Hsp90 binds directly to fibronectin (FN) and inhibition reduces the extracellular fibronectin matrix in breast cancer cells:

Title: Hsp90 binds directly to fibronectin (FN) and inhibition reduces the extracellular fibronectin matrix in breast cancer cells:
Creator: Hunter, Morgan C
Creator: O’Hagan, Kyle L
Creator: Kenyon, Amy
Creator: Dhanani, Karim C H
Creator: Prinsloo, Earl
Creator: Edkins, Adrienne L
Date Issued: 2014
Date: 2014
Type: text
Type: article
Identifier: http://hdl.handle.net/10962/164841
Identifier: vital:41177
Identifier: DOI: 10.1371/journal.pone.0086842
Description: Heat shock protein 90 (Hsp90) has been identified in the extracellular space and has been shown to chaperone a finite number of extracellular proteins involved in cell migration and invasion. We used chemical cross-linking and immunoprecipitation followed by tandem mass spectrometry (MS/MS) to isolate a complex containing Hsp90 and the matrix protein fibronectin (FN) from breast cancer cells.
Format: 18 pages
Format: pdf
Language: English
Relation: PloS one
Relation: Hunter, M.C., O’Hagan, K.L., Kenyon, A., Dhanani, K.C., Prinsloo, E. and Edkins, A.L., 2014. Hsp90 binds directly to fibronectin (FN) and inhibition reduces the extracellular fibronectin matrix in breast cancer cells. PloS one, 9(1), p.e86842
Relation: PloS one volume 9 number 1 1 17 January 2014 1932-6203
Rights: Publisher
Rights: Use of this resource is governed by the terms and conditions of the PLOSOne Terms of Use Statement (https://www.plos.org/terms-of-use )

Collections

Prinsloo, Earl (Dr)

RU DST/NRF SARChI for Molecular and Cellular Biology of the Eukaryotic Stress Response

Edkins, Adrienne Lesley (Associate Prof)

SDG 09. Industry, Innovation and Infrastructure

RU Department of Biochemistry, Microbiology and Bioinformatics

SDG 03. Good Health and Well-Being

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