- Title
- Structure based docking and molecular dynamic studies of plasmodial cysteine proteases against a South African natural compound and its analogs:
- Creator
- Musyoka, Thommas M
- Creator
- Kanzi, Aquillah M
- Creator
- Lobb, Kevin A
- Creator
- Tastan Bishop, Özlem
- Date Issued
- 2016
- Date
- 2016
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/148027
- Identifier
- vital:38703
- Identifier
- DOI: 10.1038/srep23690
- Description
- Identification of potential drug targets as well as development of novel antimalarial chemotherapies with unique mode of actions due to drug resistance by Plasmodium parasites are inevitable. Falcipains (falcipain-2 and falcipain-3) of Plasmodium falciparum, which catalyse the haemoglobin degradation process, are validated drug targets. Previous attempts to develop peptide based drugs against these enzymes have been futile due to the poor pharmacological profiles and susceptibility to degradation by host enzymes. This study aimed to identify potential non-peptide inhibitors against falcipains and their homologs from other Plasmodium species.
- Format
- 13 pages
- Format
- Language
- English
- Relation
- Scientific reports
- Relation
- Musyoka, T.M., Kanzi, A.M., Lobb, K.A. and Bishop, Ö.T., 2016. Structure based docking and molecular dynamic studies of plasmodial cysteine proteases against a South African natural compound and its analogs. Scientific reports, 6, p.23690.
- Relation
- Scientific reports volume 6 number 23690 23690 March 2016 2045-2322
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the Nature Open Access statement (http://www.nature.com/openresearch/publishing-with-npg/)
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Tastan Bishop, Ozlem (Prof)
RU Research Unit in Bioinformatics (RUBi)
Lobb, Kevin Allan (Assoc Prof)
RU Department of Chemistry
SDG 03. Good Health and Well-Being
RU Department of Biochemistry, Microbiology and Bioinformatics
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | SOURCE1 | Structure based docking and molecular dynamic studies of plasmodial.pdf | 5 MB | Adobe Acrobat PDF | View Details Download |