- Title
- Non-aggregated lipophilic water-soluble tin porphyrins as photosensitizers for photodynamic therapy and photodynamic antimicrobial chemotherapy:
- Creator
- Babu, Balaji
- Creator
- Soy, Rodah C
- Creator
- Mack, John
- Creator
- Nyokong, Tebello
- Date Issued
- 2020
- Date
- 2020
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/158241
- Identifier
- vital:40165
- Identifier
- DOI: 10.1039/d0nj01564d
- Description
- Two readily synthesized water-soluble Sn(IV) porphyrins have been prepared with quaternized pyridyl nitrogens and 2-naphthalato trans-axial ligands. Methyl and hexyl groups were attached to the quaternized nitrogens to form lipophilic dyes with high singlet oxygen quantum yields (ca. 0.90) and unusually long triplet state lifetimes. The dyes exhibit good photodynamic activity against MCF-7 cells with IC50 values of 14.3 and 8.5 μM, respectively. The hexyl quaternized dye exhibited a 9.69 log reduction value (0.5 μM) towards S. aureus under illumination for 90 min (250 mW cm−2). The results demonstrate that this set of structural modification strategies for photosensitizer dyes merits further in depth study.
- Format
- 7 pages
- Format
- Language
- English
- Relation
- New Journal of Chemistry
- Relation
- Babu, B., Soy, R.C., Mack, J. and Nyokong, T., 2020. Non-aggregated lipophilic water-soluble tin porphyrins as photosensitizers for photodynamic therapy and photodynamic antimicrobial chemotherapy. New Journal of Chemistry, 44(26), pp.11006-11012.
- Relation
- New Journal of Chemistry volume 44 number 26 11006 11012 June 2020 1369-9261
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the Royal Society of Chemistry Terms and Conditions Statement (https://0-www.rsc.org.wam.seals.ac.za/help-legal/)
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Collections
Mack, John (Associate Prof)
RU Centre for Nanotechnology Innovation
Nyokong, Tebello (Distinguished Professor)
RU DST/NRF SARChI for Medicinal Chemistry and Nanotechnology
RU Department of Chemistry
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