- Title
- Probing the binding sites of novel 2-substituted imidazole-4,5-dicarboxylic acids : Towards new imidazole-based drugs
- Creator
- Clark, Candyce Raine
- Subject
- Heterocyclic compounds Coordination compounds
- Date Issued
- 2021
- Date
- 2021
- Type
- Thesis
- Type
- Doctoral
- Type
- PhD
- Identifier
- http://hdl.handle.net/10948/50848
- Identifier
- vital:42957
- Description
- A series of benzimidazole and imidazole-4,5-dicarboxylic acids were prepared using known and adapted protocols. Novel ligands synthesised in this study include 2-tert-butyl-benzimidazole, 2-tert-butyl-imidazole-4,5-dicarboxylic acid, an intermediate in the synthesis of 1,2- bis(2-benzimidazyl)-1,2,-dihydroxyethane and 2-(2-hydroxyphenyl)-benzimidazole with a salicylic acid co-crystallisate. All ligands prepared were reacted with metal salt solutions in order to prepare metal coordination compounds. Complexes with Cu(II), Ag(I), Mn(II), Ni(II) and Cd(II) ions and 2-phenyl-imidazole-4,5-dicarboxylic acid were prepared, as well as Cu(II) and Mn(II) with 2-trifluoro-methyl-imidazole-4,5-dicarboxylic acid and Cu(II) ions with 2-(2- hydroxyphenyl)-benzimidazole. The ligands and complexes were characterised by means of single-crystal X-ray diffraction studies, NMR analysis, UV spectrophotometric analysis and IR spectroscopy. DFT studies were carried out for selected ligands in order to provide theoretical values for comparison. Antimicrobial studies were performed on some of the ligands and complexes and these results show promise for the future development of new imidazole-based drugs.
- Format
- xvi, 208 leaves
- Format
- Publisher
- Nelson Mandela Metropolitan University
- Publisher
- Faculty of Science
- Language
- English
- Rights
- Nelson Mandela Metropolitan University
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NMU School of BioMolecular and Chemical Sciences
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | SOURCE1 | Clark.pdf | 4 MB | Adobe Acrobat PDF | View Details Download |