- Title
- The effects of silica based nanoparticles on the photophysicochemical properties, in vitro dark viability and photodynamic therapy study of zinc monocarboxyphenoxy phthalocyanine
- Creator
- Oluwole, David O
- Creator
- Uddin, Imran
- Creator
- Prinsloo, Earl
- Creator
- Nyokong, Tebello
- Subject
- To be catalogued
- Date Issued
- 2016
- Date
- 2016
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/240371
- Identifier
- vital:50828
- Identifier
- xlink:href="https://doi.org/10.1016/j.jphotochem.2016.07.002"
- Description
- Aminopropyl triethoxysilane functionalized core SiO2 and core/shell ZnO/SiO2 nanoparticles (NP) were covalently linked to zinc monocarboxyphenoxy phthalocyanine (ZnMCPPc, complex 1) via amide bond formation. The photophysicochemical behavior, in vitro dark viability and photodynamic therapy (PDT) activity against human breast adenocarcinoma cell line (MCF-7 cells) of the conjugates were studied. The nanoconjugates showed enhanced photophysicochemical behavior as compared to complex 1 alone. Complex 1 showed higher dark toxicity against MCF-7 cells when compared to the conjugates. In the dark, complex 1 accounted for less than 50% viable cells at 28.6 μg/mL and 57.1 μg/mL compared to the conjugates which accounted for more than 50% cell viability at these concentrations. The in vitro dark viability and PDT activity of complex 1 was reduced in the presence of these nanoparticles.
- Format
- computer
- Format
- online resource
- Format
- application/pdf
- Format
- 1 online resource (11 pages)
- Format
- Publisher
- Elsevier
- Language
- English
- Relation
- Journal of Photochemistry and Photobiology A: Chemistry
- Relation
- Oluwole, D.O., Uddin, I., Prinsloo, E. and Nyokong, T., 2016. The effects of silica based nanoparticles on the photophysicochemical properties, in vitro dark viability and photodynamic therapy study of zinc monocarboxyphenoxy phthalocyanine. Journal of Photochemistry and Photobiology A: Chemistry, 329, pp.221-231
- Relation
- Journal of Photochemistry and Photobiology A: Chemistry volume 329 p. 221 2016 1010-6030
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the Elsevier Terms and Conditions Statement (https://www.elsevier.com/legal/elsevier-website-terms-and-conditions)
- Rights
- Closed Access
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Collections
Nyokong, Tebello (Distinguished Professor)
Prinsloo, Earl (Dr)
RU DST/NRF SARChI for Medicinal Chemistry and Nanotechnology
RU DST/NRF SARChI for Biotechnology Innovation and Engagement
RU Department of Chemistry
SDG 03. Good Health and Well-Being
SDG 09. Industry, Innovation and Infrastructure
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | SOURCE1 | The effects of silica based nanoparticles on the photophysicochemical properties.pdf | 743 KB | Adobe Acrobat PDF | View Details Download |