- Title
- Preparation and characterization of isoniazid-loaded crude soybean lecithin liposomes
- Creator
- Nkanga, Christian I
- Creator
- Isaacs, Michelle
- Creator
- Noundou, Xavier S
- Creator
- Krause, Rui W M
- Creator
- Walker, Roderick B
- Date Issued
- 2017
- Date
- 2017
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/125654
- Identifier
- vital:35804
- Identifier
- https://doi.org/10.1016/j.ijpharm.2017.04.074
- Description
- Unexpected substituent-dependent regioselectivty challenges in the synthesis of C-benzylated (N-arylcarbamoyl)phosphonate esters have been resolved. The C-benzylated N-furfurylcarbamoyl derivative showed low micromolar PfLDH inhibition, while one of the C-benzylated N-arylcarbamoyl analogues was active against Nagana Trypanosoma brucei parasites which are responsible for African trypanosomiasis in cattle.
- Format
- 7 pages
- Format
- Language
- English
- Relation
- Tetrahedron
- Relation
- Adeyemi, C.M., Isaacs, M., Mnkandhla, D., Klein, R., Hoppe, H.C., Krause, R.W., Lobb, K.A. and Kaye, P.T., 2017. Synthesis and anti-parasitic activity of C-benzylated (N-arylcarbamoyl) alkylphosphonate esters. Tetrahedron, 73(13), pp.1661-1667.
- Relation
- Tetrahedron number 526 number 1-2 466 473 2017 1873-3476
- Rights
- International journal of pharmaceutics
- Rights
- Use of this resource is governed by the terms and conditions of the Elsevier Terms and Conditions Statement (https://www.elsevier.com/legal/elsevier-website-terms-and-conditions)
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Walker, Roderick Bryan (Prof)
Isaacs, Michelle (Mrs)
RU Department of Pharmacy
Krause, Rui Werner Maçedo (Prof)
RU Department of Chemistry
SDG 03. Good Health and Well-Being
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