- Title
- Phenylpropanolamine hydrochloride
- Creator
- Kanfer, Isadore
- Creator
- Haigh, John M
- Creator
- Dowse, Roslind
- Date Issued
- 1983
- Date
- 1983
- Type
- Article
- Identifier
- vital:6385
- Identifier
- http://hdl.handle.net/10962/d1006306
- Description
- Phenylpropanolamine hydrochloride belongs to the sympathomimetic amine class of drugs and is structurally related to ephedrine hydrochloride. Its synthesis was first reported in 1910 and the first American patent was registered in 1939. The effects of phenylpropanolamine hydrochloride are largely the result of alpha-adrenergic agonist activity resulting from both direct stimulation of adrenergic receptors and release of neuronal norepinephrine. The principal adverse effect of phenylpropanolamine hydrochloride is dose-related hypertension and ventricular arrhythmia has been described. Phenylpropanolamine hydrochloride is widely used as a decongestant and it has been used as an anorectic agent for over 40 years. A report in 1939 described its effect as an hypertensive agent when administered parenterally.
- Format
- 27 pages
- Format
- Language
- English
- Relation
- Kanfer, I. and Haigh, J.M. and Dowse, R. (1983) Phenylpropanolamine hydrochloride. Analytical Profiles of Drug Substances, 12 . pp. 357-383.
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Collections
Kanfer, Isadore (Prof)
RU Department of Pharmacy
Dowse, Ros (Emeritus Assoc Prof)
Haigh, JM (Prof)
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