http://vital.seals.ac.za:8080/vital/access/manager/Index ${session.getAttribute("locale")} 5 http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:10341 0.5 - 4 mg/mL. The aqueous extract of A. afra displayed inhibition of HIV-1 integrase ˃52.16 percent at 0.5 mg/mL increasing to 72.89 percent at 4 mg/ml of the extract. A. muricata was cytotoxic at an IC50 of 30 μg/mL and 77 μg/mL on Chang Liver and HepG2 cells respectively, whilst A. afra aqueous and ethanol extracts were not cytotoxic to both cell lines. The ethanolic extract of A. muricata showed both antagonistic and synergistic properties at various IC values, when used in conjunction with rifampicin. A. afra ethanolic extract interrupted GST activity while aqueous extracts of A. afra and A. muricata had a slight effect. All extracts interrupted CYP3A4 activity, however the ethanolic extracts of A. muricata and A. afra showed greater inhibition than the aqueous extract of A. afra. These extracts should be investigated further as they could be an important source of compounds for treatment of M. tuberculosis and HIV respectively.]]> Wed 12 May 2021 19:09:52 SAST ]]> http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:11302 Wed 12 May 2021 18:20:05 SAST ]]> http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:41600 Wed 12 May 2021 14:54:37 SAST ]]> http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:10316 125 μg/ml. These results suggest that the extract may be selective for specific cell types. Bio-assay guided fractionation of the S. ellipticum ethanolic extract yielded two active fractions; chloroform and ethyl acetate. Two compounds isolated from the chloroform extract were screened against the three cancer cell lines and found to be inactive. Three compounds were isolated from the ethyl acetate fraction and revealed IC50 values < 62.5 and < 31 μg/ml against MCF-7. Unfortunately these two compounds soon lost activity before any further work could be done on them and work was continued with the crude extract.]]> Thu 13 May 2021 05:53:54 SAST ]]> http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:11883 Thu 13 May 2021 00:48:32 SAST ]]> http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:10315 Thu 13 May 2021 00:16:57 SAST ]]>