- Title
- Synthesis, antiplasmodial and antitrypanosomal evaluation of a series of novel 2-oxoquinoline-based thiosemicarbazone derivatives
- Creator
- Darrell, Oliver T
- Creator
- Hulushe, Siyabonga T
- Creator
- Mtshare, Thanduxolo Elihle
- Creator
- Beteck, Richard M
- Creator
- Isaacs, Michelle
- Creator
- Laming, Dustin
- Creator
- Khanye, Setshaba D
- Creator
- Hoppe, Heinrich C
- Creator
- Krause, Rui W M
- Date Issued
- 2018
- Date
- 2018
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/123117
- Identifier
- vital:35407
- Identifier
- https://doi.org/10.17159/0379-4350/2018/v71a25
- Description
- Herein a series of novel thiosemicarbazones (TSCs) derived from 2-oxoquinoline scaffold is reported, and the target compounds have been successfully synthesized and characterized using standard spectroscopic techniques. The in vitro biological activities of synthesized molecules were evaluated against Plasmodium falciparum malaria parasites (strain 3D7), Trypanosoma brucei brucei parasites (strain 427) and HeLa cells. All the compounds displayed modest or no activity at a concentration of 20 μM and percentage viability of >50 % was often observed. Except for compound 9o, none of the final compounds exhibited cytotoxic effects against HeLa cells at 20 μM.
- Format
- 8 pages
- Format
- Language
- English
- Relation
- South African Journal of Chemistry
- Relation
- Darrell, O.T., Hulushe, S.T., Mtshare, T.E., Beteck, R.M., Isaacs, M., Laming, D., Hoppe, H.C., Krause, R.W. and Khanye, S.D., 2018. Synthesis, antiplasmodial and antitrypanosomal evaluation of a series of novel 2-oxoquinoline-based thiosemicarbazone derivatives. South African Journal of Chemistry, 71(1), pp.174-181.
- Relation
- South African Journal of Chemistry number 71 174 181 March 2018 1996-840X
- Rights
- South African Journal of Chemistry
- Rights
- Use of this resource is governed by the terms and conditions of the South African Journal of Chemistry Open Access Statement (http://www.scielo.org.za/revistas/sajc/iaboutj.htm)
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Khanye, David Setshaba (Associate Prof)
Krause, Rui Werner Maçedo (Prof)
RU Centre for Chemico- and Biomedicinal Research (CCBR)
Hoppe, Heinrich C (Prof)
Isaacs, Michelle (Mrs)
RU Department of Pharmacy
SDG 03. Good Health and Well-Being
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