- Title
- Application of quality by design principles for optimizing process variables of Extrusion and Spheronization of a Captopril Pellet Formulation:
- Creator
- Veerubhotla, Krishna
- Creator
- Walker, Roderick B
- Date Issued
- 2020
- Date
- 2020
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/178312
- Identifier
- vital:40098
- Identifier
- DOI: 10.36468/pharmaceutical-sciences.624
- Description
- Product development using quality by design is a proactive and risk-based approach that shifts the manufacturing process from empirical to science-based. Risk assessment was performed to identify and analyse risk areas for the manufacture of captopril pellets. Twelve experimental runs were performed using a Plackett-Burman screening design. Pareto plots revealed the effect of formulation and process variables on the responses monitored and facilitated the identification of the most critical parameters for optimization of the formulation. A response surface methodology approach in conjunction with a central composite design was used to optimize the Eudragit® RL 30D (15-30 ml), microcrystalline cellulose (20-40 % w/w), sodium starch glycolate (2-5 % w/w) and spheronizer speed (650-1050 rpm).
- Format
- 9 pages
- Format
- Language
- English
- Relation
- Indian Journal of Pharmaceutical Sciences
- Relation
- Veerubhotla, K. and Walker, R.B., 2020. Application of quality by design principles for optimizing process variables of Extrusion and Spheronization of a Captopril Pellet Formulation. Indian Journal of Pharmaceutical Sciences, 82(1), pp.76-84
- Relation
- Indian Journal of Pharmaceutical Sciences volume 82 number 1 76 84 2020 1998-3743
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the SpringerLink Terms of Use Statement ( https://link.springer.com/termsandconditions)
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Collections
Walker, Roderick Bryan (Prof)
RU Department of Pharmacy
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