- Title
- Melatonin alters the photodegradation of paracetamol
- Creator
- Anoopkumar-Dukie, Shailendra
- Creator
- Glass, Beverley D
- Creator
- Walker, Roderick B
- Creator
- Daya, Santylal
- Subject
- To be catalogued
- Date Issued
- 2000
- Date
- 2000
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/184357
- Identifier
- vital:44211
- Identifier
- xlink:href="https://doi.org/10.1211/146080800128735755"
- Description
- The effects of melatonin, a known free-radical scavenger, on paracetamol in the presence of UV irradiation was studied by use of HPLC. The experiments were performed in air and nitrogen. The results show that the rate of photodegradation of melatonin is faster in air than in nitrogen whereas that of paracetamol is similar in air and nitrogen. When the two drugs were combined, melatonin retarded the degradation of paracetamol for up to 6h in the presence of nitrogen. However, in the presence of air melatonin rapidly enhances the photodegradation of paracetamol. This study shows that a combination of melatonin and paracetamol in the presence of air and UV irradiation can lead to rapid inactivation of both agents, thus raising important concerns about the possible use of melatonin as sunscreen
- Format
- computer
- Format
- online resource
- Format
- application/pdf
- Format
- 1 online resource (3 pages)
- Format
- Publisher
- Wiley Library Online
- Language
- English
- Relation
- Pharmacy and Pharmacology Communications
- Relation
- Anoopkumar‐Dukie, S., Glass, B.D., Walker, R.B. and Daya, S., 2000. Melatonin alters the photodegradation of paracetamol. Pharmacy and Pharmacology Communications, 6(3), pp.125-127
- Relation
- Pharmacy and Pharmacology Communications volume 6 number 3 p.125 2000 1460-8081
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the Wiley Library Online Terms of Use Statement (https://onlinelibrary.wiley.com/terms-and-conditions)
- Rights
- Closed Access
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Collections
Daya, Santylal (Prof)
Walker, Roderick Bryan (Prof)
RU Department of Pharmacy
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | SOURCE1 | Melatonin alters the photodegradation of paracetamol.pdf | 752 KB | Adobe Acrobat PDF | View Details Download |