The evaluation of melatonin as a possible antidepressive

Title: The evaluation of melatonin as a possible antidepressive
Creator: Skene, Debra Jean
Subject: Melatonin
Subject: Antidepressants
Date Issued: 1980
Date: 1980
Type: Thesis
Type: Masters
Type: MSc
Identifier: vital:3728
Identifier: http://hdl.handle.net/10962/d1001465
Description: Melatonin, a hormone of the pineal gland, was evaluated in a variety of animal models of depression. Measurements of the frog righting reflex and rat locomotor activity showed that low doses of melatonin have a serotonin-like potentiating effect following monoamine oxidase inhibition. High doses of melatonin caused a reduction in the duration of rat immobility in the Porsolt model of depression and exerted a chlorpromazine-like effect on conditioned avoidance behaviour. In view of the indoleamine hypothesis of depressive disorders, the possibility of melatonin being a potential antidepressive is discussed and it is concluded that melatonin might be useful in the treatment of "agitated" depressions
Format: 349 leaves
Format: pdf
Publisher: Rhodes University
Publisher: Faculty of Pharmacy, Pharmacy
Language: English
Rights: Skene, Debra Jean

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