http://vital.seals.ac.za:8080/vital/access/manager/Index ${session.getAttribute("locale")} 5 http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:34985 Wed 13 Mar 2024 14:24:45 SAST ]]> http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:27022 Wed 13 Mar 2024 14:24:31 SAST ]]> http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:27146 Wed 13 Mar 2024 10:40:19 SAST ]]> http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:28713 Wed 13 Mar 2024 10:33:51 SAST ]]> http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:28710 Wed 13 Mar 2024 10:19:37 SAST ]]> http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:28245 Wed 13 Mar 2024 10:12:49 SAST ]]> http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:28237 Wed 13 Mar 2024 10:12:23 SAST ]]> http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:28743 Wed 13 Mar 2024 10:05:43 SAST ]]> http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:27123 Wed 13 Mar 2024 09:58:13 SAST ]]> http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:27121 Wed 13 Mar 2024 09:16:36 SAST ]]> http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:20351 Wed 12 Jul 2023 19:04:25 SAST ]]> http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:28243 Tue 24 May 2022 13:55:37 SAST ]]> http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:35054 Tue 12 Mar 2024 15:27:11 SAST ]]> http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:20633 Tue 10 Aug 2021 12:31:37 SAST ]]> http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:28624 Tue 07 May 2024 11:01:47 SAST ]]> http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:29104 Tue 07 May 2024 10:40:36 SAST ]]> http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:28202 Tue 07 May 2024 10:26:25 SAST ]]> http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:28263 Tue 07 May 2024 10:19:11 SAST ]]> http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:27396 Tue 07 May 2024 10:02:12 SAST ]]> http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:20381 Thu 29 Sep 2022 14:28:44 SAST ]]> http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:20338 Thu 23 Jun 2022 11:24:04 SAST ]]> http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:20319 Thu 16 Mar 2023 12:59:53 SAST ]]> http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:35011 Thu 14 Mar 2024 14:52:04 SAST ]]> http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:39094 Thu 13 May 2021 16:55:53 SAST ]]> http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:39224 0.05) were found amongst all growth performance parameters. The cost efficient treatment to feed, which accumulated the cheapest cost of feed per weight gain (R33.62/kg gain) was T2 (5percent BSC+MM). The second trial was conducted to evaluate the effect of feeding diets containing graded levels of baoabab (A. digitata) seedcake on performance, apparent digestibility and digestive organ weights of broilers chickens. A total of 200 Ross 308 day-old chicks of mixed sex were randomly allocated into 4 treatment groups (T1, T2, T3 and T4). The trial diets were as follows: T1 (control), was a commercial starter diet; while T2, T3 and T4 diets contained baobab seedcake meal at 0, 5, 10, and 15percent; respectively. Inclusion of BSC in diets only affected FI during the first and third weeks. In the first week, FI had significant differences (P < 0.05) during the first and third week of the trial, respectively. Birds in T4 had the least FI, while those in T3 had the highest (P<0.05). In the third week, T3 birds had the highest FI (P<0.05), while T1 birds had the lowest. Significant differences for changes in bodyweight were only evident in the second and forth weeks of the study. During week 2, birds in T had the highest BWG, whereas T4 birds had the lowest (P<0.05); however, in week 4, there were no statistical differences (P>0.05) amongst birds in T1, T2 and T4; respectively, while T4 had the lowest BWG (P<0.05). The FCR was not statistically different among treatment groups, except in week 3, where it was highest in T4birds with T3 birds having the lowest (P<0.05). No significant differences (P>0.05) were observed among treatment groups for all parameters that were considered for digestibility and digestive organ weights. Due to the fact that two different trials were conducted, it was concluded that blend of baobab seedcake and maize from the first trial can be supplemented up to 5 percent replacement level for optimum production; while up to 10 percent baobab seedcake graded level can be used on the second trial without resulting in any negative consequences on growth performance, nutrient utilization and digestive organ weights.]]> Thu 13 May 2021 16:43:57 SAST ]]> http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:29743 Thu 13 May 2021 16:09:25 SAST ]]> http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:26938 Thu 13 May 2021 16:06:08 SAST ]]> http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:29537 Thu 13 May 2021 15:50:41 SAST ]]> http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:27600 Thu 13 May 2021 15:49:26 SAST ]]> http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:20714 Thu 13 May 2021 14:04:26 SAST ]]> http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:26915 Thu 13 May 2021 13:48:30 SAST ]]> http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:26324 Thu 13 May 2021 13:39:47 SAST ]]> http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:27125 Thu 13 May 2021 13:06:44 SAST ]]> http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:27077 Thu 13 May 2021 12:52:31 SAST ]]> http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:20012 Thu 13 May 2021 12:50:32 SAST ]]> http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:39101 Thu 13 May 2021 12:46:24 SAST ]]> http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:27042 Thu 13 May 2021 12:44:37 SAST ]]> http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:28634 Thu 13 May 2021 12:26:59 SAST ]]> http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:28250 Thu 13 May 2021 12:22:53 SAST ]]> http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:20534 Thu 13 May 2021 12:05:56 SAST ]]> http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:2515 Thu 13 May 2021 11:10:48 SAST ]]> http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:26939 Thu 13 May 2021 10:52:27 SAST ]]> http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:27044 Thu 13 May 2021 09:51:22 SAST ]]> http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:27136 Thu 13 May 2021 09:34:06 SAST ]]> http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:26965 Thu 13 May 2021 08:55:37 SAST ]]> http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:26599 0.999 were obtained for each assessment of linearity and FTC, TNF and EFV are linear in the range 0.4-40 μg/ml, 0.6-60 μg/ml and 1.2-120 μg/ml. The equation of the best-fit least squares regression lines for FTC, TNF and EFV were y = 0.0191x+0.0007, y = 0.0163x+0.0116 and y = 0.01x+0.016, respectively. The method is accurate as the y-intercept was < 2% of the detector response for all ARV, and the method is precise in terms of intra- and inter-assay precision as all % RSD < 2%. The stability-indicating nature of the method was demonstrated under acidic, alkaline and oxidative stress in addition to UV exposure and elevated temperatures, and the individual chromatograms were overlaid using Empower® 3 Software to establish whether there was interference with the peaks of interest. The forced degradation studies demonstrated the selectivity of the method for the ARV compounds. The method was applied to assay and in vitro dissolution studies of commercially available tablets. The amount of each active ingredient released from Atripla® was determined and compared to the amount of each drug released from Aspen Efavirenz® and Truvada® (a combination of FTC and TNF). The percent FTC released from Atripla® and Truvada® was similar based on the acceptance criteria for immediate-release BCS class 1 compounds. Statistical analysis was undertaken to compare the dissolution profiles of FTC, TNF and EFV. The percent of these compounds released in these studies indicate that bioequivalence testing would be required to declare these products interchangeable. The validated RP-HPLC and in vitro dissolution test method are suitable for routine quality control testing of solid oral dosage forms containing EFV, FTC and TNF, and as the dissolution method can discriminate between different formulations of the same molecule, these tools can also be used for analysis during formulation development studies. The method is not suitable for the analysis of the ARV plasma due to lack of sensitivity and an inability to quantitate the compounds at the required concentration levels. The use of HPLC with mass spectroscopy for quantitation would enhance the sensitivity of the method and may eliminate the quantitation of the molecules in the presence of interference that was observed when using UV detection. Fixed dose combination tablets are convenient for patient therapy and it is likely that in the future more molecules will be formulated into such dosage forms. However formulations such as these can pose significant difficulties when developing and using analytical methods for the quantitation of all compounds in the dosage form at the same time, in particular when the compounds have vastly different physico-chemical properties that impact the quality of a separation and therefore the analysis. Therefore when embarking on the development of FDC product cognisance of the difficulties of developing single methods for the analyses is required and approaches to overcome these difficulties should be considered.]]> Thu 13 May 2021 08:54:37 SAST ]]> http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:39104 Thu 13 May 2021 08:52:39 SAST ]]> http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:20550 Thu 13 May 2021 08:49:20 SAST ]]> http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:28468 Thu 13 May 2021 08:48:08 SAST ]]> http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:20044 Thu 13 May 2021 08:47:55 SAST ]]> http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:20314 Thu 13 May 2021 08:44:57 SAST ]]> http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:38918 Thu 13 May 2021 08:25:28 SAST ]]> http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:6013 Thu 13 May 2021 08:23:15 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