Allosteric Modulation of Human Hsp90α Conformational Dynamics:

Penkler, David L; Atilgan, Canan; Tastan Bishop, Özlem

Title: Allosteric Modulation of Human Hsp90α Conformational Dynamics:
Creator: Penkler, David L
Creator: Atilgan, Canan
Creator: Tastan Bishop, Özlem
Date Issued: 2018
Date: 2018
Type: text
Type: article
Identifier: http://hdl.handle.net/10962/162936
Identifier: vital:40998
Identifier: https://doi.org/10.1021/acs.jcim.7b00630
Description: Central to Hsp90’s biological function is its ability to interconvert between various conformational states. Drug targeting of Hsp90’s regulatory mechanisms, including its modulation by cochaperone association, presents as an attractive therapeutic strategy for Hsp90 associated pathologies. In this study, we utilized homology modeling techniques to calculate full-length structures of human Hsp90α in closed and partially open conformations and used these structures as a basis for several molecular dynamics based analyses aimed at elucidating allosteric mechanisms and modulation sites in human Hsp90α.
Format: 23 page
Format: pdf
Language: English
Relation: Journal of Chemical Information and Modeling
Relation: Penkler, D.L., Atilgan, C. and Tastan Bishop, O., 2018. Allosteric Modulation of Human Hsp90α Conformational Dynamics. Journal of Chemical Information and Modeling, 58(2), pp.383-404
Relation: Journal of Chemical Information and Modeling volume 58 number 2 383 404 January 2018 1549-960X
Rights: Publisher
Rights: Use of this resource is governed by the terms and conditions of the ACS Publications Terms of Use Statement (https://0-www.acs.org.wam.seals.ac.za/content/acs/en/terms.html)

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Tastan Bishop, Ozlem (Prof)

RU Research Unit in Bioinformatics (RUBi)

RU Department of Biochemistry, Microbiology and Biotechnology

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