- Title
- A heavy-atom-free π-extended N-confused porphyrin as a photosensitizer for photodynamic therapy
- Creator
- Babu, Balaji
- Creator
- Mack, John
- Creator
- Nyokong, Tebello
- Subject
- To be catalogued
- Date Issued
- 2021
- Date
- 2021
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/185909
- Identifier
- vital:44447
- Identifier
- xlink:href="https://doi.org/10.1039/d1nj00112d"
- Description
- The synthesis and characterization of a novel 1,3-diethyl-2-thiobarbituric-acid-substituted N-confused porphyrin (NCP-TB) is reported, along with a study of its photodynamic activity against MCF-7 cells using 530 (110 mW cm−2) and 660 nm (280 mW cm−2) Thorlabs light-emitting diodes for 30 min. The singlet oxygen quantum yield for NCP-TB is 0.38 compared to 0.23 for the parent unsubstituted N-confused porphyrin (NCP) due to the presence of a sulfur atom. NCP-TB exhibits enhanced PDT activity compared to NCP at both wavelengths. A significantly lower IC50 value of 5.2 μM was obtained at 530 nm (14.7 μM at 660 nm) despite a smaller light dose, due to a large red shift of the intense B band into the green region of the spectrum. 2′,7′-Dichlorofluorescein diacetate (DCFDA) assays demonstrate that there is intracellular generation of reactive oxygen species upon exposure to light.
- Format
- computer
- Format
- online resource
- Format
- application/pdf
- Format
- 1 online resource (5 pages)
- Format
- Publisher
- Royal Society of Chemistry
- Language
- English
- Relation
- New Journal of Chemistry
- Relation
- Babu, B., Mack, J. and Nyokong, T., 2021. A heavy-atom-free π-extended N-confused porphyrin as a photosensitizer for photodynamic therapy. New Journal of Chemistry, 45(12), pp.5654-5658
- Relation
- New Journal of Chemistry volume 45 number 12 p. 5654 2021 1369-9261
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the Royal Society of Chemistry Terms and Conditions Statement (https://0-www.rsc.org.wam.seals.ac.za/help-legal/)
- Rights
- Open Access
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- Downloads: 174
Collections
Mack, John (Associate Prof)
Nyokong, Tebello (Distinguished Professor)
RU DST/NRF SARChI for Medicinal Chemistry and Nanotechnology
RU Department of Chemistry
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