Regulation of the extracellular matrix by heat shock proteins and molecular chaperones:

Boel, Natasha M-E; Edkins, Adrienne L

Title: Regulation of the extracellular matrix by heat shock proteins and molecular chaperones:
Creator: Boel, Natasha M-E
Creator: Edkins, Adrienne L
Date Issued: 2018
Date: 2018
Type: text
Type: book
Identifier: http://hdl.handle.net/10962/164368
Identifier: vital:41112
Identifier: ISBN 978-3-319-69040-7
Identifier: DOI: 10.1007/978-3-319-69042-1_6
Description: The extracellular matrix (ECM) serves as a scaffold for cells within tissues and is composed of an intricate network of glycoproteins, growth factors and matricellular proteins which cooperatively function in cell processes such as migration, adhesion and wound healing. ECM morphology is constantly undergoing remodelling (synthesis, assembly and degradation) during normal cell processes and when deregulated may contribute to disease. Heat shock proteins (Hsps) are involved in regulating processes that determine the assembly and degradation of the ECM at multiple levels, in both normal and diseased states. These roles include mediating the activation of ECM-degrading enzymes, maintaining matrix stability and clearing aggregated/misfolded proteins. Hsp may serve as chaperones and receptors or have cytokine-like functions. In this chapter, we review how Hsp90, Hsp70, Hsp40 and a number of ER resident chaperones contribute to ECM regulation. The role of the non-Hsp chaperones, SPARC and clusterin in the ECM is also discussed.
Format: 26 pages
Format: pdf
Publisher: Springer
Language: English
Relation: Boel, N.M.E. and Edkins, A.L., 2018. Regulation of the extracellular matrix by heat shock proteins and molecular chaperones. In Heat Shock Proteins in the Immune System (pp. 97-121). Springer, Cham
Rights: Publisher
Rights: Use of this resource is governed by the terms and conditions of the SpringerLink Terms of Use Statement ( https://link.springer.com/termsandconditions)

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RU DST/NRF SARChI for Molecular and Cellular Biology of the Eukaryotic Stress Response

RU Department of Biochemistry, Microbiology and Biotechnology

Edkins, Adrienne Lesley (Associate Prof)

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