- Title
- Fabrication of asymmetrical morpholine phthalocyanines conjugated chitosan-polyacrylonitrile nanofibers for improved photodynamic antimicrobial chemotherapy activity
- Creator
- Sindelo, Azole
- Creator
- Mafukidze, Donovan M
- Creator
- Nyokong, Tebello
- Subject
- To be catalogued
- Date Issued
- 2022
- Date
- 2022
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/229873
- Identifier
- vital:49719
- Identifier
- xlink:href="https://doi.org/10.1016/j.pdpdt.2022.102760"
- Description
- The work is based on the synthesis and photodynamic antimicrobial chemotherapy (PACT) activities of neutral (1 and 2) and cationic (1Q and 2Q) morpholine substituted phthalocyanines. For applicability, these complexes were covalently linked to modified polyacrylonitrile (PAN) to form 1-PAN, 2-PAN, 1Q-PAN, and 2Q-PAN, respectively. Chitosan was conjugated to PAN (to form PAN-CS) which was then linked to the Pcs to form PAN-CS-1, PAN-CS-2, PAN-CS-1Q, and PAN-CS-2Q, respectively. Singlet oxygen quantum yields improved following the inclusion of chitosan. The PACT activities of the complexes alone and when anchored to both PAN and PAN-CS was evaluated against bacteria: S. aureus, E. coli and fungi C. albicans. Cationic phthalocyanine showed high efficacy values of >7 log reduction value for all microorganisms. These results translated into excellent bacterial colony reduction of >90% against both S. aureus and C. albicans after 1 h of photoirradiation on PAN-CS support.
- Format
- computer
- Format
- online resource
- Format
- application/pdf
- Format
- 1 online resource (14 pages)
- Format
- Publisher
- Elsevier
- Language
- English
- Relation
- Photodiagnosis and Photodynamic Therapy
- Relation
- Sindelo, A., Mafukidze, D.M. and Nyokong, T., 2022. Fabrication of asymmetrical morpholine phthalocyanines conjugated chitosan-polyacrylonitrile nanofibers for improved photodynamic antimicrobial chemotherapy activity. Photodiagnosis and Photodynamic Therapy, 38, pp.102760-102760
- Relation
- Photodiagnosis and Photodynamic Therapy volume 38 p. 102760 2022 1572-1000
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the Elsevier Terms and Conditions Statement (https://www.elsevier.com/legal/elsevier-website-terms-and-conditions)
- Rights
- Closed Access
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Nyokong, Tebello (Distinguished Professor)
RU DST/NRF SARChI for Medicinal Chemistry and Nanotechnology
RU Department of Chemistry
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | SOURCE1 | Fabrication of asymmetrical morpholine phthalocyanines conjugated chitosan-polyacrylonitrile nanofibers.pdf | 833 KB | Adobe Acrobat PDF | View Details Download |