‘There is nothing to hold onto here’:

Shabangu, Samuel M; Babu, Balaji; Soy, Rodah C; Managa, Muthumuni; Sekhosana, Kutloano E; Nyokong, Tebello

Title: ‘There is nothing to hold onto here’:
Creator: Shabangu, Samuel M
Creator: Babu, Balaji
Creator: Soy, Rodah C
Creator: Managa, Muthumuni
Creator: Sekhosana, Kutloano E
Creator: Nyokong, Tebello
Date Issued: 2020
Date: 2020
Type: text
Type: article
Identifier: http://hdl.handle.net/10962/156410
Identifier: vital:39987
Identifier: DOI: 10.1080/00958972.2020.1739273
Description: Asymmetric mono-carboxy-porphyrins, (5-(4-carboxyphenyl)−10,15,20-tris(pentafluorophenyl)porphyrinato zinc(II) (1), 5-(4-carboxyphenyl)−10,15,20-triphenylporphyrinato zinc(II) (2) and 5-(4-carboxyphenyl)−10,15,20-tris(2-thienyl)porphyrinato zinc(II) (3), were linked to Ag nanoparticles (AgNPs) through amide bonds and self-assembly (the latter only for 3). The porphyrins and conjugates were used for photodynamic antimicrobial chemotherapy (PACT) against Staphylococcus aureus. PACT uses singlet oxygen for antimicrobial activity. Complex 3 and its conjugates had higher singlet oxygen quantum yields and higher log reduction when compared with the rest of the porphyrins and corresponding conjugates. These high log reductions for 3 and its conjugate were attributed to the presence of sulfur groups whereby there was more interaction with the bacterial membrane.
Format: 17 pages
Format: pdf
Language: English
Relation: Journal of Coordination Chemistry
Relation: Shabangu, S.M., Babu, B., Soy, R.C., Managa, M., Sekhosana, K.E. and Nyokong, T., 2020. Photodynamic antimicrobial chemotherapy of asymmetric porphyrin-silver conjugates towards photoinactivation of Staphylococcus aureus. Journal of Coordination Chemistry, 73(4), pp.593-608.
Relation: Journal of Coordination Chemistry volume 73 number 4 593 603 2020 1029-0389
Rights: Publisher
Rights: Use of this resource is governed by the terms and conditions of the Taylor and Francis Online Terms and Conditions Statement (https://www.tandfonline.com/terms-and-conditions)

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Nyokong, Tebello (Distinguished Professor)

RU DST/NRF SARChI for Medicinal Chemistry and Nanotechnology

RU Department of Chemistry

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