No evidence for association with APOL1 kidney disease risk alleles and Human African Trypanosomiasis in two Ugandan populations:

Kimuda, Magambo Phillip; Noyes, Harry; Mulindwa, Julius; Enyaru, John; Alibu, Vincent Pius; Sidibe, Issa; Mumba, Dieuodonne; Hertz-Fowler, Christiane; MacLeod, Annette; Tastan Bishop, Özlem; Matovu, Enock

Title: No evidence for association with APOL1 kidney disease risk alleles and Human African Trypanosomiasis in two Ugandan populations:
Creator: Kimuda, Magambo Phillip
Creator: Noyes, Harry
Creator: Mulindwa, Julius
Creator: Enyaru, John
Creator: Alibu, Vincent Pius
Creator: Sidibe, Issa
Creator: Mumba, Dieuodonne
Creator: Hertz-Fowler, Christiane
Creator: MacLeod, Annette
Creator: Tastan Bishop, Özlem
Creator: Matovu, Enock
Date Issued: 2017
Date: 2017
Type: text
Type: article
Identifier: http://hdl.handle.net/10962/148272
Identifier: vital:38725
Identifier: doi: 10.1371/journal.pntd.0006300
Description: Human African trypanosomiasis (HAT) manifests as an acute form caused by Trypanosoma brucei rhodesiense (Tbr) and a chronic form caused by Trypanosoma brucei gambiense (Tbg). Previous studies have suggested a host genetic role in infection outcomes, particularly for APOL1. We have undertaken a candidate gene association studies (CGAS) in a Ugandan Tbr and a Tbg HAT endemic area, to determine whether polymorphisms in IL10, IL8, IL4, HLAG, TNFA, TNX4LB, IL6, IFNG, MIF, APOL1, HLAA, IL1B, IL4R, IL12B, IL12R, HP, HPR, and CFH have a role in HAT.
Format: 24 pages
Format: pdf
Language: English
Relation: bioRxiv
Relation: Kimuda, M.P., Noyes, H., Mulindwa, J., Enyaru, J., Alibu, V.P., Sidibe, I., Mumba, D., Hertz-Fowler, C., MacLeod, A., Bishop, O.T. and Matovu, E., 2017. No evidence for association with APOL1 kidney disease risk alleles and Human African Trypanosomiasis in two Ugandan populations. bioRxiv, p.180679.
Relation: bioRxiv volume number p.180679 2017
Rights: Publisher
Rights: Use of this resource is governed by the terms and conditions of the bioRxiv Open Access Statement (https://www.biorxiv.org/about-biorxiv)

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Tastan Bishop, Ozlem (Prof)

RU Research Unit in Bioinformatics (RUBi)

RU Department of Biochemistry, Microbiology and Biotechnology

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