The in vitro antiplasmodial and antiproliferative activity of new ferrocene-based α-aminocresols targeting hemozoin inhibition and DNA interaction:

Mbaba, Mziyanda; Dingle, Laura M K; Swart, Tarryn; Cash, Devon; Laming, Dustin; de la Mare, Jo-Anne; Taylor, Dale; Hoppe, Heinrich C; Biot, Christophe; Edkins, Adrienne L; Khanye, Setshaba D

Title: The in vitro antiplasmodial and antiproliferative activity of new ferrocene-based α-aminocresols targeting hemozoin inhibition and DNA interaction:
Creator: Mbaba, Mziyanda
Creator: Dingle, Laura M K
Creator: Swart, Tarryn
Creator: Cash, Devon
Creator: Laming, Dustin
Creator: de la Mare, Jo-Anne
Creator: Taylor, Dale
Creator: Hoppe, Heinrich C
Creator: Biot, Christophe
Creator: Edkins, Adrienne L
Creator: Khanye, Setshaba D
Date Issued: 2020
Date: 2020
Type: text
Type: article
Identifier: http://hdl.handle.net/10962/149347
Identifier: vital:38827
Identifier: https://0-doi.org.wam.seals.ac.za/10.1002/cbic.202000132
Description: Compounds incorporating ferrocene in a aminocresol scaffold showed antiplasmodial and anticancer activity. SAR studies revealed that an OH group and rotatable C–NH bond are vital for biological activity, with spectrophotometric techniques and docking simulations suggesting a dual mode of action involving hemozoin inhibition and DNA interaction. Targeting multiple pathways could delay the development of clinical resistance.
Format: 17 pages
Format: pdf
Language: English
Relation: ChemBioChem
Relation: Mbaba, M., Dingle, L.M., Swart, T., Cash, D., Laming, D., de la Mare, J.A., Taylor, D., Hoppe, H.C., Biot, C., Edkins, A.L. and Khanye, S.D., 2020. The in vitro antiplasmodial and antiproliferative activity of new ferrocene‐based α‐aminocresols targeting hemozoin inhibition and DNA interaction. ChemBioChem.
Relation: ChemBioChem volume number April 2020 1439-7633
Rights: Publisher
Rights: Use of this resource is governed by the terms and conditions of the Chemistry Europe Terms of use Statement (https://0-onlinelibrary.wiley.com.wam.seals.ac.za/terms-and-conditions)

Hits: 4697
Visitors: 4782
Downloads: 138

Collections