frutescens and Tarchonanthus camphoratus) and two macrofungal species (Ganoderma lucidum and Hericium erinaceus) were explored. The screening model consisted of approximately 22 assays exploring the antidiabetic effects of selected aqueous and ethanolic extracts in five well-characterised antidiabetic targets: the intestine, liver, skeletal muscle, adipose tissue/ obesity and pancreatic β-cells. These targets were further categorised and scored under three mechanistic classes/ therapeutic targets (postprandial hyperglycaemia; insulin resistance and inflammation; pancreatic β-cell function) to elucidate their potential mechanisms of action and select appropriate animal models for future studies. Almost any normal or diabetic rodent model would be suitable to explore the antidiabetic potential of extracts such as A. linearis, B. discolor ethanol, C. deliciosus ethanol or T. camphoratus which obtained high cumulative scores under postprandial hyperglycaemia while high fat diet and genetic models of obesity appear more suited towards extracts such as H. erinaceus aqueous that obtained their highest cumulative score under insulin resistance. In general, a combination of rodent models ranging from non-obese models to models of obesity and β-cell destruction presenting symptoms from all three mechanistic classes should be considered due to the pleiotropic nature of the tested extracts, however, establishing appropriate experimental designs is crucial. To demonstrate the versatility of the screening platform and emphasise the importance of in vitro screening pertaining to diabetic complications, a more detailed biochemical investigation into the potential therapeutic benefits of A. linearis in the treatment of diabetic wounds was conducted. Several properties supporting the therapeutic potential of rooibos were highlighted with the green and fermented extracts presenting distinctly different characteristics. The pro-inflammatory nature of fermented rooibos may have therapeutic value for wounds characterised with a delayed initial inflammatory phase, such as early diabetic wounds while the green extract appears more suited to wounds burdened with excessive inflammation as it attenuated COX-2 levels and effectively protected fibroblasts against oxidative stress. To date, this appears to be the most comprehensive antidiabetic screening platform in existence and consequently provides the only feasible solution that will enable natural product antidiabetic research to progress to the point where natural products can be commercialised and incorporated into meaningful healthcare programs. Future research should be focussed towards further expanding this model by incorporating additional targets, more sophisticated cell culturing techniques, multiplexed high content screening assays and carrying out combination treatments that explore the antidiabetic effects of two or more crude extracts to establish whether they are capable of acting in a synergistic manner.
- Full Text:
- Date Issued: 2020
Conflict related sexual violence against males:recognition by and responses of humanitarian organizations in Africa
- Authors: Akurut, Catherine
- Date: 2020
- Subjects: Male rape victims -- Africa , Gender in conflict management --Africa
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10948/46648 , vital:39605
- Description: The study investigated the knowledge, attitudes, and experiences of humanitarian service providers concerning the recognition of and response to the phenomenon of male victims of conflict-related sexual violence against males. Sources of literature in respect to the awareness, understanding, and recognition of conflict-related sexual violence against males were explored. Perceptions about the recognition of male victims were discovered. Response strategies available to male victims were explored through the experiences of humanitarian organisation representatives, including, inter alia, programme managers, gender-based violence advisers, protection officers and activists. Mechanisms to augment any existing practices to allow for the care of and support for male victims were examined. A qualitative research approach was used to explore the topic of this study. Data was collected using semi-structured interview questions that were developed. And document review was also used as the second means of data collection. The research participants were recruited using purposive sampling, which was complemented by snowballing until data saturation. Triangulation was used by combining the two data collection methods to avoid relying on one source. A narrative literature review was aimed to obtain further information about the phenomenon of conflict-related sexual violence against males.
- Full Text:
- Date Issued: 2020
- Authors: Akurut, Catherine
- Date: 2020
- Subjects: Male rape victims -- Africa , Gender in conflict management --Africa
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10948/46648 , vital:39605
- Description: The study investigated the knowledge, attitudes, and experiences of humanitarian service providers concerning the recognition of and response to the phenomenon of male victims of conflict-related sexual violence against males. Sources of literature in respect to the awareness, understanding, and recognition of conflict-related sexual violence against males were explored. Perceptions about the recognition of male victims were discovered. Response strategies available to male victims were explored through the experiences of humanitarian organisation representatives, including, inter alia, programme managers, gender-based violence advisers, protection officers and activists. Mechanisms to augment any existing practices to allow for the care of and support for male victims were examined. A qualitative research approach was used to explore the topic of this study. Data was collected using semi-structured interview questions that were developed. And document review was also used as the second means of data collection. The research participants were recruited using purposive sampling, which was complemented by snowballing until data saturation. Triangulation was used by combining the two data collection methods to avoid relying on one source. A narrative literature review was aimed to obtain further information about the phenomenon of conflict-related sexual violence against males.
- Full Text:
- Date Issued: 2020
Conservation biology of an apex predator in the Anthropocene : poaching, pastoralism and lions in multi-use landscapes, South-Eastern Africa
- Authors: Everatt, Kristoffer T
- Date: 2020
- Subjects: Conservation biology -- Africa, Southern
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10948/48290 , vital:40839
- Description: Many of the world’s apex predators are experiencing catastrophic declines as a result of competition with humans. Understanding the mechanisms and ecosystem impacts of apex predator declines is a fundamental ecological question crucial to conserving the Earth’s biodiversity and functioning ecosystems. In this thesis I used the African lion Panthera leo, as a model species to investigate the impacts of anthropogenic pressures on the conservation and ecology of an apex predator. Specifically, I investigated the relative and cumulative influences of pastoralism and poaching on lion occurrence, population connectivity, ecological role, space use, prey selection and viability across a 73 000 km2 multi-use landscape in southern Africa. Using landscape occupancy spoor surveys, I tested the hypotheses that lions were most limited by either interference or by exploitative competition with humans and identified thresholds of lion tolerance to human activities. My results showed that lions occupied only a fraction of the landscape and were limited by a combination of interference and exploitative competition with humans. Interference competition with pastoralism however was the biggest driver limiting lion occupancy, creating a clear disturbance threshold for lions cumulating in their near complete loss from the landscape. I employed call-up surveys, pride monitoring and mortality analysis to investigate the numerical impacts of anthropogenic pressures on the viability of a lion sub-population. I found that persecution by pastoralists was the greatest source of lion mortalities across the landscape. However, the targeted poaching of lions for body parts had emerged as the greatest threat to lions in a nominally protected National Park where I documented a steep population decline and collapse of lion prides. I used GPS tracking and diet analysis of lions at the human-wildlands interface to test if lions foraged optimally or were constrained by competition with humans. I fount that individual lions appeared to select for prey and habitat optimally, while also showing some level of risk avoidance towards anthropogenic pressures. I then considered landscape resistances to test if sink habitats may provide connectivity between sources or act as ecological traps. I found that potential connectivity for lions between the region’s two source populations was limited by a loss of habitat and prey. Furthermore, the impacts of by-catch in snares risked transforming the few remaining potential conservation corridors into ecological traps. Finally, I examined interactions between lions and syntopic mesopredators across gradients of anthropogenic pressures to test if the functional role of lions was affected by human pressures. I found that lions showed limited suppression of mesopredators, however, anthropogenic pressures increased lion’s interactions with syntopic predators. As an apex predator, lions have evolved limited capacity to mitigate top-down competitive pressures, however, like many of the world’s apex predators, they are becoming increasingly limited by anthropogenic pressures. This study provides a predictive understanding of an apex predator’s ecological responses to top-down anthropogenic pressures which can be applied globally to the question of conservation in the Anthropocene.
- Full Text:
- Date Issued: 2020
- Authors: Everatt, Kristoffer T
- Date: 2020
- Subjects: Conservation biology -- Africa, Southern
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10948/48290 , vital:40839
- Description: Many of the world’s apex predators are experiencing catastrophic declines as a result of competition with humans. Understanding the mechanisms and ecosystem impacts of apex predator declines is a fundamental ecological question crucial to conserving the Earth’s biodiversity and functioning ecosystems. In this thesis I used the African lion Panthera leo, as a model species to investigate the impacts of anthropogenic pressures on the conservation and ecology of an apex predator. Specifically, I investigated the relative and cumulative influences of pastoralism and poaching on lion occurrence, population connectivity, ecological role, space use, prey selection and viability across a 73 000 km2 multi-use landscape in southern Africa. Using landscape occupancy spoor surveys, I tested the hypotheses that lions were most limited by either interference or by exploitative competition with humans and identified thresholds of lion tolerance to human activities. My results showed that lions occupied only a fraction of the landscape and were limited by a combination of interference and exploitative competition with humans. Interference competition with pastoralism however was the biggest driver limiting lion occupancy, creating a clear disturbance threshold for lions cumulating in their near complete loss from the landscape. I employed call-up surveys, pride monitoring and mortality analysis to investigate the numerical impacts of anthropogenic pressures on the viability of a lion sub-population. I found that persecution by pastoralists was the greatest source of lion mortalities across the landscape. However, the targeted poaching of lions for body parts had emerged as the greatest threat to lions in a nominally protected National Park where I documented a steep population decline and collapse of lion prides. I used GPS tracking and diet analysis of lions at the human-wildlands interface to test if lions foraged optimally or were constrained by competition with humans. I fount that individual lions appeared to select for prey and habitat optimally, while also showing some level of risk avoidance towards anthropogenic pressures. I then considered landscape resistances to test if sink habitats may provide connectivity between sources or act as ecological traps. I found that potential connectivity for lions between the region’s two source populations was limited by a loss of habitat and prey. Furthermore, the impacts of by-catch in snares risked transforming the few remaining potential conservation corridors into ecological traps. Finally, I examined interactions between lions and syntopic mesopredators across gradients of anthropogenic pressures to test if the functional role of lions was affected by human pressures. I found that lions showed limited suppression of mesopredators, however, anthropogenic pressures increased lion’s interactions with syntopic predators. As an apex predator, lions have evolved limited capacity to mitigate top-down competitive pressures, however, like many of the world’s apex predators, they are becoming increasingly limited by anthropogenic pressures. This study provides a predictive understanding of an apex predator’s ecological responses to top-down anthropogenic pressures which can be applied globally to the question of conservation in the Anthropocene.
- Full Text:
- Date Issued: 2020
Consumer behaviour regarding stock market participation in South Africa
- Authors: Mbewe, Wise
- Date: 2020
- Subjects: Financial Literacy -- South Africa , Stock ownership -- South Africa
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10948/50328 , vital:42107
- Description: South Africa (SA) has a highly sophisticated financial services sector that contributes significantly to the economy. A stock market forms a significant component of the financial sector of any economy. While the Johannesburg Stock Exchange (JSE) has managed to arouse interest of many South Africans, there appears to be apathy and inertia when it comes to actual participation in the stock market by South African consumers. Stock market non-participation is considered a “puzzle” in microeconomics and finance literature because it is not easy to explain the reason why many consumers, in spite of high stock returns, do not own listed shares. Thus, the primary objective of this study was to investigate consumer behaviour regarding stock market participation in SA by considering the antecedents and outcomes of stock market participation in SA.The study presented a theoretical literature review on the factors influencing stock market participation in SA. From the literature review, three sets of variables classified as independent variables, an intervening variable and dependent variables were identified. The independent variables (Demographic characteristics; Financial literacy; Investment risk tolerance; Communication; and Consumer trust) were identified as possibly influencing the intervening variable (Stock market participation) and ultimately the dependent variables (Client satisfaction and loyalty, Financial sustainability and Repurchase intentions). These variables were used to construct a hypothesised model and research hypotheses. The study further presented the research methodology (following a positivistic paradigm and quantitative research method), and the results of this study. In order to establish the influence of the independent variables on stock market participation, as well as ultimate influences on the dependent variables, an empirical investigation was conducted. Since it was not possible to reach all members of the target population, the population of this study was South African consumers located in four of the nine provinces, namely, Eastern Cape, Western Cape, Kwa-Zulu Natal and Gauteng. A sample of 510 respondents participated in the study.
- Full Text:
- Date Issued: 2020
- Authors: Mbewe, Wise
- Date: 2020
- Subjects: Financial Literacy -- South Africa , Stock ownership -- South Africa
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10948/50328 , vital:42107
- Description: South Africa (SA) has a highly sophisticated financial services sector that contributes significantly to the economy. A stock market forms a significant component of the financial sector of any economy. While the Johannesburg Stock Exchange (JSE) has managed to arouse interest of many South Africans, there appears to be apathy and inertia when it comes to actual participation in the stock market by South African consumers. Stock market non-participation is considered a “puzzle” in microeconomics and finance literature because it is not easy to explain the reason why many consumers, in spite of high stock returns, do not own listed shares. Thus, the primary objective of this study was to investigate consumer behaviour regarding stock market participation in SA by considering the antecedents and outcomes of stock market participation in SA.The study presented a theoretical literature review on the factors influencing stock market participation in SA. From the literature review, three sets of variables classified as independent variables, an intervening variable and dependent variables were identified. The independent variables (Demographic characteristics; Financial literacy; Investment risk tolerance; Communication; and Consumer trust) were identified as possibly influencing the intervening variable (Stock market participation) and ultimately the dependent variables (Client satisfaction and loyalty, Financial sustainability and Repurchase intentions). These variables were used to construct a hypothesised model and research hypotheses. The study further presented the research methodology (following a positivistic paradigm and quantitative research method), and the results of this study. In order to establish the influence of the independent variables on stock market participation, as well as ultimate influences on the dependent variables, an empirical investigation was conducted. Since it was not possible to reach all members of the target population, the population of this study was South African consumers located in four of the nine provinces, namely, Eastern Cape, Western Cape, Kwa-Zulu Natal and Gauteng. A sample of 510 respondents participated in the study.
- Full Text:
- Date Issued: 2020
Contesting boundaries: a case of municipal demarcation disputes in Vuwani Vhembe District
- Authors: Khowa, Thandeka Promise
- Date: 2020
- Subjects: Geographical boundaries
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10948/50767 , vital:42670
- Description: The research study in Vuwani Vhembe district sought to investigate demarcation disputes, the relationship between service delivery and demarcation disputes. The study further investigates the role of municipal demarcation board and local government adherence to sound governance principles and the causes of the demarcation dispute in Vuwani. The study additionally examines the conceptions and misconceptions, their impact on the current demarcation disputes in Vuwani. It further intended to establish the role and involvement of Vuwani stakeholders such as traditional structures/ leaders, civil unions, community members etc. in the processes of demarcating Vuwani. “What is the cause of Vuwani community member’s rejection of the re-demarcation, which is said to correct the past spatial injustices and promote municipal sizing, thus enabling better performance in service provision by municipalities?” The study employed a mixed-method involving the use of both quantitative (mini-survey) and qualitative (use of in-depth, semi structures interviews and focus group discussions). Research findings suggest that re-demarcation is a sensitive aspect/process in South Africa, mainly due to the past Apartheid era. There was forceful removal of people from their land supported by Apartheid legislation such as the Native Land Act 1913, Group Act 1950, Native Resettlement Act 1954 etc. Thus, fears of the past Apartheid system cloud any attempt to correct spatial injustices of the country. The new democratic South African government, therefore, needs to be cautious in its acts to correct the spatial injustices, thus adhering to sound governance principles. Findings reveal that several misconceptions and lack of adherence of good governance principles by the Municipal Demarcation Board and Local government have, to some extent, fueled the demarcation disputes in Vuwani. Municipal performance in the rendering of service delivery has a major impact and contributes to the community’s acceptance or rejection of demarcation/ amalgamations. The study further reveals that in Vuwani municipal performance with the establishment of the new Collins Chabane municipality has been clouded by fear of the unknown as this form of “demarcation of establishing a new municipality” altogether is relatively new. Rural land authority, the role of traditional leaders, ethnicity ties have all been found to have contributed to the disputes in Vuwani. Limpopo Province is home to three ethnic groups, namely, vaVhenda, baPedi and xiTsonga. The study findings have presented traits of tribalism as contributing to on-going demarcation disputes in Vuwani.
- Full Text:
- Date Issued: 2020
- Authors: Khowa, Thandeka Promise
- Date: 2020
- Subjects: Geographical boundaries
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10948/50767 , vital:42670
- Description: The research study in Vuwani Vhembe district sought to investigate demarcation disputes, the relationship between service delivery and demarcation disputes. The study further investigates the role of municipal demarcation board and local government adherence to sound governance principles and the causes of the demarcation dispute in Vuwani. The study additionally examines the conceptions and misconceptions, their impact on the current demarcation disputes in Vuwani. It further intended to establish the role and involvement of Vuwani stakeholders such as traditional structures/ leaders, civil unions, community members etc. in the processes of demarcating Vuwani. “What is the cause of Vuwani community member’s rejection of the re-demarcation, which is said to correct the past spatial injustices and promote municipal sizing, thus enabling better performance in service provision by municipalities?” The study employed a mixed-method involving the use of both quantitative (mini-survey) and qualitative (use of in-depth, semi structures interviews and focus group discussions). Research findings suggest that re-demarcation is a sensitive aspect/process in South Africa, mainly due to the past Apartheid era. There was forceful removal of people from their land supported by Apartheid legislation such as the Native Land Act 1913, Group Act 1950, Native Resettlement Act 1954 etc. Thus, fears of the past Apartheid system cloud any attempt to correct spatial injustices of the country. The new democratic South African government, therefore, needs to be cautious in its acts to correct the spatial injustices, thus adhering to sound governance principles. Findings reveal that several misconceptions and lack of adherence of good governance principles by the Municipal Demarcation Board and Local government have, to some extent, fueled the demarcation disputes in Vuwani. Municipal performance in the rendering of service delivery has a major impact and contributes to the community’s acceptance or rejection of demarcation/ amalgamations. The study further reveals that in Vuwani municipal performance with the establishment of the new Collins Chabane municipality has been clouded by fear of the unknown as this form of “demarcation of establishing a new municipality” altogether is relatively new. Rural land authority, the role of traditional leaders, ethnicity ties have all been found to have contributed to the disputes in Vuwani. Limpopo Province is home to three ethnic groups, namely, vaVhenda, baPedi and xiTsonga. The study findings have presented traits of tribalism as contributing to on-going demarcation disputes in Vuwani.
- Full Text:
- Date Issued: 2020
Creating Citizen-Science for Groundwater Monitoring prior to potential Shale Gas Development in Cradock (South-Eastern Karoo, South Africa)
- Authors: Dhliwayo, Nyaradzo
- Date: 2020
- Subjects: Natural gas -- Prospecting -- Environmental aspects -- South Africa
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10948/48224 , vital:40526
- Description: Citizen Science is an integral tool for community engagement in scientific project design, implementation, data interpretation and reporting, in the quest to promote local capacity development as well as scientific knowledge. Based on the relevance of public engagement in aspects of the natural environment and associated scientific issues associated with the risks and opportunities of potential Shale Gas Development (SGD), a Citizen-Science (CS) study was designed in the Eastern Karoo region of South Africa linked to a Shale Gas Baseline Study initiated by the Africa Earth Observatory Network (AEON). As the pilot area of the baseline study, the town of Cradock was chosen to be the study area for this research; and CS was used to facilitate the identification of the Cradock community’s abilities to monitor the effects of potential SGD in this region. The development of new knowledge, skills and support, as well as a deeper understanding of the community’s role in Citizen Science studies, was also facilitated by this process. This study demonstrates the feasibility of integrating Citizen Science into existing community structures in Africa, thereby encouraging community engagement in the developmental programmes through participatory methods. Using a collaborative Action-Research Approach, consistent community roundtable meetings and key informant interviews served as invaluable platforms for the establishment of a 7-member community working group, that played the liaison role between the researcher and the Cradock community in the CS implementation process. Coupled with this was the recruitment and the training of eight young citizens in conducting a hydro-census and groundwater sampling for six boreholes within the identified Cradock commonage farms, as well as two boreholes on the farm of an identified emergent farmer. The engagements between the researcher, AEON scientists, the community working group and the community at large, enabled the successful implementation of CS training in two groundwater monitoring aspects and the testing of eleven water quality parameters. The training process was combined with the design and the development of a customised ‘Xoras’ Online Application, which was used to capture and share the hydro-census data recorded. Experiential learning in hydro-census and groundwater sampling resulted subsequently in an increased understanding and awareness of these aspects (Figure A). Even if SGD does not materialise in the South-Eastern Karoo, CS training will enable communities in the Shale-Gas Development precincts to participate in local decision-making forums on ground water, health, or on any related regional development projects. It is anticipated that the adoption of CS will ix promote future community engagements, especially about water across this water-scarce region, allowing for greater community-voice representation in resource-policy decisions related to potential Shale-Gas and related natural resource industries in the Karoo.
- Full Text:
- Date Issued: 2020
- Authors: Dhliwayo, Nyaradzo
- Date: 2020
- Subjects: Natural gas -- Prospecting -- Environmental aspects -- South Africa
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10948/48224 , vital:40526
- Description: Citizen Science is an integral tool for community engagement in scientific project design, implementation, data interpretation and reporting, in the quest to promote local capacity development as well as scientific knowledge. Based on the relevance of public engagement in aspects of the natural environment and associated scientific issues associated with the risks and opportunities of potential Shale Gas Development (SGD), a Citizen-Science (CS) study was designed in the Eastern Karoo region of South Africa linked to a Shale Gas Baseline Study initiated by the Africa Earth Observatory Network (AEON). As the pilot area of the baseline study, the town of Cradock was chosen to be the study area for this research; and CS was used to facilitate the identification of the Cradock community’s abilities to monitor the effects of potential SGD in this region. The development of new knowledge, skills and support, as well as a deeper understanding of the community’s role in Citizen Science studies, was also facilitated by this process. This study demonstrates the feasibility of integrating Citizen Science into existing community structures in Africa, thereby encouraging community engagement in the developmental programmes through participatory methods. Using a collaborative Action-Research Approach, consistent community roundtable meetings and key informant interviews served as invaluable platforms for the establishment of a 7-member community working group, that played the liaison role between the researcher and the Cradock community in the CS implementation process. Coupled with this was the recruitment and the training of eight young citizens in conducting a hydro-census and groundwater sampling for six boreholes within the identified Cradock commonage farms, as well as two boreholes on the farm of an identified emergent farmer. The engagements between the researcher, AEON scientists, the community working group and the community at large, enabled the successful implementation of CS training in two groundwater monitoring aspects and the testing of eleven water quality parameters. The training process was combined with the design and the development of a customised ‘Xoras’ Online Application, which was used to capture and share the hydro-census data recorded. Experiential learning in hydro-census and groundwater sampling resulted subsequently in an increased understanding and awareness of these aspects (Figure A). Even if SGD does not materialise in the South-Eastern Karoo, CS training will enable communities in the Shale-Gas Development precincts to participate in local decision-making forums on ground water, health, or on any related regional development projects. It is anticipated that the adoption of CS will ix promote future community engagements, especially about water across this water-scarce region, allowing for greater community-voice representation in resource-policy decisions related to potential Shale-Gas and related natural resource industries in the Karoo.
- Full Text:
- Date Issued: 2020
Designing a parental involvement programme to enhance parental engagement in the educational support programme at a disadvantaged primary school in the Nelson Mandela Bay Metropole, South Africa through participatory action research
- WIlliams, Pearl Juanita Cherrol
- Authors: WIlliams, Pearl Juanita Cherrol
- Date: 2020
- Subjects: Education -- Parent participation -- South Africa -- Nelson Mandela Bay Municipality
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10948/47303 , vital:39841
- Description: Over the past decades parental involvement in education has increased rapidly within disadvantaged schools in South Africa. This transformation is evident in the legislation of the country which celebrates a spirit of Ubuntu in a democratised society, and, education at large. The ideal of effective school-home partnership across racial boundaries are, for example, emphasised and strengthened via parental involvement at all public schools. Parents, according to the Department of Education (DoE, 1996b:11; 2000c:29; 2001b:29; 2008:23; 2009:17; 2014b:27; n.d.:6), are considered key role-players in school governance and encouraged to support equal educational opportunities for all learners. It implies that the praxis of parental involvement – especially at disadvantaged schools – is a huge benefit to learners with existing backlogs in education. In relation to this view, Stofile and Green (2007:63) emphasise the significance of parental involvement in school life as it can assist greatly in addressing the divere needs of disadvantaged learners. The dynamics associated with parental involvement are investigated in this study through two cycles of participatory action research. Initially ten parents from one of the disadvantaged primary schools within the Nelson Mandela Bay Metropole were purposively selected to participate in an in-depth qualitative research study pertaining to the design of a suitable parental involvement programme for disadvantaged learners. All the relevant information was gathered during action learning sets, individual interviews, and observations to triangulate the data and fill in possible gaps. This data was coded and categorised throughout the cyclical process via inductive participatory data analysis, as described by Patton (2015:216 & 551). Three main themes with sub-themes emerged from the study, namely (1) deficits of the academic programme: remedial education, teacher-assistants, homeworksupport, technical abilities; (2) the neglect of social wellness programmes: need for parental guidance, necessary professional assistance, upgrading of safety measures, availability of clothing bank, sustainability of a nutritional programme; and (3) voids in communication and relationships: the home environment, community, school environment. These themes and sub-themes successfully answered all the research questions. An increasing number of learners at disadvataged primary schools are neglected and/or leave school at a very young age. This scenario is often linked to poor communication and/or a lack of adequate educational support programmes to enhance better learning outcomes. The design of a PIP aimed to address the diverse needs of learners at a specific disadvantaged primary school with the full cooperation of their parents. Nested within the Ecological Model of Bronfenbrenner, the participating parents were engaged in comprehensive discussions about educational support programmes that the school could embark on with them. Numerous programmes were identified as fundamental to transforming the quality of education for many disadvantaged learners. This research therefore encouraged greater parental involvement at disadvantaged primary schools in order to sustain better learning outcomes.
- Full Text:
- Date Issued: 2020
- Authors: WIlliams, Pearl Juanita Cherrol
- Date: 2020
- Subjects: Education -- Parent participation -- South Africa -- Nelson Mandela Bay Municipality
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10948/47303 , vital:39841
- Description: Over the past decades parental involvement in education has increased rapidly within disadvantaged schools in South Africa. This transformation is evident in the legislation of the country which celebrates a spirit of Ubuntu in a democratised society, and, education at large. The ideal of effective school-home partnership across racial boundaries are, for example, emphasised and strengthened via parental involvement at all public schools. Parents, according to the Department of Education (DoE, 1996b:11; 2000c:29; 2001b:29; 2008:23; 2009:17; 2014b:27; n.d.:6), are considered key role-players in school governance and encouraged to support equal educational opportunities for all learners. It implies that the praxis of parental involvement – especially at disadvantaged schools – is a huge benefit to learners with existing backlogs in education. In relation to this view, Stofile and Green (2007:63) emphasise the significance of parental involvement in school life as it can assist greatly in addressing the divere needs of disadvantaged learners. The dynamics associated with parental involvement are investigated in this study through two cycles of participatory action research. Initially ten parents from one of the disadvantaged primary schools within the Nelson Mandela Bay Metropole were purposively selected to participate in an in-depth qualitative research study pertaining to the design of a suitable parental involvement programme for disadvantaged learners. All the relevant information was gathered during action learning sets, individual interviews, and observations to triangulate the data and fill in possible gaps. This data was coded and categorised throughout the cyclical process via inductive participatory data analysis, as described by Patton (2015:216 & 551). Three main themes with sub-themes emerged from the study, namely (1) deficits of the academic programme: remedial education, teacher-assistants, homeworksupport, technical abilities; (2) the neglect of social wellness programmes: need for parental guidance, necessary professional assistance, upgrading of safety measures, availability of clothing bank, sustainability of a nutritional programme; and (3) voids in communication and relationships: the home environment, community, school environment. These themes and sub-themes successfully answered all the research questions. An increasing number of learners at disadvataged primary schools are neglected and/or leave school at a very young age. This scenario is often linked to poor communication and/or a lack of adequate educational support programmes to enhance better learning outcomes. The design of a PIP aimed to address the diverse needs of learners at a specific disadvantaged primary school with the full cooperation of their parents. Nested within the Ecological Model of Bronfenbrenner, the participating parents were engaged in comprehensive discussions about educational support programmes that the school could embark on with them. Numerous programmes were identified as fundamental to transforming the quality of education for many disadvantaged learners. This research therefore encouraged greater parental involvement at disadvantaged primary schools in order to sustain better learning outcomes.
- Full Text:
- Date Issued: 2020
Development of a UV-tolerant strain of the South African isolate of Cryptophlebia leucotreta granulovirus for use as an enhanced biopesticide for Thaumatotibia leucotreta control on citrus
- Authors: Mwanza, Patrick
- Date: 2020
- Subjects: Baculoviruses -- South Africa , Ultraviolet astronomy
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10948/48533 , vital:40885
- Description: Baculoviruses are pathogenic to insects in the orders Diptera, Hymenoptera, and Lepidoptera. As a result of this natural relationship with insects they provide an environmentally friendly method to combat crop and forest pests. As such, a number of baculoviruses have been formulated into biopesticides. The use of baculovirus biopesticides is gaining popularity as the use of chemical pesticides has come under stringent regulatory conditions imposed by governments and continental blocks such as the European Union. Baculoviruses have a narrow host range and therefore do not harm non-pests or humans who consume the crops. One such baculovirus is Cryptophlebia leucotreta granulovirus (CrleGV), which is pathogenic to the citrus pest Thaumatotibia leucotreta, commonly referred to as the false codling moth (FCM). CrleGV has an occlusion body (OB) that encloses a single virion. Several CrleGV biopesticides have been registered in South Africa for use on citrus, avocadoes, macadamias, grapes and other crops by two commercial producers, River Bioscience (SA) and Andermatt (Switzerland). These biopesticides are used as part of the FCM integrated pest management (IPM) programme, a multifacetted approach to controlling FCM. However, baculoviruses are susceptible to the ultraviolet (UV) radiation component of sunlight and lose their activity within hours to a few days, after exposure to UV. Several substances have been tested as UV protectants to improve the persistence of baculovirus biopesticides in the field. These include optical brighteners, UV absorbers and anti-oxidants. While very promising in the laboratory, UV-protectants have not been as successful in the field. A few published reports have reported, that UV-tolerant baculoviruses could be isolated from a population by repeatedly exposing and re-exposing the virus to UV irradiation with a propagation step in insect host fourth or fifth instars between each exposure cycle. In this study, the South African isolate of Cryptophlebia leucotreta (CrleGV-SA) was exposed to UV irradiation for 5 exposure cycles in a Q-Sun Xe-3 HC test chamber (Qlab, USA) with parameters set to mimic a typical summer day in the Sundays River Valley, Eastern Cape Province, in South Africa. In between exposures the virus survivors were allowed to multiply in FCM fifth instars. Surface dose bioassays were also conducted to determine the LC50 of the virus after each exposure cycle. Samples from exposure cycle 1 and cycle 5 (UV-tolerant) irradiated for 72 h were prepared for Next Generation Sequencing (NGS) of DNA. The resultant sequence data were analysed using the Geneious R11 software (New Zealand) and compared with the unexposed CrleGV-SA sequence. In-silico restriction enzyme analsysis (REN) with several enzymes was also carried on both the cycle 1 and cycle 5 exposed samples and the resulting digestion patterns were compared with the original CrleGV-SA digestion patterns. The same samples were also analysed by transmission electron microscopy (TEM) and Attenuated Reflectance Fourier Transform Infrared Spectroscopy (ATR-FTIR) to evaluate the effect of UV irradiation on the structure of the CrleGV-SA OB. In addition, three UV protectants, lignin sulphate (Sappi, SA), BREAK-THRU®OE446 (OE446) (Evonik Industries, Germany) and Uvinul Easy (BASF, Germany) were prepared with CrleGV-SA to give final protectant concentrations of 0.09 %, 0.9 % and 9 %. The protectant-virus suspensions were exposed to UV for 24 h in the Q-Sun test chamber and bioassays conducted to determine the protective effect of each protectant concentration. The most successful protectants were then combined with the UV-tolerant CrleGV-SA and exposed to UV for 24 h in the Q-Sun test chamber and surface dose bioassays conducted afterwards. Samples exposed to UV in cycle 5 had lower LC50 values compared to samples in the early cycles. With each re-exposure cycle the LC50 values moved closer to that of the unexposed control. The LC50 of virus samples decreased from 2.89 x 108 OBs/ml after 24 h UV-exposure in cycle 1 to 2.16 x 105 OBs/ml after the same duration of exposure in cycle 5; and from 2.11 x 109 OBs/ml in cycle 1 after 72 h UV-exposure to 1.73 x 106 OBs/ml after the same duration of exposure. This represented a 1338-fold difference and a 1220-fold difference, respectively. When the UV-tolerant samples were sequenced seven SNPs were identified in cycle 1, which were thought to help establish UV tolerance, while a further seven SNPs were identified in cycle 5 samples; these were thought to further establish and maintain the UV-tolerance. Additionally, REN analysis with EcoR1 for both test samples yielded digestion patterns that were different from those of the original CrleGV-SA. TEM data showed that UV damages the virion as well as the crystalline structure of the OB. This is the first time visual evidence for UV damage to baculoviruses has been published. Comparison of cycle 1 and cycle 5 UV exposed OBs revealed that the cycle 5 OBs were significantly larger than the cycle 1 OBs (P<0.05). In addition, several peaks in the fingerprint region were shown to have either appeared or disapeered from the ATR-FTIR spectra after UV irradiation. However, there was no difference in the spectra of the Cycle 1 and Cycle 5 virus samples. The tests with potential UV-protectants revealed that the 0.9 % lignin, 9 % OE446 and 9 % Uvinul Easy were the most effective in protecting the virus from UV. However, there was no significant difference in their protection of UV tolerant CrleGV-SA and wild type CrleGV-SA. Going forward, it is recommended that the 0.9 % lignin, 9 % OE446 and 9 % Uvinul Easy combinations be explored further in future studies, particulary in the field. This study therefore forms an important foundation for the development of UV-tolerant baculovirus that will last longer in the field.
- Full Text:
- Date Issued: 2020
- Authors: Mwanza, Patrick
- Date: 2020
- Subjects: Baculoviruses -- South Africa , Ultraviolet astronomy
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10948/48533 , vital:40885
- Description: Baculoviruses are pathogenic to insects in the orders Diptera, Hymenoptera, and Lepidoptera. As a result of this natural relationship with insects they provide an environmentally friendly method to combat crop and forest pests. As such, a number of baculoviruses have been formulated into biopesticides. The use of baculovirus biopesticides is gaining popularity as the use of chemical pesticides has come under stringent regulatory conditions imposed by governments and continental blocks such as the European Union. Baculoviruses have a narrow host range and therefore do not harm non-pests or humans who consume the crops. One such baculovirus is Cryptophlebia leucotreta granulovirus (CrleGV), which is pathogenic to the citrus pest Thaumatotibia leucotreta, commonly referred to as the false codling moth (FCM). CrleGV has an occlusion body (OB) that encloses a single virion. Several CrleGV biopesticides have been registered in South Africa for use on citrus, avocadoes, macadamias, grapes and other crops by two commercial producers, River Bioscience (SA) and Andermatt (Switzerland). These biopesticides are used as part of the FCM integrated pest management (IPM) programme, a multifacetted approach to controlling FCM. However, baculoviruses are susceptible to the ultraviolet (UV) radiation component of sunlight and lose their activity within hours to a few days, after exposure to UV. Several substances have been tested as UV protectants to improve the persistence of baculovirus biopesticides in the field. These include optical brighteners, UV absorbers and anti-oxidants. While very promising in the laboratory, UV-protectants have not been as successful in the field. A few published reports have reported, that UV-tolerant baculoviruses could be isolated from a population by repeatedly exposing and re-exposing the virus to UV irradiation with a propagation step in insect host fourth or fifth instars between each exposure cycle. In this study, the South African isolate of Cryptophlebia leucotreta (CrleGV-SA) was exposed to UV irradiation for 5 exposure cycles in a Q-Sun Xe-3 HC test chamber (Qlab, USA) with parameters set to mimic a typical summer day in the Sundays River Valley, Eastern Cape Province, in South Africa. In between exposures the virus survivors were allowed to multiply in FCM fifth instars. Surface dose bioassays were also conducted to determine the LC50 of the virus after each exposure cycle. Samples from exposure cycle 1 and cycle 5 (UV-tolerant) irradiated for 72 h were prepared for Next Generation Sequencing (NGS) of DNA. The resultant sequence data were analysed using the Geneious R11 software (New Zealand) and compared with the unexposed CrleGV-SA sequence. In-silico restriction enzyme analsysis (REN) with several enzymes was also carried on both the cycle 1 and cycle 5 exposed samples and the resulting digestion patterns were compared with the original CrleGV-SA digestion patterns. The same samples were also analysed by transmission electron microscopy (TEM) and Attenuated Reflectance Fourier Transform Infrared Spectroscopy (ATR-FTIR) to evaluate the effect of UV irradiation on the structure of the CrleGV-SA OB. In addition, three UV protectants, lignin sulphate (Sappi, SA), BREAK-THRU®OE446 (OE446) (Evonik Industries, Germany) and Uvinul Easy (BASF, Germany) were prepared with CrleGV-SA to give final protectant concentrations of 0.09 %, 0.9 % and 9 %. The protectant-virus suspensions were exposed to UV for 24 h in the Q-Sun test chamber and bioassays conducted to determine the protective effect of each protectant concentration. The most successful protectants were then combined with the UV-tolerant CrleGV-SA and exposed to UV for 24 h in the Q-Sun test chamber and surface dose bioassays conducted afterwards. Samples exposed to UV in cycle 5 had lower LC50 values compared to samples in the early cycles. With each re-exposure cycle the LC50 values moved closer to that of the unexposed control. The LC50 of virus samples decreased from 2.89 x 108 OBs/ml after 24 h UV-exposure in cycle 1 to 2.16 x 105 OBs/ml after the same duration of exposure in cycle 5; and from 2.11 x 109 OBs/ml in cycle 1 after 72 h UV-exposure to 1.73 x 106 OBs/ml after the same duration of exposure. This represented a 1338-fold difference and a 1220-fold difference, respectively. When the UV-tolerant samples were sequenced seven SNPs were identified in cycle 1, which were thought to help establish UV tolerance, while a further seven SNPs were identified in cycle 5 samples; these were thought to further establish and maintain the UV-tolerance. Additionally, REN analysis with EcoR1 for both test samples yielded digestion patterns that were different from those of the original CrleGV-SA. TEM data showed that UV damages the virion as well as the crystalline structure of the OB. This is the first time visual evidence for UV damage to baculoviruses has been published. Comparison of cycle 1 and cycle 5 UV exposed OBs revealed that the cycle 5 OBs were significantly larger than the cycle 1 OBs (P<0.05). In addition, several peaks in the fingerprint region were shown to have either appeared or disapeered from the ATR-FTIR spectra after UV irradiation. However, there was no difference in the spectra of the Cycle 1 and Cycle 5 virus samples. The tests with potential UV-protectants revealed that the 0.9 % lignin, 9 % OE446 and 9 % Uvinul Easy were the most effective in protecting the virus from UV. However, there was no significant difference in their protection of UV tolerant CrleGV-SA and wild type CrleGV-SA. Going forward, it is recommended that the 0.9 % lignin, 9 % OE446 and 9 % Uvinul Easy combinations be explored further in future studies, particulary in the field. This study therefore forms an important foundation for the development of UV-tolerant baculovirus that will last longer in the field.
- Full Text:
- Date Issued: 2020
Development of bio-based xylan composites for food packaging applications
- Authors: Naidu, Darrel Sarvesh
- Date: 2020
- Subjects: Xylanases
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10948/48544 , vital:40886
- Description: Currently a large number of chemicals and plastics are produced from petroleum-based resources. However, due to the concerns surrounding the depletion of petroleum resources and growing carbon emissions, there is a desire to produce chemicals and plastics from renewable and carbon natural sources. Lignocellulosic biomass (biomass consisting of cellulose, lignin and hemicellulose) is the most common biomass on earth and is renewable and carbon neutral. Of the three main constituents of lignocellulosic biomass, hemicellulose is composed of a mixture of sugars which can be converted into chemicals and plastics. The most common form of hemicellulose found in nature is xylan. This study is aimed at extracting xylan from maize stalk waste residues and the development of xylan films with properties that are suitable for food packaging applications. Xylan was extracted from maize stalk waste residues using an alkaline pre-treatment method. The effects of bleaching conditions (time, temperature and bleach concentration) prior to alkaline treatment on the yield and purity of xylan extracted was studied using a Box-Behnken experimental design. It was observed that the experimental conditions tested had no effect on the yield of the xylan extracted but the bleach concentration had a significant effect on the purity of the xylan extracted. The samples with the lowest lignin content were found to be the samples treated with 3wt% bleach prior to alkaline pre-treatment. One of the main disadvantages of xylan is that it has poor film forming properties, a method of overcoming this is to combine it with another abundantly available biopolymer that has good film forming properties, such as alginate. The effect of xylan, alginate and glycerol content on the mechanical, thermal, moisture uptake and water barrier properties of the films were investigated. It was observed that with an increase in the alginate content there was an increase in the tensile strength and Young’s modulus of the films, whereas the water vapour permeability (WVP) of the films decreased. This was attributed to the greater cohesion between alginate polymer chains compared to the cohesion between xylan polymer chains. The xylanalginate films exhibited better optical and water sorption properties at higher xylan content. In order to improve the inherently poor mechanical and barrier properties of the xylan-alginate films, bentonite and halloysite were incorporated into the films. It was found that 5wt% incorporation of either bentonite or halloysite resulted in a 49% decrease of the WVP, which was attributed to water vapour impermeable nature of the silicate layers that make up both clays. The incorporation of the clays into the xylan-alginate matrix resulted in a significant
- Full Text:
- Date Issued: 2020
- Authors: Naidu, Darrel Sarvesh
- Date: 2020
- Subjects: Xylanases
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10948/48544 , vital:40886
- Description: Currently a large number of chemicals and plastics are produced from petroleum-based resources. However, due to the concerns surrounding the depletion of petroleum resources and growing carbon emissions, there is a desire to produce chemicals and plastics from renewable and carbon natural sources. Lignocellulosic biomass (biomass consisting of cellulose, lignin and hemicellulose) is the most common biomass on earth and is renewable and carbon neutral. Of the three main constituents of lignocellulosic biomass, hemicellulose is composed of a mixture of sugars which can be converted into chemicals and plastics. The most common form of hemicellulose found in nature is xylan. This study is aimed at extracting xylan from maize stalk waste residues and the development of xylan films with properties that are suitable for food packaging applications. Xylan was extracted from maize stalk waste residues using an alkaline pre-treatment method. The effects of bleaching conditions (time, temperature and bleach concentration) prior to alkaline treatment on the yield and purity of xylan extracted was studied using a Box-Behnken experimental design. It was observed that the experimental conditions tested had no effect on the yield of the xylan extracted but the bleach concentration had a significant effect on the purity of the xylan extracted. The samples with the lowest lignin content were found to be the samples treated with 3wt% bleach prior to alkaline pre-treatment. One of the main disadvantages of xylan is that it has poor film forming properties, a method of overcoming this is to combine it with another abundantly available biopolymer that has good film forming properties, such as alginate. The effect of xylan, alginate and glycerol content on the mechanical, thermal, moisture uptake and water barrier properties of the films were investigated. It was observed that with an increase in the alginate content there was an increase in the tensile strength and Young’s modulus of the films, whereas the water vapour permeability (WVP) of the films decreased. This was attributed to the greater cohesion between alginate polymer chains compared to the cohesion between xylan polymer chains. The xylanalginate films exhibited better optical and water sorption properties at higher xylan content. In order to improve the inherently poor mechanical and barrier properties of the xylan-alginate films, bentonite and halloysite were incorporated into the films. It was found that 5wt% incorporation of either bentonite or halloysite resulted in a 49% decrease of the WVP, which was attributed to water vapour impermeable nature of the silicate layers that make up both clays. The incorporation of the clays into the xylan-alginate matrix resulted in a significant
- Full Text:
- Date Issued: 2020
Financial integration in the BRICS countries
- Authors: Nach, Marida Nephertiti
- Date: 2020
- Subjects: Autogression (Statistics) -- mathematical models , Monetary policy -- Econometric models
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10948/50609 , vital:42278
- Description: An optimum currency area (OCA) owes its definition to Robert Mundell (1961). In his seminal paper, Mundell (1961) defines an OCA as an area for which the costs of relinquishing the exchange rate as an internal instrument of adjustments are outweighed by the benefits of adopting a single currency or a fixed exchange rate regime. Mundell (1961) emphasises two major benefits of adopting a single currency: the elimination of transaction costs and a better performance of money as a medium of exchange and as a unit of account. Thus far, OCA theory has served as the framework for the discussion about monetary integration and has provided an explanation for the monetary integration processes around the world both developed and developing countries in Europe, Asia, Africa, and Latin America. The emergence of the BRICS (Brazil, Russia, India, China, South Africa) countries can be a model and a representation of developing and emerging countries in the global economic and financial system. Hence, this has made the BRICS economies the object of many discussions and recent empirical researches. The research presented in this thesis uses a structural vector autoregression (SVAR) econometric model to explore whether there is a feasibility of macroeconomic convergence among the BRICS economies. The SVAR model permitted to examine the symmetry of shocks (supply, demand and monetary) among the five BRICS countries. The findings of this research showed that there was some degree of symmetry of shocks among the BRICS countries. Nevertheless, there is a need for more policy coordination in order to achieve the desired level of symmetry of shocks among these countries.
- Full Text:
- Date Issued: 2020
- Authors: Nach, Marida Nephertiti
- Date: 2020
- Subjects: Autogression (Statistics) -- mathematical models , Monetary policy -- Econometric models
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10948/50609 , vital:42278
- Description: An optimum currency area (OCA) owes its definition to Robert Mundell (1961). In his seminal paper, Mundell (1961) defines an OCA as an area for which the costs of relinquishing the exchange rate as an internal instrument of adjustments are outweighed by the benefits of adopting a single currency or a fixed exchange rate regime. Mundell (1961) emphasises two major benefits of adopting a single currency: the elimination of transaction costs and a better performance of money as a medium of exchange and as a unit of account. Thus far, OCA theory has served as the framework for the discussion about monetary integration and has provided an explanation for the monetary integration processes around the world both developed and developing countries in Europe, Asia, Africa, and Latin America. The emergence of the BRICS (Brazil, Russia, India, China, South Africa) countries can be a model and a representation of developing and emerging countries in the global economic and financial system. Hence, this has made the BRICS economies the object of many discussions and recent empirical researches. The research presented in this thesis uses a structural vector autoregression (SVAR) econometric model to explore whether there is a feasibility of macroeconomic convergence among the BRICS economies. The SVAR model permitted to examine the symmetry of shocks (supply, demand and monetary) among the five BRICS countries. The findings of this research showed that there was some degree of symmetry of shocks among the BRICS countries. Nevertheless, there is a need for more policy coordination in order to achieve the desired level of symmetry of shocks among these countries.
- Full Text:
- Date Issued: 2020
Genetic connectivity in sandy beach macroinfauna with contrasting life histories and zonation patterns
- Authors: Bezuidenhout, Karien
- Date: 2020
- Subjects: Fishes -- Genetics , Seashore ecology -- South Africa
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10948/45944 , vital:39380
- Description: Open-ocean sandy beaches are highly dynamic ecosystems that continuously respond to waves, tides and storms. These beaches support a suite of uniquely adapted fauna that exhibits a high degree of endemism. This diversity, which also includes some economically important resource species, contributes to the great socio-economic and ecological value of sandy beach systems, which provide ecosystem services such as nutrient recycling and water purification, fish nursery habitat (surf zone), and natural buffering against storms. Despite their broad global distribution comprising ~70 % of the world’s ice-free coastline, beaches are naturally fragmented by other intertidal marine habitats and extensive coastal development. Sea-level rise is now threatening beaches, particularly along developed coasts through coastal squeeze, with an increased risk of habitat loss and exacerbated fragmentation. Such habitat loss has important implications for population and species persistence, depending on the level of connectivity among populations. While sandy beach macroinfauna tend to be highly mobile across and along shore, they also show a strong bias towards direct, or aplanktonic, development; the latter could reduce opportunities for dispersal and sustained population connectivity. However, comparatively little is known about population connectivity on sandy beaches, limiting scientifically sound management of much of the world’s coastline. This study aims to address this knowledge gap by working towards a conceptual model quantifying population connectivity, and by investigating the specific roles of life history, across-shore zonation, and geographic range as putative indicators and possibly drivers of genetic differentiation (ΦST) and connectivity (gene flow) among beach macroinvertebrate populations. The main hypotheses are that 1) species with a pelagic larval stage will display lower genetic differentiation with higher rates of gene flow among populations than species with a benthic lecithotrophic larval stage or direct development; and 2) genetic differentiation among populations will decrease along an across-shore axis, from the supratidal to the low water mark. Two opposing hypotheses were tested concerning the relationship between genetic structure and distributional range: 3a) Species with a large range (measured as distance and number of latitudes) will show less genetic differentiation than those with a narrow range, because they are more able to disperse; or 3b) more widely distributed species may occur across more phylogenetic | v breaks, and thus show higher genetic differentiation than species restricted to a smaller ranges and single biogeographic provinces. First, the extent and likely drivers of population connectivity were investigated for a suite of temperate South African macroinfauna. Very low, non-significant genetic differentiation was demonstrated for the beach clam Donax serra, thus supporting the hypothesis that pelagic larval dispersers display low/no genetic differentiation among populations (Chapter 2). Statistical power of the COI locus was, however, low in this species, due to reduced genetic variability which could be attributed to an expansion from a small source population into extant habitats. The results highlighted the need for caution when interpreting a lack of genetic differentiation as evidence for population connectivity. Nevertheless, COI sequences verified that D. serra occupying the cool and warm-temperate regions of the South African coast, constitute a single species, despite morphological and behavioural differences between inhabitants of these two bioregions. D. sordidus, a congener of D. serra, and endemic to the warm-temperate (Agulhas) bioregion of South Africa, was investigated to test two opposing hypotheses (Chapter 3): 1) this pelagic larval disperser lack genetic differentiation with high rates of gene flow across its range, or alternatively 2) these clams are genetically structured across their range due to the influence of freshwater input (measured as distance to nearest estuary), and morphodynamics of the surf zone (represented by surf-zone width). Significant global ΦST was estimated for D. sordidus, with differentiation predominantly driven by haplotype frequencies at a single study site and estimates of gene flow among most sample locations generally high. Tentative evidence suggested that natural selection driven by differences in water salinity due to estuarine runoff and surf-zone width, might be maintaining two dominant haplotypes across the range of this species. Beach clams from the Southern Hemisphere, occupying different distributional ranges, were compared to test the hypothesis that genetic structure decreases with an increase in range. This hypothesis was poorly supported by the results; opposite (yet mostly non-significant) trends demonstrated for ΦST and haplotype diversity, thus providing some support for the alternative hypothesis that more phylogeographic breaks in broad-ranging species results in higher estimates of genetic structure in these species.
- Full Text:
- Date Issued: 2020
- Authors: Bezuidenhout, Karien
- Date: 2020
- Subjects: Fishes -- Genetics , Seashore ecology -- South Africa
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10948/45944 , vital:39380
- Description: Open-ocean sandy beaches are highly dynamic ecosystems that continuously respond to waves, tides and storms. These beaches support a suite of uniquely adapted fauna that exhibits a high degree of endemism. This diversity, which also includes some economically important resource species, contributes to the great socio-economic and ecological value of sandy beach systems, which provide ecosystem services such as nutrient recycling and water purification, fish nursery habitat (surf zone), and natural buffering against storms. Despite their broad global distribution comprising ~70 % of the world’s ice-free coastline, beaches are naturally fragmented by other intertidal marine habitats and extensive coastal development. Sea-level rise is now threatening beaches, particularly along developed coasts through coastal squeeze, with an increased risk of habitat loss and exacerbated fragmentation. Such habitat loss has important implications for population and species persistence, depending on the level of connectivity among populations. While sandy beach macroinfauna tend to be highly mobile across and along shore, they also show a strong bias towards direct, or aplanktonic, development; the latter could reduce opportunities for dispersal and sustained population connectivity. However, comparatively little is known about population connectivity on sandy beaches, limiting scientifically sound management of much of the world’s coastline. This study aims to address this knowledge gap by working towards a conceptual model quantifying population connectivity, and by investigating the specific roles of life history, across-shore zonation, and geographic range as putative indicators and possibly drivers of genetic differentiation (ΦST) and connectivity (gene flow) among beach macroinvertebrate populations. The main hypotheses are that 1) species with a pelagic larval stage will display lower genetic differentiation with higher rates of gene flow among populations than species with a benthic lecithotrophic larval stage or direct development; and 2) genetic differentiation among populations will decrease along an across-shore axis, from the supratidal to the low water mark. Two opposing hypotheses were tested concerning the relationship between genetic structure and distributional range: 3a) Species with a large range (measured as distance and number of latitudes) will show less genetic differentiation than those with a narrow range, because they are more able to disperse; or 3b) more widely distributed species may occur across more phylogenetic | v breaks, and thus show higher genetic differentiation than species restricted to a smaller ranges and single biogeographic provinces. First, the extent and likely drivers of population connectivity were investigated for a suite of temperate South African macroinfauna. Very low, non-significant genetic differentiation was demonstrated for the beach clam Donax serra, thus supporting the hypothesis that pelagic larval dispersers display low/no genetic differentiation among populations (Chapter 2). Statistical power of the COI locus was, however, low in this species, due to reduced genetic variability which could be attributed to an expansion from a small source population into extant habitats. The results highlighted the need for caution when interpreting a lack of genetic differentiation as evidence for population connectivity. Nevertheless, COI sequences verified that D. serra occupying the cool and warm-temperate regions of the South African coast, constitute a single species, despite morphological and behavioural differences between inhabitants of these two bioregions. D. sordidus, a congener of D. serra, and endemic to the warm-temperate (Agulhas) bioregion of South Africa, was investigated to test two opposing hypotheses (Chapter 3): 1) this pelagic larval disperser lack genetic differentiation with high rates of gene flow across its range, or alternatively 2) these clams are genetically structured across their range due to the influence of freshwater input (measured as distance to nearest estuary), and morphodynamics of the surf zone (represented by surf-zone width). Significant global ΦST was estimated for D. sordidus, with differentiation predominantly driven by haplotype frequencies at a single study site and estimates of gene flow among most sample locations generally high. Tentative evidence suggested that natural selection driven by differences in water salinity due to estuarine runoff and surf-zone width, might be maintaining two dominant haplotypes across the range of this species. Beach clams from the Southern Hemisphere, occupying different distributional ranges, were compared to test the hypothesis that genetic structure decreases with an increase in range. This hypothesis was poorly supported by the results; opposite (yet mostly non-significant) trends demonstrated for ΦST and haplotype diversity, thus providing some support for the alternative hypothesis that more phylogeographic breaks in broad-ranging species results in higher estimates of genetic structure in these species.
- Full Text:
- Date Issued: 2020