Determination of phenylpropanolamine in serum and urine by high performance liquid chromatography

Title: Determination of phenylpropanolamine in serum and urine by high performance liquid chromatography
Creator: Dowse, Roslind
Creator: Haigh, John M
Creator: Kanfer, Isadore
Date Issued: 1983
Date: 1983
Type: Article
Identifier: vital:6361
Identifier: http://hdl.handle.net/10962/d1006056
Description: A high-performance liquid chromatographic analysis of phenylpropanolamine in human serum and urine without prior derivatization is presented. Using direct UV detection the method is sufficiently sensitive to detect 25 ng of drug/ml of serum or urine; the coefficients of variation at 25 ng/ml and 500 ng/ml were 5.16 and 2.12, respectively, in serum. The method involves serum and urine extraction at a basic pH with chloroform, a single back-extraction, and chromatography on a reverse-phase column. Serum and urine data following administration of a single 150-mg sustained-release tablet of phenylpropanolamine hydrochloride in 6 healthy volunteers demonstrates the suitability of the analytical method.
Format: 3 pages
Format: pdf
Language: English
Relation: Dowse, R. and Haigh, J.M. and Kanfer, I. (1983) Determination of phenylpropanolamine in serum and urine by high performance liquid chromatography. Journal of Pharmaceutical Sciences, 72 (9). pp. 1018-1020. Available: http://dx.doi.org/10.1002/jps.2600720912

Collections

Kanfer, Isadore (Prof)

RU Department of Pharmacy

Dowse, Ros (Emeritus Assoc Prof)

Haigh, JM (Prof)

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