Simultaneous liposomal encapsulation of antibiotics and proteins: co-loading and characterization of rifampicin and Human Serum Albumin in soy-liposomes

Bapolisi, Alain M; Nkanga, Christian I; Walker, Roderick B; Krause, Rui W M

Title: Simultaneous liposomal encapsulation of antibiotics and proteins: co-loading and characterization of rifampicin and Human Serum Albumin in soy-liposomes
Creator: Bapolisi, Alain M
Creator: Nkanga, Christian I
Creator: Walker, Roderick B
Creator: Krause, Rui W M
Date Issued: 2020
Date: 2020
Type: text
Type: article
Identifier: http://hdl.handle.net/10962/148617
Identifier: vital:38755
Identifier: https://doi.org/10.1016/j.jddst.2020.101751
Description: The recurrent development of resistance to antimicrobial agents threatens the ability for successful treatment of infectious diseases. Hydrophobic antibiotics such as rifampicin (Rif) are particularly affected due to poor bioavailability. On the other hand, proteins play important roles in drug delivery and release. Further, the combination of antimicrobials with therapeutic proteins and their encapsulation in liposomes seems a promising approach for improvement of antimicrobial efficacy. This study aimed to encapsulate Rif simultaneously with a large protein, Human Serum Albumin (HSA) in liposomes made from an inexpensive crude soy lecithin (CSL).
Format: 13 pages
Format: pdf
Language: English
Relation: Journal of Drug Delivery Science and Technology
Relation: Bapolisi, A.M., Nkanga, C.I., Walker, R.B. and Krause, R.W.M., 2020. Simultaneous liposomal encapsulation of antibiotics and proteins: Co-loading and characterization of rifampicin and Human Serum Albumin in soy-liposomes. Journal of Drug Delivery Science and Technology, 58, p.101751.
Relation: Journal of Drug Delivery Science and Technology volume 58 number p.101751 August 2020 1773-2247
Rights: Publisher
Rights: Use of this resource is governed by the terms and conditions of the Elsevier Terms and Conditions Statement (https://www.elsevier.com/legal/elsevier-website-terms-and-conditions)

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RU Centre for Chemico- and Biomedicinal Research (CCBR)

Walker, Roderick Bryan (Prof)

RU Department of Pharmacy

Krause, Rui Werner Maçedo (Prof)

RU Department of Chemistry

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