Cyanide-induced free radical production and lipid peroxidation in rat brain homogenate is reduced by aspirin

Daya, Santylal; Anoopkumar-Dukie, Shailendra

Title: Cyanide-induced free radical production and lipid peroxidation in rat brain homogenate is reduced by aspirin
Creator: Daya, Santylal
Creator: Walker, Roderick B
Creator: Anoopkumar-Dukie, Shailendra
Subject: To be catalogued
Date Issued: 2000
Date: 2000
Type: text
Type: article
Identifier: http://hdl.handle.net/10962/184346
Identifier: vital:44210
Identifier: xlink:href="https://doi.org/10.1007/BF02674529"
Description: The neuroprotective properties of aspirin were investigated using cyanide-induced neurotoxicity as model. Cyanide, a known neurotoxic agent significantly increased lipid peroxidation and superoxide anion levels in rat brain homogenate in a concentration-dependent manner (0.25–1.0 mM). When homogenate, containing 1.0 mM KCN was cotreated with aspirin (1.0 mM) there was a significant decrease in lipid peroxidation. Aspirin (0.5 mM and 1.0 mM) also significantly reduced KCN-induced superoxide anion generation. The results of the present report therefore indicate a neuroprotective role for aspirin.
Format: computer
Format: online resource
Format: application/pdf
Format: 1 online resource (8 pages)
Format: pdf
Publisher: SpringerLink
Language: English
Relation: Metabolic Brain Disease
Relation: Daya, S., Walker, R.B. and Anoopkumar-Dukie, S., 2000. Cyanide-induced free radical production and lipid peroxidation in rat brain homogenate is reduced by aspirin. Metabolic Brain Disease, 15(3), pp.203-210
Relation: Metabolic Brain Disease volume 15 number 3 p.203 2000 1573-7365
Rights: Publisher
Rights: Use of this resource is governed by the terms and conditions of the SpringerLink Terms of Use Statement ( https://link.springer.com/termsandconditions)
Rights: Open Access

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Daya, Santylal (Prof)

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RU Department of Pharmacy

SDG 03. Good Health and Well-Being

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