http://vital.seals.ac.za:8080/vital/access/manager/Index ${session.getAttribute("locale")} 5 Analysis of macrolide antibiotics http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:7011 Wed 15 May 2024 15:01:03 SAST ]]> A stability-indicating high performance liquid chromatographic assay for the determination of orlistat in capsules http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:6407 Wed 12 May 2021 17:05:39 SAST ]]> DSC screening of potential prochlorperazine-excipient interactions in preformulation studies http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:44212 Wed 08 May 2024 17:31:23 SAST ]]> A comparative study of the effect of different stabilizers on the critical quality attributes of self-assembling nano co-crystals http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:43931 Wed 08 May 2024 15:56:39 SAST ]]> Top-Down Synthesis of a Lamivudine-Zidovudine Nano Co-Crystal http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:43918 Wed 08 May 2024 15:56:19 SAST ]]> Nano Co-Crystal Embedded Stimuli-Responsive Hydrogels: A Potential Approach to Treat HIV/AIDS http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:43915 Wed 08 May 2024 15:55:59 SAST ]]> The identification of the UV degradants of melatonin and their ability to scavenge free radicals http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:44198 Tue 14 May 2024 12:23:38 SAST ]]> Role of percutaneous penetration enhancers http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:6446 Tue 14 May 2024 12:13:49 SAST ]]> Analysis of chromameter results obtained from corticosteroid-induced skin blanching. I. Manipulation of data http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:6424 Tue 14 May 2024 12:12:30 SAST ]]> Melatonin alters the photodegradation of paracetamol http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:44211 Tue 14 May 2024 12:11:47 SAST ]]> Cyanide-induced free radical production and lipid peroxidation in rat brain homogenate is reduced by aspirin http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:44210 Tue 14 May 2024 12:11:22 SAST ]]> Application of the Minolta chromameter to the assessment of corticosteroid-induced skin blanching http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:6451 Tue 14 May 2024 12:10:50 SAST ]]> An investigation into the neuroprotective properties of ibuprofen http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:44209 Tue 14 May 2024 12:10:24 SAST ]]> The effect of variations in pH and temperature on stability of melatonin in aqueous solution http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:44207 Tue 14 May 2024 12:10:00 SAST ]]> A sensitive and reliable method for the detection of lipid peroxidation in biological tissues http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:44208 Tue 14 May 2024 12:09:37 SAST ]]> An assessment of the efficacy of two lysine microencapsulation techniques to determine the quantitative lysine requirement of the South African abalone, Haliotis midae L http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:44197 0.05). The failure of the crystalline L-lysine to illicit growth and nutritional responses is discussed.]]> Tue 14 May 2024 12:09:09 SAST ]]> 6-Hydroxymelatonin protects against cyanide induced oxidative stress in rat brain homogenates http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:6405 Tue 14 May 2024 12:08:45 SAST ]]> Spotlight on research: 50 years of Pharmaceutical Sciences Research Excellence Faculty of Pharmacy Rhodes University http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:44193 Tue 14 May 2024 12:08:09 SAST ]]> A stability-indicating high performance liquid chromatographic assay for the determination of orlistat in capsules http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:44195 Tue 14 May 2024 12:07:00 SAST ]]> Development and validation of a stability-indicating method for the quantitation of paclitaxel in pharmaceutical dosage forms http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:44196 Tue 14 May 2024 12:02:22 SAST ]]> The determination of acetaminophen using a carbon nanotube: graphite-based electrode http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:6414 Tue 14 May 2024 12:01:53 SAST ]]> Development of a stability-indicating high performance liquid chromatographic method for the analysis of topiramate and dissolution rate testing in topiramate tablets http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:6412 Tue 14 May 2024 12:00:38 SAST ]]> The use of experimental design in the development of an HPLC–ECD method for the analysis of captopril http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:44163 Tue 14 May 2024 11:59:47 SAST ]]> Selection and characterization of suitable lipid excipients for use in the manufacture of didanosine-loaded solid lipid nanoparticles and nanostructured lipid carriers http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:44156 Tue 14 May 2024 11:59:25 SAST ]]> Formulation development and in vitro evaluation of didanosine-loaded nanostructured lipid carriers for the potential treatment of AIDS dementia complex http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:44190 Tue 14 May 2024 11:59:01 SAST ]]> Evaluation of the kinetics and mechanism of drug release from Econazole nitrate nanosponge loaded Carbapol Hydrogel http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:6437 Tue 14 May 2024 11:58:32 SAST ]]> Evaluation of the in vitro differential protein adsorption patterns of didanosine-loaded nanostructured lipid carriers (NLCs) for potential targeting to the brain http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:44160 Tue 14 May 2024 11:58:13 SAST ]]> The use of response surface methodology to evaluate the impact of level 2 SUPAC–IR changes on the in vitro release of metronidazole and ranitidine from a fixed-dose combination tablet http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:6391 Tue 14 May 2024 11:57:36 SAST ]]> The use of hot and cold high pressure homogenization to enhance the loading capacity and encapsulation efficiency of nanostructured lipid carriers for the hydrophilic antiretroviral drug, didanosine for potential administration to paediatric patients http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:44170 Tue 14 May 2024 11:57:11 SAST ]]> Syntheses, protonation constants and antimicrobial activity of 2-substituted N-alkylimidazole derivatives http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:44165 2500 µg mL–1) bacteria and all the compounds were inactive against the yeast (Candida albicans).]]> Tue 14 May 2024 11:56:44 SAST ]]> Forced degradation studies of clobetasol 17‐propionate in methanol, propylene glycol, as bulk drug and cream formulations by RP‐HPLC http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:44154 Tue 14 May 2024 11:56:10 SAST ]]> HPLC method for simultaneous analysis of ranitidine and metronidazole in dosage forms http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:44272 Tue 14 May 2024 11:55:37 SAST ]]> Electro‐oxidation of acetaminophen on nickel/poly (o‐aminophenol)/multi‐walled carbon nanotube nanocomposite modified graphite electrode. http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:44173 Tue 14 May 2024 11:55:13 SAST ]]> Electropolymerized Fluorinated Aniline-Based Fiber for Headspace Solid-Phase Microextraction and Gas Chromatographic Determination of Benzaldehyde in Injectable Pharmaceutical Formulations http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:44175 Tue 14 May 2024 11:54:39 SAST ]]> Synthesis and characterization of ZnO nanoparticle synthesized by a microwave-assisted combustion method and catalytic activity for the removal of ortho-nitrophenol http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:44075 Tue 14 May 2024 11:54:16 SAST ]]> Amoxicillin removal from aqueous media using multi-walled carbon nanotubes http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:44076 Tue 14 May 2024 11:53:48 SAST ]]> Academy of Pharmaceutical Sciences http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:44270 Tue 14 May 2024 11:52:49 SAST ]]> Quantitation of zolpidem in biological fluids by electro-driven microextraction combined with HPLC-UV analysis http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:44266 75 within 15 minutes. The effect of carbon nanotubes (as solid nano-sorbents) on the membrane performance and EME efficiency was evaluated. The method was linear over the range of 10-1000 ng/mL for zolpidem (R2 >0.9991) with repeatability (%RSD) between 0.3 % and 7.3 % (n = 3). The limits of detection and quantitation were 3 and 10 ng/mL, respectively. The sensitivity of HPLC-UV for the determination of zolpidem was enhanced by electromembrane extraction. Finally, the method was employed for the quantitation of zolpidem in biological samples with relative recoveries in the range of 60-79 %.]]> Tue 14 May 2024 11:52:00 SAST ]]> Development, manufacture and characterization of niosomes for the delivery for nevirapine http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:44002 Tue 14 May 2024 11:51:22 SAST ]]> Development and Validation of a Stability-indicating RP-HPLC Method Using Quality by Design for Estimating Captopril http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:44003 2) for captopril and the internal standard with retention times of 3.1 and 6.2 min, respectively. The experimental data revealed that acetonitrile content in the mobile phase and pH are significant factors that affect the retention time and resolution of captopril. Normal probability plots revealed that the residual and predicted data fall approximately on a straight line, indicating that the experimental error for these studies was evenly distributed suggesting that the model could be used to navigate the design space. This approach is useful to expedite method development and optimization activities in analytical laboratories.]]> Tue 14 May 2024 11:50:59 SAST ]]> The impact of formulation variables on the optimization of pilot scale clobetasol 17-propionate creams http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:43937 Tue 14 May 2024 11:50:16 SAST ]]> Quality by Design Optimization of Cold Sonochemical Synthesis of Zidovudine-Lamivudine Nanosuspensions: http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:38738 Tue 14 May 2024 11:49:46 SAST ]]> Improved Stability of Rifampicin in the Presence of Gastric-Resistant Isoniazid Microspheres in Acidic Media http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:43929 Tue 14 May 2024 11:49:17 SAST ]]> Application of quality by design principles for optimizing process variables of Extrusion and Spheronization of a Captopril Pellet Formulation: http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:40098 Tue 14 May 2024 11:47:44 SAST ]]> Preformulation characterization and identification of excipients for nevirapine loaded niosomes http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:43914 Tue 14 May 2024 11:47:04 SAST ]]> Short term stability testing of efavirenz-loaded solid lipid nanoparticle (SLN) and nanostructured lipid carrier (NLC) dispersions http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:44000 90%. The optimized nanocarriers exhibited biphasic in vitro release patterns with an initial burst release during the initial 0–3 h followed by sustained release over a 24 h period The colloidal systems showed excellent stability in terms of Zeta potential, particle size, polydispersity index and encapsulation efficiency when stored for 8 weeks at 25 °C/60% RH in comparison to when stored at 40 °C/75% RH. The formulations manufactured using the optimized conditions and composition proved to be physically stable as aqueous dispersions.]]> Tue 14 May 2024 11:14:37 SAST ]]> Preformulation studies of efavirenz with lipid excipients using thermal and spectroscopic techniques http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:43934 Tue 14 May 2024 11:13:58 SAST ]]> Nano-biomimetic drug delivery vehicles: Potential approaches for COVID-19 treatment http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:43991 Tue 14 May 2024 11:13:22 SAST ]]> Biocompatibility of biomaterials for nanoencapsulation: Current approaches http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:43939 Tue 14 May 2024 11:12:53 SAST ]]> Enhancement of Biological and Pharmacological Properties of an Encapsulated Polyphenol: Curcumin http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:43917 Tue 14 May 2024 11:12:23 SAST ]]> Evaluation of rate of swelling and erosion of verapamil (VRP) sustained-release matrix tablets http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:44192 Tue 14 May 2024 11:05:45 SAST ]]> The effects of buffer molarity, agitation rate and mesh size on verapamil release from modified release mini-tablets using USP Apparatus 3 http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:6386 Tue 14 May 2024 11:05:12 SAST ]]> The evaluation of Eudragit microcapsules manufactured by solvent evaporation using USP Apparatus 1 http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:6389 Tue 14 May 2024 11:04:45 SAST ]]> Swelling, erosion and drug release characteristics of salbutamol sulfate from hydroxypropyl methylcellulose-based matrix tablets http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:44177 Tue 14 May 2024 11:04:25 SAST ]]> Drug transport mechanisms from carbopol/eudragit verapamil sustained-release tablets http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:44273 Tue 14 May 2024 11:03:40 SAST ]]> The use of response surface methodology in the evaluation of captopril microparticles manufactured using an oil in oil solvent evaporation technique http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:44191 Tue 14 May 2024 11:03:22 SAST ]]> In vitro dissolution kinetics of Captopril from microspheres manufactured by solvent evaporation http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:6390 Tue 14 May 2024 11:02:59 SAST ]]> The impact of manufacturing variables on in vitro release of clobetasol 17-propionate from pilot scale cream formulations http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:44077 Tue 14 May 2024 11:02:38 SAST ]]> Development and assessment of a USP Apparatus 3 dissolution test method for sustained-release Nevirapine matrix tablets http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:44271 80% NVP was released from the tablets over the test period. The NVP release rate increased with an increase in the mesh pore size; however, the extent of release was not affected by this parameter. Dissolution test samples were analyzed using HPLC, and dissolution methods were validated for NVP stability in the dissolution medium, specificity, linearity and range, repeatability, intermediate precision, and accuracy as defined by ICH. The dissolution method used for testing NVP tablets can be regarded as an appropriate tool for the evaluation of sustained-release (SR) NVP formulations and the impact of formulation composition and product quality attributes on drug release.]]> Tue 14 May 2024 11:01:21 SAST ]]> The use of experimental design for the development of a capillary zone electrophoresis method for the quantitation of captopril http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:44073 Tue 14 May 2024 10:59:49 SAST ]]> The use of experimental design for the development and validation of an HPLC-ECD method for the quantitation of efavirenz http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:44006 Tue 14 May 2024 10:59:25 SAST ]]> Stability indicating HPLC-ECD method for the analysis of clarithromycin in pharmaceutical dosage forms: Method scaling versus re-validation. http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:43984 Tue 14 May 2024 10:58:54 SAST ]]> Design, evaluation and optimization of taste masked clarithromycin powder http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:44001 Tue 14 May 2024 10:58:36 SAST ]]> An artificial neural network approach to predict the effects of formulation and process variables on prednisone release from a multipartite system http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:43933 Tue 14 May 2024 10:58:09 SAST ]]> The use of quantitative analysis and Hansen solubility parameter predictions for the selection of excipients for lipid nanocarriers to be loaded with water soluble and insoluble compounds http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:43981 Tue 14 May 2024 10:57:46 SAST ]]> Formulation optimization of smart thermosetting lamotrigine loaded hydrogels using response surface methodology, box benhken design and artificial neural networks http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:43936 Tue 14 May 2024 10:57:23 SAST ]]> Formulation and Characterisation of a Combination Captopril and Hydrochlorothiazide Microparticulate Dosage Form http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:43926 75% for both hydrochlorothiazide and captopril. The microparticulate technology is able to offer potential resolution to the half-life mediated dosing frequency of captopril as sustained release of the molecule was observed over a 12-h period. The release of hydrochlorothiazide of >80% suggests an improvement in solubility limited dissolution.]]> Tue 14 May 2024 10:56:57 SAST ]]> Design, Optimization, Manufacture and Characterization of Efavirenz-Loaded Flaxseed Oil Nanoemulsions http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:43919 Tue 14 May 2024 10:55:07 SAST ]]> Assessment of taste masking of captopril by ion-exchange resins using electronic gustatory system http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:44265 Tue 14 May 2024 10:54:47 SAST ]]> Muco-adhesive clarithromycin-loaded nanostructured lipid carriers for ocular delivery: Formulation, characterization, cytotoxicity and stability http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:43916 Tue 14 May 2024 10:54:28 SAST ]]> Sensitive high-performance liquid chromatographic determination of cyclizine and its demethylated metabolite, norcyclizine, in biological fluids using coulometric detection http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:6452 Tue 14 May 2024 10:46:51 SAST ]]> Pharmacokinetics of cyclizine following intravenous administration to human volunteers http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:44214 Tue 14 May 2024 10:46:29 SAST ]]> Evaluation of the proposed FDA pilot-dose response methodology for topical corticosteroid bioeqivalence testing [authors' reply in Letters to the Editor] http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:6423 Tue 14 May 2024 10:44:40 SAST ]]> Bioequivalence assessment of generic products an innovative South African approach http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:44194 Tue 14 May 2024 10:40:36 SAST ]]> Suppositories: An underutilized dosage form http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:44264 Tue 14 May 2024 06:40:41 SAST ]]> In vitro release of amoxycillin from lipophilic suppositories http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:44213 Tue 14 May 2024 06:39:32 SAST ]]> Co-encapsulation of rifampicin and isoniazid in crude soybean lecithin liposomes http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:44005 Tue 07 May 2024 15:41:08 SAST ]]> Simultaneous liposomal encapsulation of antibiotics and proteins: co-loading and characterization of rifampicin and Human Serum Albumin in soy-liposomes http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:38755 Tue 07 May 2024 15:39:13 SAST ]]> Encapsulation and physicochemical evaluation of efavirenz in liposomes http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:43988 Tue 07 May 2024 15:38:35 SAST ]]> Co-loading of isoniazid-grafted phthalocyanine-in-cyclodextrin and rifampicin in crude soybean lecithin liposomes: Formulation, spectroscopic and biological characterization http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:43999 Tue 07 May 2024 15:37:11 SAST ]]> Ultrasound-Triggered Release of 5-Fluorouracil from Soy Lecithin Echogenic Liposomes http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:43913 Tue 07 May 2024 15:34:35 SAST ]]> Preparation and characterization of isoniazid-loaded crude soybean lecithin liposomes http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:35804 Tue 07 May 2024 12:39:53 SAST ]]>