In vitro Anti-trypanosomal activities of indanone-based chalcones:

Beteck, Richard M; Legoabe, Lesetje J; Isaacs, Michelle; Hoppe, Heinrich C

Title: In vitro Anti-trypanosomal activities of indanone-based chalcones:
Creator: Beteck, Richard M
Creator: Legoabe, Lesetje J
Creator: Isaacs, Michelle
Creator: Hoppe, Heinrich C
Date Issued: 2019
Date: 2019
Type: text
Type: article
Identifier: http://hdl.handle.net/10962/158280
Identifier: vital:40169
Identifier: https://doi.org/10.3354/meps12953
Description: Human African trypanosomiasis is a neglected infectious disease that affects mostly people living in the rural areas of Africa. Current treatment options are limited to just four drugs that have been in use of four to nine decades. The life-threatening toxic side-effects associated with the use of these drugs are disconcerting. Poor efficacy, low oral bioavailability, and high cost are other shortcomings of current HAT treatments. Evaluating the potentials of known hits for other therapeutic areas may be a fast and convenient method to discover new hit compounds against alternative targets. A library of 34 known indanone based chalcones was screened against T.b. brucei and nine potent hits, having IC50 values between 0.5–8.9 µM, were found. The SAR studies of this series could provide useful information in guiding future exploration of this class of compounds in search of more potent, safe, and low cost anti-trypanosomal agents.
Format: 14 pages
Format: pdf
Language: English
Relation: Marine Ecology Progress Series
Relation: Maggs, J.Q., Cowley, P.D., Porter, S.N. and Childs, A.R., 2019. Should I stay or should I go? Intra-population variability in movement behaviour of wide-ranging and resident coastal fishes. Marine Ecology Progress Series, 619, pp.111-124
Relation: Marine Ecology Progress Series volume 619 number 111 124 2019 1616-1599
Rights: Publisher
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RU Department of Biochemistry, Microbiology and Biotechnology

Isaacs, Michelle (Mrs)

RU Centre for Chemico- and Biomedicinal Research (CCBR)

Hoppe, Heinrich C (Prof)

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