http://vital.seals.ac.za:8080/vital/access/manager/Index ${session.getAttribute("locale")} 5 http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:10341 0.5 - 4 mg/mL. The aqueous extract of A. afra displayed inhibition of HIV-1 integrase ˃52.16 percent at 0.5 mg/mL increasing to 72.89 percent at 4 mg/ml of the extract. A. muricata was cytotoxic at an IC50 of 30 μg/mL and 77 μg/mL on Chang Liver and HepG2 cells respectively, whilst A. afra aqueous and ethanol extracts were not cytotoxic to both cell lines. The ethanolic extract of A. muricata showed both antagonistic and synergistic properties at various IC values, when used in conjunction with rifampicin. A. afra ethanolic extract interrupted GST activity while aqueous extracts of A. afra and A. muricata had a slight effect. All extracts interrupted CYP3A4 activity, however the ethanolic extracts of A. muricata and A. afra showed greater inhibition than the aqueous extract of A. afra. These extracts should be investigated further as they could be an important source of compounds for treatment of M. tuberculosis and HIV respectively.]]> Wed 12 May 2021 19:09:52 SAST ]]> http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:20453 Wed 12 May 2021 18:01:45 SAST ]]> http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:20395 Wed 12 May 2021 17:46:30 SAST ]]> http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:28276 Thu 13 May 2021 09:28:28 SAST ]]>