- Title
- Targeting conserved pathways as a strategy for novel drug development: disabling the cellular stress response:
- Creator
- Edkins, Adrienne L
- Creator
- Blatch, Gregory L
- Date Issued
- 2012
- Date
- 2012
- Type
- text
- Type
- book
- Identifier
- http://hdl.handle.net/10962/165129
- Identifier
- vital:41211
- Identifier
- ISBN 978-3-642-28174-7
- Identifier
- DOI: 10.1007/978-3-642-28175-4_4
- Description
- The ability to respond to and cope with stress at a molecular level is essential for cell survival. The stress response is conserved across organisms by the expression of a group of molecular chaperones known as heat shock proteins (HSP). HSP are ubiquitous and highly conserved proteins that regulate cellular protein homeostasis and trafficking under physiological and stressful conditions, including diseases such as cancer and malaria. HSP are good drug targets for the treatment of human diseases, as the significant functional and structural data available suggest that they are essential for cell survival and that, despite conservation across species, there are biophysical and biochemical differences between HSP in normal and disease states that allow HSP to be selectively targeted. In this chapter, we review the international status of this area of research and highlight progress by us and other African researchers towards the characterisation and targeting of HSP from humans and parasites from Plasmodium and Trypanosoma as drug targets.
- Format
- 15 pages
- Format
- Publisher
- Springer
- Language
- English
- Relation
- Edkins, A.L. and Blatch, G.L., 2012. Targeting conserved pathways as a strategy for novel drug development: disabling the cellular stress response. In Drug Discovery in Africa (pp. 85-99). Springer, Berlin, Heidelberg
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the SpringerLink Terms of Use Statement ( https://link.springer.com/termsandconditions)
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Blatch, Gregory Lloyd (Prof)
Edkins, Adrienne Lesley (Associate Prof)
RU Department of Biochemistry, Microbiology and Biotechnology
RU Books and Book Chapters
| Thumbnail | File | Description | Size | Format | |||
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| View Details Download | SOURCE1 | Targeting conserved pathways as a.pdf | 571 KB | Adobe Acrobat PDF | View Details Download |