- Title
- Repurposing a polymer precursor: Synthesis and in vitro medicinal potential of ferrocenyl 1, 3-benzoxazine derivatives
- Creator
- Mbaba, Mziyanda
- Creator
- Dingle, Laura M K
- Creator
- Cash, Devon
- Creator
- de la Mare, Jo-Anne
- Creator
- Laming, Dustin
- Creator
- Taylor, Dale
- Creator
- Hoppe, Heinrich C
- Creator
- Edkins, Adrienne L
- Creator
- Khanye, Setshaba D
- Date Issued
- 2020
- Date
- 2020
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/165395
- Identifier
- vital:41240
- Identifier
- https://doi.org/10.1016/j.ejmech.2019.111924
- Description
- Cancer and malaria remain relevant pathologies in modern medicinal chemistry endeavours. This is compounded by the threat of development of resistance to existing clinical drugs in use as first-line option for treatment of these diseases. To counter this threat, strategies such as drug repurposing and hybridization are constantly adapted in contemporary drug discovery for the expansion of the drug arsenal and generation of novel chemotypes with potential to avert or delay resistance. In the present study, a polymer precursor scaffold, 1,3-benzoxazine, has been repurposed by incorporation of an organometallic ferrocene unit to produce a novel class of compounds showing in vitro biological activity against breast cancer, malaria and trypanosomiasis.
- Format
- 16 pages
- Format
- Language
- English
- Relation
- European Journal of Medicinal Chemistry
- Relation
- Mbaba, M., Dingle, L.M., Cash, D., de la Mare, J.A., Laming, D., Taylor, D., Hoppe, H.C., Edkins, A.L. and Khanye, S.D., 2020. Repurposing a polymer precursor: Synthesis and in vitro medicinal potential of ferrocenyl 1, 3-benzoxazine derivatives. European Journal of Medicinal Chemistry, 187, p.111924
- Relation
- European Journal of Medicinal Chemistry volume 187 number 1 15 February 2020 0223-5234
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the Elsevier Terms and Conditions Statement (https://www.elsevier.com/legal/elsevier-website-terms-and-conditions)
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Collections
RU DST/NRF SARChI for Molecular and Cellular Biology of the Eukaryotic Stress Response
RU Department of Biochemistry, Microbiology and Biotechnology
De la Mare, Jo-Anne (Dr)
Hoppe, Heinrich C (Prof)
Edkins, Adrienne Lesley (Associate Prof)
Khanye, David Setshaba (Associate Prof)
RU Department of Chemistry
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | SOURCE1 | Repurposing a polymer precursor.pdf | 671 KB | Adobe Acrobat PDF | View Details Download |