The In Silico Prediction of hotspot residues that contribute to the structural stability of subunit interfaces of a Picornavirus Capsid:

Upfold, Nicole; Ross, Caroline J; Tastan Bishop, Özlem; Knox, Caroline M

Title: The In Silico Prediction of hotspot residues that contribute to the structural stability of subunit interfaces of a Picornavirus Capsid:
Creator: Upfold, Nicole
Creator: Ross, Caroline J
Creator: Tastan Bishop, Özlem
Creator: Knox, Caroline M
Date Issued: 2020
Date: 2020
Type: text
Type: article
Identifier: http://hdl.handle.net/10962/149970
Identifier: vital:38919
Identifier: https://doi.org/10.3390/v12040387
Description: The assembly of picornavirus capsids proceeds through the stepwise oligomerization of capsid protein subunits and depends on interactions between critical residues known as hotspots. Few studies have described the identification of hotspot residues at the protein subunit interfaces of the picornavirus capsid, some of which could represent novel drug targets. Using a combination of accessible web servers for hotspot prediction, we performed a comprehensive bioinformatic analysis of the hotspot residues at the intraprotomer, interprotomer and interpentamer interfaces of the Theiler’s murine encephalomyelitis virus (TMEV) capsid.
Format: 22 pages
Format: pdf
Language: English
Relation: Viruses
Relation: Upfold, N., Ross, C., Tastan Bishop, Ö. and Knox, C., 2020. The In Silico Prediction of Hotspot Residues that Contribute to the Structural Stability of Subunit Interfaces of a Picornavirus Capsid. Viruses, 12(4), p.387.
Relation: Viruses volume 12 number 4 p.387 March 2020 1999-4915
Rights: Publisher
Rights: Use of this resource is governed by the terms and conditions of the MDPI Open Access Statement (https://www.int-res.com/journals/terms-of-use/)

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Knox, Caroline M (Prof)

Tastan Bishop, Ozlem (Prof)

RU Research Unit in Bioinformatics (RUBi)

RU Department of Biochemistry, Microbiology and Bioinformatics

SDG 03. Good Health and Well-Being

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