- Title
- In vitro release of amoxycillin from lipophilic suppositories
- Creator
- Webster, Jessica A
- Creator
- Dowse, Roslind
- Creator
- Walker, Roderick B
- Subject
- To be catalogued
- Date Issued
- 1998
- Date
- 1998
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/184377
- Identifier
- vital:44213
- Identifier
- xlink:href="https://doi.org/10.3109/03639049809085636"
- Description
- The in vitro release characteristics of amoxycillin from different lipophilic suppository bases were investigated using the USP rotating basket method. Suppositories containing 250 mg amoxycillin were prepared in theobroma oil and in the semisynthetic bases Witepsol W35, Suppocire A32, Novata BD, and Novata 299. Both freshly prepared and 1-month-old suppositories were tested. Analysis of amoxycillin was performed using a validated high-performance liquid chromatographic (HPLC) technique. Release profiles differed significantly between bases, with the greatest amount of amoxycillin being released from both newly made and 1-month-old Novata BD bases (87.57 ± 8.18 and 99.66 ± 6.63%, respectively), and the lowest amount released from the newly manufactured theobroma suppositories (8.82 ± 0.75%) and the 1-month-old Suppocire A32 suppositories (7.78 ± 0.27%).
- Format
- computer
- Format
- online resource
- Format
- application/pdf
- Format
- 1 online resource (6 pages)
- Format
- Publisher
- Taylor and Francis Online
- Language
- English
- Relation
- Drug Development and Industrial Pharmacy
- Relation
- Webster, J.A., Dowse, R. and Walker, R.B., 1998. In vitro release of amoxycillin from lipophilic suppositories. Drug development and industrial pharmacy, 24(4), pp.395-399
- Relation
- Drug Development and Industrial Pharmacy volume 24 number 4 p.395 1998 1999-4907
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the Taylor and Francis Online Terms and Conditions Statement (https://www.tandfonline.com/terms-and-conditions)
- Rights
- Open Access
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Collections
Walker, Roderick Bryan (Prof)
RU Department of Pharmacy
Dowse, Ros (Emeritus Assoc Prof)
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | SOURCE1 | In vitro release of amoxycillin from lipophilic suppositories.pdf | 529 KB | Adobe Acrobat PDF | View Details Download |